JP2018521971A5 - - Google Patents
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- Publication number
- JP2018521971A5 JP2018521971A5 JP2017560505A JP2017560505A JP2018521971A5 JP 2018521971 A5 JP2018521971 A5 JP 2018521971A5 JP 2017560505 A JP2017560505 A JP 2017560505A JP 2017560505 A JP2017560505 A JP 2017560505A JP 2018521971 A5 JP2018521971 A5 JP 2018521971A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- receptor
- compound according
- serotonin
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 claims 52
- 150000001875 compounds Chemical class 0.000 claims 40
- 102000005962 receptors Human genes 0.000 claims 11
- 108020003175 receptors Proteins 0.000 claims 11
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229940076279 serotonin Drugs 0.000 claims 4
- 230000008484 agonism Effects 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 102000040125 5-hydroxytryptamine receptor family Human genes 0.000 claims 2
- 108091032151 5-hydroxytryptamine receptor family Proteins 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000002612 cardiopulmonary effect Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- -1 methyl compound Chemical class 0.000 claims 2
- 125000001624 naphthyl group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 108010074922 Cytochrome P-450 CYP1A2 Proteins 0.000 claims 1
- 108010026925 Cytochrome P-450 CYP2C19 Proteins 0.000 claims 1
- 108010000543 Cytochrome P-450 CYP2C9 Proteins 0.000 claims 1
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 claims 1
- 108010001202 Cytochrome P-450 CYP2E1 Proteins 0.000 claims 1
- 108010081668 Cytochrome P-450 CYP3A Proteins 0.000 claims 1
- 102100026533 Cytochrome P450 1A2 Human genes 0.000 claims 1
- 102100029363 Cytochrome P450 2C19 Human genes 0.000 claims 1
- 102100029358 Cytochrome P450 2C9 Human genes 0.000 claims 1
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 claims 1
- 102100024889 Cytochrome P450 2E1 Human genes 0.000 claims 1
- 102100039205 Cytochrome P450 3A4 Human genes 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical group C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 206010017943 Gastrointestinal conditions Diseases 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010022678 Intestinal infections Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 230000008485 antagonism Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 210000004556 brain Anatomy 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000009977 dual effect Effects 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 208000018578 heart valve disease Diseases 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000004031 partial agonist Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000002815 pulmonary hypertension Diseases 0.000 claims 1
- 229940075993 receptor modulator Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562163652P | 2015-05-19 | 2015-05-19 | |
| US62/163,652 | 2015-05-19 | ||
| PCT/US2016/033185 WO2016187377A1 (en) | 2015-05-19 | 2016-05-19 | Compounds and methods for modulating serotonin receptors in the periphery |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018521971A JP2018521971A (ja) | 2018-08-09 |
| JP2018521971A5 true JP2018521971A5 (https=) | 2019-06-27 |
| JP6888827B2 JP6888827B2 (ja) | 2021-06-16 |
Family
ID=57320754
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560505A Active JP6888827B2 (ja) | 2015-05-19 | 2016-05-19 | 末梢におけるセロトニン受容体をモジュレートするための化合物または方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10548856B2 (https=) |
| EP (1) | EP3297979B1 (https=) |
| JP (1) | JP6888827B2 (https=) |
| CN (1) | CN107614467A (https=) |
| BR (1) | BR112017024745A2 (https=) |
| CA (1) | CA3015750A1 (https=) |
| DK (1) | DK3297979T3 (https=) |
| WO (1) | WO2016187377A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102483492B1 (ko) * | 2019-09-02 | 2023-01-02 | 한양대학교 에리카산학협력단 | 2,5-이치환된 피리미딘 유도체 및 이를 포함하는 약학적 조성물 |
| EP4200287A4 (en) * | 2020-08-19 | 2024-12-18 | Northeastern University | SEROTONIN RECEPTOR MODULATORS |
| AU2022310353A1 (en) * | 2021-07-14 | 2024-02-01 | Northeastern University | Serotonin 5-ht2a, 5-ht2b, and 5-ht2c receptor inverse agonists |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9601110D0 (sv) * | 1996-03-22 | 1996-03-22 | Astra Ab | Substituted 1,2,3,4-tetrahydronaphthalene derivatives |
| WO2006105117A2 (en) * | 2005-03-28 | 2006-10-05 | Dynogen Pharmaceuticals, Inc. | Method of treating disorders and conditions using peripherally-restricted antagonists and inhibitors |
| EP2029566B1 (en) * | 2006-06-22 | 2011-04-27 | Ramot, at Tel Aviv University Ltd. | Novel serotonin reuptake inhibitors as drugs having peripheral-system-restricted activity |
| EP1956006A1 (en) * | 2007-02-06 | 2008-08-13 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted-tetrahydro-naphthalen derivatives as 5-HT7 receptor ligands |
| EP1975161A1 (en) * | 2007-03-28 | 2008-10-01 | Laboratorios del Dr. Esteve S.A. | Heterocyclyl-substituted- tetrahydro-napthalen-amine derivatives, their preparation and use as medicaments |
| EP2164324B1 (en) * | 2007-06-15 | 2014-08-13 | University Of Florida Research Foundation | Therapeutic compounds |
| WO2008154044A1 (en) * | 2007-06-15 | 2008-12-18 | University Of Florida Research Foundation | Therapeutic compounds and methods of use |
| WO2009061436A1 (en) * | 2007-11-06 | 2009-05-14 | University Of Florida Research Foundation | Compound for activating 5-ht2c receptors in combination with an amphetamine compound |
| JP5932636B2 (ja) | 2009-05-05 | 2016-06-08 | ユニバーシティ オブ フロリダ リサーチ ファウンデーション，インコーポレイテッド | 治療化合物 |
| BR112016027096B1 (pt) * | 2014-05-19 | 2023-04-11 | Northeastern University | Composições farmacêuticas e compostos de receptores-alvo de serotonina e seus usos |
-
2016
- 2016-05-19 CN CN201680028629.4A patent/CN107614467A/zh active Pending
- 2016-05-19 JP JP2017560505A patent/JP6888827B2/ja active Active
- 2016-05-19 BR BR112017024745A patent/BR112017024745A2/pt not_active Application Discontinuation
- 2016-05-19 CA CA3015750A patent/CA3015750A1/en active Pending
- 2016-05-19 DK DK16797266.0T patent/DK3297979T3/da active
- 2016-05-19 EP EP16797266.0A patent/EP3297979B1/en active Active
- 2016-05-19 WO PCT/US2016/033185 patent/WO2016187377A1/en not_active Ceased
- 2016-05-19 US US15/574,971 patent/US10548856B2/en active Active
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