JP2018048143A5 - - Google Patents
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- Publication number
- JP2018048143A5 JP2018048143A5 JP2017183651A JP2017183651A JP2018048143A5 JP 2018048143 A5 JP2018048143 A5 JP 2018048143A5 JP 2017183651 A JP2017183651 A JP 2017183651A JP 2017183651 A JP2017183651 A JP 2017183651A JP 2018048143 A5 JP2018048143 A5 JP 2018048143A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- group
- methyl
- urea
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014217540 | 2014-10-24 | ||
| JP2014217540 | 2014-10-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Division JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018048143A JP2018048143A (ja) | 2018-03-29 |
| JP2018048143A5 true JP2018048143A5 (https=) | 2018-11-15 |
| JP6627835B2 JP6627835B2 (ja) | 2020-01-08 |
Family
ID=55761020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Active JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
| JP2017183651A Expired - Fee Related JP6627835B2 (ja) | 2014-10-24 | 2017-09-25 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Active JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9809544B2 (https=) |
| EP (1) | EP3210969B1 (https=) |
| JP (2) | JP6217866B2 (https=) |
| KR (1) | KR20170076673A (https=) |
| CN (1) | CN107108485B (https=) |
| AU (1) | AU2015336458B2 (https=) |
| BR (1) | BR112017008178A2 (https=) |
| CA (1) | CA2965467A1 (https=) |
| ES (1) | ES2871673T3 (https=) |
| IL (1) | IL251827B (https=) |
| MX (1) | MX373603B (https=) |
| PH (1) | PH12017500737B1 (https=) |
| RU (1) | RU2712163C2 (https=) |
| SG (1) | SG11201703284XA (https=) |
| TW (1) | TWI664166B (https=) |
| WO (1) | WO2016063990A1 (https=) |
| ZA (1) | ZA201703498B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI664166B (zh) * | 2014-10-24 | 2019-07-01 | 日商小野藥品工業股份有限公司 | Ｋｃｎｑ２至５通道活化劑 |
| JP6943239B2 (ja) * | 2016-04-22 | 2021-09-29 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル活性化剤 |
| JP6197971B1 (ja) * | 2016-04-22 | 2017-09-20 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤 |
| JP6265313B1 (ja) * | 2016-04-22 | 2018-01-24 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル活性化剤の結晶多形 |
| KR102735800B1 (ko) * | 2017-12-21 | 2024-11-28 | 교린 세이야쿠 가부시키가이샤 | 야간빈뇨 치료제 |
| CN109232380B (zh) * | 2018-10-22 | 2021-08-10 | 新乡市润宇新材料科技有限公司 | 一种4-溴咔唑的合成方法 |
| CN109232383B (zh) * | 2018-12-04 | 2022-02-01 | 河南省科学院高新技术研究中心 | 一种合成4-溴咔唑的方法 |
| HRP20240012T1 (hr) * | 2019-02-06 | 2024-03-29 | Eli Lilly And Company | Derivati 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)uree kao kcnq potencijatori |
| AU2021295422A1 (en) * | 2020-06-25 | 2023-02-23 | Idorsia Pharmaceuticals Ltd | Cyclobutyl-urea derivatives |
| US20240300939A1 (en) * | 2021-06-14 | 2024-09-12 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH623044A5 (en) | 1974-12-02 | 1981-05-15 | Scherico Ltd | Process for the preparation of novel anilino-2-oxazolines |
| ES442992A1 (es) * | 1974-12-02 | 1977-08-01 | Scherico Ltd | Un procedimiento para preparar 2-anilino-oxazolinas. |
| US4058612A (en) * | 1974-12-02 | 1977-11-15 | Schering Corporation | 6-(Polyhaloisopropyl)quinazoline-2,4-diones |
| KR100637564B1 (ko) * | 2001-01-26 | 2006-10-20 | 추가이 세이야쿠 가부시키가이샤 | 대사 조절자로서 유용한 말로닐-코에이 데카르복실라제억제제 |
| ES2284817T3 (es) * | 2001-01-26 | 2007-11-16 | Chugai Seiyaku Kabushiki Kaisha | Procedimientos para el tratamiento de enfermedades con inhibidores de la malonil coa descarboxilasa. |
| WO2003055848A2 (en) | 2001-12-26 | 2003-07-10 | Bayer Healthcare Ag | Urea derivatives as vr1- antagonists |
| JP2003192660A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| ATE552236T1 (de) | 2003-01-14 | 2012-04-15 | Cytokinetics Inc | Verbindungen, zusammensetzungen und verfahren zur behandlung von herzinsuffizienz |
| UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| KR20080043314A (ko) | 2005-09-09 | 2008-05-16 | 하. 룬트벡 아크티에 셀스카브 | 피리미딘 유도체 및 ｋｃｎｑ 포타슘 채널 개방제로서의그의 용도 |
| AR070513A1 (es) * | 2007-08-01 | 2010-04-14 | Lundbeck & Co As H | Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sis-tema dopaminergico como por ejemplo esquizofrenia y trastorno depresivo mayor |
| JP2010037311A (ja) | 2008-08-08 | 2010-02-18 | Bayer Cropscience Ag | 新規殺虫性アシルアミノベンズアミド誘導体 |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| SG182285A1 (en) | 2010-01-11 | 2012-08-30 | Inotek Pharmaceuticals Corp | Combination, kit and method of reducing intraocular pressure |
| WO2011085351A2 (en) * | 2010-01-11 | 2011-07-14 | The Johns Hopkins University | Method of treating kcnq related disorders |
| JP2014521616A (ja) | 2011-07-26 | 2014-08-28 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | バニロイド受容体リガンドとしての置換ヘテロ芳香族ピラゾール含有カルボキサミドおよび尿素誘導体 |
| WO2013064450A1 (en) * | 2011-11-02 | 2013-05-10 | Boehringer Ingelheim International Gmbh | Heterocyclic compounds, medicaments containing said compounds, use thereof and processes for the preparation thereof |
| TWI664166B (zh) * | 2014-10-24 | 2019-07-01 | 日商小野藥品工業股份有限公司 | Ｋｃｎｑ２至５通道活化劑 |
-
2015
- 2015-10-23 TW TW104134839A patent/TWI664166B/zh not_active IP Right Cessation
- 2015-10-23 CA CA2965467A patent/CA2965467A1/en not_active Abandoned
- 2015-10-23 BR BR112017008178A patent/BR112017008178A2/pt not_active Application Discontinuation
- 2015-10-23 WO PCT/JP2015/080034 patent/WO2016063990A1/ja not_active Ceased
- 2015-10-23 KR KR1020177010846A patent/KR20170076673A/ko not_active Withdrawn
- 2015-10-23 JP JP2016555419A patent/JP6217866B2/ja active Active
- 2015-10-23 AU AU2015336458A patent/AU2015336458B2/en not_active Ceased
- 2015-10-23 US US15/515,243 patent/US9809544B2/en not_active Expired - Fee Related
- 2015-10-23 SG SG11201703284XA patent/SG11201703284XA/en unknown
- 2015-10-23 EP EP15852712.7A patent/EP3210969B1/en active Active
- 2015-10-23 RU RU2017117566A patent/RU2712163C2/ru active
- 2015-10-23 ES ES15852712T patent/ES2871673T3/es active Active
- 2015-10-23 MX MX2017005044A patent/MX373603B/es active IP Right Grant
- 2015-10-23 CN CN201580057252.0A patent/CN107108485B/zh not_active Expired - Fee Related
-
2017
- 2017-04-20 IL IL251827A patent/IL251827B/en active IP Right Grant
- 2017-04-21 PH PH12017500737A patent/PH12017500737B1/en unknown
- 2017-05-22 ZA ZA2017/03498A patent/ZA201703498B/en unknown
- 2017-08-08 US US15/671,428 patent/US10196358B2/en not_active Expired - Fee Related
- 2017-09-25 JP JP2017183651A patent/JP6627835B2/ja not_active Expired - Fee Related
-
2018
- 2018-08-09 US US16/059,270 patent/US10676438B2/en not_active Expired - Fee Related
-
2020
- 2020-01-24 US US16/752,076 patent/US20200157050A1/en not_active Abandoned
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