JP2018048143A5 - - Google Patents
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- Publication number
- JP2018048143A5 JP2018048143A5 JP2017183651A JP2017183651A JP2018048143A5 JP 2018048143 A5 JP2018048143 A5 JP 2018048143A5 JP 2017183651 A JP2017183651 A JP 2017183651A JP 2017183651 A JP2017183651 A JP 2017183651A JP 2018048143 A5 JP2018048143 A5 JP 2018048143A5
- Authority
- JP
- Japan
- Prior art keywords
- ring
- group
- methyl
- urea
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014217540 | 2014-10-24 | ||
| JP2014217540 | 2014-10-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Division JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018048143A JP2018048143A (ja) | 2018-03-29 |
| JP2018048143A5 true JP2018048143A5 (https=) | 2018-11-15 |
| JP6627835B2 JP6627835B2 (ja) | 2020-01-08 |
Family
ID=55761020
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Active JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
| JP2017183651A Expired - Fee Related JP6627835B2 (ja) | 2014-10-24 | 2017-09-25 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016555419A Active JP6217866B2 (ja) | 2014-10-24 | 2015-10-23 | Ｋｃｎｑ２〜５チャネル活性化剤 |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US9809544B2 (https=) |
| EP (1) | EP3210969B1 (https=) |
| JP (2) | JP6217866B2 (https=) |
| KR (1) | KR20170076673A (https=) |
| CN (1) | CN107108485B (https=) |
| AU (1) | AU2015336458B2 (https=) |
| BR (1) | BR112017008178A2 (https=) |
| CA (1) | CA2965467A1 (https=) |
| ES (1) | ES2871673T3 (https=) |
| IL (1) | IL251827B (https=) |
| MX (1) | MX373603B (https=) |
| PH (1) | PH12017500737B1 (https=) |
| RU (1) | RU2712163C2 (https=) |
| SG (1) | SG11201703284XA (https=) |
| TW (1) | TWI664166B (https=) |
| WO (1) | WO2016063990A1 (https=) |
| ZA (1) | ZA201703498B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2965467A1 (en) * | 2014-10-24 | 2016-04-28 | Ono Pharmaceutical Co., Ltd. | Kcnq2-5 channel activator |
| EP3447045B9 (en) * | 2016-04-22 | 2021-07-21 | ONO Pharmaceutical Co., Ltd. | 1-(1-hydroxy-2,3-dihydro-1h-inden-5-yl)-urea derivatives and related compounds kcnq 2-5 channel activators for treating dysuria |
| JP6197971B1 (ja) * | 2016-04-22 | 2017-09-20 | 小野薬品工業株式会社 | Ｋｃｎｑ２〜５チャネル関連疾患の予防および／または治療剤 |
| SG11201809184VA (en) * | 2016-04-22 | 2018-11-29 | Ono Pharmaceutical Co | Crystal polymorphism of kcnq2-5 channel activator |
| CA3085745A1 (en) * | 2017-12-21 | 2019-06-27 | Kyorin Pharmaceutical Co., Ltd. | An agent for treating nocturnal pollakiuria |
| CN109232380B (zh) * | 2018-10-22 | 2021-08-10 | 新乡市润宇新材料科技有限公司 | 一种4-溴咔唑的合成方法 |
| CN109232383B (zh) * | 2018-12-04 | 2022-02-01 | 河南省科学院高新技术研究中心 | 一种合成4-溴咔唑的方法 |
| HUE064734T2 (hu) | 2019-02-06 | 2024-04-28 | Lilly Co Eli | 1-((2-(2,2,2-trifluoretoxi)piridin-4-il)metil)karbamid származékok mint KCNQ potenciátorok |
| CA3183298A1 (en) * | 2020-06-25 | 2021-12-30 | Olivier Bezencon | Cyclobutyl-urea derivatives |
| WO2022265993A1 (en) * | 2021-06-14 | 2022-12-22 | Scorpion Therapeutics, Inc. | Urea derivatives which can be used to treat cancer |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH623044A5 (en) * | 1974-12-02 | 1981-05-15 | Scherico Ltd | Process for the preparation of novel anilino-2-oxazolines |
| US4058612A (en) * | 1974-12-02 | 1977-11-15 | Schering Corporation | 6-(Polyhaloisopropyl)quinazoline-2,4-diones |
| ES442992A1 (es) * | 1974-12-02 | 1977-08-01 | Scherico Ltd | Un procedimiento para preparar 2-anilino-oxazolinas. |
| AU2002236830A1 (en) * | 2001-01-26 | 2002-08-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for the treatment of diseases using malonyl-coa decarbox ylase inhibitors |
| ES2362270T3 (es) | 2001-01-26 | 2011-06-30 | Chugai Seiyaku Kabushiki Kaisha | Inhibidores de malonil-coa decarboxilasa útiles como moduladores metabólicos. |
| WO2003055848A2 (en) | 2001-12-26 | 2003-07-10 | Bayer Healthcare Ag | Urea derivatives as vr1- antagonists |
| JP2003192660A (ja) * | 2001-12-26 | 2003-07-09 | Bayer Ag | 尿素誘導体 |
| CA2511970C (en) | 2003-01-14 | 2012-06-26 | Cytokinetics, Inc. | Urea derivatives useful in the treatment of heart failure |
| UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| EP1937653A1 (en) | 2005-09-09 | 2008-07-02 | H.Lundbeck A/S | Pyrimidine derivatives and their use as kcnq potassium channels openers |
| CN101790374A (zh) | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
| JP2010037311A (ja) | 2008-08-08 | 2010-02-18 | Bayer Cropscience Ag | 新規殺虫性アシルアミノベンズアミド誘導体 |
| WO2010065333A1 (en) | 2008-12-01 | 2010-06-10 | Lexicon Pharmaceuticals, Inc. | 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds for the treatment of osteoporosis |
| TWI475020B (zh) * | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| LT2523669T (lt) | 2010-01-11 | 2017-04-25 | Inotek Pharmaceuticals Corporation | Akispūdžio mažinimo būdas, derinys ir rinkinys |
| WO2011085351A2 (en) | 2010-01-11 | 2011-07-14 | The Johns Hopkins University | Method of treating kcnq related disorders |
| HK1198697A1 (en) * | 2011-07-26 | 2015-05-29 | Grünenthal GmbH | Substituted heteroaromatic pyrazole-containing carboxamide and urea derivatives as vanilloid receptor ligands |
| KR102006612B1 (ko) * | 2011-11-02 | 2019-08-02 | 베링거 인겔하임 인터내셔날 게엠베하 | 헤테로사이클릭 화합물, 상기 화합물을 포함하는 약제, 이의 용도, 및 이의 제조 방법 |
| CA2965467A1 (en) * | 2014-10-24 | 2016-04-28 | Ono Pharmaceutical Co., Ltd. | Kcnq2-5 channel activator |
-
2015
- 2015-10-23 CA CA2965467A patent/CA2965467A1/en not_active Abandoned
- 2015-10-23 EP EP15852712.7A patent/EP3210969B1/en active Active
- 2015-10-23 RU RU2017117566A patent/RU2712163C2/ru active
- 2015-10-23 KR KR1020177010846A patent/KR20170076673A/ko not_active Withdrawn
- 2015-10-23 SG SG11201703284XA patent/SG11201703284XA/en unknown
- 2015-10-23 WO PCT/JP2015/080034 patent/WO2016063990A1/ja not_active Ceased
- 2015-10-23 US US15/515,243 patent/US9809544B2/en not_active Expired - Fee Related
- 2015-10-23 AU AU2015336458A patent/AU2015336458B2/en not_active Ceased
- 2015-10-23 TW TW104134839A patent/TWI664166B/zh not_active IP Right Cessation
- 2015-10-23 JP JP2016555419A patent/JP6217866B2/ja active Active
- 2015-10-23 ES ES15852712T patent/ES2871673T3/es active Active
- 2015-10-23 CN CN201580057252.0A patent/CN107108485B/zh not_active Expired - Fee Related
- 2015-10-23 BR BR112017008178A patent/BR112017008178A2/pt not_active Application Discontinuation
- 2015-10-23 MX MX2017005044A patent/MX373603B/es active IP Right Grant
-
2017
- 2017-04-20 IL IL251827A patent/IL251827B/en active IP Right Grant
- 2017-04-21 PH PH12017500737A patent/PH12017500737B1/en unknown
- 2017-05-22 ZA ZA2017/03498A patent/ZA201703498B/en unknown
- 2017-08-08 US US15/671,428 patent/US10196358B2/en not_active Expired - Fee Related
- 2017-09-25 JP JP2017183651A patent/JP6627835B2/ja not_active Expired - Fee Related
-
2018
- 2018-08-09 US US16/059,270 patent/US10676438B2/en not_active Expired - Fee Related
-
2020
- 2020-01-24 US US16/752,076 patent/US20200157050A1/en not_active Abandoned
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