JP6864621B2 - Ｄｎａコード化ライブラリーをタグ付けするための方法 - Google Patents
Ｄｎａコード化ライブラリーをタグ付けするための方法 Download PDFInfo
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- JP6864621B2 JP6864621B2 JP2017534592A JP2017534592A JP6864621B2 JP 6864621 B2 JP6864621 B2 JP 6864621B2 JP 2017534592 A JP2017534592 A JP 2017534592A JP 2017534592 A JP2017534592 A JP 2017534592A JP 6864621 B2 JP6864621 B2 JP 6864621B2
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- C07H1/00—Processes for the preparation of sugar derivatives
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
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- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
- C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps
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| US11384376B2 (en) * | 2018-05-31 | 2022-07-12 | Roche Molecular Systems, Inc. | Reagents and methods for post-synthetic modification of nucleic acids |
| CN110658163A (zh) * | 2018-06-29 | 2020-01-07 | 成都先导药物开发股份有限公司 | 一种合成dna编码化合物中的反应监测方法 |
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| WO2021115319A1 (zh) * | 2019-12-10 | 2021-06-17 | 成都先导药物开发股份有限公司 | 同时结合多个生物靶标的dna编码化合物库筛选方法 |
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| CN106337046B (zh) * | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
| JP5646127B2 (ja) * | 2003-12-17 | 2014-12-24 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ | コードされたライブラリーの合成のための方法 |
| US8846883B2 (en) * | 2011-08-16 | 2014-09-30 | University Of Southhampton | Oligonucleotide ligation |
| SG10201605812YA (en) * | 2011-09-07 | 2016-09-29 | Chem Inc X | Methods for tagging dna-encoded libraries |
| KR102146721B1 (ko) * | 2012-07-13 | 2020-08-21 | 엑스-켐, 인크. | 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리 |
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2015
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Also Published As
| Publication number | Publication date |
|---|---|
| EA201791312A1 (ru) | 2017-10-31 |
| EP3240795A1 (en) | 2017-11-08 |
| IL278117A (en) | 2020-11-30 |
| AU2015374309A1 (en) | 2017-07-27 |
| JP2018501796A (ja) | 2018-01-25 |
| CA2972275A1 (en) | 2016-07-07 |
| AU2015374309B2 (en) | 2020-06-11 |
| AU2020230345A1 (en) | 2020-10-01 |
| HK1246301A1 (zh) | 2018-09-07 |
| IL253154A0 (en) | 2017-08-31 |
| CN107428795B (zh) | 2021-06-18 |
| EP3240795A4 (en) | 2019-02-13 |
| MX2017008772A (es) | 2018-03-15 |
| US20180002688A1 (en) | 2018-01-04 |
| BR112017013904A2 (pt) | 2018-01-02 |
| SG11201705350XA (en) | 2017-08-30 |
| MA41298A (fr) | 2017-11-07 |
| KR20170094445A (ko) | 2017-08-17 |
| WO2016109423A1 (en) | 2016-07-07 |
| IL253154B (en) | 2020-10-29 |
| CN107428795A (zh) | 2017-12-01 |
| WO2016109423A8 (en) | 2017-07-20 |
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