KR20170094445A - Dna-코딩된 라이브러리에 태그부착하는 방법 - Google Patents

Dna-코딩된 라이브러리에 태그부착하는 방법 Download PDF

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Publication number
KR20170094445A
KR20170094445A KR1020177019616A KR20177019616A KR20170094445A KR 20170094445 A KR20170094445 A KR 20170094445A KR 1020177019616 A KR1020177019616 A KR 1020177019616A KR 20177019616 A KR20177019616 A KR 20177019616A KR 20170094445 A KR20170094445 A KR 20170094445A
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South Korea
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headpiece
nucleotides
ligation
chemical
oligonucleotide
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English (en)
Korean (ko)
Inventor
앤서니 디. 키프
알렉산더 리토브치크
매튜 클락
리차드 더블유. 와그너
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엑스-켐, 인크.
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Publication of KR20170094445A publication Critical patent/KR20170094445A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Structural Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020177019616A 2014-12-30 2015-12-28 Dna-코딩된 라이브러리에 태그부착하는 방법 Withdrawn KR20170094445A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462098037P 2014-12-30 2014-12-30
US62/098,037 2014-12-30
PCT/US2015/067667 WO2016109423A1 (en) 2014-12-30 2015-12-28 Methods for tagging dna-encoded libraries

Publications (1)

Publication Number Publication Date
KR20170094445A true KR20170094445A (ko) 2017-08-17

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Family Applications (1)

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KR1020177019616A Withdrawn KR20170094445A (ko) 2014-12-30 2015-12-28 Dna-코딩된 라이브러리에 태그부착하는 방법

Country Status (15)

Country Link
US (1) US20180002688A1 (enExample)
EP (1) EP3240795A4 (enExample)
JP (1) JP6864621B2 (enExample)
KR (1) KR20170094445A (enExample)
CN (1) CN107428795B (enExample)
AU (2) AU2015374309B2 (enExample)
BR (1) BR112017013904A2 (enExample)
CA (1) CA2972275A1 (enExample)
EA (1) EA201791312A1 (enExample)
HK (1) HK1246301A1 (enExample)
IL (2) IL253154B (enExample)
MA (1) MA41298A (enExample)
MX (1) MX2017008772A (enExample)
SG (1) SG11201705350XA (enExample)
WO (1) WO2016109423A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
WO2018195134A1 (en) * 2017-04-18 2018-10-25 X-Chem, Inc. Methods for identifying compounds
WO2018204420A1 (en) 2017-05-02 2018-11-08 Haystack Sciences Corporation Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same
US11384376B2 (en) * 2018-05-31 2022-07-12 Roche Molecular Systems, Inc. Reagents and methods for post-synthetic modification of nucleic acids
CN110658163A (zh) * 2018-06-29 2020-01-07 成都先导药物开发股份有限公司 一种合成dna编码化合物中的反应监测方法
CN109468310B (zh) * 2018-10-25 2020-12-01 深圳劲宇生物科技有限公司 Dna编码碎片分子库的合成方法和连接基团的筛选方法
JP7646212B2 (ja) * 2019-03-14 2025-03-17 ヘイスタック サイエンシーズ コーポレイション オリゴヌクレオチドコード化分子を加工または分析する方法および系
WO2021115319A1 (zh) * 2019-12-10 2021-06-17 成都先导药物开发股份有限公司 同时结合多个生物靶标的dna编码化合物库筛选方法
EP4240863A4 (en) * 2020-11-06 2025-03-12 The University of Chicago HAIRPIN OLIGONUCLEOTIDES AND THEIR USES
WO2025053257A1 (ja) * 2023-09-07 2025-03-13 旭化成ファーマ株式会社 オリゴヌクレオチドによりコード化された化合物の製造方法、およびその応用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996038726A1 (en) * 1995-05-30 1996-12-05 Ecole Polytechnique Federale De Lausanne (Epfl) Covalently immobilized phospholipid bilayers on solid surfaces
CN106337046B (zh) * 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
JP5646127B2 (ja) * 2003-12-17 2014-12-24 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ コードされたライブラリーの合成のための方法
US8846883B2 (en) * 2011-08-16 2014-09-30 University Of Southhampton Oligonucleotide ligation
SG10201605812YA (en) * 2011-09-07 2016-09-29 Chem Inc X Methods for tagging dna-encoded libraries
KR102146721B1 (ko) * 2012-07-13 2020-08-21 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리

Also Published As

Publication number Publication date
EA201791312A1 (ru) 2017-10-31
EP3240795A1 (en) 2017-11-08
IL278117A (en) 2020-11-30
JP6864621B2 (ja) 2021-04-28
AU2015374309A1 (en) 2017-07-27
JP2018501796A (ja) 2018-01-25
CA2972275A1 (en) 2016-07-07
AU2015374309B2 (en) 2020-06-11
AU2020230345A1 (en) 2020-10-01
HK1246301A1 (zh) 2018-09-07
IL253154A0 (en) 2017-08-31
CN107428795B (zh) 2021-06-18
EP3240795A4 (en) 2019-02-13
MX2017008772A (es) 2018-03-15
US20180002688A1 (en) 2018-01-04
BR112017013904A2 (pt) 2018-01-02
SG11201705350XA (en) 2017-08-30
MA41298A (fr) 2017-11-07
WO2016109423A1 (en) 2016-07-07
IL253154B (en) 2020-10-29
CN107428795A (zh) 2017-12-01
WO2016109423A8 (en) 2017-07-20

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Patent event date: 20201224

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