JP6862348B2 - アルブミン融合タンパク質を精製する方法 - Google Patents

アルブミン融合タンパク質を精製する方法 Download PDF

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JP6862348B2
JP6862348B2 JP2017548053A JP2017548053A JP6862348B2 JP 6862348 B2 JP6862348 B2 JP 6862348B2 JP 2017548053 A JP2017548053 A JP 2017548053A JP 2017548053 A JP2017548053 A JP 2017548053A JP 6862348 B2 JP6862348 B2 JP 6862348B2
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JP2018513124A (ja
JP2018513124A5 (enExample
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パブスト，ティモシー
フォンセカ，マリコ
トンプソン，クリストファー
ハンター，アラン
ワン，シアンヤン
ティエ，リウ
リー，イミン
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メディミューン，エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643—Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017548053A 2015-03-12 2016-03-11 アルブミン融合タンパク質を精製する方法 Active JP6862348B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021061713A JP7320550B2 (ja) 2015-03-12 2021-03-31 アルブミン融合タンパク質を精製する方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562132198P 2015-03-12 2015-03-12
US62/132,198 2015-03-12
PCT/US2016/022003 WO2016145307A1 (en) 2015-03-12 2016-03-11 Method of purifying albumin-fusion proteins

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JP2021061713A Division JP7320550B2 (ja) 2015-03-12 2021-03-31 アルブミン融合タンパク質を精製する方法

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JP2018513124A JP2018513124A (ja) 2018-05-24
JP2018513124A5 JP2018513124A5 (enExample) 2019-04-18
JP6862348B2 true JP6862348B2 (ja) 2021-04-21

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JP2017548053A Active JP6862348B2 (ja) 2015-03-12 2016-03-11 アルブミン融合タンパク質を精製する方法
JP2021061713A Active JP7320550B2 (ja) 2015-03-12 2021-03-31 アルブミン融合タンパク質を精製する方法
JP2023080507A Active JP7826243B2 (ja) 2015-03-12 2023-05-16 アルブミン融合タンパク質を精製する方法

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JP2023080507A Active JP7826243B2 (ja) 2015-03-12 2023-05-16 アルブミン融合タンパク質を精製する方法

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US (3) US10683340B2 (enExample)
EP (2) EP3268389B1 (enExample)
JP (3) JP6862348B2 (enExample)
KR (2) KR20170124592A (enExample)
CN (1) CN107428817B (enExample)
AU (4) AU2016228806B2 (enExample)
CA (2) CA3260163A1 (enExample)
ES (1) ES2839211T3 (enExample)
IL (1) IL253971B (enExample)
WO (1) WO2016145307A1 (enExample)

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EP3753567A1 (en) 2011-10-11 2020-12-23 Viela Bio, Inc. Cd40l-specific tn3-derived scaffolds and methods of use thereof
ES2991988T3 (es) 2017-10-30 2024-12-05 Takeda Pharmaceuticals Co Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica
EA202092778A1 (ru) 2018-05-16 2021-05-27 ЛИБ ТЕРАПЬЮТИКС, ЭлЭлСи Композиции, содержащие pcsk9-связывающие молекулы, и способы применения
CN113286806A (zh) * 2018-11-09 2021-08-20 尼欧派普制药有限两合公司 治疗压力、免疫反应和中风综合征的多肽
EP3711772A1 (en) 2019-03-20 2020-09-23 Oslo Universitetssykehus HF Recombinant proteins and fusion proteins
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AU2021268026A1 (en) 2020-05-08 2023-01-19 Regeneron Pharmaceuticals, Inc. VEGF traps and mini-traps and methods for treating ocular disorders and cancer
JP2023532544A (ja) * 2020-07-01 2023-07-28 メディミューン，エルエルシー 生物学的製剤を精製するための洗浄剤及び方法
CN112062833A (zh) * 2020-10-09 2020-12-11 国药集团武汉血液制品有限公司 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法
CN115677848A (zh) * 2022-10-24 2023-02-03 通化安睿特生物制药股份有限公司 一种制备高纯度高稳定性蛋白质的方法

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CA3260163A1 (en) 2026-03-02
AU2023204271B2 (en) 2026-04-02
AU2016228806A1 (en) 2017-08-31
WO2016145307A1 (en) 2016-09-15
JP2018513124A (ja) 2018-05-24
CN107428817A (zh) 2017-12-01
IL253971A0 (en) 2017-10-31
EP3268389A1 (en) 2018-01-17
EP3268389A4 (en) 2018-08-08
US10683340B2 (en) 2020-06-16
AU2023204271A1 (en) 2023-07-27
JP7826243B2 (ja) 2026-03-09
US11548933B2 (en) 2023-01-10
AU2021200423A1 (en) 2021-02-25
AU2026201911A1 (en) 2026-04-02
AU2016228806B2 (en) 2020-10-22
KR20170124592A (ko) 2017-11-10
US20180105575A1 (en) 2018-04-19
US20230340074A1 (en) 2023-10-26
EP3842451A1 (en) 2021-06-30
ES2839211T3 (es) 2021-07-05
IL253971B (en) 2021-10-31
JP2023103368A (ja) 2023-07-26
EP3268389B1 (en) 2020-09-30
AU2021200423B2 (en) 2023-04-06
JP7320550B2 (ja) 2023-08-03
KR20240093725A (ko) 2024-06-24
JP2021105025A (ja) 2021-07-26
BR112017019401A2 (pt) 2018-05-02
CA2977675A1 (en) 2016-09-15
CN107428817B (zh) 2022-07-12
US20200407423A1 (en) 2020-12-31

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