JP6857613B2 - タンパク質の安定化 - Google Patents
タンパク質の安定化 Download PDFInfo
- Publication number
- JP6857613B2 JP6857613B2 JP2017551685A JP2017551685A JP6857613B2 JP 6857613 B2 JP6857613 B2 JP 6857613B2 JP 2017551685 A JP2017551685 A JP 2017551685A JP 2017551685 A JP2017551685 A JP 2017551685A JP 6857613 B2 JP6857613 B2 JP 6857613B2
- Authority
- JP
- Japan
- Prior art keywords
- protein
- preferentially
- composition
- carbon atoms
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01002—Beta-amylase (3.2.1.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nutrition Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1552899A FR3034418B1 (fr) | 2015-04-03 | 2015-04-03 | Utilisation de combinaisons particulieres de carbohydrates pour stabiliser des proteines, et compositions proteiques contenant de telles combinaisons |
| FR1552899 | 2015-04-03 | ||
| PCT/FR2016/050709 WO2016156734A1 (fr) | 2015-04-03 | 2016-03-30 | Stabilisation de proteines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516239A JP2018516239A (ja) | 2018-06-21 |
| JP2018516239A5 JP2018516239A5 (cg-RX-API-DMAC7.html) | 2019-03-07 |
| JP6857613B2 true JP6857613B2 (ja) | 2021-04-14 |
Family
ID=53483991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017551685A Active JP6857613B2 (ja) | 2015-04-03 | 2016-03-30 | タンパク質の安定化 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10822372B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3277702B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6857613B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN107531747A (cg-RX-API-DMAC7.html) |
| DK (1) | DK3277702T3 (cg-RX-API-DMAC7.html) |
| FR (1) | FR3034418B1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016156734A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7039308B2 (ja) * | 2017-02-08 | 2022-03-22 | 三洋化成工業株式会社 | 細胞培養用担体 |
| CN108424035A (zh) * | 2018-04-19 | 2018-08-21 | 中原工学院 | 一种聚合物水泥发泡剂及其发泡混凝土的制备方法 |
| WO2020184596A1 (ja) * | 2019-03-11 | 2020-09-17 | ナガセケムテックス株式会社 | アミラーゼ組成物 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0229810B1 (en) | 1985-07-09 | 1991-10-16 | Quadrant Bioresources Limited | Protection of proteins and the like |
| GB9010742D0 (en) * | 1990-05-14 | 1990-07-04 | Quadrant Bioresources Ltd | Stabilization of biological macromolecular substances |
| CA2177429A1 (en) * | 1995-06-29 | 1996-12-30 | Charles Allen Rodgers | Reduced fat cheese-flavored snack filling |
| US5876992A (en) * | 1996-07-03 | 1999-03-02 | Molecular Biology Resources, Inc. | Method and formulation for stabilization of enzymes |
| WO2000062759A1 (en) * | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Dry, mouldable drug formulation |
| FI20021312A7 (fi) * | 2002-07-03 | 2004-01-04 | Danisco Sweeteners Oy | Polyolikoostumusten kiteyttäminen, kiteinen polyolikoostumustuote ja sen käyttö |
| EP1549147B1 (en) * | 2002-09-11 | 2011-02-23 | Puratos Naamloze Vennootschap | Use of family 8 enzymes with xylanolytic activity in baking |
| EP1574567A1 (en) * | 2004-03-11 | 2005-09-14 | Puratos Naamloze Vennootschap | Novel xylanases and their use |
| CN101312742B (zh) * | 2005-09-16 | 2012-07-25 | 梅瑞尔有限公司 | 用于冷冻干燥的疫苗的稳定剂 |
| JP5990176B2 (ja) * | 2010-10-12 | 2016-09-07 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | タンパク質の安定化に好適な哺乳動物性賦形剤非含有製剤 |
| RU2470520C1 (ru) * | 2011-07-18 | 2012-12-27 | Валентина Андреевна Васькина | Способ производства нуги "мандариновой" |
| CN103827303B (zh) * | 2011-09-26 | 2021-10-22 | 普瑞阿那利提克斯有限公司 | 细胞外核酸的稳定化和分离 |
| CN102533689A (zh) * | 2011-12-30 | 2012-07-04 | 华东师范大学 | 一种谷氨酰胺转胺酶真空干燥的制备方法 |
| CN103159839B (zh) * | 2013-03-28 | 2014-07-30 | 云南天保桦生物资源开发有限公司 | 热稳定保护的α-淀粉酶抑制剂及其用途 |
| WO2015021600A1 (en) * | 2013-08-13 | 2015-02-19 | Danisco Us Inc. | Beta-amylase and methods of use |
| CN104099313B (zh) * | 2014-07-18 | 2016-04-06 | 天津天绿健科技有限公司 | 一种啤酒液体复配酶 |
-
2015
- 2015-04-03 FR FR1552899A patent/FR3034418B1/fr active Active
-
2016
- 2016-03-30 DK DK16718427.4T patent/DK3277702T3/da active
- 2016-03-30 WO PCT/FR2016/050709 patent/WO2016156734A1/fr not_active Ceased
- 2016-03-30 CN CN201680018706.8A patent/CN107531747A/zh active Pending
- 2016-03-30 EP EP16718427.4A patent/EP3277702B1/fr active Active
- 2016-03-30 US US15/563,871 patent/US10822372B2/en active Active
- 2016-03-30 JP JP2017551685A patent/JP6857613B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| FR3034418B1 (fr) | 2018-09-28 |
| US10822372B2 (en) | 2020-11-03 |
| JP2018516239A (ja) | 2018-06-21 |
| FR3034418A1 (fr) | 2016-10-07 |
| CN107531747A (zh) | 2018-01-02 |
| US20180118779A1 (en) | 2018-05-03 |
| DK3277702T3 (da) | 2023-12-04 |
| WO2016156734A1 (fr) | 2016-10-06 |
| EP3277702A1 (fr) | 2018-02-07 |
| EP3277702B1 (fr) | 2023-09-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2640922C1 (ru) | Лиофилизированный препарат ботулотоксина | |
| US20110014676A1 (en) | Protein stabilization | |
| EP3476386A1 (en) | Liquid pharmaceutical composition | |
| CN103041383A (zh) | 一种活疫苗的耐热冻干保护剂、活疫苗冻干粉及其制备方法 | |
| US11534403B2 (en) | Liquid pharmaceutical composition | |
| JP6857613B2 (ja) | タンパク質の安定化 | |
| JP7449243B2 (ja) | 安定な融合タンパク質製剤 | |
| WO2013133702A1 (en) | Methods and compositions for stabilizing dried biological materials | |
| TW202535466A (zh) | 抗-il-23p19抗體調配物 | |
| Wan et al. | Development of stabilizing formulations of a trivalent inactivated poliovirus vaccine in a dried state for delivery in the Nanopatch™ microprojection array | |
| EP3207936B1 (en) | Stable peptide composition | |
| JPS63230085A (ja) | 安定なフラクト−スデヒドロゲナ−ゼ組成物 | |
| WO2017114214A1 (zh) | 一种组合物及其应用、含有该组合物的稳定剂 | |
| KR20230047124A (ko) | 조직 플라스미노겐 활성인자 제형 | |
| JP2009062384A (ja) | ヒト血液凝固第xiii因子の安定化された水性液製剤 | |
| HK40043029A (en) | Lyophilized preparation of botulinum toxin | |
| HK1246174B (en) | Lyophilized preparation of botulinum toxin | |
| JP2007174978A (ja) | Adamts13の安定化方法 | |
| Eriksson | Analytical techniques and formulation strategies for the therapeutic protein alkaline phosphatase | |
| Nandhakumar et al. | Lyophillization formulation development with novel excipients for Pegylated therapeutic proteins: A case study | |
| HK40014147B (en) | Novel stable formulation for fxia antibodies |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190124 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190124 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20191007 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20191029 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200121 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200602 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20200806 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20201028 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20201125 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210316 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210322 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6857613 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |