JP6850886B2 - 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 - Google Patents
置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 Download PDFInfo
- Publication number
- JP6850886B2 JP6850886B2 JP2019531209A JP2019531209A JP6850886B2 JP 6850886 B2 JP6850886 B2 JP 6850886B2 JP 2019531209 A JP2019531209 A JP 2019531209A JP 2019531209 A JP2019531209 A JP 2019531209A JP 6850886 B2 JP6850886 B2 JP 6850886B2
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- pyrazolo
- ethyl
- spiro
- oxo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CCC1=C=CN(CCCC(C(C(C2)C=CC=C2C(O)=O)=O)=C)C(CCCOCCC*2)C1C1C2=C1 Chemical compound CCC1=C=CN(CCCC(C(C(C2)C=CC=C2C(O)=O)=O)=C)C(CCCOCCC*2)C1C1C2=C1 0.000 description 3
- ILYZMKOKIALGOI-UHFFFAOYSA-N CC(C1)C=CC=C1C([O]=C)=O Chemical compound CC(C1)C=CC=C1C([O]=C)=O ILYZMKOKIALGOI-UHFFFAOYSA-N 0.000 description 1
- KCAXGMNKHGPQKC-MLWJPKLSSA-N CC(C1)[C@H]1OCCCNN Chemical compound CC(C1)[C@H]1OCCCNN KCAXGMNKHGPQKC-MLWJPKLSSA-N 0.000 description 1
- SCUVHRLVYMCGDU-UHFFFAOYSA-N CC(C=C1CCOCC1)=O Chemical compound CC(C=C1CCOCC1)=O SCUVHRLVYMCGDU-UHFFFAOYSA-N 0.000 description 1
- YAEGMGMKLJYYJE-UHFFFAOYSA-N CC(CC1=CCOCC1)=O Chemical compound CC(CC1=CCOCC1)=O YAEGMGMKLJYYJE-UHFFFAOYSA-N 0.000 description 1
- NVAAQCYDYDGIDM-UHFFFAOYSA-N CCOC(C(C1(CCOCC1)CC(O)=C1)C1=O)=O Chemical compound CCOC(C(C1(CCOCC1)CC(O)=C1)C1=O)=O NVAAQCYDYDGIDM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2016/080548 WO2018108230A1 (en) | 2016-12-12 | 2016-12-12 | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020500920A JP2020500920A (ja) | 2020-01-16 |
| JP6850886B2 true JP6850886B2 (ja) | 2021-03-31 |
Family
ID=57539258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531209A Expired - Fee Related JP6850886B2 (ja) | 2016-12-12 | 2016-12-12 | 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10906915B2 (https=) |
| EP (1) | EP3551633B1 (https=) |
| JP (1) | JP6850886B2 (https=) |
| CN (1) | CN110088108B (https=) |
| DK (1) | DK3551633T3 (https=) |
| ES (1) | ES2875128T3 (https=) |
| RU (1) | RU2762279C2 (https=) |
| WO (1) | WO2018108230A1 (https=) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020511410A (ja) * | 2016-12-12 | 2020-04-16 | レオ ファーマ アクティーゼルスカブ | 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
| US11981681B2 (en) | 2017-12-15 | 2024-05-14 | UNION therapeutics A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| US12084457B2 (en) | 2017-06-20 | 2024-09-10 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| US12409172B2 (en) | 2023-05-05 | 2025-09-09 | UNION therapeutics A/S | Dosage regimen |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2803299B1 (fr) * | 2000-01-05 | 2004-09-17 | Warner Lambert Co | NOUVELLES PYRAZOLO [4,3-e] DIAZEPINES SUBSTITUEES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| WO2004098520A2 (en) | 2003-05-01 | 2004-11-18 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| TW200745106A (en) * | 2005-10-03 | 2007-12-16 | Astrazeneca Ab | Chemical compounds |
| ES2372320T3 (es) | 2006-11-15 | 2012-01-18 | Vertex Pharmceuticals Incorporated | Compuestos útiles como inhibidores de proteínas quinasas. |
| CA2676933C (en) * | 2007-02-28 | 2015-09-29 | Leo Pharma A/S | Novel phosphodiesterase inhibitors |
| GB0704652D0 (en) | 2007-03-09 | 2007-04-18 | Syngenta Participations Ag | Novel herbicides |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
-
2016
- 2016-12-12 JP JP2019531209A patent/JP6850886B2/ja not_active Expired - Fee Related
- 2016-12-12 DK DK16809388.8T patent/DK3551633T3/da active
- 2016-12-12 WO PCT/EP2016/080548 patent/WO2018108230A1/en not_active Ceased
- 2016-12-12 US US16/468,420 patent/US10906915B2/en active Active
- 2016-12-12 ES ES16809388T patent/ES2875128T3/es active Active
- 2016-12-12 RU RU2019121006A patent/RU2762279C2/ru active
- 2016-12-12 EP EP16809388.8A patent/EP3551633B1/en active Active
- 2016-12-12 CN CN201680091502.7A patent/CN110088108B/zh not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020511410A (ja) * | 2016-12-12 | 2020-04-16 | レオ ファーマ アクティーゼルスカブ | 置換ピラゾロアゼピン−４−オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
| JP7008073B2 (ja) | 2016-12-12 | 2022-01-25 | ユニオン・セラピューティクス・アクティエセルスカブ | 置換ピラゾロアゼピン－４－オンおよびそれらのホスホジエステラーゼ阻害剤としての使用 |
| US12084457B2 (en) | 2017-06-20 | 2024-09-10 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
| US11981681B2 (en) | 2017-12-15 | 2024-05-14 | UNION therapeutics A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| US12409172B2 (en) | 2023-05-05 | 2025-09-09 | UNION therapeutics A/S | Dosage regimen |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110088108A (zh) | 2019-08-02 |
| RU2019121006A (ru) | 2021-01-12 |
| US20200010477A1 (en) | 2020-01-09 |
| US10906915B2 (en) | 2021-02-02 |
| RU2019121006A3 (https=) | 2021-01-12 |
| JP2020500920A (ja) | 2020-01-16 |
| CN110088108B (zh) | 2024-06-14 |
| DK3551633T3 (da) | 2021-06-28 |
| RU2762279C2 (ru) | 2021-12-17 |
| EP3551633A1 (en) | 2019-10-16 |
| EP3551633B1 (en) | 2021-03-31 |
| ES2875128T3 (es) | 2021-11-08 |
| WO2018108230A1 (en) | 2018-06-21 |
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