JP6850131B2 - 非セルロース多糖を含む、乱用抑止性即時放出製剤 - Google Patents
非セルロース多糖を含む、乱用抑止性即時放出製剤 Download PDFInfo
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- JP6850131B2 JP6850131B2 JP2016575456A JP2016575456A JP6850131B2 JP 6850131 B2 JP6850131 B2 JP 6850131B2 JP 2016575456 A JP2016575456 A JP 2016575456A JP 2016575456 A JP2016575456 A JP 2016575456A JP 6850131 B2 JP6850131 B2 JP 6850131B2
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- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 229940072172 tetracycline antibiotic Drugs 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 229960000337 tetryzoline Drugs 0.000 description 1
- 229960002784 thioridazine Drugs 0.000 description 1
- 239000005495 thyroid hormone Substances 0.000 description 1
- 229940036555 thyroid hormone Drugs 0.000 description 1
- OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 description 1
- 229960004659 ticarcillin Drugs 0.000 description 1
- 229960005221 timolol maleate Drugs 0.000 description 1
- 229960005013 tiotixene Drugs 0.000 description 1
- XFYDIVBRZNQMJC-UHFFFAOYSA-N tizanidine Chemical compound ClC=1C=CC2=NSN=C2C=1NC1=NCCN1 XFYDIVBRZNQMJC-UHFFFAOYSA-N 0.000 description 1
- 229960000488 tizanidine Drugs 0.000 description 1
- 229960000707 tobramycin Drugs 0.000 description 1
- NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229960004380 tramadol Drugs 0.000 description 1
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
- 229960003386 triazolam Drugs 0.000 description 1
- 229920000428 triblock copolymer Polymers 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- WCTAGTRAWPDFQO-UHFFFAOYSA-K trisodium;hydrogen carbonate;carbonate Chemical compound [Na+].[Na+].[Na+].OC([O-])=O.[O-]C([O-])=O WCTAGTRAWPDFQO-UHFFFAOYSA-K 0.000 description 1
- LQCLVBQBTUVCEQ-QTFUVMRISA-N troleandomycin Chemical compound O1[C@@H](C)[C@H](OC(C)=O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](C)C(=O)O[C@H](C)[C@H](C)[C@H](OC(C)=O)[C@@H](C)C(=O)[C@@]2(OC2)C[C@H](C)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)OC(C)=O)[C@H]1C LQCLVBQBTUVCEQ-QTFUVMRISA-N 0.000 description 1
- 229960005041 troleandomycin Drugs 0.000 description 1
- 229960003688 tropisetron Drugs 0.000 description 1
- UIVFDCIXTSJXBB-ITGUQSILSA-N tropisetron Chemical compound C1=CC=C[C]2C(C(=O)O[C@H]3C[C@H]4CC[C@@H](C3)N4C)=CN=C21 UIVFDCIXTSJXBB-ITGUQSILSA-N 0.000 description 1
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 description 1
- 229960000497 trovafloxacin Drugs 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 235000016788 valerian Nutrition 0.000 description 1
- MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
- 229960000604 valproic acid Drugs 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000010455 vermiculite Substances 0.000 description 1
- 229910052902 vermiculite Inorganic materials 0.000 description 1
- 235000019354 vermiculite Nutrition 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- ARAIBEBZBOPLMB-UFGQHTETSA-N zanamivir Chemical compound CC(=O)N[C@@H]1[C@@H](N=C(N)N)C=C(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO ARAIBEBZBOPLMB-UFGQHTETSA-N 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 229960000820 zopiclone Drugs 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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- A—HUMAN NECESSITIES
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- A61K9/00—Medicinal preparations characterised by special physical form
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- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Description
本発明は、例えば、以下の項目を提供する。
(項目1)
少なくとも1つの医薬品有効成分(API)または薬学的に許容されるそれらの塩、少なくとも1つの非セルロース多糖、少なくとも1つの親水性ゲル化ポリマー、及び発泡システムを含む、医薬組成物。
(項目2)
USP認定の生体外放出手順を使用して溶解が測定される場合、前記APIの少なくとも約70%が、45分以内に放出される、項目1に記載の前記医薬組成物。
(項目3)
約250ミクロンを超えて大きい平均粒径を有する粒子の過半数が、前記組成物を、粉砕、すりつぶし、または粉末化にして形成される、項目1または2に記載の前記医薬組成物。
(項目4)
前記非セルロース多糖が、天然ガム、ヘミセルロース、ペクチン、キチン、澱粉、またはそれらの組み合わせであり、及び前記多糖が、前記医薬組成物の重量で、約2%から約60%の量で存在する、項目1から3のいずれかに記載の前記医薬組成物。
(項目5)
前記天然ガムが、グルコマンナン、キサンタンガム、ジェランガム、デキストラン、ウェランガム、デュータンガム、プルラン、ネムノキガム、アロエ粘液、ベータ−グルカン、チクルガム、ダンマルガム、フェヌグリークガム、グアーガム、アラビアゴム、ガムコパル、ガムガティ、トラガカントゴム、ハケアガム、ブツソウゲガム、アメリカサイカチガム、フプ(hupu)ガム、カラヤガム、サイモンカヤガム、コショウソウガム、ローカストビーンガム、マスティックガム、ミモザスカブレラガム、オジギソウガム、オクラガム、オオバコ種子殻、スプルースガム、ピンポンノキ属・フェティダ (Sterculia foetida)ガム、タマリンドガム、タラガム、アルギン酸、フコイダン、ラミナラン、寒天、カラギーナン、またはそれらの組み合わせである、項目4に記載の前記医薬組成物。
(項目6)
前記親水性ゲル化ポリマーが、セルロースエーテル、ポリアルキレンオキサイド、ポリアクリル酸、またはこれらの組み合わせであり、及び前記親水性ゲル化ポリマーが、前記医薬組成物の重量で、約5%から約80%の量で存在する、項目1から5のいずれかに記載の前記医薬組成物。
(項目7)
前記発泡システムが、a)有機酸、無機酸、またはそれらの組み合わせから選ばれる酸成分、及びb)アルカリ金属重炭酸塩、アルカリ土類金属重炭酸塩、アルカリ金属炭酸塩、有機炭酸塩、またはこれらの組み合わせから選ばれる塩基成分を含み、且つ前記発泡システムが、前記医薬組成物の重量で、約20%から約90%の量で存在する、項目1から6のいずれかに記載の前記医薬組成物。
(項目8)
前記APIが、オピオイドまたはオピオイドと非オピオイド鎮痛薬の組み合わせであり、及び前記オピオイドが、オキシコドン、オキシモルホン、ヒドロコドン、ヒドロモルホン、コデイン、またはモルヒネである、項目1から7のいずれかに記載の前記医薬組成物。
(項目9)
前記非セルロース多糖が、グルコマンナン、キサンタンガム、またはそれらの組み合わせであり、前記親水性ゲル化ポリマーが、ポリエチレンオキサイド、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロースナトリウム、またはそれらの組み合わせであり、及び前記発泡システムが、有機酸およびアルカリ金属重炭酸塩を含む、項目1に記載の前記医薬組成物。
(項目10)
前記非セルロース多糖が、前記医薬組成物の重量で約5%から約40%の量で存在し、前記親水性ゲル化ポリマーが、前記医薬組成物の重量で約10%から約50%の量で存在し、及び前記発泡システムが、前記医薬組成物の重量で約30%から約60%の量で存在する、項目9に記載の前記医薬組成物。
(項目11)
前記APIが、オキシコドン、オキシモルホン、ヒドロコドン、ヒドロモルホン、コデイン、またはモルヒネである、項目10に記載の前記医薬組成物。
(項目12)
前記APIが、オキシコドンある、項目10に記載の前記医薬組成物。
(項目13)
前記医薬組成物が、固形剤形である、先行項目のいずれか1項に記載の前記医薬組成物。
(項目14)
前記固形剤形が、錠剤である、項目13に記載の前記医薬組成物。
(項目15)
前記固形剤形が、
a)前記APIまたは薬学的に許容されるそれらの塩、前記非セルロース多糖、前記親水性ゲル化ポリマー、及び前記発泡システムを含む混合物を形成すること、
b)前記混合物を、固形投薬単位にすること、及び
c)前記固形投薬単位を加熱して、前記固形剤形を産出すること、
を含むプロセスで調合される、項目13に記載の前記医薬組成物。
本開示の1つの態様は、当該有効医薬成分の即時放出性を与える、乱用抑止用医薬組成物を提供する。以下の詳細は、当該組成物の成分、当該組成物の放出特性、及び当該組成物の乱用抑止特性である。
本明細書に開示の当該医薬組成物は、少なくとも1つの非セルロース多糖、少なくとも1つの親水性ゲル化ポリマー、及び発泡システムを含む。当該非セルロース多糖、当該親水性ゲル化ポリマー、及び当該発泡システムの組み合わせは、その有効成分の急速かつ即時放出を与える一方で、乱用抑止特性(例えば、微粉末に粉砕することまたは水溶液で抽出することが困難である)を有する組成物を生じる。
多様な非セルロース多糖は、本明細書に開示の医薬組成物に含まれてよい。適切な多糖には、非限定的に、天然ガム、ヘミセルロース(キシログルカン、キシラン、及びマンナンなど)、ペクチン(例えば、柑橘類、りんご、西洋ナシ、グーズベリーなどに由来する)、キチン、澱粉(例えば、トウモロコシ、ジャガイモ、米などに由来する)、グリコーゲン、クリソラミナリン、それらの誘導体、及びそれらの組み合わせを含む。
本明細書に開示の医薬組成物はまた、少なくとも1つの親水性ゲル化ポリマーを含む。用語「親水性ゲル化ポリマー」は、水に親和性を有するポリマーを指し、そのため水若しくは水溶液を吸収し及び/または水若しくは水溶液との接触で膨潤して、粘性の混合物またはゲルを形成する。
本明細書に開示の医薬組成物はまた、発泡システムを含む。ここで使用する「発泡システム」は、酸成分及び塩基成分を一般に含むシステムを指し、ここで当該システムは、水溶液との接触で二酸化炭素を遊離する。いかなる特定の理論にも拘束されないが、当該発泡システムは、非セルロース多糖(類)及び親水性ゲル化ポリマー(類)の組み合わせを含む組成物からの、当該APIの急速溶解を促進する、と考える。
いくつかの実施形態において、本明細書に開示の当該医薬組成物はまた、潤滑剤を含んで良い。適切な潤滑剤の非限定的な例示には、ステアリン酸マグネシウム、ステアリン酸カルシウム、ステアリン酸亜鉛などのステアリン酸金属塩、ポリエチレングリコール、ポロキサマー、コロイド状二酸化ケイ素、ベヘン酸グリセリル、軽油、水素化植物油、ラウリル硫酸マグネシウム、三ケイ酸マグネシウム、ポリオキシエチレンモノステアレート、フマル酸ナトリウムステアロイル、フマル酸ナトリウムステアリル、安息香酸ナトリウム、ラウリル硫酸ナトリウム、ステアリン酸、水素化綿実油、タルク、及びそれらの組み合わせを含む。特定の実施形態において、当該潤滑剤は、ステアリン酸金属塩であって良い。1つの反復形態において、当該潤滑剤は、ステアリン酸マグネシウムであって良い。
本明細書に開示の当該医薬組成物は、少なくとも1つのAPIまたは薬学的に許容されるそれらの塩を含む。適切なAPIには、非限定的に、オピオイド鎮痛薬(例えば、アズルミン(adulmine)、アルフェンタニル、アロクリプトピン(allocryptopine)、アリルプロジン、アルファプロジン、アニレリジン、アポルフィン、ベンジルモルヒネ、ベルベリン、ビククリン、ビクシン、ベジトラミド(bezitramide)、ブプレノルフィン、ブルボカプリン(bulbocaprine)、ブトルファノール、クロニタゼン、コデイン、デソモルヒネ、デキストロモラミド、デゾシン、ジアンプロミド、ジアモルフォン、ジヒドロコデイン、ジヒドロモルヒネ、ジメノキサドール、ジメフェプタノール、ジメチルチアンブテン、ジオキサフェチルブチレート、ジピパノン、エプタゾシン、エトヘプタジン、エチルメチルチアンブテン、エチルモルヒネ、エトニタゼン、フェンタニル、ヘロイン、ヒドロコドン、ヒドロモルホン、ヒドロキシペチジン、イソメタドン、ケトベミドン、レボルファノール、レボフェナシルモルファン、ロフェンタニル、メペリジン、メプタジノール、メタゾシン、メタドン、メトポン、モルヒネ、ミロフィン(myrophine)、ナルセイン、ニコモルヒネ、ノルレボルファノール(norlevorphanol)、ノルメタドン、ナロルフィン、ナルブフィン、ナルメフェン、ノルモルヒネ、ノルピパノン、アヘン、オキシコドン、オキシモルホン、パパベレタム、ペンタゾシン、フェナドキソン、フェノモルファン、フェナゾシン、フェノペリジン、ピミノジン、ピリトラミド、プロフェプタジン、プロメドール、プロペリジン(properidine)、プロポキシフェン、スフェンタニル、タペンタドール、チリジン、及びトラマドール)、オピオイド拮抗薬(例えば、ナロキソン、ナルトレキソン、アルビモパン、シプロダイム、ジプレノルフィン、ゲマゾシン、5’−グアニジノナルトリンドール(5’−guanidinonaltrindole)、レバロルファン、メチルナルトレキソン、ナルデメジン、ナルメキソン(nalmexone)、ナロルフィン、ナロキサゾン、ナロキソール、ナロキソナジン、6β−ナルトレキソン−d4、ナルトリベン、ナルトリンドール、ノルビナルトルフィミン、オキシロルファン、クァダゾシン、及び サミドルファン)、非オピオイド鎮痛薬(例えば、アセチルサリチル酸、アセトアミノフェン、パラセタモール、イブプロフェン、ケトプロフェン、インドメタシン、ジフルニサル(diflunisol)、ナプロキセン、ケトロラック、ジクロフェナク(dichlophenac)、トルメチン、スリンダク、フェナセチン、ピロキシカム、及びメフェナム酸(mefamanic acid))、抗炎症薬(例えば、アルクロメタゾン、フルオシノニド、メチルプレドニゾロン、トリアムシノロン、及びデキサメタゾンなどのグルココルチコイド、セレコキシブ、デラコキシブ、ケトプロフェン、ルミラコキシブ、メロキシカム、パレコキシブ、ロフェコキシブ、及びバルデコキシブなどの非ステロイド系抗炎症薬)鎮咳薬(例えば、デキストロメトルファン、コデイン、ヒドロコドン、カラミフェン、カルベタペンタン、及びデキストロメトルファン)、解熱剤(例えば、アセチルサリチル酸及びアセトアミノフェン)、抗生物質製剤(例えば、アミカシン、ゲンタマイシン、カナマイシン、ネオマイシン、ネチルマイシン、ストレプトマイシン、トブラマイシンなどのアミノグリコシド類、ロラカルベフなどのカルバセフェム類、エルタペネム(certapenem)、イミペネム、メロペネムなどのカルバペネム類、セファドロキシルセファゾリン、セファレキシン、セファクロル、セファマンドール、セファレキシン、セフォキシチン、セフプロジル、セフロキシム、セフィキシム、セフジニル、セフジトレン、セフォペラゾン、セフォタキシム、セフポドキシム、セフタジジム、セフチブテン、セフチゾキシム、及びセフトリアキソンなどのセファロスポリン類、アジスロマイシン、クラリスロマイシン、ジリトロマイシン、エリスロマイシン、及びトリアセチルオレアンドマイシンなどのマクロライド類、モノバクタム類、アモキシシリン、アンピシリン、カルベニシリン、クロキサシリン、ジクロキサシリン、ナフシリン、オキサシリン、ペニシリンG、ペニシリンV、ピペラシリン、及びチカルシリンなどのペニシリン類、バシトラシン、コリスチン、及びポリミキシンBなどのポリペプチド類、シプロフロキサシン、エノキサシン、ガチフロキサシン、レボフロキサシン、ロメフロキサシン、モキシフロキサシン、ノルフロキサシン、オフロキサシン、及びトロバフロキサシンなどのキノロン類、マフェニド、スルファセタミド、スルファメチゾール、スルファサラジン、スルフイソキサゾール、及びトリメトプリム−スルファメトキサゾールなどのスルホンアミド類、デメクロサイクリン、ドキシサイクリン、ミノサイクリン、オキシテトラサイクリンなどのテトラサイクリン系抗生物質)、抗菌薬(例えば、ケトコナゾール、アモキシシリン、セファレキシン、ミコナゾール、エコナゾール、アシクロビル、及びネルフィナビル)、抗ウイルス薬(例えば、アシクロビル、ガンシクロビル(gangciclovir)、オセルタミビル、及びリレンザ)、ステロイド(例えば、エストラジ オール、テストステロン、コルチゾール、アルドステロン、プレドニゾン、及びコーチゾン)、アンフェタミン刺激薬(例えば、アンフェタミン及びアンフェタミン様薬剤)、非アンフェタミン刺激薬(例えば、メチルフェニ デート、ニコチン、及びカフェイン)、緩下薬(例えば、ビサコジル、カサンスラノール、セナ、及びヒマシ油)、制嘔吐薬(例えば、ドラセトロン、グラニセトロン、オンダンセトロン、トロピセトロン、メクリジン、及びシクリジン)、食欲抑制薬(例えば、フェンフルラミン、デクス、マジンドール、フェンテルミン、及びアミノレックス)、抗ヒスタミン薬(例えば、フェンカロール、セチリジン、シンナリジン、エタミジンドール(ethamidindole)、アザタジン、ブロムフェニラミン、ヒドロキシジン、及びクロルフェニラミン)、抗喘息薬(例えば、ジロートン、モンテルカスト、オマリズマブ、フルチカゾン、及びザフィルルカスト)、抗利尿薬(例えば、デスモプレシン、バソプレッシン、及びリプレシン)、抗片頭痛薬(例えば、ナラトリプタン、フロバトリプタン、エレトリプタン、ジヒドロエルゴタミン、ゾルミトリプタン、アルモトリプタン、スマトリプタン)、鎮痙薬(例えば、ジサイクロミン、ヒオスシアミン、及び ペパーミントオイル)、抗糖尿病薬(例えば、メトホルミン、アカルボース、ミグリトール、ピオグリタゾン、ロシグリタゾン、ナテグリニド、レパグリニド、ミチグリニド、サキサグリプチン、シタグリプチン、ビルダグリプチン、アセトヘキサミド、クロルプロパミド、グリクラジド、グリメピリド、グリピジド、グリブリド、トラザミド、及びトルブタミド)、呼吸器薬(例えば、アルブテロール、エフェドリン、メタプロテレノール、テルブタリン)、交感神経刺激薬(例えば、プソイド エフェドリン、フェニレフリン、フェニルプロパノールアミン、エピネフリン、ノルエピネフリン、ドーパミン、及びエフェドリン)、H2遮断薬(例えば、シメチジン、ファモチジン、ニザチジン、及びラニチジン)、抗高脂血症薬(例えば、クロフィブラート、クレステラミン、コレスチポール、フルバスタチン、アトルバスタチン、ゲムフィブロジル、ロバスタチン、ナイアシン、プラバスタチン、フェノフィブラート、コレセベラム、及びシンバスタチン)、抗高コレステロール薬(例えば、ロバスタチン、シンバスタチン、プラバスタチン、フルバスタチン、アトルバスタチン、クレステラミン、コレスチポール、コレセベラム、ニコチン酸、ゲムフィブロジル、及びエゼチミブ)、強心薬(例えば、ジギタリス、ユビデカレノン、及びドーパミン)、血管拡張薬(例えば、ニトログリセリン、カプトプリル、ジヒドララジン、ジルチアゼム、及び硝酸イソソルビド)、血管収縮薬(例えば、ジヒドロエルゴトキシン、ジヒドロエルゴタミン)、抗凝血薬(例えば、ワルファリン、ヘパリン、及びXa因子阻害剤)、鎮静剤(例えば、アモバルビタール、ペントバルビタール、セコバルビタール、クロメチアゾール、ジフェンヒドラミン塩酸塩、及びアルプラゾラム)、催眠薬(例えば、ザレプロン、ゾルピデム、エスゾピクロン、ゾピクロン、抱水クロラール、及びクロメチアゾール)、抗痙攣薬(例えば、ラモトリギン、オキシカルバメジン(oxycarbamezine)、フェニトイン、メフェニトイン、エトスクシミド、メタスクシンイミド、カルバマゼピン、バルプロ酸、ガバペンチン、トピラマート、フェルバメート、及び フェノバルビタール)、筋弛緩剤(例えば、バクロフェン、カリソプロドル、クロルゾキサゾン、シクロベンザプリン、ダントロレンナトリウム、メタキサロン、オルフェナドリン、臭化パンクロニウム、及びチザニジン)、抗精神病薬(例えば、フェノチアジン、クロルプロマジン、フルフェナジン、ペルフェナジン、プロクロルペラジン、チオリダジン、トリフルオペラジン、ハロペリドール、ドロペリドール、ピモジド、クロザピン、オランザピン、リスペリドン、クエチアピン、ジプラシドン、メルペロン、及びパリペリドン)、抗不安薬(例えば、ロラゼパム、アルプラゾラム、クロナゼパム、ジアゼパム、ブスピロン、メプロバメート、及びフルニトラゼパム)、抗過活動薬(例えば、メチルフェニデート、アンフェタミン、及びデキストロアンフェタミン)、降圧薬(例えば、アルファ−メチルドーパ、クロルタリドン、レセルピン、シロシンゴピン、レシナミン、プラゾシン、フェントラミン、フェロジピン、プロプラノロール(propanolol)、ピンドロール、ラベタロール、クロニジン、カプトプリル、エナラプリル、及びリシノプリル)、抗組織新生薬(例えば、タキソール、アクチノマイシン、ブレオマイシンA2、マイトマイシンC、ダウノルビシン、ドキソルビシン、エピルビシン、イダルビシン、及びミトキサントロン)、催眠剤(例えば、ゾルピデム酒石酸塩、エスゾピクロン、ラメルテオン、及びザレプロン)、精神安定剤(例えば、アルプラゾラム、クロナゼパム、ジアゼパム、フルニトラゼパム、ロラゼパム、トリアゾラム、クロルプロマジン、フルフェナジン、ハロペリドール、コハク酸ロキサピン、ペルフェナジン、プロクロルペラジン、チオチキセン、及びトリフルオペラジン)、充血除去薬(例えば、エフェドリン、フェニレフリン、ナファゾリン、及びテトラヒドロゾリン)、ベータ遮断薬(例えば、レボブノロール、ピンドロール、マレイン酸チモロール、ビソプロロール、カルベジロール、及びブトキサミン)、アルファ遮断薬(例えば、ドキサゾシン、プラゾシン、フェノキシベンザミン、フェントラミン、タムスロシン、アルフゾシン、及びテラゾシン)、非ステロイドホルモン剤(例えば、コルチコトロピン、バソプレッシン、オキシトシン、インスリン、オキセンドロン、甲状腺ホルモン、及び副腎ホルモン)、勃起機能障害改善薬(例えば、カンゾウ、アロエ、ニンニク、ニゲラサティバ、ラウオルフィア、セイヨウオトギリソウ、及びバレリアン)、酵素(例えば、リパーゼ、プロテアーゼ、アミラーゼ、ラクターゼ、リゾチーム、及びウロキナーゼ)、体液性薬(例えば、プロスタグランジン、天然および合成の、例えば、PGE1、PGE2アルファ、PGF2アルファ、PGE1類似体ミソプロストール)、精神賦活剤(例えば、3−(2−アミノプロピル)インドール、及び3−(2−アミノブチル)インドール)、栄養剤、必須脂肪酸、非必須脂肪酸、ビタミン、ミネラル、及びそれらの組み合わせを含む。
多様な実施形態において、本明細書に開示の当該医薬組成はさらに、少なくとも1つの薬学的に許容される賦形剤を含んで良い。適切な賦形剤の非限定的な例示には、粘土鉱物、結合剤、充填剤、希釈剤、崩壊剤、キレート剤、香料、着色剤、味マスキング剤、及びそれらの組み合わせを含む。
当該医薬組成物が、経口固形剤形である実施形態において、その固形剤形はさらに、水溶性薄膜コーティング剤を含む。通常、この薄膜コーティング剤は、少なくとも1つの親水性ポリマーを含み、及び当該コーティング剤は、当該医薬組成物の即時放出性または乱用抑止特性に悪影響を与えない。当該薄膜コーティング剤は、湿気の保護、外観の強調、機械的特性の完全性の増加、飲み込み性の改善、味の向上、及び/または悪臭のマスキングを提供する。
特定の実施形態において、当該医薬組成物は、グルコマンナン、キサンタンガム、またはそれらの組み合わせから選ばれる、非セルロース多糖の重量で約5%から約40%、ポリエチレンオキサイド、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、カルボキシメチルセルロースナトリウム、またはそれらの組み合わせから選ばれる、親水性ゲル化ポリマーの重量で約10%から約50%、有機酸およびアルカリ金属重炭酸塩を含む、発泡システムの重量で約30%から約60%、及びオキシコドン、オキシモルホン、ヒドロコドン、ヒドロモルホン、コデイン、またはモルヒネから選ばれるAPIを含む。
本明細書に開示の当該医薬組成物の物理的形態は、変動でき及び変動するだろう。一般に、当該医薬組成物は、経口投与に対応して調合された固形剤形である。この固形剤形は、多様な固形投薬単位の1つである。適切な固形投薬単位の非限定的な例示には、錠剤、小型錠剤、小粒錠剤、カプセル型錠剤、丸薬、及びカプセルを含む。そのような投薬単位は、医薬処方の分野で公知の従来の方法を使用して調合されて良く、及び、関連記事に、例えば、Gennaro,A.R.,(編)“Remington:The Science & Practice of Pharmacy”,21(版),2006,Williams & Williams、及び“Physician‘s Desk Reference”,66(版),2014,PDR Staffに、記載されている。
本明細書に開示の当該医薬組成物は、当該APIが、その組成物から急速に放出されるように処方される。したがって、当該組成物は、即時放出医薬組成物と呼ばれる。本明細書で使用する「即時放出」とは、USP認定の生体外放出試験を利用して、当該APIの平均放出量が、45分以内に少なくとも70%であることを指す。多数の即時放出組成物とは異なって、本明細書に開示の当該医薬組成物は、高分子量の非セルロース多糖(類)及び親水性ゲル化ポリマー(類)の混合物を含む。しかしながら、本開示の組成物はまた、当該組成物の即時の溶解及び当該APIの急速な放出を促進する発泡システムを含む。
本明細書に開示の固形剤形医薬組成物はまた、乱用抑止の特徴がある。当該発泡システムにおける非セルロース多糖(類)及び親水性ゲル化ポリマーの組み合わせは、固形剤形組成物に適切な機械的特性の完全性(すなわち、強度、硬さなど)を与え、そのためその組成物は、小粒子を含む粉末を形成するための、粉砕、すりつぶし、裁断、または粉末化に対して耐性がある。さらに、その非セルロース多糖(類)及び親水性ゲル化ポリマー(類)の存在によって、当該固形剤形組成物(またはそれらの断片)が、様々な温度で、小容積の適切な溶媒に接触した場合、粘性な混合物またはゲルを形成する。
本開示の他の態様は、本明細書に開示の当該医薬組成物の固形剤形の調合に対応したプロセスを包含する。当該プロセスは、(a)少なくとも1つの非セルロース多糖、少なくとも1つの親水性ゲル化ポリマー、及び発泡システムを含む混合物を形成すること、(b)その混合物を固形投薬単位にすること、及び(c)その固形投薬単位を加熱して、当該固形剤形を形成することを含む。当該固形剤形は任意で、切れ目を入れて良く、及び任意で水溶性の薄膜コーティング剤でコートされて良い。
当該プロセスの最初のステップは、前述のセクション(I)(a)で詳細に記載した、当該医薬組成物の成分を含む混合物を形成することを含む。一般に、当該混合物は、少なくとも1つのAPI、少なくとも1つの非セルロース多糖、少なくとも1つの親水性ゲル化ポリマー、酸成分及び塩基成分を含む発泡システム、ならびに潤滑剤を含む。当該成分は、任意の順序で組み合わせて良く、または一緒に組み合わせる前に、多様な組み合わせで予備混合して良い。例えば、1つの実施形態において、当該発泡システムの酸成分は、その残りの成分と混合される前に、ポリアルキレングリコールまたはポロキサマーと共処理されて良い。他の実施形態において、当該APIは、その残りの成分と組み合わされる前に、その成分のいくつかと組み合わされて良い。したがって、多様な順序の混合の組み合わせが可能である。
当該プロセスはさらに、ステップ(a)から固形投薬単位への混合物を形成することを含む。適切な固形投薬単位は、前述のセクション(I)(b)に記載される。固形投薬単位を形成する手段は、当技術分野では公知である。例えば、Gennaro,A.R.,(編)“Remington:The Science & Practice of Pharmacy”,21(版),2006,Williams & Williams、及び“Physician‘s Desk Reference”,66(版),2014,PDR Staffを参照のこと。特定の実施形態において、当該固形投薬単位は、錠剤であって良い。当該錠剤は、圧縮錠剤、成形錠剤、小型錠剤、またはプレス錠剤であって良い。例示的な実施形態において、当該錠剤は、直接圧縮により形成されて良い。当該錠剤の形状は、多様であって良い。非限定的な錠剤形状には、丸形、楕円形、長方形、及び三角形を含む。当該錠剤の大きさ及び質量は、多様であって良い。多様な実施形態において、当該錠剤の質量は、約100mgから約1000mgの範囲であって良い。例示的な実施形態において、当該錠剤の質量は、約300mgから約500mgの範囲であって良い。当該固形投薬単位は、適切なダイス及び/またはパンチ器の選択により、切れ目を入れて良い。
当該プロセスはさらに、ステップ(b)から当該固形投薬単位を加熱すること含む。この加熱ステップは、当該固形投薬単位を乾燥し及び硬化させ、ここでその硬化した固形剤形は、未硬化の固形投薬単位に比べて、その特性及び性質が改善されて良い。例えば、当該加熱ステップは、その固形投薬単位から水分を除去して良く、それゆえに当該発泡システムを、早期の泡立ちから保護する。さらに、当該加熱ステップは、そのポリマーのいくつかを可塑化して良く、それゆえに粉砕/粉末化への耐性を増加させ及び/またはより急速な当該APIの放出をもたらす。
当該固形剤形は、薄膜コーティング剤でコートされて良い。適切な薄膜コーティング剤が、前述のセクション(I)(a)(viii)に詳細に記載される。この任意のコーティングは、その加熱ステップの前に、当該固形投薬単位に適用されて良く、またはこの任意のコーティングは、その加熱ステップの後に、当該固形剤形に適用されて良い。
本明細書に記載の実施形態の構成要素を導入する場合、冠詞の「a」、「an」、「the」及び「said」は、その要素の1つ以上があることを意味している。用語「comprising」、「including」及び「having」は、そこに網羅された要素以外の追加要素があることを包含し及び意味している。
以下の表1に表わす各製剤の50gバッチを、プラスチック袋の中でステアリン酸マグネシウム以外の全ての成分を組み合わせて調合し、及びその混合物を、手動で5分間混ぜ合わせた。次いでステアリン酸マグネシウムを添加し、及びさらに2〜3分間、その混合物を混ぜ合わせた。次いで、その混合物を、単品用のNatoli錠剤プレス器を使用して、約21kNの圧縮力で楕円形錠剤に圧縮成形した。その錠剤を、アルミニウム皿に置き、及び実験オーブン中で、80℃で3時間過熱して硬化させた。
オキシコドン塩酸塩の生体外放出量を、USP認証試験を使用して決定した。その溶解パラメーターは、USP2型装置(パドル型)、50rpm、及び500mLの水または0.1NのHCl、37℃±0.5℃であった。その溶解液中のオキシコドンHClの量を、決められた間隔で決定した。その溶解データを、表2及び3に提供する。3製剤のすべてが、その有効成分の即時放出を示した。
製剤1〜3を用いて硬化した錠剤を、Cuisinart DCG−20Nコーヒーグラインダーを使用して、高剪断条件のもとで粉に挽いた。その粉砕は、トータル3分のミル時間に対して、各30秒のミル、その後30秒の一時停止を行った(すなわち、30秒が6回)。そのミル化物を、粒径分析で特徴づけた。表4に、500μmを超えた大きさ、250から500μm、及び250μmを下回って報告された粒径で、このミル化実験から得た粒径データを提供する。一般に、250μmを超えた大きさは、吸引が困難であると考えられ、及びそのため、250μmを超えた粒子が大部分を占める製剤が、この乱用の経路に対して良好な抑止力を有するとされる。
製剤1〜3の錠剤に対して、オキシコドンが、多様な溶媒及び様々な温度でどのくらい抽出できるかを決定する試験を行った。抽出される有効成分が少ないほど、乱用スケジュールIV薬物投与に対して、当該製剤によって与えられる抑止力は良好である。
Claims (11)
- 少なくとも1つのオピオイドまたは薬学的に許容されるそれらの塩、グルコマンナンとキサンタンガムとを含む少なくとも2つの非セルロース多糖、1つ以上のポリエチレンオキサイドと1つ以上のセルロースエーテルとを含む少なくとも2つの親水性ゲル化ポリマー、及び有機酸とアルカリ金属重炭酸塩またはアルカリ金属炭酸塩とを含む発泡システムを含む、医薬組成物であって、前記医薬組成物が、前記オピオイドの即時放出をもたらし、前記少なくとも1つのオピオイドが、オキシコドン、オキシモルホン、ヒドロコドン、ヒドロモルホン、コデイン、またはモルヒネであり、前記セルロースエーテルが、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、またはカルボキシメチルセルロースナトリウムのうちの少なくとも1つである、医薬組成物。
- USP認定の生体外放出手順を使用して溶解が測定される場合、前記オピオイドの少なくとも70%が、45分以内に放出される、請求項1に記載の前記医薬組成物。
- 250ミクロンを超えて大きい平均粒径を有する粒子の過半数が、前記組成物を、粉砕、すりつぶし、または粉末化にして形成される、請求項1または2に記載の前記医薬組成物。
- 前記少なくとも2つの非セルロース多糖が、前記医薬組成物の重量で、2%から60%の量で存在する、請求項1から3のいずれかに記載の前記医薬組成物。
- 前記少なくとも2つの親水性ゲル化ポリマーが、前記医薬組成物の重量で、5%から80%の量で存在する、請求項1から4のいずれかに記載の前記医薬組成物。
- 前記発泡システムが、前記医薬組成物の重量で、20%から90%の量で存在する、請求項1から5のいずれかに記載の前記医薬組成物。
- 前記少なくとも2つの非セルロース多糖が、前記医薬組成物の重量で5%から40%の量で存在し、前記少なくとも2つの親水性ゲル化ポリマーが、前記医薬組成物の重量で10%から50%の量で存在し、及び前記発泡システムが、前記医薬組成物の重量で30%から60%の量で存在する、請求項1〜6のいずれか1項に記載の前記医薬組成物。
- 前記少なくとも1つのオピオイドが、オキシコドンである、請求項1〜7のいずれか1項に記載の前記医薬組成物。
- 前記医薬組成物が、固形剤形である、請求項1〜8のいずれか1項に記載の前記医薬組成物。
- 前記固形剤形が、錠剤である、請求項9に記載の前記医薬組成物。
- 前記固形剤形が、
a)前記少なくとも1つのオピオイドまたは薬学的に許容されるそれらの塩、前記少なくとも2つの非セルロース多糖、前記少なくとも2つの親水性ゲル化ポリマー、及び前記発泡システムを含む混合物を形成すること、
b)前記混合物を、固形投薬単位にすること、及び
c)前記固形投薬単位を加熱して、前記固形剤形を産出すること、
を含むプロセスで調合される、請求項9に記載の前記医薬組成物。
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Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2838516B1 (en) | 2012-04-18 | 2018-10-17 | SpecGx LLC | Immediate release, abuse deterrent pharmaceutical compositions |
AU2015284078B2 (en) | 2014-07-03 | 2020-01-30 | SpecGx LLC | Abuse deterrent immediate release formulations comprising non-cellulose polysaccharides |
US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
EP3413893A4 (en) * | 2016-02-08 | 2019-08-28 | SpecGx LLC | PHARMACEUTICAL COMPOSITIONS COMPRISING GLUCOMANNAN WITH EXTENDED RELEASE AND WITH ABUSE DISSUASION PROPERTIES |
US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
EP3473246A1 (en) | 2017-10-19 | 2019-04-24 | Capsugel Belgium NV | Immediate release abuse deterrent formulations |
WO2020068510A1 (en) | 2018-09-25 | 2020-04-02 | SpecGx LLC | Abuse deterrent immediate release capsule dosage forms |
CN110101679A (zh) * | 2019-05-15 | 2019-08-09 | 上海宣泰生物科技有限公司 | 海藻小苏打微泡腾片及其制备方法和应用 |
Family Cites Families (89)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2211485A (en) | 1940-08-13 | Effervescent acetyl salicylic acid | ||
JPS537495B2 (ja) | 1973-05-21 | 1978-03-18 | ||
US3980766A (en) | 1973-08-13 | 1976-09-14 | West Laboratories, Inc. | Orally administered drug composition for therapy in the treatment of narcotic drug addiction |
DE2530563C2 (de) | 1975-07-09 | 1986-07-24 | Bayer Ag, 5090 Leverkusen | Analgetische Arzneimittel mit vermindertem Mißbrauchspotential |
US4678661A (en) | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
JPH0747532B2 (ja) | 1985-10-16 | 1995-05-24 | 花王株式会社 | 錠剤の製造方法 |
US5096714A (en) | 1988-06-28 | 1992-03-17 | Hauser-Kuhrts, Inc. | Prolonged release drug tablet formulations |
US4956182A (en) * | 1989-03-16 | 1990-09-11 | Bristol-Myers Company | Direct compression cholestyramine tablet and solvent-free coating therefor |
JP2628231B2 (ja) | 1992-12-30 | 1997-07-09 | エフ エム シー コーポレーション | 放出調整賦形剤として容易に入手できるコンニャクグルコマンナン |
GB9401894D0 (en) | 1994-02-01 | 1994-03-30 | Rhone Poulenc Rorer Ltd | New compositions of matter |
US6071539A (en) | 1996-09-20 | 2000-06-06 | Ethypharm, Sa | Effervescent granules and methods for their preparation |
US6200604B1 (en) | 1998-03-27 | 2001-03-13 | Cima Labs Inc. | Sublingual buccal effervescent |
CA2343148C (en) | 1998-09-10 | 2005-11-15 | Nycomed Danmark A/S | Quick release pharmaceutical compositions of drug substances |
US20080102121A1 (en) | 1998-11-02 | 2008-05-01 | Elan Pharma International Limited | Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone |
FR2785191B1 (fr) | 1998-11-02 | 2002-05-31 | Rhodia Chimie Sa | Utilisation de gommes xanthanes pour la preparation de compositions pharmaceutiques |
US6264981B1 (en) | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
US6541025B1 (en) | 1999-12-30 | 2003-04-01 | Shear/Kershman Laboratories, Inc. | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
US6340471B1 (en) | 1999-12-30 | 2002-01-22 | Alvin Kershman | Method for preparing solid delivery system for encapsulated and non-encapsulated pharmaceuticals |
US6660302B1 (en) | 2000-09-06 | 2003-12-09 | Chr. Hansen, Inc. | Dry-powder film coating composition and method of preparation |
GB0102342D0 (en) | 2001-01-30 | 2001-03-14 | Smithkline Beecham Plc | Pharmaceutical formulation |
US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
US20080050422A1 (en) | 2001-10-12 | 2008-02-28 | Monosolrx, Llc. | Method of administering a film product containing a drug |
WO2003032954A1 (en) | 2001-10-17 | 2003-04-24 | Dr. Reddy's Laboratories Ltd. | Stabilized pharmaceutical formulations containing amlodipine maleate |
AUPR839001A0 (en) | 2001-10-19 | 2001-11-15 | Eli Lilly And Company | Dosage form, device and methods of treatment |
US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
US20040005359A1 (en) | 2002-06-27 | 2004-01-08 | Cheng Xiu Xiu | Controlled release oral dosage form |
US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
DE102004020220A1 (de) | 2004-04-22 | 2005-11-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
PL1658054T3 (pl) | 2003-08-06 | 2007-11-30 | Gruenenthal Gmbh | Postać aplikacyjna zabezpieczona przed nadużyciem |
DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
KR20060085686A (ko) | 2003-10-10 | 2006-07-27 | 라이프사이클 파마 에이/에스 | 피브레이트를 포함하는 고형 제제 |
AU2013206525B2 (en) * | 2003-11-26 | 2015-09-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
US20050165038A1 (en) | 2004-01-22 | 2005-07-28 | Maxwell Gordon | Analgetic dosage forms that are resistant to parenteral and inhalation dosing and have reduced side effects |
WO2006002836A1 (de) | 2004-07-01 | 2006-01-12 | Losan Pharma Gmbh | Brausezusammensetzungen von einschlafmitteln |
DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
US8093408B2 (en) | 2005-06-21 | 2012-01-10 | The Company Wockhardt | Antidepressant oral pharmaceutical compositions |
PL116330U1 (en) | 2005-10-31 | 2007-04-02 | Alza Corp | Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation |
US8329744B2 (en) * | 2005-11-02 | 2012-12-11 | Relmada Therapeutics, Inc. | Methods of preventing the serotonin syndrome and compositions for use thereof |
US8652529B2 (en) | 2005-11-10 | 2014-02-18 | Flamel Technologies | Anti-misuse microparticulate oral pharmaceutical form |
US20090317355A1 (en) | 2006-01-21 | 2009-12-24 | Abbott Gmbh & Co. Kg, | Abuse resistant melt extruded formulation having reduced alcohol interaction |
RU2435569C2 (ru) | 2006-03-16 | 2011-12-10 | Трис Фарма, Инк. | Композиции с модифицированным высвобождением, содержащие комплексы лекарственное вещество - ионообменная смола |
AU2007230730B2 (en) | 2006-03-24 | 2013-03-28 | Auxilium International Holdings, Inc. | Stabilized compositions containing alkaline labile drugs |
US20100048451A1 (en) | 2006-04-06 | 2010-02-25 | Taro Pharmaceuticals North America, Inc. | Novel spill-resistant formulations comprising hydrocolloidal polymers |
US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
ES2300188B1 (es) | 2006-05-24 | 2009-05-01 | Ferrer Internacional, S.A. | Comprimido bicapa para la prevencion de los accidentes cardiovasculares. |
US20080069891A1 (en) | 2006-09-15 | 2008-03-20 | Cima Labs, Inc. | Abuse resistant drug formulation |
SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
US8445018B2 (en) | 2006-09-15 | 2013-05-21 | Cima Labs Inc. | Abuse resistant drug formulation |
RU2428186C2 (ru) | 2007-03-02 | 2011-09-10 | Теика Фармасьютикал Ко., Лтд. | Лекарственная композиция для чрескожной абсорбции, изделие, сохраняющее лекарственную композицию, и содержащий ее препарат для чрескожной абсорбции |
AU2008240044B2 (en) | 2007-04-13 | 2013-09-12 | Teva Pharamceuticals International Gmbh | Oral cephalotaxine dosage forms |
CA2689594A1 (en) | 2007-06-07 | 2008-12-11 | Sato Pharmaceutical Co., Ltd. | Film preparation with rapidly dissolving property and flexibility |
US20090124650A1 (en) | 2007-06-21 | 2009-05-14 | Endo Pharmaceuticals, Inc. | Method of Treating Pain Utilizing Controlled Release Oxymorphone Pharmaceutical Compositions and Instructions on Effects of Alcohol |
CN101801350A (zh) | 2007-08-13 | 2010-08-11 | 阿巴斯迪特宁医药有限公司 | 抗滥用药物、使用方法和制备方法 |
PL2200588T3 (pl) | 2007-09-25 | 2019-09-30 | Solubest Ltd. | Kompozycje zawierające lipofilowe związki aktywne i sposób ich wytwarzania |
US8486448B2 (en) | 2007-12-17 | 2013-07-16 | Paladin Labs Inc. | Misuse preventative, controlled release formulation |
EP2249811A1 (en) | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmaceutical dosage form |
US7918929B2 (en) | 2008-02-19 | 2011-04-05 | John Christopher Sunnucks | Water erodible denture adhesive |
US8729070B2 (en) | 2008-02-20 | 2014-05-20 | Targia Pharmaceuticals | CNS pharmaceutical compositions and methods of use |
WO2009136625A1 (ja) | 2008-05-07 | 2009-11-12 | 大日本住友製薬株式会社 | 環状アミン-1-カルボン酸エステル誘導体およびそれを含有する医薬組成物 |
AU2009279619A1 (en) | 2008-08-07 | 2010-02-11 | Avantor Performance Materials, Inc. | Sustained release compositions comprising gums and sugar alcohols |
EP2344136B1 (en) | 2008-09-18 | 2016-06-15 | Purdue Pharma LP | Pharmaceutical dosage forms comprising poly(e-caprolactone) |
US20110268666A1 (en) | 2008-09-29 | 2011-11-03 | Yissum Research Development Company of the Research University of Jerusalem, Ltd. | Novel gastroretentive delivery system |
EP2393487B1 (en) * | 2009-02-06 | 2016-11-02 | Egalet Ltd. | Pharmaceutical compositions resistant to abuse |
WO2010089132A1 (en) * | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
GB0909680D0 (en) | 2009-06-05 | 2009-07-22 | Euro Celtique Sa | Dosage form |
PL2456424T3 (pl) | 2009-07-22 | 2013-12-31 | Gruenenthal Gmbh | Stabilizowana przed utlenianiem odporna na naruszenie postać dawkowania |
PL2456427T3 (pl) | 2009-07-22 | 2015-07-31 | Gruenenthal Gmbh | Wytłaczana na gorąco postać dawki o kontrolowanym uwalnianiu |
WO2011041414A1 (en) | 2009-09-30 | 2011-04-07 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
JP5017516B2 (ja) | 2009-11-13 | 2012-09-05 | 株式会社ホットアルバム炭酸泉タブレット | 錠剤の製造方法 |
WO2011066980A2 (en) | 2009-12-04 | 2011-06-09 | Lars Holger Hermann | Oral dosage forms with reduced potential for drug abuse |
WO2011079074A1 (en) | 2009-12-24 | 2011-06-30 | Acura Phamaceuticals, Inc. | Pharmaceutical compositions for deterring misuse, abuse, and diversion |
US20120321674A1 (en) | 2011-02-17 | 2012-12-20 | Michael Vachon | Technology for Preventing Abuse of Solid Dosage Forms |
JP6141583B2 (ja) | 2010-02-24 | 2017-06-07 | シマ ラブス インク. | 濫用耐性製剤 |
US20130202705A1 (en) | 2010-05-11 | 2013-08-08 | Cima Labs Inc. | Alcohol-resistant formulations |
JP2013526523A (ja) | 2010-05-11 | 2013-06-24 | シマ ラブス インク. | メトプロロールを含むアルコール耐性持続放出性経口剤形 |
EP2579857A1 (en) | 2010-05-11 | 2013-04-17 | Cima Labs Inc. | Alcohol-resistant extended release dosage forms comprising venlafaxine |
EP2409683A1 (en) | 2010-07-06 | 2012-01-25 | KRKA, D.D., Novo Mesto | Stable aqueous formulations comprising poorly water soluble active ingredients |
AU2012219322A1 (en) | 2011-02-17 | 2013-05-09 | QRxPharma Ltd. | Technology for preventing abuse of solid dosage forms |
CA2853764C (en) | 2011-11-22 | 2017-05-16 | Watson Pharmaceuticals, Inc. | Immediate release abuse deterrent tablet |
EP2838516B1 (en) * | 2012-04-18 | 2018-10-17 | SpecGx LLC | Immediate release, abuse deterrent pharmaceutical compositions |
US20130280176A1 (en) * | 2012-04-18 | 2013-10-24 | Mallinckrodt Llc | Immediate Release Pharmaceutical Compositions with Abuse Deterrent Properties |
US9549899B2 (en) | 2012-07-06 | 2017-01-24 | Egalet Ltd. | Abuse deterrent pharmaceutical compositions for controlled release |
CA2791206A1 (en) * | 2012-09-28 | 2014-03-28 | Pharmascience Inc. | Abuse deterrent pharmaceutical formulation |
PL2968182T3 (pl) | 2013-03-15 | 2018-10-31 | SpecGx, LLC | Zniechęcająca do nadużywania stała postać dawkowania dla natychmiastowego uwalniania z funkcjonalnym rowkiem |
AU2015284078B2 (en) | 2014-07-03 | 2020-01-30 | SpecGx LLC | Abuse deterrent immediate release formulations comprising non-cellulose polysaccharides |
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HUE065006T2 (hu) | 2024-04-28 |
CA2953396C (en) | 2022-11-08 |
BR112016030648A2 (pt) | 2021-09-08 |
MX2017000041A (es) | 2017-05-01 |
DK3164117T3 (da) | 2023-12-04 |
AU2015284078B2 (en) | 2020-01-30 |
PT3164117T (pt) | 2023-12-12 |
PL3164117T3 (pl) | 2024-03-11 |
ES2963078T3 (es) | 2024-03-25 |
AU2015284078A1 (en) | 2017-01-05 |
EP3164117A4 (en) | 2017-12-06 |
CA2953396A1 (en) | 2016-01-07 |
US20200368148A1 (en) | 2020-11-26 |
EP3164117B1 (en) | 2023-09-06 |
EP3164117A1 (en) | 2017-05-10 |
JP2017519783A (ja) | 2017-07-20 |
US11617712B2 (en) | 2023-04-04 |
US20160000703A1 (en) | 2016-01-07 |
US11517521B2 (en) | 2022-12-06 |
BR112016030648B1 (pt) | 2023-10-03 |
WO2016004170A1 (en) | 2016-01-07 |
US11583493B2 (en) | 2023-02-21 |
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