JP6836508B2 - キメラタンパク質 - Google Patents

キメラタンパク質 Download PDF

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JP6836508B2
JP6836508B2 JP2017542093A JP2017542093A JP6836508B2 JP 6836508 B2 JP6836508 B2 JP 6836508B2 JP 2017542093 A JP2017542093 A JP 2017542093A JP 2017542093 A JP2017542093 A JP 2017542093A JP 6836508 B2 JP6836508 B2 JP 6836508B2
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cells
domain
caspase
nucleic acid
chimeric protein
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JP2018506975A (ja
JP2018506975A5 (https=
Inventor
マーティン プーレ，
マーティン プーレ，
ライアン トローブリッジ，
ライアン トローブリッジ，
エドワード ホジキン，
エドワード ホジキン，
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UCL Business Ltd
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UCL Business Ltd
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/14—Hydrolases (3)
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    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
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    • C12Y304/22062—Caspase-9 (3.4.22.62)
    • A—HUMAN NECESSITIES
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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JP2017542093A 2015-02-24 2016-02-23 キメラタンパク質 Active JP6836508B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB201503133A GB201503133D0 (en) 2015-02-24 2015-02-24 Chimeric protein
GB1503133.9 2015-02-24
PCT/GB2016/050451 WO2016135470A1 (en) 2015-02-24 2016-02-23 Chimeric protein

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020038667A Division JP2020078359A (ja) 2015-02-24 2020-03-06 キメラタンパク質

Publications (3)

Publication Number Publication Date
JP2018506975A JP2018506975A (ja) 2018-03-15
JP2018506975A5 JP2018506975A5 (https=) 2019-02-14
JP6836508B2 true JP6836508B2 (ja) 2021-03-03

Family

ID=52822149

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017542093A Active JP6836508B2 (ja) 2015-02-24 2016-02-23 キメラタンパク質
JP2020038667A Withdrawn JP2020078359A (ja) 2015-02-24 2020-03-06 キメラタンパク質
JP2022092922A Pending JP2022111273A (ja) 2015-02-24 2022-06-08 キメラタンパク質
JP2024111258A Pending JP2024133176A (ja) 2015-02-24 2024-07-10 キメラタンパク質

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020038667A Withdrawn JP2020078359A (ja) 2015-02-24 2020-03-06 キメラタンパク質
JP2022092922A Pending JP2022111273A (ja) 2015-02-24 2022-06-08 キメラタンパク質
JP2024111258A Pending JP2024133176A (ja) 2015-02-24 2024-07-10 キメラタンパク質

Country Status (20)

Country Link
US (3) US10098911B2 (https=)
EP (2) EP4147696A1 (https=)
JP (4) JP6836508B2 (https=)
KR (2) KR20230156817A (https=)
CN (2) CN107207621B (https=)
AU (1) AU2016225190B2 (https=)
CA (1) CA2973107C (https=)
CL (1) CL2017002134A1 (https=)
DK (1) DK3197453T3 (https=)
ES (1) ES2930623T3 (https=)
GB (1) GB201503133D0 (https=)
HU (1) HUE060267T2 (https=)
IL (1) IL252840B (https=)
MX (1) MX392658B (https=)
PL (1) PL3197453T3 (https=)
PT (1) PT3197453T (https=)
RU (1) RU2746755C2 (https=)
SG (1) SG11201705300VA (https=)
WO (1) WO2016135470A1 (https=)
ZA (1) ZA201704231B (https=)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201503133D0 (en) * 2015-02-24 2015-04-08 Ucl Business Plc And Syncona Partners Llp Chimeric protein
US20170166877A1 (en) * 2015-12-14 2017-06-15 Bellicum Pharmaceuticals, Inc. Dual controls for therapeutic cell activation or elimination
ES3051391T3 (en) 2016-10-06 2025-12-29 Poseida Therapeutics Inc Inducible caspases and methods for use
CN110191955B (zh) * 2016-12-13 2024-05-31 西雅图儿童医院（Dba西雅图儿童研究所） 在体外和体内对工程化的细胞中表达的化学物质诱导的信号传导复合物进行外源性药物激活的方法
JP2020503390A (ja) 2017-01-09 2020-01-30 オイシン バイオテクノロジーズ， インコーポレイテッド 治療用タンパク質の標的細胞特異的な産生のため、および標的細胞に関連する疾患、状態、または障害の治療のための、膜融合性脂質ナノ粒子、ならびにその作製および使用のための方法
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