JP6825163B2 - 抗癌剤としての置換［５，６］シクロ−４（３ｈ）−ピリミジノン - Google Patents
抗癌剤としての置換［５，６］シクロ−４（３ｈ）−ピリミジノン Download PDFInfo
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- JP6825163B2 JP6825163B2 JP2020500788A JP2020500788A JP6825163B2 JP 6825163 B2 JP6825163 B2 JP 6825163B2 JP 2020500788 A JP2020500788 A JP 2020500788A JP 2020500788 A JP2020500788 A JP 2020500788A JP 6825163 B2 JP6825163 B2 JP 6825163B2
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- compound
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- pyrimidine
- pharmaceutically acceptable
- thieno
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- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
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- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
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| US201762509128P | 2017-05-21 | 2017-05-21 | |
| US62/509,128 | 2017-05-21 | ||
| PCT/US2018/031474 WO2018217439A1 (en) | 2017-05-21 | 2018-05-08 | Substituted [5,6]cyclic-4(3h)-pyrimidinones as anticancer agents |
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| JP2020511542A JP2020511542A (ja) | 2020-04-16 |
| JP2020511542A5 JP2020511542A5 (https=) | 2020-05-28 |
| JP6825163B2 true JP6825163B2 (ja) | 2021-02-03 |
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| Country | Link |
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| US (1) | US10745410B2 (https=) |
| JP (1) | JP6825163B2 (https=) |
| CN (2) | CN112409373A (https=) |
| WO (1) | WO2018217439A1 (https=) |
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| CN116490507A (zh) * | 2020-09-10 | 2023-07-25 | 薛定谔公司 | 用于治疗癌症的杂环包缩合cdc7激酶抑制剂 |
| CN112661770B (zh) * | 2020-12-24 | 2022-11-08 | 南京正济医药研究有限公司 | 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法 |
| TW202300150A (zh) * | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
| CN114544811B (zh) * | 2022-02-17 | 2023-10-20 | 南京正济医药研究有限公司 | 一种cdc7抑制剂有关物质的检测方法 |
| CN121021530A (zh) * | 2022-05-19 | 2025-11-28 | 南京正济医药研究有限公司 | 一种[5,6]环-4(3h)-嘧啶酮类化合物的晶型iii及其药物组合物、用途 |
| WO2025239965A1 (en) * | 2024-05-17 | 2025-11-20 | Purdue Research Foundation | Inhibitors of cdc14 phosphatases and related compositions and methods of use |
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| US20090030196A1 (en) * | 2006-12-29 | 2009-01-29 | Abbott Laboratories | Pim kinase inhibitors as cancer chemotherapeutics |
| WO2010101302A1 (en) * | 2009-03-05 | 2010-09-10 | Takeda Pharmaceutical Company Limited | Thienopyrimidine as cdc7 kinase inhibitors |
| SG183304A1 (en) * | 2010-02-17 | 2012-09-27 | Takeda Pharmaceutical | Heterocyclic compound |
| DK3436463T3 (da) * | 2016-03-28 | 2021-08-30 | Takeda Pharmaceuticals Co | Krystalline former af 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-on hemi-hydrat |
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2018
- 2018-05-08 WO PCT/US2018/031474 patent/WO2018217439A1/en not_active Ceased
- 2018-05-08 JP JP2020500788A patent/JP6825163B2/ja not_active Expired - Fee Related
- 2018-05-08 US US16/487,832 patent/US10745410B2/en not_active Expired - Fee Related
- 2018-05-08 CN CN202011093268.6A patent/CN112409373A/zh active Pending
- 2018-05-08 CN CN201880014693.6A patent/CN110381950B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN110381950A (zh) | 2019-10-25 |
| US20200055867A1 (en) | 2020-02-20 |
| CN110381950B (zh) | 2020-09-04 |
| US10745410B2 (en) | 2020-08-18 |
| WO2018217439A1 (en) | 2018-11-29 |
| JP2020511542A (ja) | 2020-04-16 |
| CN112409373A (zh) | 2021-02-26 |
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