CN112409373A - 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮 - Google Patents

作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮 Download PDF

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Publication number
CN112409373A
CN112409373A CN202011093268.6A CN202011093268A CN112409373A CN 112409373 A CN112409373 A CN 112409373A CN 202011093268 A CN202011093268 A CN 202011093268A CN 112409373 A CN112409373 A CN 112409373A
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CN
China
Prior art keywords
ring
compound
hydrocarbon
limited
aromatic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN202011093268.6A
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English (en)
Chinese (zh)
Inventor
H·张
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanjing Zhengji Pharmaceutical Research Co ltd
Original Assignee
Nanjing Zhengji Pharmaceutical Research Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Nanjing Zhengji Pharmaceutical Research Co ltd filed Critical Nanjing Zhengji Pharmaceutical Research Co ltd
Publication of CN112409373A publication Critical patent/CN112409373A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN202011093268.6A 2017-05-21 2018-05-08 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮 Pending CN112409373A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762509128P 2017-05-21 2017-05-21
US62/509,128 2017-05-21
CN201880014693.6A CN110381950B (zh) 2017-05-21 2018-05-08 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201880014693.6A Division CN110381950B (zh) 2017-05-21 2018-05-08 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮

Publications (1)

Publication Number Publication Date
CN112409373A true CN112409373A (zh) 2021-02-26

Family

ID=64395863

Family Applications (2)

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CN202011093268.6A Pending CN112409373A (zh) 2017-05-21 2018-05-08 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮
CN201880014693.6A Active CN110381950B (zh) 2017-05-21 2018-05-08 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮

Family Applications After (1)

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CN201880014693.6A Active CN110381950B (zh) 2017-05-21 2018-05-08 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮

Country Status (4)

Country Link
US (1) US10745410B2 (https=)
JP (1) JP6825163B2 (https=)
CN (2) CN112409373A (https=)
WO (1) WO2018217439A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116490507A (zh) * 2020-09-10 2023-07-25 薛定谔公司 用于治疗癌症的杂环包缩合cdc7激酶抑制剂
CN112661770B (zh) * 2020-12-24 2022-11-08 南京正济医药研究有限公司 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法
TW202300150A (zh) * 2021-03-18 2023-01-01 美商薛定諤公司 環狀化合物及其使用方法
CN114544811B (zh) * 2022-02-17 2023-10-20 南京正济医药研究有限公司 一种cdc7抑制剂有关物质的检测方法
CN121021530A (zh) * 2022-05-19 2025-11-28 南京正济医药研究有限公司 一种[5,6]环-4(3h)-嘧啶酮类化合物的晶型iii及其药物组合物、用途
WO2025239965A1 (en) * 2024-05-17 2025-11-20 Purdue Research Foundation Inhibitors of cdc14 phosphatases and related compositions and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120040981A1 (en) * 2009-03-05 2012-02-16 Takeda Pharmaceutical Company Limited Thienopyrimidine as cdc7 kinase inhibitors
US20160310494A1 (en) * 2010-02-17 2016-10-27 Takeda Pharmaceutical Company Limited Heterocyclic compound

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090030196A1 (en) * 2006-12-29 2009-01-29 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics
DK3436463T3 (da) * 2016-03-28 2021-08-30 Takeda Pharmaceuticals Co Krystalline former af 2-[(2s)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1h-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3h)-on hemi-hydrat

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120040981A1 (en) * 2009-03-05 2012-02-16 Takeda Pharmaceutical Company Limited Thienopyrimidine as cdc7 kinase inhibitors
US20160310494A1 (en) * 2010-02-17 2016-10-27 Takeda Pharmaceutical Company Limited Heterocyclic compound

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
马英: "《药物化学（第2版）》", 31 August 2012, 河南科学技术出版社, pages: 7 *

Also Published As

Publication number Publication date
CN110381950A (zh) 2019-10-25
US20200055867A1 (en) 2020-02-20
CN110381950B (zh) 2020-09-04
US10745410B2 (en) 2020-08-18
WO2018217439A1 (en) 2018-11-29
JP2020511542A (ja) 2020-04-16
JP6825163B2 (ja) 2021-02-03

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