JP6821163B2 - ゴシュユ抽出物又はエボジアミンを有効成分として含むカフェイン中毒による疾患の予防又は治療用組成物 - Google Patents
ゴシュユ抽出物又はエボジアミンを有効成分として含むカフェイン中毒による疾患の予防又は治療用組成物 Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
Description
エボジアミン、カフェイン、DMSO(dimethyl sulfoxide)及びTween−20は、シグマ社(Sigma−Aldrich Chemistry Co.)から購入して用いた。エントバルは、Han lim Pharmacy Co.Ltd.から購買して用いた。
4週齢のICR系雄マウス(20〜22g)をコアテック(平沢、大韓民国)から供給を受け、成均館大学校薬学大学の動物飼育室で1週以上飼育し、適応させて用いた。水と飼料は自由に摂取するようにし、温度(23±2℃)、湿度(55±10%)及び明暗周期(12時間)は自動に調節されるようにした。
ゴシュユは、京東市場(ソウル、大韓民国)で中国産を購入して用いた。乾燥されたゴシュユ193gを完全に乾燥した後に粉碎し、70〜80℃の水で沸かした後、40℃で冷やし、これを濾過紙(Whatman社、アメリカ)で濾過した後、減圧濃縮器(EYELA社、N−1000、日本)で減圧濃縮した。凍結乾燥してゴシュユ粗抽出物を31g収得した。
カフェイン誘導による中枢神経の興奮に対するエボジアミンの抑制効果を測定するために、実施例2で準備したマウスを各群当たり12匹ずつ4群に分けてエボジアミン及びカフェインをそれぞれ異にして投与して準備した。第1群は、10%のDMSOを含んだ蒸溜水投与群とし(対照群)、第2群は、10%のDMSOを含んだ蒸溜水及びカフェイン10mg/kg、第3群は、エボジアミン10mg/kg及びカフェイン10mg/kg投与群、第4群は、エボジアミン20mg/kg及びカフェイン10mg/kg投与群とした。
ゴシュユ抽出物のカフェインによる睡眠障害の改善を確認するために、実施例2で準備したマウスを各群当たり12匹ずつ4群(第1群〜第4群)に分け、実施例3で製造したゴシュユ抽出物、エントバル及びカフェインを各群別に異にして投与して準備した。具体的に、第1群は、10%のDMSOを含んだ蒸溜水及びエントバル40mg/kg投与群で対照群とし、第2群は、10%のDMSOを含んだ蒸溜水、カフェイン50mg/kg及びエントバル40mg/kg投与群、第3群は、ゴシュユ抽出物200mg/kg、カフェイン50mg/kg及びエントバル40mg/kg投与群、第4群は、ゴシュユ抽出物400mg/kg、カフェイン50mg/kg及びエントバル40mg/kg投与群とした。
ゴシュユ抽出物とエボジアミンのカフェインによる睡眠障害の改善効果を比較するために、実施例3で製造したゴシュユの熱水抽出物、エタノール抽出物及びエボジアミンを、実施例2で準備したマウスに1日1回3日間経口投与し、最終投与してから30分後にカフェイン50mg/kgを腹腔注射した。その後、30分後にエントバル40mg/kgを腹腔注射して睡眠を誘導し、以後睡眠に到達する(Sleep onset)までの時間及び総睡眠時間(Sleep duration)を測定した。
全ての実験結果は、ANOVA(one way anlysis of variance)を用いて統計処理し、有意性が検証される場合、LSD testを用いてp<0.05レベル以下で有意性検定を実施した。
Claims (3)
- エボジアミンを有効成分として含むカフェイン中毒による疾患の予防又は治療用薬学組成物。
- 前記疾患は、カフェインの投与による不眠症、下痢、興奮症状、頭痛、集中力低下、めまい、吐き気、憂鬱感、不安感、本態性振戦症及び筋肉痛からなる群より選択される疾患であることを特徴とする、請求項1に記載の薬学組成物。
- エボジアミンを有効成分として含むカフェイン中毒による疾患の予防又は改善用健康機能食品組成物。
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KR1020160165353A KR101923721B1 (ko) | 2016-12-06 | 2016-12-06 | 오수유 추출물 또는 에보디아민을 유효성분으로 포함하는 카페인 중독에 의한 질환의 예방 또는 치료용 조성물 |
KR10-2016-0165353 | 2016-12-06 | ||
PCT/KR2017/014021 WO2018105960A1 (ko) | 2016-12-06 | 2017-12-01 | 오수유 추출물 또는 에보디아민을 유효성분으로 포함하는 카페인 중독에 의한 질환의 예방 또는 치료용 조성물 |
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KR880001296A (ko) | 1986-07-09 | 1988-04-22 | 이시복 | 중독해독제 및 이의 제조방법 |
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US8669264B2 (en) * | 2011-06-17 | 2014-03-11 | Linnet Biopharmaceuticals, Inc. | Rutaecarpine derivatives for activating CYP1A2 in a subject |
US20120322813A1 (en) | 2011-06-17 | 2012-12-20 | Linnet Timothy N | Rutaecarpine derivatives for treating caffeine toxicity |
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