JP6818551B2 - Ｃｍｖワクチン - Google Patents
Ｃｍｖワクチン Download PDFInfo
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- JP6818551B2 JP6818551B2 JP2016536893A JP2016536893A JP6818551B2 JP 6818551 B2 JP6818551 B2 JP 6818551B2 JP 2016536893 A JP2016536893 A JP 2016536893A JP 2016536893 A JP2016536893 A JP 2016536893A JP 6818551 B2 JP6818551 B2 JP 6818551B2
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| US11260090B2 (en) | 2016-03-08 | 2022-03-01 | University Of Vermont And State Agricultural College | Modified arenavirus |
| IL322403A (en) | 2016-04-15 | 2025-09-01 | Univ Pennsylvania | Preparations for the treatment of wet age-related macular degeneration |
| EP3528821A4 (en) * | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | HUMAN CYTOMEGALOVIRUS VACCINE |
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| TW201903146A (zh) | 2017-04-14 | 2019-01-16 | 美商銳進科斯生物股份有限公司 | 使用由人類神經或膠細胞產生的重組人類艾杜糖醛酸鹽 (iduronate)-2-硫酸酯酶 (ids) 之黏多醣病ii之治療 |
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| JP2021535730A (ja) * | 2018-05-11 | 2021-12-23 | シティ・オブ・ホープCity of Hope | 複数の部位メガロウイルス（ｃｍｖ）抗原の発現のためのｍｖａベクター及びその使用 |
| JP7584405B2 (ja) | 2018-10-17 | 2024-11-15 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 改変されたサイトメガロウイルスタンパク質及び安定化された複合体 |
| AU2019397719B2 (en) | 2018-12-10 | 2023-11-09 | Km Biologics Co., Ltd. | Vaccine for preventing or treating congenital infection with cytomegalovirus |
| AU2020377504A1 (en) | 2019-11-07 | 2022-06-02 | Universität Basel | Arenaviruses as vectors |
| KR102837045B1 (ko) * | 2020-06-09 | 2025-07-23 | 케이엠 바이올로직스 가부시키가이샤 | 사이토메갈로바이러스의 gB와 펜타머의 융합 단백질 및 당해 융합 단백질을 포함하는 백신 |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| RU2756557C1 (ru) * | 2020-11-02 | 2021-10-01 | Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") | Способ опосредованного определения титра вируса ящура в неинактивированном сырье для вакцины при амплификации вирусной нуклеиновой кислоты и детекции РНК-ампликонов с применением технологии молекулярных биконов |
| JP2024505739A (ja) | 2021-02-10 | 2024-02-07 | レジェンクスバイオ インコーポレーテッド | 組換えヒトイズロン酸－２－スルファターゼ（ｉｄｓ）によるムコ多糖症ｉｉの治療 |
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Family Cites Families (29)
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| DE68929478T2 (de) * | 1988-01-29 | 2004-04-29 | Aventis Pasteur | Rekombinante CMV-Neutralisierungsproteine |
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| US20140348863A1 (en) * | 2011-10-12 | 2014-11-27 | Alessia Bianchi | Cmv antigens and uses thereof |
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