JP6805172B2 - ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法 - Google Patents
ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法 Download PDFInfo
- Publication number
- JP6805172B2 JP6805172B2 JP2017557324A JP2017557324A JP6805172B2 JP 6805172 B2 JP6805172 B2 JP 6805172B2 JP 2017557324 A JP2017557324 A JP 2017557324A JP 2017557324 A JP2017557324 A JP 2017557324A JP 6805172 B2 JP6805172 B2 JP 6805172B2
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- alkyl
- mixture
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 C*N(*N(*)*)C(c(*(C)c1)**c1-c1n[o]c(C(F)(F)F)n1)=O Chemical compound C*N(*N(*)*)C(c(*(C)c1)**c1-c1n[o]c(C(F)(F)F)n1)=O 0.000 description 2
- MLTZNSHLFMSOPY-HNNXBMFYSA-N C[C@@H](CCC(c(cc1)ccc1-c1n[o]c(C(F)(F)F)n1)=O)CN1CCC2(CC2)CC1 Chemical compound C[C@@H](CCC(c(cc1)ccc1-c1n[o]c(C(F)(F)F)n1)=O)CN1CCC2(CC2)CC1 MLTZNSHLFMSOPY-HNNXBMFYSA-N 0.000 description 1
- NLDCYGWSPPNJSB-GFCCVEGCSA-N C[C@H](C(N(CC1)Cc2c1cccc2)=O)NC(OC(C)(C)C)=O Chemical compound C[C@H](C(N(CC1)Cc2c1cccc2)=O)NC(OC(C)(C)C)=O NLDCYGWSPPNJSB-GFCCVEGCSA-N 0.000 description 1
- QVHJQCGUWFKTSE-RXMQYKEDSA-N C[C@H](C(O)=O)NC(OC(C)(C)C)=O Chemical compound C[C@H](C(O)=O)NC(OC(C)(C)C)=O QVHJQCGUWFKTSE-RXMQYKEDSA-N 0.000 description 1
- KUENUWACNZYNKC-SNVBAGLBSA-N C[C@H](CN(CC1)Cc2c1cccc2)N Chemical compound C[C@H](CN(CC1)Cc2c1cccc2)N KUENUWACNZYNKC-SNVBAGLBSA-N 0.000 description 1
- ATPMCQLSQHGRHW-CYBMUJFWSA-N C[C@H](CN(CC1)Cc2c1cccc2)NC(OC(C)(C)C)=O Chemical compound C[C@H](CN(CC1)Cc2c1cccc2)NC(OC(C)(C)C)=O ATPMCQLSQHGRHW-CYBMUJFWSA-N 0.000 description 1
- OYXHJSOZEXCCIB-CQSZACIVSA-N C[C@H](CN(CC1)Cc2c1cccc2)NC(c(cc1)ccc1-c1n[o]c(C(F)(F)F)n1)=O Chemical compound C[C@H](CN(CC1)Cc2c1cccc2)NC(c(cc1)ccc1-c1n[o]c(C(F)(F)F)n1)=O OYXHJSOZEXCCIB-CQSZACIVSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562158363P | 2015-05-07 | 2015-05-07 | |
| US62/158,363 | 2015-05-07 | ||
| PCT/US2016/031335 WO2016179554A1 (en) | 2015-05-07 | 2016-05-06 | Histone deacetylase inhibitors and compositions and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018515489A JP2018515489A (ja) | 2018-06-14 |
| JP2018515489A5 JP2018515489A5 (OSRAM) | 2019-06-13 |
| JP6805172B2 true JP6805172B2 (ja) | 2020-12-23 |
Family
ID=57218014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557324A Active JP6805172B2 (ja) | 2015-05-07 | 2016-05-06 | ヒストンデアセチラーゼ阻害薬及び組成物並びにそれらの使用の方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10053434B2 (OSRAM) |
| EP (1) | EP3291810B1 (OSRAM) |
| JP (1) | JP6805172B2 (OSRAM) |
| KR (1) | KR20180002729A (OSRAM) |
| CN (1) | CN107735088B (OSRAM) |
| AU (1) | AU2016258188B2 (OSRAM) |
| CA (1) | CA2984618C (OSRAM) |
| EA (1) | EA036965B1 (OSRAM) |
| IL (1) | IL255448B2 (OSRAM) |
| MX (1) | MX378983B (OSRAM) |
| WO (1) | WO2016179554A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3291809B1 (en) | 2015-05-07 | 2021-08-25 | CHDI Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| US10053434B2 (en) * | 2015-05-07 | 2018-08-21 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| WO2018015447A1 (en) * | 2016-07-22 | 2018-01-25 | Syngenta Participations Ag | Microbiocidal oxadiazole derivatives |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| CN109627207A (zh) * | 2018-12-17 | 2019-04-16 | 天津药明康德新药开发有限公司 | 一种3-(二氟甲氧基)哌啶盐酸盐的制备方法 |
| WO2022174193A1 (en) * | 2021-02-15 | 2022-08-18 | The Research Foundation For The State University Of New York | Radiolabeled compositions and methods of use thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1828171B1 (en) | 2004-12-10 | 2014-03-12 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. | Heterocycle derivatives as histone deacetylase (hdac) inhibitors |
| KR101781663B1 (ko) | 2010-01-13 | 2017-09-25 | 템페로 파마슈티칼즈, 인크. | 히스톤 데아세틸라제 효소를 억제하기 위한 화합물 및 이를 제조하는 방법 |
| WO2013006408A1 (en) * | 2011-07-01 | 2013-01-10 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| US9056843B2 (en) | 2011-07-08 | 2015-06-16 | Novartis Ag | Trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| WO2013009830A1 (en) * | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| WO2013009810A1 (en) | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| SI2750677T1 (sl) | 2011-08-30 | 2017-10-30 | Chdi Foundation, Inc. | Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe |
| WO2013066835A2 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| WO2013066833A1 (en) * | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods to inhibit histone deacetylase (hdac) enzymes |
| ES2606630T3 (es) | 2011-11-28 | 2017-03-24 | Novartis Ag | Derivados de trifluorometil-oxadiazol novedosos y su uso en el tratamiento de enfermedad |
| US9822058B2 (en) * | 2012-04-05 | 2017-11-21 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| US10053434B2 (en) * | 2015-05-07 | 2018-08-21 | Chdi Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| EP3291809B1 (en) | 2015-05-07 | 2021-08-25 | CHDI Foundation, Inc. | Histone deacetylase inhibitors and compositions and methods of use thereof |
| MX376585B (es) | 2015-07-27 | 2025-03-07 | Chong Kun Dang Pharmaceutical Corp | Compuestos derivados de sulfamida de 1,3,4-oxadiazol como inhibidor de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos. |
| ES2935932T3 (es) | 2015-07-27 | 2023-03-13 | Chong Kun Dang Pharmaceutical Corp | Compuestos de derivados de 1,3,4-oxadiazolsulfonamida como inhibidor de histona desacetilasa 6, y la composición farmacéutica que comprende los mismos |
| AU2016303891B2 (en) | 2015-08-04 | 2019-08-01 | Chong Kun Dang Pharmaceutical Corp. | 1,3,4-oxadiazole derivative compounds as histone deacetylase 6 inhibitor, and the pharmaceutical composition comprising the same |
-
2016
- 2016-05-06 US US15/148,907 patent/US10053434B2/en active Active
- 2016-05-06 MX MX2017014300A patent/MX378983B/es unknown
- 2016-05-06 JP JP2017557324A patent/JP6805172B2/ja active Active
- 2016-05-06 EP EP16790203.0A patent/EP3291810B1/en active Active
- 2016-05-06 WO PCT/US2016/031335 patent/WO2016179554A1/en not_active Ceased
- 2016-05-06 KR KR1020177034461A patent/KR20180002729A/ko not_active Withdrawn
- 2016-05-06 AU AU2016258188A patent/AU2016258188B2/en active Active
- 2016-05-06 CN CN201680040061.8A patent/CN107735088B/zh active Active
- 2016-05-06 CA CA2984618A patent/CA2984618C/en active Active
- 2016-05-06 EA EA201792247A patent/EA036965B1/ru not_active IP Right Cessation
-
2017
- 2017-11-06 IL IL255448A patent/IL255448B2/en unknown
-
2018
- 2018-07-26 US US16/046,254 patent/US20190202795A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP3291810A4 (en) | 2018-11-07 |
| WO2016179554A1 (en) | 2016-11-10 |
| JP2018515489A (ja) | 2018-06-14 |
| AU2016258188A1 (en) | 2017-11-23 |
| IL255448A0 (en) | 2017-12-31 |
| BR112017023711A2 (pt) | 2018-07-17 |
| AU2016258188B2 (en) | 2021-08-26 |
| US10053434B2 (en) | 2018-08-21 |
| CN107735088A (zh) | 2018-02-23 |
| MX378983B (es) | 2025-03-10 |
| CA2984618C (en) | 2024-01-09 |
| EP3291810B1 (en) | 2022-08-10 |
| CN107735088B (zh) | 2021-11-02 |
| MX2017014300A (es) | 2018-08-09 |
| IL255448B2 (en) | 2023-07-01 |
| EP3291810A1 (en) | 2018-03-14 |
| HK1252487A1 (en) | 2019-05-24 |
| CA2984618A1 (en) | 2016-11-10 |
| EA036965B1 (ru) | 2021-01-20 |
| KR20180002729A (ko) | 2018-01-08 |
| EA201792247A1 (ru) | 2018-06-29 |
| US20190202795A1 (en) | 2019-07-04 |
| IL255448B1 (en) | 2023-03-01 |
| US20160326124A1 (en) | 2016-11-10 |
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