JP6800842B2 - プリドピジンの類似体、それらの製造および使用 - Google Patents

プリドピジンの類似体、それらの製造および使用 Download PDF

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Publication number
JP6800842B2
JP6800842B2 JP2017520772A JP2017520772A JP6800842B2 JP 6800842 B2 JP6800842 B2 JP 6800842B2 JP 2017520772 A JP2017520772 A JP 2017520772A JP 2017520772 A JP2017520772 A JP 2017520772A JP 6800842 B2 JP6800842 B2 JP 6800842B2
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compound
predopidine
phenyl
bis
concentration
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JP2017519839A (ja
JP2017519839A5 (https=
Inventor
シュミット、マーレ
ペリ、マーレ
ラオス、マリット
マッサル、アンツ
カルユステ、カレ
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プリレニア ニューロセラピューティクス リミテッド
プリレニア ニューロセラピューティクス リミテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/42—Oxygen atoms attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/24—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by sulfur atoms to which a second hetero atom is attached
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8872—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample impurities

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017520772A 2014-06-30 2015-06-29 プリドピジンの類似体、それらの製造および使用 Active JP6800842B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462019337P 2014-06-30 2014-06-30
US62/019,337 2014-06-30
US201462076436P 2014-11-06 2014-11-06
US62/076,436 2014-11-06
PCT/US2015/038349 WO2016003919A1 (en) 2014-06-30 2015-06-29 Analogs of pridopidine, their preparation and use

Related Child Applications (1)

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JP2020077160A Division JP7035108B2 (ja) 2014-06-30 2020-04-24 プリドピジンの類似体、それらの製造および使用

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JP2017519839A JP2017519839A (ja) 2017-07-20
JP2017519839A5 JP2017519839A5 (https=) 2018-08-09
JP6800842B2 true JP6800842B2 (ja) 2020-12-16

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JP2017520772A Active JP6800842B2 (ja) 2014-06-30 2015-06-29 プリドピジンの類似体、それらの製造および使用
JP2020077160A Active JP7035108B2 (ja) 2014-06-30 2020-04-24 プリドピジンの類似体、それらの製造および使用

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US (4) US10130621B2 (https=)
EP (2) EP3160470B1 (https=)
JP (2) JP6800842B2 (https=)
CN (2) CN106456618A (https=)
AU (1) AU2015284385B2 (https=)
BR (1) BR112016030968B1 (https=)
CA (1) CA2951494C (https=)
DK (1) DK3160470T3 (https=)
EA (1) EA201790101A1 (https=)
ES (1) ES2927888T3 (https=)
HU (1) HUE060242T2 (https=)
IL (2) IL249601B (https=)
MX (1) MX382649B (https=)
PL (1) PL3160470T3 (https=)
TW (1) TW201613859A (https=)
UY (1) UY36192A (https=)
WO (1) WO2016003919A1 (https=)

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CN115551505B (zh) * 2020-05-04 2026-03-17 普瑞尼亚神经治疗有限公司 使用选择性s1r激动剂治疗病毒性感染、疾病或病症
CN116472043A (zh) * 2020-10-20 2023-07-21 普瑞尼亚神经治疗有限公司 普利多匹定和类似物用于治疗焦虑和抑郁的用途
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EP4415714A4 (en) * 2021-10-11 2025-10-15 Prilenia Neurotherapeutics Ltd PRIDOPIDINE AND ANALOGUES THEREOF FOR THE TREATMENT OF NEURODEGENERATIVE EYE DISEASE
CN114716391B (zh) * 2022-04-24 2023-12-12 杭州仟源保灵药业有限公司 一种醋甲唑胺杂质及其制备方法和应用
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Publication number Publication date
BR112016030968B1 (pt) 2023-11-21
HUE060242T2 (hu) 2023-02-28
TW201613859A (en) 2016-04-16
AU2015284385B2 (en) 2021-01-21
HK1231406A1 (en) 2017-12-22
US20150374677A1 (en) 2015-12-31
CA2951494C (en) 2023-10-03
JP2017519839A (ja) 2017-07-20
US20190030016A1 (en) 2019-01-31
CA2951494A1 (en) 2016-01-07
PL3160470T3 (pl) 2022-11-21
BR112016030968A2 (pt) 2018-07-17
US20220023280A1 (en) 2022-01-27
ES2927888T3 (es) 2022-11-11
MX382649B (es) 2025-03-13
WO2016003919A8 (en) 2017-01-26
AU2015284385A1 (en) 2017-02-02
IL272306B (en) 2021-04-29
EP3160470A1 (en) 2017-05-03
IL249601B (en) 2020-01-30
EP3160470A4 (en) 2018-01-10
EA201790101A1 (ru) 2017-06-30
US10406145B2 (en) 2019-09-10
IL249601A0 (en) 2017-02-28
JP7035108B2 (ja) 2022-03-14
EP3160470B1 (en) 2022-08-03
US10130621B2 (en) 2018-11-20
MX2016017332A (es) 2017-05-12
IL272306A (en) 2020-03-31
DK3160470T3 (da) 2022-10-24
WO2016003919A1 (en) 2016-01-07
EP4049998A1 (en) 2022-08-31
JP2020143072A (ja) 2020-09-10
CN106456618A (zh) 2017-02-22
US11141412B2 (en) 2021-10-12
UY36192A (es) 2016-01-29
US20200030308A1 (en) 2020-01-30
CN113511997A (zh) 2021-10-19

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