JP6789941B2 - Ｔｇｆ−ベータ阻害剤としての縮合イミダゾール誘導体 - Google Patents

Ｔｇｆ−ベータ阻害剤としての縮合イミダゾール誘導体 Download PDF

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JP6789941B2
JP6789941B2 JP2017527370A JP2017527370A JP6789941B2 JP 6789941 B2 JP6789941 B2 JP 6789941B2 JP 2017527370 A JP2017527370 A JP 2017527370A JP 2017527370 A JP2017527370 A JP 2017527370A JP 6789941 B2 JP6789941 B2 JP 6789941B2
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dihydro
pyrrolo
imidazol
imidazole
pyridine
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JP2018501209A5 (enExample
JP2018501209A (ja
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ラジンダー・シン
トッド・キンセラ
ジアシン・ユー
マリーナ・ジェルマン
イハブ・エス・ダーウィッシュ
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ライジェル ファーマシューティカルズ， インコーポレイテッド
ライジェル ファーマシューティカルズ， インコーポレイテッド
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    • C07—ORGANIC CHEMISTRY
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    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/4164—1,3-Diazoles
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JP2017527370A 2014-11-21 2015-11-16 Ｔｇｆ−ベータ阻害剤としての縮合イミダゾール誘導体 Expired - Fee Related JP6789941B2 (ja)

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US201462082959P 2014-11-21 2014-11-21
US62/082,959 2014-11-21
US201562141509P 2015-04-01 2015-04-01
US62/141,509 2015-04-01
PCT/US2015/060872 WO2016081364A1 (en) 2014-11-21 2015-11-16 Fused imidazole derivatives as tgf-beta inhibitors

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JP2018501209A JP2018501209A (ja) 2018-01-18
JP2018501209A5 JP2018501209A5 (enExample) 2018-12-27
JP6789941B2 true JP6789941B2 (ja) 2020-11-25

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US (1) US10696693B2 (enExample)
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CN (1) CN107207531B (enExample)
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US10696693B2 (en) 2020-06-30
WO2016081364A1 (en) 2016-05-26
JP2018501209A (ja) 2018-01-18
US20180346487A1 (en) 2018-12-06
EP3221318B1 (en) 2021-08-25
CN107207531B (zh) 2021-05-25
CN107207531A (zh) 2017-09-26
EP3221318A1 (en) 2017-09-27

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