JP6773496B2 - 化学分析装置、前処理装置及び化学分析方法 - Google Patents
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Description
次に、分子鋳型ポリマーの製造方法について、さらに詳細に説明する。以下では、上記の手順に従い、化学分析を擾乱する測定阻害物質であるリン脂質を捕捉するための分子鋳型ポリマー微粒子を合成する場合について説明する。
実験例1では、リン脂質を捕捉する分子鋳型ポリマーを、S−ケトプロフェン(S−ketoprofen)をテンプレート分子として用いて合成した。
実施例1で合成した分子鋳型ポリマー(MIP)を用いて、リン脂質の除去能力を評価した。まず、事前実験として、種々のリン脂質濃度における吸光度を測定した。各リン脂質濃度における吸光度の測定値を表2に示す。これらの吸光度の測定値を、各リン脂質濃度に対してプロットして検量線を作成し、リン脂質濃度と吸光度との関係を算出した。なお、検量線の作製には、リン脂質として、1−Palmitoyl−2−oleoyl−sn−glycero−3−PC(1,2−POPC,1−Palmitoyl−2−oleoyl−sn−glycero−3−Phosphocholine)を用いた。図6に、リン脂質濃度と吸光度との関係を示す。図6に示すとおり、各リン脂質濃度に対する吸光度のプロットは、線形の関係となった。リン脂質濃度をx、吸光度をyとしたとき、これらの関係は、y=0.0324x+0.0165の計算式で近似され、相関係数R2=0.9894となった。
Claims (9)
- 検体に含まれる、極性基を有する分子として、リン脂質、リン脂質誘導体、リンタンパク質、リンペプチドからなる群から選択される少なくとも一つを捕捉する分子鋳型ポリマーを収容する前処理部と、
前記前処理部に接続され、前記分子鋳型ポリマーにより物質が除去された、前記検体に含まれる成分を定量する定量部と、を有することを特徴とする化学分析装置。 - 前記定量部に接続される送出流路と、
ドレインに接続される排出流路と、
前記前処理部に接続されて、前記送出流路と、前記排出流路とを切り替える切り替え部と、を有し、
前記切り替え部は、前記排出流路に切り替えて、前記分子鋳型ポリマーにより捕捉された前記物質を排出し、
前記送出流路に切り替えて、前記検体を前記定量部に送液する
ことを特徴とする請求項1に記載の化学分析装置。 - 一の前記定量部に、前記切り替え部を介して、複数の前記前処理部が接続される
ことを特徴とする請求項1に記載の化学分析装置。 - 前記前処理部は、前記分子鋳型ポリマーとして、ケトプロフェン骨格を有する分子と特異的に結合可能な認識部位を有するポリマーを収容することを特徴とする請求項1に記載の化学分析装置。
- 前記定量部は、質量分析装置、液体クロマトグラフ又は液体クロマトグラフ質量分析装置であることを特徴とする請求項1に記載の化学分析装置。
- 前記分子鋳型ポリマーの微粒子のコア層として、酸化鉄を用いる
ことを特徴とする請求項1に記載の化学分析装置。 - 分子鋳型ポリマーにより、検体に含まれる、極性基を有する分子として、リン脂質、リン脂質誘導体、リンタンパク質、リンペプチドからなる群から選択される少なくとも一つを捕捉する前処理ステップと、
前記前処理ステップにおいて前記分子鋳型ポリマーにより物質が除去された後に、前記検体に含まれる成分を定量する定量ステップと、を有することを特徴とする化学分析方法。 - 記分子鋳型ポリマーとして、ケトプロフェン骨格を有する分子と特異的に結合可能な認識部位を有するポリマーを用いる
ことを特徴とする請求項7に記載の化学分析方法。 - 前記分子鋳型ポリマーの微粒子のコア層として、酸化鉄を用いる
ことを特徴とする請求項7に記載の化学分析方法。
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