JP6771491B2 - Ｅｂｎａ１阻害剤およびその使用方法 - Google Patents

Ｅｂｎａ１阻害剤およびその使用方法 Download PDF

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JP6771491B2
JP6771491B2 JP2017559303A JP2017559303A JP6771491B2 JP 6771491 B2 JP6771491 B2 JP 6771491B2 JP 2017559303 A JP2017559303 A JP 2017559303A JP 2017559303 A JP2017559303 A JP 2017559303A JP 6771491 B2 JP6771491 B2 JP 6771491B2
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indole
benzoic acid
compound
phenylethynyl
ethynyl
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JP2018520096A5 (enExample
JP2018520096A (ja
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トロイ イー． メシック
トロイ イー． メシック
ギャリー アール． スミス
ギャリー アール． スミス
アレン ビー． ライツ
アレン ビー． ライツ
ポール エム． リーバーマン
ポール エム． リーバーマン
マーク イー． マクドネル
マーク イー． マクドネル
ヤン チャン
ヤン チャン
マリアンヌ カールセン
マリアンヌ カールセン
シュアイ チェン
シュアイ チェン
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ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー
ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/42—Oxazoles
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    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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