AU2016262572B2 - EBNA1 inhibitors and methods using same - Google Patents

EBNA1 inhibitors and methods using same Download PDF

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AU2016262572B2
AU2016262572B2 AU2016262572A AU2016262572A AU2016262572B2 AU 2016262572 B2 AU2016262572 B2 AU 2016262572B2 AU 2016262572 A AU2016262572 A AU 2016262572A AU 2016262572 A AU2016262572 A AU 2016262572A AU 2016262572 B2 AU2016262572 B2 AU 2016262572B2
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indol
compound
benzoic acid
certain embodiments
phenyl
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AU2016262572A
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AU2016262572A1 (en
Inventor
Marianne Carlsen
Shuai Chen
Paul M. Lieberman
Mark E. Mcdonnell
Troy E. Messick
Allen B. Reitz
Garry R. Smith
Yan Zhang
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Wistar Institute of Anatomy and Biology
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Wistar Institute of Anatomy and Biology
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    • C07—ORGANIC CHEMISTRY
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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