JP6768515B2 - 二重アシル化ｇｌｐ−１化合物 - Google Patents
二重アシル化ｇｌｐ−１化合物 Download PDFInfo
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- JP6768515B2 JP6768515B2 JP2016561311A JP2016561311A JP6768515B2 JP 6768515 B2 JP6768515 B2 JP 6768515B2 JP 2016561311 A JP2016561311 A JP 2016561311A JP 2016561311 A JP2016561311 A JP 2016561311A JP 6768515 B2 JP6768515 B2 JP 6768515B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
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- Obesity (AREA)
- Reproductive Health (AREA)
- Cardiology (AREA)
- Child & Adolescent Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gynecology & Obstetrics (AREA)
- Emergency Medicine (AREA)
- Pregnancy & Childbirth (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14163697.7 | 2014-04-07 | ||
| EP14163697 | 2014-04-07 | ||
| PCT/EP2015/057442 WO2015155151A1 (en) | 2014-04-07 | 2015-04-07 | Double-acylated glp-1 compounds |
Publications (3)
| Publication Number | Publication Date |
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| JP2017514801A JP2017514801A (ja) | 2017-06-08 |
| JP2017514801A5 JP2017514801A5 (cg-RX-API-DMAC7.html) | 2018-05-10 |
| JP6768515B2 true JP6768515B2 (ja) | 2020-10-14 |
Family
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| JP2016561311A Active JP6768515B2 (ja) | 2014-04-07 | 2015-04-07 | 二重アシル化ｇｌｐ−１化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10689429B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3129041B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6768515B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN106132985B (cg-RX-API-DMAC7.html) |
| ES (1) | ES2741507T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015155151A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| JP7053480B2 (ja) | 2016-03-03 | 2022-04-12 | ノヴォ ノルディスク アー／エス | Ｇｌｐ－１誘導体及びその使用 |
| AR112015A1 (es) | 2017-06-09 | 2019-09-11 | Novo Nordisk As | Composiciones sólidas para administración oral |
| EP4360651A3 (en) | 2017-08-24 | 2024-07-17 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
| RS64643B1 (sr) | 2018-02-02 | 2023-10-31 | Novo Nordisk As | Čvrste kompozicije koje sadrže glp-1 agonist i so n-(8-(2-hidroksibenzoil)amino)kaprilne kiseline i lubrikant |
| WO2019200594A1 (zh) * | 2018-04-19 | 2019-10-24 | 杭州先为达生物科技有限公司 | 酰化的glp-1衍生物 |
| TWI829687B (zh) | 2018-05-07 | 2024-01-21 | 丹麥商諾佛 儂迪克股份有限公司 | 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物 |
| BR112021006823A2 (pt) | 2018-10-11 | 2021-07-27 | Intarcia Therapeutics, Inc. | polipeptídeos análogos de amilina humana e métodos de uso |
| CN111378027B (zh) * | 2018-12-29 | 2022-04-15 | 万新医药科技(苏州)有限公司 | 一种索玛鲁肽前体的制备方法 |
| BR112022002189A2 (pt) * | 2019-09-02 | 2022-04-26 | Novo Nordisk As | Processo de produção de um comprimido, e, comprimido |
| WO2021089678A1 (en) | 2019-11-06 | 2021-05-14 | Novo Nordisk A/S | Glp-1 receptor agonists in dementia |
| US20220395559A1 (en) | 2019-11-07 | 2022-12-15 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist, an sglt2 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid |
| KR20220143036A (ko) | 2020-02-18 | 2022-10-24 | 노보 노르디스크 에이/에스 | 약학적 제형 |
| CN115461044B (zh) | 2020-04-29 | 2025-06-10 | 诺和诺德股份有限公司 | 包含glp-1激动剂和组氨酸的固体组合物 |
| JP2023542867A (ja) * | 2020-09-11 | 2023-10-12 | グリンプス バイオ， インコーポレイテッド | 疾患の検出／診断、病期分類、モニタリング及び処置のための生体外でのプロテアーゼ活性検出 |
| CN115925994B (zh) | 2020-09-30 | 2023-09-22 | 北京质肽生物医药科技有限公司 | 多肽缀合物和使用方法 |
| WO2023012263A1 (en) | 2021-08-04 | 2023-02-09 | Novo Nordisk A/S | Solid oral peptide formulations |
| CA3252113A1 (en) | 2022-03-30 | 2023-10-05 | Beijing Ql Biopharmaceutical Co., Ltd. | Liquid pharmaceutical compositions of polypeptide conjugates and their methods of use |
| WO2024110614A1 (en) | 2022-11-25 | 2024-05-30 | Novo Nordisk A/S | Oral administration of peptide therapeutics, such as glp-1 |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL128332A0 (en) | 1996-08-30 | 2000-01-31 | Novo Nordisk As | GLP-1 derivatives |
| WO1999043708A1 (en) | 1998-02-27 | 1999-09-02 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
| DE69942306D1 (de) | 1998-02-27 | 2010-06-10 | Novo Nordisk As | Abkömmlinge von glp-1 analogen |
| PL202367B1 (pl) | 1998-12-07 | 2009-06-30 | Sod Conseils Rech Applic | Związki stanowiące analogi GLP-1, kompozycje zawierające te związki oraz zastosowanie tych związków |
| JP2003516322A (ja) | 1999-11-12 | 2003-05-13 | ノボ ノルディスク アクティーゼルスカブ | ベータ細胞変性抑制のためのｇｌｐ−１アゴニストの使用 |
| US6693094B2 (en) * | 2001-03-22 | 2004-02-17 | Chrono Rx Llc | Biguanide and sulfonylurea formulations for the prevention and treatment of insulin resistance and type 2 diabetes mellitus |
| US7291594B2 (en) | 2002-10-11 | 2007-11-06 | Sanwa Kagaku Kenkyusho Co., Ltd. | GLP-1 derivative and preparation thereof absorbable via mucous membrane |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| TWI362392B (en) | 2005-03-18 | 2012-04-21 | Novo Nordisk As | Acylated glp-1 compounds |
| WO2009030771A1 (en) | 2007-09-05 | 2009-03-12 | Novo Nordisk A/S | Peptides derivatized with a-b-c-d- and their therapeutical use |
| CN102686607B (zh) * | 2009-12-16 | 2014-10-29 | 诺沃—诺迪斯克有限公司 | 双酰化glp-1衍生物 |
| US9006178B2 (en) * | 2010-11-09 | 2015-04-14 | Novo Nordisk A/S | Double-acylated GLP-1 derivatives with a linker |
| EP2665470A1 (en) * | 2011-01-19 | 2013-11-27 | Novo Nordisk A/S | Glp-1 particles and compositions |
| EP3225631B1 (en) | 2011-04-12 | 2019-01-09 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| JP6126097B2 (ja) * | 2011-09-06 | 2017-05-10 | ノヴォ ノルディスク アー／エス | Ｇｌｐ−１誘導体 |
| EP2846823B1 (en) | 2012-05-08 | 2019-12-04 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| WO2013167455A1 (en) * | 2012-05-08 | 2013-11-14 | Novo Nordisk A/S | Double-acylated glp-1 derivatives |
| HK1217443A1 (zh) * | 2013-01-29 | 2017-01-13 | 奥莎迪药品管理有限公司 | 用於糖尿病的口服治疗的药物组合物 |
-
2015
- 2015-04-07 WO PCT/EP2015/057442 patent/WO2015155151A1/en not_active Ceased
- 2015-04-07 CN CN201580018073.6A patent/CN106132985B/zh active Active
- 2015-04-07 ES ES15713772T patent/ES2741507T3/es active Active
- 2015-04-07 US US15/301,960 patent/US10689429B2/en active Active
- 2015-04-07 JP JP2016561311A patent/JP6768515B2/ja active Active
- 2015-04-07 EP EP15713772.0A patent/EP3129041B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015155151A1 (en) | 2015-10-15 |
| EP3129041B1 (en) | 2019-06-12 |
| CN106132985A (zh) | 2016-11-16 |
| US20170114116A1 (en) | 2017-04-27 |
| JP2017514801A (ja) | 2017-06-08 |
| CN106132985B (zh) | 2020-10-13 |
| US10689429B2 (en) | 2020-06-23 |
| ES2741507T3 (es) | 2020-02-11 |
| EP3129041A1 (en) | 2017-02-15 |
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