JP6755886B2 - ペニシリンｇアシラーゼ - Google Patents

ペニシリンｇアシラーゼ Download PDF

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Publication number
JP6755886B2
JP6755886B2 JP2017557457A JP2017557457A JP6755886B2 JP 6755886 B2 JP6755886 B2 JP 6755886B2 JP 2017557457 A JP2017557457 A JP 2017557457A JP 2017557457 A JP2017557457 A JP 2017557457A JP 6755886 B2 JP6755886 B2 JP 6755886B2
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JP
Japan
Prior art keywords
pga
sequence
polypeptide
acylase
penicillin
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JP2017557457A
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English (en)
Japanese (ja)
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JP2018515089A (ja
JP2018515089A5 (enExample
Inventor
ゴウタミ バナージー，
ゴウタミ バナージー，
ジエ ヤン，
ジエ ヤン，
シユン ザン，
シユン ザン，
エリカ エム． ミルチェク，
エリカ エム． ミルチェク，
メリッサ アン メイヨー，
メリッサ アン メイヨー，
スティーブン ジェンヌ，
スティーブン ジェンヌ，
Original Assignee
コデクシス， インコーポレイテッド
コデクシス， インコーポレイテッド
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Publication of JP2018515089A publication Critical patent/JP2018515089A/ja
Publication of JP2018515089A5 publication Critical patent/JP2018515089A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C12N9/84—Penicillin amidase (3.5.1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01011—Penicillin amidase (3.5.1.11), i.e. penicillin-amidohydrolase

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017557457A 2015-05-07 2016-05-06 ペニシリンｇアシラーゼ Active JP6755886B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562158118P 2015-05-07 2015-05-07
US62/158,118 2015-05-07
PCT/US2016/031132 WO2016179464A1 (en) 2015-05-07 2016-05-06 Penicillin-g acylases

Publications (3)

Publication Number Publication Date
JP2018515089A JP2018515089A (ja) 2018-06-14
JP2018515089A5 JP2018515089A5 (enExample) 2019-04-11
JP6755886B2 true JP6755886B2 (ja) 2020-09-16

Family

ID=57218075

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017557457A Active JP6755886B2 (ja) 2015-05-07 2016-05-06 ペニシリンｇアシラーゼ

Country Status (13)

Country Link
US (6) US9944916B2 (enExample)
EP (1) EP3292136B1 (enExample)
JP (1) JP6755886B2 (enExample)
KR (1) KR102604503B1 (enExample)
CN (1) CN107531762A (enExample)
AU (1) AU2016258091B2 (enExample)
CA (1) CA2983620A1 (enExample)
DK (1) DK3292136T3 (enExample)
HU (1) HUE053863T2 (enExample)
IL (1) IL255245B (enExample)
MX (1) MX381306B (enExample)
SG (1) SG11201708356PA (enExample)
WO (1) WO2016179464A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531762A (zh) 2015-05-07 2018-01-02 科德克希思公司 青霉素g酰化酶
KR102382489B1 (ko) 2016-05-05 2022-04-01 코덱시스, 인코포레이티드 페니실린 ｇ 아실라제
KR102696584B1 (ko) 2017-01-05 2024-08-19 코덱시스, 인코포레이티드 페니실린 ｇ 아실라아제
EP3645713A4 (en) * 2017-06-27 2021-06-30 Codexis, Inc. PENICILLIN-G ACYLASES
KR101985911B1 (ko) * 2017-12-28 2019-06-04 아미코젠주식회사 Achromobacter sp. CCM 4824 유래 페니실린 G 아실라제 변이체 및 이의 이용
CN109207466B (zh) * 2018-11-08 2021-01-08 山东鲁抗医药股份有限公司 一种青霉素酰化酶的固定化方法及固定化酶
KR102363768B1 (ko) * 2019-11-15 2022-02-16 아미코젠주식회사 세파졸린 생산성이 증가된 페니실린 g 아실라제 변이체 및 이의 이용
CN120699945A (zh) * 2024-10-08 2025-09-26 浙江师范大学行知学院 一种高活性青霉素g酰化酶突变体、编码核苷酸及其应用

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Also Published As

Publication number Publication date
MX381306B (es) 2025-03-12
SG11201708356PA (en) 2017-11-29
EP3292136A4 (en) 2019-04-10
US12378541B2 (en) 2025-08-05
CN107531762A (zh) 2018-01-02
JP2018515089A (ja) 2018-06-14
EP3292136A1 (en) 2018-03-14
AU2016258091B2 (en) 2020-10-01
US20190345474A1 (en) 2019-11-14
WO2016179464A1 (en) 2016-11-10
HUE053863T2 (hu) 2021-07-28
NZ736220A (en) 2024-03-22
KR102604503B1 (ko) 2023-11-20
DK3292136T3 (da) 2021-03-22
US20250346882A1 (en) 2025-11-13
US20160326508A1 (en) 2016-11-10
US20180201919A1 (en) 2018-07-19
EP3292136B1 (en) 2021-02-17
MX2017014213A (es) 2018-03-28
US11180747B2 (en) 2021-11-23
IL255245B (en) 2020-03-31
CA2983620A1 (en) 2016-11-10
KR20180004169A (ko) 2018-01-10
US9944916B2 (en) 2018-04-17
AU2016258091A1 (en) 2017-11-02
IL255245A0 (en) 2017-12-31
US10781436B2 (en) 2020-09-22
US20200385699A1 (en) 2020-12-10
US10400231B2 (en) 2019-09-03
US20220042004A1 (en) 2022-02-10

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