JP6754828B2 - ピリジン及びピリミジン誘導体 - Google Patents
ピリジン及びピリミジン誘導体 Download PDFInfo
- Publication number
- JP6754828B2 JP6754828B2 JP2018506863A JP2018506863A JP6754828B2 JP 6754828 B2 JP6754828 B2 JP 6754828B2 JP 2018506863 A JP2018506863 A JP 2018506863A JP 2018506863 A JP2018506863 A JP 2018506863A JP 6754828 B2 JP6754828 B2 JP 6754828B2
- Authority
- JP
- Japan
- Prior art keywords
- benzamide
- tert
- butyl
- methyl
- propan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AWEIUYNPTFMPPS-UHFFFAOYSA-N CC(C)(C(F)(F)F)NC(c1cc(I)cc(-c(cc2)ccc2Cl)c1)=O Chemical compound CC(C)(C(F)(F)F)NC(c1cc(I)cc(-c(cc2)ccc2Cl)c1)=O AWEIUYNPTFMPPS-UHFFFAOYSA-N 0.000 description 1
- BTQSNPMFNMKKED-UHFFFAOYSA-N CC(C)(C)NC(c1cc(-c(cc2)ccc2Cl)cc(-c2c(C)ccnc2)c1)=O Chemical compound CC(C)(C)NC(c1cc(-c(cc2)ccc2Cl)cc(-c2c(C)ccnc2)c1)=O BTQSNPMFNMKKED-UHFFFAOYSA-N 0.000 description 1
- RXJITZUCKZVHCK-UHFFFAOYSA-N CC(C)(C)NC(c1cc(-c2c(C)ncnc2)cc(-c(cc2)ccc2Cl)c1)=O Chemical compound CC(C)(C)NC(c1cc(-c2c(C)ncnc2)cc(-c(cc2)ccc2Cl)c1)=O RXJITZUCKZVHCK-UHFFFAOYSA-N 0.000 description 1
- KCIHZYZBUNMRJZ-UHFFFAOYSA-N CC(C)(C)NC(c1cc(B2OC(C)(C)C(C)(C)O2)cc(-c(cc2)ccc2F)c1)=O Chemical compound CC(C)(C)NC(c1cc(B2OC(C)(C)C(C)(C)O2)cc(-c(cc2)ccc2F)c1)=O KCIHZYZBUNMRJZ-UHFFFAOYSA-N 0.000 description 1
- CRIPULLKBSDLQK-UHFFFAOYSA-N CC(C)c(ncnc1)c1-c1cc(I)cc(C(NC(C)(C)C#N)=O)c1 Chemical compound CC(C)c(ncnc1)c1-c1cc(I)cc(C(NC(C)(C)C#N)=O)c1 CRIPULLKBSDLQK-UHFFFAOYSA-N 0.000 description 1
- BNXOKCYXMRXNJX-UHFFFAOYSA-N CCc(ncnc1)c1-c1cc(-c(cc2)ccc2F)cc(C(NC(C)(C)C)=O)c1 Chemical compound CCc(ncnc1)c1-c1cc(-c(cc2)ccc2F)cc(C(NC(C)(C)C)=O)c1 BNXOKCYXMRXNJX-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180759.1 | 2015-08-12 | ||
| EP15180759 | 2015-08-12 | ||
| PCT/EP2016/068919 WO2017025523A1 (en) | 2015-08-12 | 2016-08-09 | Pyridine and pyrimidine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522916A JP2018522916A (ja) | 2018-08-16 |
| JP2018522916A5 JP2018522916A5 (enExample) | 2019-09-26 |
| JP6754828B2 true JP6754828B2 (ja) | 2020-09-16 |
Family
ID=53835950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506863A Expired - Fee Related JP6754828B2 (ja) | 2015-08-12 | 2016-08-09 | ピリジン及びピリミジン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10005736B1 (enExample) |
| EP (1) | EP3334727B1 (enExample) |
| JP (1) | JP6754828B2 (enExample) |
| CN (1) | CN107922391B (enExample) |
| AR (1) | AR105662A1 (enExample) |
| TW (1) | TW201718499A (enExample) |
| WO (1) | WO2017025523A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019517476A (ja) * | 2016-05-27 | 2019-06-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｅａａｔ３阻害剤としてのピラゾール化合物 |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10577332B2 (en) | 2015-04-23 | 2020-03-03 | Hoffmann-La Roche Inc. | Tetrazole derivatives |
| WO2017060202A1 (en) | 2015-10-06 | 2017-04-13 | F. Hoffmann-La Roche Ag | Triazole derivatives |
| WO2017072083A1 (en) * | 2015-10-28 | 2017-05-04 | F. Hoffmann-La Roche Ag | Pyridine or pyrimidine derivatives |
| EP3411365B1 (en) | 2016-02-02 | 2019-11-20 | H. Hoffnabb-La Roche Ag | Pyrazol-pyridine derivatives as eaat3 inhibitors |
| WO2018069362A1 (en) | 2016-10-14 | 2018-04-19 | F. Hoffmann-La Roche Ag | Imidazole compounds as eaat3 inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2069313A2 (en) * | 2006-06-29 | 2009-06-17 | Alantos Pharmaceuticals Holdings, Inc. | Metalloprotease inhibitors |
| US20110237578A1 (en) * | 2008-09-18 | 2011-09-29 | Zhi-Liang Wei | Amide compounds, compositions and uses thereof |
| CA2741666C (en) * | 2008-10-31 | 2017-04-11 | Merck Sharp & Dohme Corp. | P2x3, receptor antagonists for treatment of pain |
-
2016
- 2016-08-09 WO PCT/EP2016/068919 patent/WO2017025523A1/en not_active Ceased
- 2016-08-09 EP EP16748125.8A patent/EP3334727B1/en not_active Not-in-force
- 2016-08-09 CN CN201680044820.8A patent/CN107922391B/zh not_active Expired - Fee Related
- 2016-08-09 JP JP2018506863A patent/JP6754828B2/ja not_active Expired - Fee Related
- 2016-08-10 AR ARP160102450A patent/AR105662A1/es unknown
- 2016-08-11 TW TW105125661A patent/TW201718499A/zh unknown
-
2018
- 2018-02-08 US US15/891,922 patent/US10005736B1/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019517476A (ja) * | 2016-05-27 | 2019-06-24 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｅａａｔ３阻害剤としてのピラゾール化合物 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2017025523A1 (en) | 2017-02-16 |
| TW201718499A (zh) | 2017-06-01 |
| JP2018522916A (ja) | 2018-08-16 |
| AR105662A1 (es) | 2017-10-25 |
| US20180162824A1 (en) | 2018-06-14 |
| US10005736B1 (en) | 2018-06-26 |
| CN107922391A (zh) | 2018-04-17 |
| EP3334727A1 (en) | 2018-06-20 |
| CN107922391B (zh) | 2020-09-25 |
| HK1251226A1 (zh) | 2019-01-25 |
| EP3334727B1 (en) | 2019-05-15 |
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| Date | Code | Title | Description |
|---|---|---|---|
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| LAPS | Cancellation because of no payment of annual fees |