JP6744302B2 - ミクロ流体装置における粒子の分類 - Google Patents
ミクロ流体装置における粒子の分類 Download PDFInfo
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- JP6744302B2 JP6744302B2 JP2017524008A JP2017524008A JP6744302B2 JP 6744302 B2 JP6744302 B2 JP 6744302B2 JP 2017524008 A JP2017524008 A JP 2017524008A JP 2017524008 A JP2017524008 A JP 2017524008A JP 6744302 B2 JP6744302 B2 JP 6744302B2
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- fluid
- microfluidic channel
- microfluidic
- channel
- particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
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- Pathology (AREA)
- Fluid Mechanics (AREA)
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- Cell Biology (AREA)
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- Engineering & Computer Science (AREA)
- Public Health (AREA)
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- Physical Or Chemical Processes And Apparatus (AREA)
- Micromachines (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Filtration Of Liquid (AREA)
- Extraction Or Liquid Replacement (AREA)
- Separation Of Solids By Using Liquids Or Pneumatic Power (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462074315P | 2014-11-03 | 2014-11-03 | |
| US201462074213P | 2014-11-03 | 2014-11-03 | |
| US62/074,315 | 2014-11-03 | ||
| US62/074,213 | 2014-11-03 | ||
| PCT/US2015/058834 WO2016073481A1 (en) | 2014-11-03 | 2015-11-03 | Sorting particles in a microfluidic device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018502700A JP2018502700A (ja) | 2018-02-01 |
| JP2018502700A5 JP2018502700A5 (enExample) | 2020-02-20 |
| JP6744302B2 true JP6744302B2 (ja) | 2020-08-19 |
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Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017524008A Active JP6744302B2 (ja) | 2014-11-03 | 2015-11-03 | ミクロ流体装置における粒子の分類 |
| JP2017523990A Active JP6649377B2 (ja) | 2014-11-03 | 2015-11-03 | ミクロ流体装置による粒子の複合式分類および濃縮 |
| JP2017523989A Active JP6757723B2 (ja) | 2014-11-03 | 2015-11-03 | ミクロ流体装置における粒子の濃縮 |
| JP2020005143A Active JP7042289B2 (ja) | 2014-11-03 | 2020-01-16 | ミクロ流体装置による粒子の複合式分類および濃縮 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017523990A Active JP6649377B2 (ja) | 2014-11-03 | 2015-11-03 | ミクロ流体装置による粒子の複合式分類および濃縮 |
| JP2017523989A Active JP6757723B2 (ja) | 2014-11-03 | 2015-11-03 | ミクロ流体装置における粒子の濃縮 |
| JP2020005143A Active JP7042289B2 (ja) | 2014-11-03 | 2020-01-16 | ミクロ流体装置による粒子の複合式分類および濃縮 |
Country Status (6)
| Country | Link |
|---|---|
| US (14) | US9610582B2 (enExample) |
| EP (5) | EP3215854B1 (enExample) |
| JP (4) | JP6744302B2 (enExample) |
| CN (3) | CN107110766B (enExample) |
| CA (3) | CA2966603C (enExample) |
| WO (3) | WO2016073448A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| US8186913B2 (en) * | 2007-04-16 | 2012-05-29 | The General Hospital Corporation | Systems and methods for particle focusing in microchannels |
| US9068181B2 (en) * | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| WO2010006174A2 (en) | 2008-07-10 | 2010-01-14 | Reichenbach Steven H | Method and apparatus for sorting particles using asymmetrical particle shifting |
| US8691145B2 (en) | 2009-11-16 | 2014-04-08 | Flodesign Sonics, Inc. | Ultrasound and acoustophoresis for water purification |
| US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
| US10322949B2 (en) | 2012-03-15 | 2019-06-18 | Flodesign Sonics, Inc. | Transducer and reflector configurations for an acoustophoretic device |
| US9796956B2 (en) | 2013-11-06 | 2017-10-24 | Flodesign Sonics, Inc. | Multi-stage acoustophoresis device |
| US9783775B2 (en) | 2012-03-15 | 2017-10-10 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
| US10370635B2 (en) | 2012-03-15 | 2019-08-06 | Flodesign Sonics, Inc. | Acoustic separation of T cells |
| US9272234B2 (en) | 2012-03-15 | 2016-03-01 | Flodesign Sonics, Inc. | Separation of multi-component fluid through ultrasonic acoustophoresis |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US10689609B2 (en) | 2012-03-15 | 2020-06-23 | Flodesign Sonics, Inc. | Acoustic bioreactor processes |
| US9752113B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US9745548B2 (en) | 2012-03-15 | 2017-08-29 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| US9567559B2 (en) | 2012-03-15 | 2017-02-14 | Flodesign Sonics, Inc. | Bioreactor using acoustic standing waves |
| US9752114B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc | Bioreactor using acoustic standing waves |
| US10953436B2 (en) | 2012-03-15 | 2021-03-23 | Flodesign Sonics, Inc. | Acoustophoretic device with piezoelectric transducer array |
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US10737953B2 (en) | 2012-04-20 | 2020-08-11 | Flodesign Sonics, Inc. | Acoustophoretic method for use in bioreactors |
| WO2013177560A1 (en) | 2012-05-25 | 2013-11-28 | The Regents Of The University Of California | Microfluidic systems for particle trapping and separation |
| CN105264127B (zh) | 2013-03-15 | 2019-04-09 | Gpb科学有限责任公司 | 颗粒的片上微流体处理 |
| US20150064153A1 (en) | 2013-03-15 | 2015-03-05 | The Trustees Of Princeton University | High efficiency microfluidic purification of stem cells to improve transplants |
| CN105247042B (zh) | 2013-03-15 | 2021-06-11 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
| US8961904B2 (en) | 2013-07-16 | 2015-02-24 | Premium Genetics (Uk) Ltd. | Microfluidic chip |
| US9745569B2 (en) | 2013-09-13 | 2017-08-29 | Flodesign Sonics, Inc. | System for generating high concentration factors for low cell density suspensions |
| US11796449B2 (en) | 2013-10-30 | 2023-10-24 | Abs Global, Inc. | Microfluidic system and method with focused energy apparatus |
| CA2935960C (en) | 2014-01-08 | 2023-01-10 | Bart Lipkens | Acoustophoresis device with dual acoustophoretic chamber |
| KR102596508B1 (ko) | 2014-04-10 | 2023-10-30 | 10엑스 제노믹스, 인크. | 시약을 캡슐화 및 구획화하기 위한 유체 디바이스, 시스템, 및 방법, 및 이의 응용 |
| US9744483B2 (en) | 2014-07-02 | 2017-08-29 | Flodesign Sonics, Inc. | Large scale acoustic separation device |
| JP6727198B2 (ja) | 2014-10-28 | 2020-07-22 | マサチューセッツ インスティテュート オブ テクノロジー | デジタル的に実装された位相ロックループアレイを用いる多数の共振の同時振動および周波数追跡 |
| WO2016073448A1 (en) * | 2014-11-03 | 2016-05-12 | The General Hospital Corporation | Combined sorting and concentrating particles in a microfluidic device |
| US9975122B2 (en) | 2014-11-05 | 2018-05-22 | 10X Genomics, Inc. | Instrument systems for integrated sample processing |
| EP3259579B1 (en) | 2015-02-19 | 2022-09-14 | 1087 Systems, Inc. | Scanning infrared measurement system |
| US10106770B2 (en) | 2015-03-24 | 2018-10-23 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| CA2984492A1 (en) | 2015-04-29 | 2016-11-03 | Flodesign Sonics, Inc. | Acoustophoretic device for angled wave particle deflection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US10976232B2 (en) | 2015-08-24 | 2021-04-13 | Gpb Scientific, Inc. | Methods and devices for multi-step cell purification and concentration |
| US9862941B2 (en) | 2015-10-14 | 2018-01-09 | Pioneer Hi-Bred International, Inc. | Single cell microfluidic device |
| KR101891890B1 (ko) * | 2015-10-23 | 2018-08-28 | 울산과학기술원 | 원심력 기반 나노 입자 분리장치 및 이를 이용한 나노 입자 분리방법 |
| KR101791671B1 (ko) * | 2015-12-31 | 2017-11-20 | 주식회사 큐리오시스 | 미세입자 분리 및 정렬 장치, 및 그 방법 |
| KR101855490B1 (ko) * | 2016-01-22 | 2018-05-08 | 한국과학기술원 | 점탄성유체와 점성유체의 병행층류를 이용한 미소 입자 분리 및 세정 방법 |
| US10710006B2 (en) | 2016-04-25 | 2020-07-14 | Flodesign Sonics, Inc. | Piezoelectric transducer for generation of an acoustic standing wave |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| EP3481361A1 (en) | 2016-05-03 | 2019-05-15 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| WO2017197343A2 (en) * | 2016-05-12 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic on-chip filters |
| WO2017197338A1 (en) | 2016-05-13 | 2017-11-16 | 10X Genomics, Inc. | Microfluidic systems and methods of use |
| US11525785B2 (en) * | 2016-06-23 | 2022-12-13 | B.G. Negev Technologies And Applications Ltd., At Ben-Gurion University | Method and device for chemiluminescence-based analysis |
| US10228381B2 (en) * | 2016-07-12 | 2019-03-12 | EMULATE, Inc. | Additive channels |
| US10094776B2 (en) * | 2016-07-18 | 2018-10-09 | Honeywell International Inc. | Dust sensor with mass separation fluid channels and fan control |
| CN109562380B (zh) * | 2016-08-02 | 2022-04-05 | Imec 非营利协会 | 用于聚集流中的物体的方法和装置 |
| US10010883B2 (en) * | 2016-09-20 | 2018-07-03 | International Business Machines Corporation | Deterministic lateral displacement arrays |
| US11090653B2 (en) | 2016-10-11 | 2021-08-17 | The Regents Of The University Of California | Systems and methods to encapsulate and preserve organic matter for analysis |
| JP2020513248A (ja) | 2016-10-19 | 2020-05-14 | フロデザイン ソニックス, インク.Flodesign Sonics, Inc. | 音響による親和性細胞抽出 |
| US11384327B2 (en) | 2016-11-01 | 2022-07-12 | California Institute Of Technology | Microfluidic devices and methods for purifying rare antigen-specific T cell populations |
| CN106823474B (zh) * | 2017-02-07 | 2023-01-24 | 重庆科技学院 | 一种血液分流器的使用方法 |
| CN106823475B (zh) * | 2017-02-07 | 2023-01-24 | 重庆科技学院 | 一种血液分流器 |
| JP2020513798A (ja) * | 2017-03-17 | 2020-05-21 | イスタンブール・テクニック・ユニヴェルシテシIstanbul Teknik Universitesi | ガン細胞の血液からの連続的分離および循環系でのその豊富化のための非対称カールにより構成されるらせん形状を有するマイクロチャネル |
| US11213824B2 (en) | 2017-03-29 | 2022-01-04 | The Research Foundation For The State University Of New York | Microfluidic device and methods |
| US11162886B2 (en) | 2017-03-31 | 2021-11-02 | Massachusetts Institute Of Technology | Systems, articles, and methods for flowing particles |
| WO2018179841A1 (ja) * | 2017-03-31 | 2018-10-04 | ソニー株式会社 | 微粒子捕捉装置、微粒子捕捉システムおよび微粒子捕捉方法 |
| WO2018223132A1 (en) | 2017-06-02 | 2018-12-06 | The General Hospital Corporation | Oscillatory focusing of particles in channels |
| WO2018227210A1 (en) | 2017-06-09 | 2018-12-13 | The Regents Of The University Of California | High-efficiency encapsulation in droplets based on hydrodynamic vortices control |
| WO2018227204A1 (en) * | 2017-06-09 | 2018-12-13 | The Regents Of The University Of California | Controlled encapsulation in droplets by liquid-liquid interfacial shearing |
| US11517901B2 (en) | 2017-06-09 | 2022-12-06 | The Regents Of The University Of California | High-efficiency particle encapsulation in droplets with particle spacing and downstream droplet sorting |
| WO2018236708A1 (en) | 2017-06-19 | 2018-12-27 | Massachusetts Institute Of Technology | Systems and methods for measuring properties of particles |
| CA3071593A1 (en) * | 2017-08-04 | 2019-02-07 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating circulating tumor cells from biological samples |
| US11648559B2 (en) | 2017-08-04 | 2023-05-16 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating circulating tumor cells from biological samples |
| US11292000B2 (en) | 2017-08-04 | 2022-04-05 | University Of Georgia Research Foundation, Inc. | Devices and methods for separating circulating tumor cells from biological samples |
| US10969324B2 (en) * | 2017-08-16 | 2021-04-06 | Washington University | Synthesis, post-modification and separation of biologics using acoustically confined substrates |
| CA3074495A1 (en) * | 2017-09-01 | 2019-03-07 | Gpb Scientific, Llc | Methods for preparing therapeutically active cells using microfluidics |
| WO2019075409A1 (en) | 2017-10-12 | 2019-04-18 | The Regents Of The University Of California | ISOLATION AND IDENTIFICATION WITHOUT MICROFLUIDIC LABEL OF CELLS USING FLUORESCENCE LIFE IMAGING (FLIM) |
| US11745179B2 (en) | 2017-10-20 | 2023-09-05 | The Regents Of The University Of California | Microfluidic systems and methods for lipoplex-mediated cell transfection |
| US11499127B2 (en) | 2017-10-20 | 2022-11-15 | The Regents Of The University Of California | Multi-layered microfluidic systems for in vitro large-scale perfused capillary networks |
| US10930380B2 (en) | 2017-11-10 | 2021-02-23 | Reliant Immune Diagnostics, Inc. | Communication loop and record loop system for parallel/serial dual microfluidic chip |
| US11124821B2 (en) | 2017-11-10 | 2021-09-21 | Reliant Immune Diagnostics, Inc. | Microfluidic testing system with cell capture/analysis regions for processing in a parallel and serial manner |
| US11527324B2 (en) | 2017-11-10 | 2022-12-13 | Reliant Immune Diagnostics, Inc. | Artificial intelligence response system based on testing with parallel/serial dual microfluidic chip |
| US11200986B2 (en) | 2017-11-10 | 2021-12-14 | Reliant Immune Diagnostics, Inc. | Database and machine learning in response to parallel serial dual microfluidic chip |
| US10930381B2 (en) | 2017-11-10 | 2021-02-23 | Reliant Immune Diagnostics, Inc. | Microfluidic testing system for mobile veterinary applications |
| US11041185B2 (en) * | 2017-11-10 | 2021-06-22 | Reliant Immune Diagnostics, Inc. | Modular parallel/serial dual microfluidic chip |
| KR20220066413A (ko) | 2017-12-14 | 2022-05-24 | 프로디자인 소닉스, 인크. | 음향 트랜스듀서 구동기 및 제어기 |
| WO2019136289A1 (en) | 2018-01-05 | 2019-07-11 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| US20190226953A1 (en) | 2018-01-19 | 2019-07-25 | International Business Machines Corporation | Microscale and mesoscale condenser devices |
| US11458474B2 (en) | 2018-01-19 | 2022-10-04 | International Business Machines Corporation | Microfluidic chips with one or more vias |
| US10946380B2 (en) | 2018-01-19 | 2021-03-16 | International Business Machines Corporation | Microfluidic chips for particle purification and fractionation |
| JP7539836B2 (ja) | 2018-04-04 | 2024-08-26 | ザ ジェネラル ホスピタル コーポレイション | 哺乳類卵母細胞を裸化するためのマイクロ流体システムおよび方法 |
| BR112020023607A2 (pt) * | 2018-05-23 | 2021-02-17 | Abs Global, Inc. | sistemas e métodos para focalização de partículas em microcanais |
| EP4477315A3 (en) | 2018-05-31 | 2025-03-05 | Donaldson Company, Inc. | Droplet sensors for fuel systems |
| IT201800006083A1 (it) * | 2018-06-06 | 2019-12-06 | Dispositivo microfluidico per la concentrazione di particelle tramite centrifugazione, e relativo dispositivo di centrifugazione e/o rilevazione | |
| EP3814775A4 (en) | 2018-06-29 | 2021-09-01 | The General Hospital Corporation | ISOLATION AND ANALYSIS OF CELLS AND RARE PARTICLES DERIVED FROM THE BRAIN |
| US11192110B2 (en) | 2018-07-06 | 2021-12-07 | Liu Lian | Methods and systems for cell-based non-invasive prenatal testing |
| CN108927232B (zh) * | 2018-07-17 | 2020-12-01 | 博奥生物集团有限公司 | 一种针对微流控芯片的流体混匀结构 |
| KR102083845B1 (ko) * | 2018-07-31 | 2020-03-03 | 광주과학기술원 | 혈액 진단 소자 |
| US11801509B2 (en) | 2018-08-10 | 2023-10-31 | Hewlett-Packard Development Company, L.P. | Serial cellular analytics |
| CN111068799B (zh) * | 2018-10-18 | 2021-03-23 | 浙江达普生物科技有限公司 | 用于产生液滴的微流体通路及其应用 |
| US11162143B2 (en) | 2018-10-21 | 2021-11-02 | The University Of Kansas | Methods for generating therapeutic delivery platforms |
| WO2020102533A1 (en) | 2018-11-15 | 2020-05-22 | Massachusetts Institute Of Technology | Multi-dimensional double spiral device and methods of use thereof |
| WO2020139936A1 (en) | 2018-12-27 | 2020-07-02 | The General Hospital Corporation | Size-based particle separation and concentration using particle size amplification |
| US12362038B2 (en) | 2019-01-10 | 2025-07-15 | Travera, Inc. | Identifying cancer therapies |
| EP3908823A4 (en) | 2019-01-10 | 2022-10-12 | Travera LLC | Calibration of a functional biomarker instrument |
| CN109550531B (zh) * | 2019-01-28 | 2021-09-07 | 武汉纺织大学 | 一种磁性尺寸依赖的微流控芯片 |
| US11889830B2 (en) | 2019-04-18 | 2024-02-06 | Abs Global, Inc. | System and process for continuous addition of cryoprotectant |
| EP3747541B1 (en) * | 2019-06-03 | 2024-02-07 | Cellular Highways Ltd. | Apparatus for sorting microfluidic particles |
| KR20220024635A (ko) * | 2019-06-18 | 2022-03-03 | 쓰리디 바이오랩스, 엘엘씨 | 마이크로채널 혈관 네트워크 장치 제작 및 마이크로채널 씨딩 시스템 및 방법 |
| US11841365B2 (en) * | 2019-07-16 | 2023-12-12 | University Of Georgia Research Foundation, Inc. | Devices, kits, and methods for label-free focusing and/or separation of sub-micron particles |
| US20210016273A1 (en) * | 2019-07-19 | 2021-01-21 | University Of Utah Research Foundation | Rapid sperm separation based on sperm morphology and motility |
| CN111909828B (zh) * | 2019-07-23 | 2024-08-06 | 北京大学 | 一种适用于循环肿瘤细胞捕获的微流控芯片 |
| US11255769B2 (en) | 2019-08-01 | 2022-02-22 | International Business Machines Corporation | Up-concentration and size sorting of nanoparticles in microfluidic devices |
| US12179199B2 (en) | 2019-08-09 | 2024-12-31 | The Regents Of The University Of California | Microfluidic single-cell pairing array for studying cell-cell interactions in isolated compartments |
| US11919002B2 (en) | 2019-08-20 | 2024-03-05 | 10X Genomics, Inc. | Devices and methods for generating and recovering droplets |
| CN110465339B (zh) * | 2019-09-03 | 2021-02-09 | 浙江大学 | 一种流固两相输运中颗粒定位的方法 |
| US20210109094A1 (en) * | 2019-10-11 | 2021-04-15 | Case Western Reserve University | Detection of disease components using magnetic particles and microfluidics |
| CN112779118A (zh) * | 2019-11-07 | 2021-05-11 | 北京机械设备研究所 | 一种循环肿瘤细胞正向分离系统 |
| WO2021102134A1 (en) | 2019-11-20 | 2021-05-27 | E Ink Corporation | Spatially variable hydrophobic layers for digital microfluidics |
| EP4065251B1 (en) * | 2019-11-29 | 2025-01-01 | Donaldson Company, Inc. | Systems and methods for separating particles in fluids |
| EP4087682A4 (en) * | 2020-01-08 | 2023-10-11 | The General Hospital Corporation | Microfluidic systems and methods for low-shear isolation of rare cells from large sample volumes |
| US11628439B2 (en) | 2020-01-13 | 2023-04-18 | Abs Global, Inc. | Single-sheath microfluidic chip |
| WO2021146573A1 (en) | 2020-01-17 | 2021-07-22 | E Ink Corporation | Spatially variable dielectric layers for digital microfluidics |
| US11946901B2 (en) | 2020-01-27 | 2024-04-02 | Nuclera Ltd | Method for degassing liquid droplets by electrical actuation at higher temperatures |
| EP4106921A4 (en) | 2020-02-18 | 2024-01-10 | Nuclera Nucleics Ltd | ADAPTIVE GATE CONTROL FOR HIGH FREQUENCY AC CONTROL OF EWD ARRAYS |
| KR20220142511A (ko) | 2020-02-19 | 2022-10-21 | 뉴클라 뉴클레익스 리미티드 | EWoD 어레이의 고주파 AC 구동을 위한 래치형 트랜지스터 구동 |
| EP4126091A4 (en) * | 2020-03-25 | 2024-10-09 | Aufbau Medical Innovations Limited | DEVICE AND METHODS FOR ISOLATING EXTRACELLULAR MATRIX BODIES |
| US20230146950A1 (en) * | 2020-04-02 | 2023-05-11 | Weibin LIANG | Deterministic lateral displacement array with a single column of bumping obstacles |
| CN115461152A (zh) | 2020-04-27 | 2022-12-09 | 核酸有限公司 | 用于数字微流体的可变驱动和短路保护的分段顶板 |
| JP2023541503A (ja) * | 2020-07-08 | 2023-10-03 | ルマサイト インコーポレイテッド | 試料採取デバイスおよびシステム |
| US20230296491A1 (en) * | 2020-08-25 | 2023-09-21 | Singapore University Of Technology And Design | Device and method for determining a mechanical property of a particle |
| WO2022086915A1 (en) * | 2020-10-20 | 2022-04-28 | The Board Of Trustees Of The Leland Stanford Junior University | Isolation of different extracellular vesicle (ev) subpopulations |
| EP4248190A4 (en) | 2020-11-23 | 2024-12-25 | ABS Global, Inc. | MODULAR FLOW CYTOMETRY SYSTEMS AND METHODS FOR PROCESSING SAMPLES |
| CN113109107B (zh) * | 2021-03-24 | 2022-06-07 | 西安交通大学 | 一种气溶胶颗粒的富集装置 |
| CN113275047A (zh) * | 2021-04-30 | 2021-08-20 | 北京机械设备研究所 | 微流控芯片及其用途 |
| US20230024264A1 (en) * | 2021-07-20 | 2023-01-26 | Transportation Ip Holdings, Llc | Fluid control device and method |
| WO2023041948A1 (en) * | 2021-09-15 | 2023-03-23 | Fundación Para La Investigación Médica Aplicada | Device suitable for exchanging a liquid medium and selecting particles in a mixture |
| WO2023245000A2 (en) * | 2022-06-13 | 2023-12-21 | Russell Van De Casteele | Methods for processing, enrichment, delivery, formulation, uptake and testing for supplements and pharmaceuticals |
| CN115337967B (zh) * | 2022-07-08 | 2024-04-02 | 南方科技大学 | 分离芯片 |
| US11772025B1 (en) | 2022-08-02 | 2023-10-03 | W. L. Gore & Associates, Inc. | Industrial filter assembly enhancement |
| CN120936392A (zh) | 2023-02-13 | 2025-11-11 | 汾沃有限公司 | 模块化生物细胞处理系统 |
| CN116099581B (zh) * | 2023-03-10 | 2025-12-02 | 东南大学 | 一种预聚焦分选细胞的微流控芯片及分选方法 |
| WO2025213101A1 (en) * | 2024-04-04 | 2025-10-09 | Cellular Vehicles Inc. | Microfluidic systems, devices, and kits for suspension therapy preparation and/or infusion and methods for use |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998008931A1 (en) * | 1996-08-26 | 1998-03-05 | Princeton University | Reversibly sealable microstructure sorting devices |
| US5968820A (en) | 1997-02-26 | 1999-10-19 | The Cleveland Clinic Foundation | Method for magnetically separating cells into fractionated flow streams |
| US6540896B1 (en) | 1998-08-05 | 2003-04-01 | Caliper Technologies Corp. | Open-Field serial to parallel converter |
| WO2000061191A2 (en) | 1999-04-09 | 2000-10-19 | Advanced Magnetics, Inc. | Heat stable coated colloidal iron oxides |
| FR2801587B1 (fr) * | 1999-11-30 | 2002-01-11 | Adir | Nouveaux derives de benzothiadiazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6720157B2 (en) | 2000-02-23 | 2004-04-13 | Zyomyx, Inc. | Chips having elevated sample surfaces |
| US7351376B1 (en) | 2000-06-05 | 2008-04-01 | California Institute Of Technology | Integrated active flux microfluidic devices and methods |
| US20020187503A1 (en) * | 2001-05-02 | 2002-12-12 | Michael Harrold | Concentration and purification of analytes using electric fields |
| AU2002320058A1 (en) | 2001-06-06 | 2002-12-16 | The General Hspital Corporation | Magnetic-nanoparticle conjugates and methods of use |
| ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
| US7560267B2 (en) * | 2002-03-18 | 2009-07-14 | City University Of Hong Kong | Apparatus and methods for on-chip monitoring of cellular reactions |
| JP4799861B2 (ja) | 2002-04-16 | 2011-10-26 | プリンストン ユニバーシティ | マイクロ流体とナノ流体間のインターフェース用勾配構造と、その製造方法および使用方法 |
| US7374678B2 (en) * | 2002-05-24 | 2008-05-20 | Biomet Biologics, Inc. | Apparatus and method for separating and concentrating fluids containing multiple components |
| EP1518115A2 (en) * | 2002-06-10 | 2005-03-30 | Phynexus, Inc. | Biomolecule open channel solid phase extraction systems and methods |
| AU2003234566A1 (en) * | 2002-06-11 | 2003-12-22 | Kionix, Inc. | Methods and devices for microfluidic extraction |
| US7699767B2 (en) * | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
| EP1585583B1 (en) * | 2002-10-23 | 2010-04-07 | The Trustees of Princeton University | Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields |
| JP4075765B2 (ja) * | 2002-10-30 | 2008-04-16 | 日本電気株式会社 | 分離装置およびその製造方法、ならびに分析システム |
| JP2004354364A (ja) * | 2002-12-02 | 2004-12-16 | Nec Corp | 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法 |
| EP1595140A2 (en) | 2003-02-18 | 2005-11-16 | Board Of Regents The University Of Texas System | Dielectric particle focusing |
| US20060068490A1 (en) * | 2004-03-05 | 2006-03-30 | Cha-Mei Tang | Flow-through chemical and biological sensor |
| US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
| US8158410B2 (en) * | 2005-01-18 | 2012-04-17 | Biocept, Inc. | Recovery of rare cells using a microchannel apparatus with patterned posts |
| US20090136982A1 (en) | 2005-01-18 | 2009-05-28 | Biocept, Inc. | Cell separation using microchannel having patterned posts |
| GB2427468B (en) * | 2005-04-05 | 2011-03-02 | Cellpoint Diagnostics | Cell separation device and method for the detection of EpCAM positive cells |
| US20070196820A1 (en) | 2005-04-05 | 2007-08-23 | Ravi Kapur | Devices and methods for enrichment and alteration of cells and other particles |
| CA2603969C (en) | 2005-04-08 | 2014-10-28 | Velocys, Inc. | Flow control through plural, parallel connecting channels to/from a manifold |
| JP5021629B2 (ja) | 2005-05-09 | 2012-09-12 | ザ ジェネラル ホスピタル コーポレイション | 水の緩和に基づくセンサ |
| US20070026419A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| US20070059781A1 (en) * | 2005-09-15 | 2007-03-15 | Ravi Kapur | System for size based separation and analysis |
| JP2007196219A (ja) * | 2005-12-28 | 2007-08-09 | Kawamura Inst Of Chem Res | 物質分離デバイスおよび物質分離方法 |
| EP2040843B1 (en) * | 2006-06-01 | 2020-02-26 | The Trustees of Princeton University | Apparatus for continuous particle separation |
| WO2008124589A2 (en) * | 2007-04-06 | 2008-10-16 | California Institute Of Technology | Microfluidic device |
| US7837040B2 (en) | 2007-04-09 | 2010-11-23 | Los Alamos National Security, Llc | Acoustic concentration of particles in fluid flow |
| US8186913B2 (en) * | 2007-04-16 | 2012-05-29 | The General Hospital Corporation | Systems and methods for particle focusing in microchannels |
| WO2009045551A1 (en) | 2007-10-04 | 2009-04-09 | The General Hospital Corporation | Miniaturized magnetic resonance systems and methods |
| FI20085299A0 (fi) * | 2008-04-10 | 2008-04-10 | Valtion Teknillinen | Mikrofluidistisia siruvälineitä ja niiden käyttö |
| WO2010006174A2 (en) * | 2008-07-10 | 2010-01-14 | Reichenbach Steven H | Method and apparatus for sorting particles using asymmetrical particle shifting |
| WO2010011934A2 (en) | 2008-07-24 | 2010-01-28 | The Trustees Of Princeton University | Bump array device having asymmetric gaps for segregation of particles |
| US9156037B2 (en) | 2009-01-15 | 2015-10-13 | Children's Medical Center Corporation | Microfluidic device and uses thereof |
| US20120037544A1 (en) | 2009-04-23 | 2012-02-16 | Logos Energy, Inc. | Lateral displacement array for microfiltration |
| BR112012018376A2 (pt) * | 2009-12-23 | 2017-10-10 | Cytovera Inc | "sistema e método para filtração de partículas" |
| ITTO20100068U1 (it) * | 2010-04-20 | 2011-10-21 | Eltek Spa | Dispositivi microfluidici e/o attrezzature per dispositivi microfluidici |
| US9422517B2 (en) * | 2010-07-30 | 2016-08-23 | The General Hospital Corporation | Microscale and nanoscale structures for manipulating particles |
| EP2641094B1 (en) * | 2010-11-18 | 2019-03-06 | The Regents of The University of California | Method for high-throughput solution exchange for cell and particle suspensions |
| EP2667710B1 (en) | 2011-01-28 | 2017-05-10 | Dow AgroSciences LLC | Insescticidal composition and processes related thereto |
| JP2012223683A (ja) * | 2011-04-18 | 2012-11-15 | Seiko Epson Corp | 微粒子分離装置および微粒子分離方法 |
| JP6158808B2 (ja) | 2011-08-04 | 2017-07-05 | セイジ サイエンス,インコーポレイティド | 流体を処理するためのシステム及び方法 |
| US20140227777A1 (en) | 2011-09-30 | 2014-08-14 | Brigham And Women's Hospital | Cell sorting by 3d flow and adhesive rolling |
| US9149806B2 (en) * | 2012-01-10 | 2015-10-06 | Biopico Systems Inc | Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics |
| CN104540594B (zh) | 2012-06-25 | 2019-07-02 | 通用医疗公司 | 使用高梯度磁场对粒子进行分类 |
| JP6501709B2 (ja) | 2012-09-28 | 2019-04-17 | キヤノン ユー.エス. ライフ サイエンシズ, インコーポレイテッドCanon U.S. Life Sciences, Inc. | スパイラル慣性濾過を使用する粒子分離及び濃縮 |
| WO2014059188A1 (en) * | 2012-10-12 | 2014-04-17 | Sage Science, Inc. | Side-eluting molecular fractionator |
| EP2941642B1 (en) | 2013-01-03 | 2020-05-13 | Brigham and Women's Hospital, Inc. | System and method for a biomimetic fluid processing |
| US20170209864A1 (en) | 2013-03-15 | 2017-07-27 | Gpb Scientific, Llc | Methods and systems for processing particles |
| CN105264127B (zh) | 2013-03-15 | 2019-04-09 | Gpb科学有限责任公司 | 颗粒的片上微流体处理 |
| US20140342375A1 (en) * | 2013-03-15 | 2014-11-20 | University Of Maryland | Microfluidic processing of leukocytes for molecular diagnostic testing |
| CN105247042B (zh) | 2013-03-15 | 2021-06-11 | 普林斯顿大学理事会 | 用于高通量纯化的方法和设备 |
| US12005453B2 (en) * | 2013-10-01 | 2024-06-11 | Owl biomedical, Inc. | Particle manipulation system with multisort valve and focusing element |
| KR102365795B1 (ko) * | 2014-01-20 | 2022-02-21 | 핼시언 바이오메디컬, 인코퍼레이티드 | 입자의 분리 및 농축 |
| WO2015116990A1 (en) | 2014-01-30 | 2015-08-06 | The General Hospital Corporation | Inertio-elastic focusing of particles in microchannels |
| WO2016023008A1 (en) | 2014-08-07 | 2016-02-11 | The General Hospital Corporation | Platelet-targeted microfluidic isolation of cells |
| WO2016073448A1 (en) | 2014-11-03 | 2016-05-12 | The General Hospital Corporation | Combined sorting and concentrating particles in a microfluidic device |
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