JP6736545B2 - 大環状ｒｉｐ２キナーゼ阻害剤 - Google Patents

大環状ｒｉｐ２キナーゼ阻害剤 Download PDF

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Publication number
JP6736545B2
JP6736545B2 JP2017514486A JP2017514486A JP6736545B2 JP 6736545 B2 JP6736545 B2 JP 6736545B2 JP 2017514486 A JP2017514486 A JP 2017514486A JP 2017514486 A JP2017514486 A JP 2017514486A JP 6736545 B2 JP6736545 B2 JP 6736545B2
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JP2017528481A5 (enExample
JP2017528481A (ja
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ホフラック，ジャン
ブロム，ペトラ
ベンドリッター，パスカル
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オンコデザイン エス．ア．
オンコデザイン エス．ア．
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017514486A 2014-09-17 2015-09-17 大環状ｒｉｐ２キナーゼ阻害剤 Active JP6736545B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14185130 2014-09-17
EP14185130.3 2014-09-17
PCT/EP2015/071347 WO2016042087A1 (en) 2014-09-17 2015-09-17 Macrocyclic rip2 kinase inhibitors

Publications (3)

Publication Number Publication Date
JP2017528481A JP2017528481A (ja) 2017-09-28
JP2017528481A5 JP2017528481A5 (enExample) 2018-09-13
JP6736545B2 true JP6736545B2 (ja) 2020-08-05

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ID=51687776

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017514486A Active JP6736545B2 (ja) 2014-09-17 2015-09-17 大環状ｒｉｐ２キナーゼ阻害剤

Country Status (26)

Country Link
US (1) US10676486B2 (enExample)
EP (1) EP3194407B1 (enExample)
JP (1) JP6736545B2 (enExample)
KR (1) KR102563829B1 (enExample)
CN (1) CN106687464B (enExample)
AU (1) AU2015316799B2 (enExample)
BR (1) BR112017004035B1 (enExample)
CA (1) CA2958782C (enExample)
DK (1) DK3194407T3 (enExample)
EA (1) EA032872B1 (enExample)
ES (1) ES2763344T3 (enExample)
HR (1) HRP20192334T1 (enExample)
HU (1) HUE048518T2 (enExample)
IL (1) IL250544B (enExample)
LT (1) LT3194407T (enExample)
MX (1) MX376087B (enExample)
MY (1) MY186523A (enExample)
PL (1) PL3194407T3 (enExample)
PT (1) PT3194407T (enExample)
SA (1) SA517381087B1 (enExample)
SG (1) SG11201701116XA (enExample)
SI (1) SI3194407T1 (enExample)
TW (1) TWI709563B (enExample)
UA (1) UA121315C2 (enExample)
WO (1) WO2016042087A1 (enExample)
ZA (1) ZA201701331B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102719387B1 (ko) * 2017-01-26 2024-10-21 한미약품 주식회사 이미다조피리다진 화합물
AR124556A1 (es) 2020-01-31 2023-04-12 Oncodesign Sa Inhibidores macrocíclicos de rip2-cinasa
WO2024051631A1 (zh) * 2022-09-07 2024-03-14 苏州朗睿生物医药有限公司 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途
CN120500490A (zh) * 2023-01-03 2025-08-15 广东新契生物医药科技有限公司 作为usp1抑制剂的大环化合物
WO2025212514A2 (en) * 2024-04-02 2025-10-09 Interline Therapeutics, Inc. Methods of treating inflammatory diseases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
SK283569B6 (sk) 1993-10-01 2003-09-11 Astra Aktiebolag Spôsob spracovania jemne deleného práškového liečiva, zariadenie na vykonávanie tohto spôsobu a aglomeráty vyrobené týmto spôsobom
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US7750007B2 (en) * 2006-11-06 2010-07-06 Supergen, Inc. Imidazo[1,2-beta]pyridazine and pyrazolo[1,5-alpha]pyrimidine derivatives and their use as protein kinase inhibitors
AR077468A1 (es) * 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
AU2011256380C1 (en) * 2010-05-20 2016-09-08 Array Biopharma Inc. Macrocyclic compounds as Trk kinase inhibitors
WO2013001310A1 (en) 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
TWI547494B (zh) * 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
ES2583477T3 (es) 2011-09-30 2016-09-21 Ipsen Pharma S.A.S. Inhibidores macrocíclicos de cinasa de LRRK2
KR20140078710A (ko) * 2011-09-30 2014-06-25 온코디자인 에스.에이. 거대고리 flt3 키나제 억제제

Also Published As

Publication number Publication date
LT3194407T (lt) 2020-01-27
DK3194407T3 (da) 2020-01-27
EP3194407A1 (en) 2017-07-26
AU2015316799B2 (en) 2019-07-11
TW201619168A (zh) 2016-06-01
TWI709563B (zh) 2020-11-11
BR112017004035A2 (pt) 2017-12-05
HUE048518T2 (hu) 2020-07-28
PT3194407T (pt) 2020-01-20
BR112017004035A8 (pt) 2023-05-09
CN106687464B (zh) 2020-03-03
CN106687464A (zh) 2017-05-17
PL3194407T3 (pl) 2020-04-30
CA2958782C (en) 2024-01-09
EA201790609A1 (ru) 2017-07-31
IL250544B (en) 2020-06-30
NZ730758A (en) 2023-09-29
WO2016042087A1 (en) 2016-03-24
JP2017528481A (ja) 2017-09-28
CA2958782A1 (en) 2016-03-24
IL250544A0 (en) 2017-03-30
EA032872B1 (ru) 2019-07-31
HRP20192334T1 (hr) 2020-03-20
US10676486B2 (en) 2020-06-09
KR102563829B1 (ko) 2023-08-03
KR20170048596A (ko) 2017-05-08
AU2015316799A1 (en) 2017-04-27
MX376087B (es) 2025-03-07
EP3194407B1 (en) 2019-10-23
UA121315C2 (uk) 2020-05-12
SI3194407T1 (sl) 2020-03-31
ZA201701331B (en) 2020-07-29
ES2763344T3 (es) 2020-05-28
SA517381087B1 (ar) 2021-02-09
MY186523A (en) 2021-07-24
MX2017003469A (es) 2017-05-08
BR112017004035B1 (pt) 2023-11-14
US20190127390A1 (en) 2019-05-02
SG11201701116XA (en) 2017-03-30

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