DK3194407T3 - Makrocykliske RIP2-kinaseinhibitorer - Google Patents

Makrocykliske RIP2-kinaseinhibitorer Download PDF

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Publication number
DK3194407T3
DK3194407T3 DK15766800.5T DK15766800T DK3194407T3 DK 3194407 T3 DK3194407 T3 DK 3194407T3 DK 15766800 T DK15766800 T DK 15766800T DK 3194407 T3 DK3194407 T3 DK 3194407T3
Authority
DK
Denmark
Prior art keywords
kinase inhibitors
rip2 kinase
macrocyclic
macrocyclic rip2
inhibitors
Prior art date
Application number
DK15766800.5T
Other languages
Danish (da)
English (en)
Inventor
Jan Hoflack
Petra Blom
Pascal Benderitter
Original Assignee
Oncodesign Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncodesign Sa filed Critical Oncodesign Sa
Application granted granted Critical
Publication of DK3194407T3 publication Critical patent/DK3194407T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK15766800.5T 2014-09-17 2015-09-17 Makrocykliske RIP2-kinaseinhibitorer DK3194407T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14185130 2014-09-17
PCT/EP2015/071347 WO2016042087A1 (en) 2014-09-17 2015-09-17 Macrocyclic rip2 kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3194407T3 true DK3194407T3 (da) 2020-01-27

Family

ID=51687776

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15766800.5T DK3194407T3 (da) 2014-09-17 2015-09-17 Makrocykliske RIP2-kinaseinhibitorer

Country Status (26)

Country Link
US (1) US10676486B2 (enExample)
EP (1) EP3194407B1 (enExample)
JP (1) JP6736545B2 (enExample)
KR (1) KR102563829B1 (enExample)
CN (1) CN106687464B (enExample)
AU (1) AU2015316799B2 (enExample)
BR (1) BR112017004035B1 (enExample)
CA (1) CA2958782C (enExample)
DK (1) DK3194407T3 (enExample)
EA (1) EA032872B1 (enExample)
ES (1) ES2763344T3 (enExample)
HR (1) HRP20192334T1 (enExample)
HU (1) HUE048518T2 (enExample)
IL (1) IL250544B (enExample)
LT (1) LT3194407T (enExample)
MX (1) MX376087B (enExample)
MY (1) MY186523A (enExample)
PL (1) PL3194407T3 (enExample)
PT (1) PT3194407T (enExample)
SA (1) SA517381087B1 (enExample)
SG (1) SG11201701116XA (enExample)
SI (1) SI3194407T1 (enExample)
TW (1) TWI709563B (enExample)
UA (1) UA121315C2 (enExample)
WO (1) WO2016042087A1 (enExample)
ZA (1) ZA201701331B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102719387B1 (ko) * 2017-01-26 2024-10-21 한미약품 주식회사 이미다조피리다진 화합물
KR20230005117A (ko) * 2020-01-31 2023-01-09 온코디자인 에스.에이. 거대고리 rip2 키나제 억제제
CN117659043A (zh) * 2022-09-07 2024-03-08 苏州朗睿生物医药有限公司 一种大环咪唑并[1,2-b]哒嗪衍生物及其制备方法和用途
CN120500490A (zh) * 2023-01-03 2025-08-15 广东新契生物医药科技有限公司 作为usp1抑制剂的大环化合物
WO2025212514A2 (en) * 2024-04-02 2025-10-09 Interline Therapeutics, Inc. Methods of treating inflammatory diseases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
CN1110300C (zh) 1993-10-01 2003-06-04 阿斯特拉公司 工艺技术ⅰ
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
MY146474A (en) * 2006-11-06 2012-08-15 Supergen Inc Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
AR077468A1 (es) * 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
HUE044025T2 (hu) * 2010-05-20 2019-09-30 Array Biopharma Inc Makrociklusos vegyületek mint TRK-kináz inhibitorok
WO2013001310A1 (en) * 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
TWI547494B (zh) * 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
WO2013045653A1 (en) 2011-09-30 2013-04-04 Oncodesign S.A. Macrocyclic flt3 kinase inhibitors
US9096609B2 (en) 2011-09-30 2015-08-04 Ipsen Pharma S.A.S. Macrocyclic LRRK2 kinase inhibitors

Also Published As

Publication number Publication date
TWI709563B (zh) 2020-11-11
SG11201701116XA (en) 2017-03-30
BR112017004035A2 (pt) 2017-12-05
MY186523A (en) 2021-07-24
WO2016042087A1 (en) 2016-03-24
HRP20192334T1 (hr) 2020-03-20
ZA201701331B (en) 2020-07-29
IL250544A0 (en) 2017-03-30
EP3194407B1 (en) 2019-10-23
LT3194407T (lt) 2020-01-27
AU2015316799A1 (en) 2017-04-27
MX376087B (es) 2025-03-07
JP6736545B2 (ja) 2020-08-05
US10676486B2 (en) 2020-06-09
BR112017004035B1 (pt) 2023-11-14
EA201790609A1 (ru) 2017-07-31
NZ730758A (en) 2023-09-29
EP3194407A1 (en) 2017-07-26
UA121315C2 (uk) 2020-05-12
KR102563829B1 (ko) 2023-08-03
KR20170048596A (ko) 2017-05-08
AU2015316799B2 (en) 2019-07-11
CN106687464A (zh) 2017-05-17
CA2958782C (en) 2024-01-09
SA517381087B1 (ar) 2021-02-09
PL3194407T3 (pl) 2020-04-30
TW201619168A (zh) 2016-06-01
JP2017528481A (ja) 2017-09-28
HUE048518T2 (hu) 2020-07-28
MX2017003469A (es) 2017-05-08
CA2958782A1 (en) 2016-03-24
ES2763344T3 (es) 2020-05-28
US20190127390A1 (en) 2019-05-02
CN106687464B (zh) 2020-03-03
PT3194407T (pt) 2020-01-20
IL250544B (en) 2020-06-30
EA032872B1 (ru) 2019-07-31
SI3194407T1 (sl) 2020-03-31
BR112017004035A8 (pt) 2023-05-09

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