DK3194407T3 - Makrocykliske RIP2-kinaseinhibitorer - Google Patents

Makrocykliske RIP2-kinaseinhibitorer Download PDF

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Publication number
DK3194407T3
DK3194407T3 DK15766800.5T DK15766800T DK3194407T3 DK 3194407 T3 DK3194407 T3 DK 3194407T3 DK 15766800 T DK15766800 T DK 15766800T DK 3194407 T3 DK3194407 T3 DK 3194407T3
Authority
DK
Denmark
Prior art keywords
kinase inhibitors
rip2 kinase
macrocyclic
macrocyclic rip2
inhibitors
Prior art date
Application number
DK15766800.5T
Other languages
Danish (da)
English (en)
Inventor
Jan Hoflack
Petra Blom
Pascal Benderitter
Original Assignee
Oncodesign Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncodesign Sa filed Critical Oncodesign Sa
Application granted granted Critical
Publication of DK3194407T3 publication Critical patent/DK3194407T3/da

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/529Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK15766800.5T 2014-09-17 2015-09-17 Makrocykliske RIP2-kinaseinhibitorer DK3194407T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14185130 2014-09-17
PCT/EP2015/071347 WO2016042087A1 (en) 2014-09-17 2015-09-17 Macrocyclic rip2 kinase inhibitors

Publications (1)

Publication Number Publication Date
DK3194407T3 true DK3194407T3 (da) 2020-01-27

Family

ID=51687776

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15766800.5T DK3194407T3 (da) 2014-09-17 2015-09-17 Makrocykliske RIP2-kinaseinhibitorer

Country Status (26)

Country Link
US (1) US10676486B2 (enExample)
EP (1) EP3194407B1 (enExample)
JP (1) JP6736545B2 (enExample)
KR (1) KR102563829B1 (enExample)
CN (1) CN106687464B (enExample)
AU (1) AU2015316799B2 (enExample)
BR (1) BR112017004035B1 (enExample)
CA (1) CA2958782C (enExample)
DK (1) DK3194407T3 (enExample)
EA (1) EA032872B1 (enExample)
ES (1) ES2763344T3 (enExample)
HR (1) HRP20192334T1 (enExample)
HU (1) HUE048518T2 (enExample)
IL (1) IL250544B (enExample)
LT (1) LT3194407T (enExample)
MX (1) MX376087B (enExample)
MY (1) MY186523A (enExample)
PL (1) PL3194407T3 (enExample)
PT (1) PT3194407T (enExample)
SA (1) SA517381087B1 (enExample)
SG (1) SG11201701116XA (enExample)
SI (1) SI3194407T1 (enExample)
TW (1) TWI709563B (enExample)
UA (1) UA121315C2 (enExample)
WO (1) WO2016042087A1 (enExample)
ZA (1) ZA201701331B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102719387B1 (ko) * 2017-01-26 2024-10-21 한미약품 주식회사 이미다조피리다진 화합물
CN115698020B (zh) 2020-01-31 2025-02-25 昂科迪塞恩精密医药公司(Opm) 大环rip2-激酶抑制剂
AU2023339247A1 (en) * 2022-09-07 2025-03-27 Suzhou Langrui Biopharmaceutical Co., Ltd. Macrocyclic imidazo[1,2-b]pyridazine derivative, preparation method therefor, and use thereof
WO2024146541A1 (en) * 2023-01-03 2024-07-11 Guangdong Newopp Biopharmaceuticals Co., Ltd. Macrocyclic compounds as usp1 inhibitors
WO2025212514A2 (en) * 2024-04-02 2025-10-09 Interline Therapeutics, Inc. Methods of treating inflammatory diseases

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IS2334B (is) 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
BR9407686A (pt) 1993-10-01 1997-02-04 Astra Ab Processo e aparelho para o tratamento de um medicamento em pó finamente dividido uso do aparelho e aglomerados
US6043358A (en) 1995-11-01 2000-03-28 Merck & Co., Inc. Hexahydro-5-imino-1,4-heteroazepine derivatives as inhibitors of nitric oxide synthases
GB9718913D0 (en) 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
NZ576234A (en) * 2006-11-06 2011-06-30 Supergen Inc Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
AR077468A1 (es) * 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
PL2918588T3 (pl) * 2010-05-20 2017-10-31 Array Biopharma Inc Związki makrocykliczne jako inhibitory kinazy TRK
WO2013001310A1 (en) * 2011-06-30 2013-01-03 Centro Nacional De Investigaciones Oncológicas (Cnio) Macrocyclic compounds and their use as cdk8 inhibitors
TWI547494B (zh) * 2011-08-18 2016-09-01 葛蘭素史克智慧財產發展有限公司 作為激酶抑制劑之胺基喹唑啉類
EP2760453B1 (en) 2011-09-30 2016-05-25 Ipsen Pharma S.A.S. Macrocyclic lrrk2 kinase inhibitors
HUE027318T2 (en) * 2011-09-30 2016-10-28 Oncodesign Sa Macrocyclic FLT3 kinase inhibitors

Also Published As

Publication number Publication date
MY186523A (en) 2021-07-24
UA121315C2 (uk) 2020-05-12
SI3194407T1 (sl) 2020-03-31
PT3194407T (pt) 2020-01-20
SG11201701116XA (en) 2017-03-30
EP3194407B1 (en) 2019-10-23
BR112017004035A2 (pt) 2017-12-05
TWI709563B (zh) 2020-11-11
AU2015316799B2 (en) 2019-07-11
EA201790609A1 (ru) 2017-07-31
MX2017003469A (es) 2017-05-08
MX376087B (es) 2025-03-07
US10676486B2 (en) 2020-06-09
CA2958782A1 (en) 2016-03-24
KR20170048596A (ko) 2017-05-08
ES2763344T3 (es) 2020-05-28
NZ730758A (en) 2023-09-29
TW201619168A (zh) 2016-06-01
LT3194407T (lt) 2020-01-27
AU2015316799A1 (en) 2017-04-27
EA032872B1 (ru) 2019-07-31
EP3194407A1 (en) 2017-07-26
CN106687464A (zh) 2017-05-17
JP2017528481A (ja) 2017-09-28
IL250544B (en) 2020-06-30
BR112017004035A8 (pt) 2023-05-09
PL3194407T3 (pl) 2020-04-30
SA517381087B1 (ar) 2021-02-09
CN106687464B (zh) 2020-03-03
JP6736545B2 (ja) 2020-08-05
KR102563829B1 (ko) 2023-08-03
BR112017004035B1 (pt) 2023-11-14
CA2958782C (en) 2024-01-09
HRP20192334T1 (hr) 2020-03-20
WO2016042087A1 (en) 2016-03-24
ZA201701331B (en) 2020-07-29
HUE048518T2 (hu) 2020-07-28
IL250544A0 (en) 2017-03-30
US20190127390A1 (en) 2019-05-02

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