JP6713992B2 - 人工肺システム及びその使用方法 - Google Patents
人工肺システム及びその使用方法 Download PDFInfo
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- 238000000034 method Methods 0.000 title claims description 19
- 210000004072 lung Anatomy 0.000 title description 4
- 239000001301 oxygen Substances 0.000 claims description 171
- 229910052760 oxygen Inorganic materials 0.000 claims description 171
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 170
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims description 168
- 239000008280 blood Substances 0.000 claims description 100
- 210000004369 blood Anatomy 0.000 claims description 100
- 229910002092 carbon dioxide Inorganic materials 0.000 claims description 84
- 239000001569 carbon dioxide Substances 0.000 claims description 84
- 239000007789 gas Substances 0.000 claims description 78
- 239000006096 absorbing agent Substances 0.000 claims description 37
- 238000010521 absorption reaction Methods 0.000 claims description 7
- 238000006213 oxygenation reaction Methods 0.000 claims description 7
- HUAUNKAZQWMVFY-UHFFFAOYSA-M sodium;oxocalcium;hydroxide Chemical compound [OH-].[Na+].[Ca]=O HUAUNKAZQWMVFY-UHFFFAOYSA-M 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 claims description 3
- 229910001882 dioxygen Inorganic materials 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- -1 Litholyme® Chemical compound 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 230000008901 benefit Effects 0.000 description 7
- 238000002618 extracorporeal membrane oxygenation Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 210000003954 umbilical cord Anatomy 0.000 description 4
- 208000019693 Lung disease Diseases 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 description 2
- 229920000557 Nafion® Polymers 0.000 description 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 description 2
- 208000011341 adult acute respiratory distress syndrome Diseases 0.000 description 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 230000001706 oxygenating effect Effects 0.000 description 2
- 238000005086 pumping Methods 0.000 description 2
- 210000005241 right ventricle Anatomy 0.000 description 2
- 241001631457 Cannula Species 0.000 description 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 description 1
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 1
- 208000010428 Muscle Weakness Diseases 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- UBAZGMLMVVQSCD-UHFFFAOYSA-N carbon dioxide;molecular oxygen Chemical group O=O.O=C=O UBAZGMLMVVQSCD-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229910001416 lithium ion Inorganic materials 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005399 mechanical ventilation Methods 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
- A61M1/3667—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines with assisted venous return
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/02—Gases
- A61M2202/0208—Oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- External Artificial Organs (AREA)
Description
Claims (15)
- 血液酸素供給のための酸素豊富なガスを提供する方法であって、
血液酸素付加装置システムは、電池電源または外部電源で選択的に酸素濃縮器を操作し、
前記血液酸素付加装置システムは、前記酸素濃縮器を外部電源で操作しているとき、前記酸素濃縮器から二酸化炭素を除去せずに血液酸素付加装置へ酸素を供給し、
前記血液酸素付加装置システムは、前記酸素濃縮器を電池で操作しているとき、前記酸素濃縮器からの酸素を二酸化炭素が除去された酸素ガスの流れと組み合わせ、血液酸素付加装置へ前記組み合わせたガスの流れを供給する方法。 - 前記血液酸素付加装置システムは、前記血液酸素付加装置から受けた二酸化炭素が高められたガスの流れから二酸化炭素を除去することによって、前記二酸化炭素が除去されたガスの流れを作り出す請求項1に記載の方法。
- 前記酸素濃縮器は、前記二酸化炭素が除去されたガスの流れと組み合わせるための毎分0.5リットルから毎分1リットルの範囲の流れを供給し、
前記二酸化炭素が除去されたガスの流れは毎分4.5リットルから毎分9リットルであり、
二酸化炭素を除去せずに前記酸素濃縮器から酸素が毎分2リットルから毎分6リットルの割合で供給される請求項2に記載の方法。 - 前記酸素付加装置システムは、前記酸素濃縮器からの前記酸素を前記血液酸素付加装置から二酸化炭素が高められたガスの流れと組み合わせることを備え、
前記二酸化炭素が高められたガスの流れは、毎分3リットルから毎分6リットルの割合で流れる請求項1乃至3のいずれか1項に記載の方法。 - 酸素豊富なガスの流れを受け、二酸化炭素が高められたガスの流れを発生する血液酸素付加装置のための酸素供給ユニットであって、
空気から酸素豊富なガスの流れを作り出す酸素濃縮器と、
二酸化炭素が高められたガスの流れから二酸化炭素を取り除く炭酸ガス吸収装置と、
電池または外部電力供給から電力を選択的に供給する電力制御装置と、
(1)前記電力制御装置が前記外部電力供給から電力を供給する場合、二酸化炭素を除去せずに、前記酸素濃縮器から前記血液酸素付加装置へ酸素豊富なガスを供給し、(2)前記電力制御装置が前記電池から電力を供給する場合、前記酸素濃縮器からの酸素豊富なガスを前記炭酸ガス吸収装置からの二酸化炭素が除去されたガスと組み合わせるように構成されたバルブ付きの網状管、を備える酸素供給ユニット。 - さらに、前記酸素濃縮器、前記炭酸ガス吸収装置、前記電力制御装置、前記バルブ付きの網状管は、筐体の中に配置される請求項5に記載の酸素供給ユニット。
- 前記筐体は、前記筐体が使用者によって引いたり押したりできるように構成された車輪を備える請求項6に記載の酸素供給ユニット。
- 前記酸素濃縮器は、電気的に駆動される内部コンプレッサを有する圧力スイング酸素濃縮器を備える請求項5乃至7のいずれか1項に記載の酸素供給ユニット。
- 前記炭酸ガス吸収装置は、吸収媒体を有するキャニスタを含む請求項5乃至8のいずれか1項に記載の酸素供給ユニット。
- 前記吸収媒体は、ソーダ石灰、Litholyme(登録商標)、Sodasorb(登録商標)、Medisorb(登録商標)、Sodasorb(登録商標)LF、及びAmsorb(登録商標)を備える請求項9に記載の酸素供給ユニット。
- 前記バルブ付きの網状管は、前記炭酸ガス吸収装置を前記流れが通る前の前記二酸化炭素が高められたガスの流れから水分を取り除く除湿機を備える請求項5乃至10のいずれか1項に記載の酸素供給ユニット。
- 前記バルブ付き網状管は、さらに前記二酸化炭素が高められたガスの流れを流すためのポンプを備える請求項11に記載の酸素供給ユニット。
- 前記バルブ付きの網状管は、さらに前記酸素豊富なガスが前記炭酸ガス吸収装置によって流れることができるバイパスラインを備える請求項12に記載の酸素供給ユニット。
- 請求項5乃至13のいずれか1項に記載の酸素供給ユニットと、患者が身につけるように構成されたポンプ血液人工肺ユニットを備える装置。
- さらに、酸素豊富な流れの管、二酸化炭素が高められた流れの管、及び血液を送り出す前記人工肺ユニットのポンプを前記酸素供給ユニットの前記電力制御装置と接続する電線を含むアンビリカルケーブルを備える請求項14に記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201462081747P | 2014-11-19 | 2014-11-19 | |
US62/081,747 | 2014-11-19 | ||
PCT/US2015/061214 WO2016081533A1 (en) | 2014-11-19 | 2015-11-18 | Artificial lung system and its methods of use |
Related Child Applications (1)
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JP2020097684A Division JP7010997B2 (ja) | 2014-11-19 | 2020-06-04 | 人工肺システム及びその使用方法 |
Publications (3)
Publication Number | Publication Date |
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JP2017538485A JP2017538485A (ja) | 2017-12-28 |
JP2017538485A5 JP2017538485A5 (ja) | 2018-12-27 |
JP6713992B2 true JP6713992B2 (ja) | 2020-06-24 |
Family
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Family Applications (4)
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JP2017527805A Active JP6713992B2 (ja) | 2014-11-19 | 2015-11-18 | 人工肺システム及びその使用方法 |
JP2020097684A Active JP7010997B2 (ja) | 2014-11-19 | 2020-06-04 | 人工肺システム及びその使用方法 |
JP2022003826A Active JP7367083B2 (ja) | 2014-11-19 | 2022-01-13 | 人工肺システム及びその使用方法 |
JP2023175943A Pending JP2024009921A (ja) | 2014-11-19 | 2023-10-11 | 人工肺システム及びその使用方法 |
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JP2020097684A Active JP7010997B2 (ja) | 2014-11-19 | 2020-06-04 | 人工肺システム及びその使用方法 |
JP2022003826A Active JP7367083B2 (ja) | 2014-11-19 | 2022-01-13 | 人工肺システム及びその使用方法 |
JP2023175943A Pending JP2024009921A (ja) | 2014-11-19 | 2023-10-11 | 人工肺システム及びその使用方法 |
Country Status (8)
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US (3) | US10413655B2 (ja) |
EP (3) | EP4378496A3 (ja) |
JP (4) | JP6713992B2 (ja) |
CN (2) | CN107073196B (ja) |
AU (3) | AU2015350026B2 (ja) |
DK (2) | DK3220973T3 (ja) |
ES (2) | ES2975684T3 (ja) |
WO (1) | WO2016081533A1 (ja) |
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US20180001012A1 (en) * | 2014-12-16 | 2018-01-04 | The Regents Of The University Of California | Portable Lung Assist Device |
CN107680464B (zh) * | 2017-11-20 | 2019-08-30 | 上海理工大学 | 一种实验教学模拟装置 |
IT201800002461A1 (it) * | 2018-02-07 | 2019-08-07 | Eurosets Srl | Dispositivo per il monitoraggio continuo di grandezze caratteristiche del sangue in circuito esterno di supporto cardiocircolatorio |
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WO2019246320A1 (en) * | 2018-06-20 | 2019-12-26 | University Of Maryland, Baltimore | System for control of a blood gas exchanger |
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EP3220973A4 (en) | 2018-05-23 |
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JP2020168389A (ja) | 2020-10-15 |
EP4000662B1 (en) | 2024-02-21 |
US10413655B2 (en) | 2019-09-17 |
JP7367083B2 (ja) | 2023-10-23 |
EP3220973A1 (en) | 2017-09-27 |
EP3220973B1 (en) | 2022-01-05 |
AU2023201261A1 (en) | 2023-04-06 |
DK3220973T3 (da) | 2022-03-14 |
CN112933320A (zh) | 2021-06-11 |
JP2017538485A (ja) | 2017-12-28 |
WO2016081533A1 (en) | 2016-05-26 |
CN112933320B (zh) | 2024-05-03 |
EP4378496A3 (en) | 2024-07-10 |
EP4000662A1 (en) | 2022-05-25 |
JP2022062721A (ja) | 2022-04-20 |
US20240050637A1 (en) | 2024-02-15 |
AU2015350026A1 (en) | 2017-07-06 |
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DK4000662T3 (da) | 2024-03-18 |
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