JP6691053B2 - 無線周波数多重化を用いた並行フローサイトメーター - Google Patents

無線周波数多重化を用いた並行フローサイトメーター Download PDF

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JP6691053B2
JP6691053B2 JP2016556971A JP2016556971A JP6691053B2 JP 6691053 B2 JP6691053 B2 JP 6691053B2 JP 2016556971 A JP2016556971 A JP 2016556971A JP 2016556971 A JP2016556971 A JP 2016556971A JP 6691053 B2 JP6691053 B2 JP 6691053B2
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frequency
light
shifted
optical
flow channel
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JP2017516073A (ja
JP2017516073A5 (enExample
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ジャラリ，バーラム
ディボールド，エリック
バックリー，ブランドン
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University of California
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N2015/1006—Investigating individual particles for cytology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/067—Electro-optic, magneto-optic, acousto-optic elements

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Microscoopes, Condenser (AREA)
JP2016556971A 2014-03-18 2015-03-18 無線周波数多重化を用いた並行フローサイトメーター Active JP6691053B2 (ja)

Applications Claiming Priority (3)

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US201461955137P 2014-03-18 2014-03-18
US61/955,137 2014-03-18
PCT/US2015/021264 WO2015143041A1 (en) 2014-03-18 2015-03-18 Parallel flow cytometer using radiofrequency mulitplexing

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JP2017516073A JP2017516073A (ja) 2017-06-15
JP2017516073A5 JP2017516073A5 (enExample) 2018-04-26
JP6691053B2 true JP6691053B2 (ja) 2020-04-28

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US (9) US9784661B2 (enExample)
EP (2) EP4253936A3 (enExample)
JP (1) JP6691053B2 (enExample)
ES (1) ES2959506T3 (enExample)
WO (1) WO2015143041A1 (enExample)

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Publication number Priority date Publication date Assignee Title
JP6338597B2 (ja) 2013-01-09 2018-06-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 無線周波数多重励起を用いた蛍光イメージングのための装置及び方法
ES2959506T3 (es) 2014-03-18 2024-02-26 Univ California Citómetro de flujo paralelo que usa multiplexación por radiofrecuencia, y método
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US10006852B2 (en) 2016-09-13 2018-06-26 Becton, Dickinson And Company Flow cytometer with optical equalization
FR3077639B1 (fr) * 2018-02-02 2020-02-14 Universite De Rennes 1 Methode de determination d'une vitesse de sedimentation
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WO2020036730A1 (en) 2018-08-15 2020-02-20 Becton, Dickinson And Company Flowrate and vacuum controlled fluid management system for a flow type particle analyzer
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EP3850335B1 (en) * 2018-09-14 2023-08-16 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Particle analysis method and apparatus for a spectrometry-based particle analysis
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US20250341455A1 (en) 2024-05-03 2025-11-06 Becton, Dickinson And Company Flow cells having an optimized flow channel geometry, flow cytometers including the same, and methods of use thereof
US20250369861A1 (en) 2024-05-31 2025-12-04 Becton, Dickinson And Company Methods and systems for singlet discrimination in flow cytometry data and systems for same
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Family Cites Families (139)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3854050A (en) 1973-09-11 1974-12-10 Department Of Health Education High precision fluorometer for measuring enzymatic substrates in tissue
US4545677A (en) 1984-03-05 1985-10-08 Becton, Dickinson And Company Prismatic beam expander for light beam shaping in a flow cytometry apparatus
DE3610396A1 (de) 1986-03-27 1987-10-01 Wella Ag Mittel und verfahren zur oxidativen faerbung von haaren
JPH0810306B2 (ja) 1990-01-26 1996-01-31 大日本スクリーン製造株式会社 光ビームの偏向制御方法
US5204884A (en) 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
EP0552241B1 (en) * 1990-10-10 2000-06-28 The University Of Maryland Method and apparatus for performing phase fluorescence lifetime measurements in flow cytometry
EP0568596A1 (en) * 1991-01-24 1993-11-10 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
US5203339A (en) 1991-06-28 1993-04-20 The Government Of The United States Of America As Represented By The Secretary Of The Department Health And Human Services Method and apparatus for imaging a physical parameter in turbid media using diffuse waves
US5309912A (en) 1991-11-08 1994-05-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multidimensional imaging using a single point detector for a phase encoded modulated optical carrier
US5192870A (en) 1992-01-14 1993-03-09 International Business Machines Corporation Optical submicron aerosol particle detector
US5255257A (en) 1992-03-04 1993-10-19 Lasertape Systems, Inc. Frequency, phase and amplitude control apparatus and method for acousto-optic deflector optimization
US6057814A (en) 1993-05-24 2000-05-02 Display Science, Inc. Electrostatic video display drive circuitry and displays incorporating same
US5296911A (en) 1992-07-16 1994-03-22 Schiapparelli Biosystems, Inc. Optical test system for a chemical analyzer
US5270548A (en) 1992-07-31 1993-12-14 The United States Of America As Represented By The United States Department Of Energy Phase-sensitive flow cytometer
US5293213A (en) 1992-08-12 1994-03-08 Klein Uwe K A Utilization of a modulated laser beam in heterodyne interferometry
US5483469A (en) 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
US5489977A (en) 1993-08-11 1996-02-06 Texaco Inc. Photomeric means for monitoring solids and fluorescent material in waste water using a falling stream water sampler
JPH0961858A (ja) 1995-08-28 1997-03-07 Minolta Co Ltd 音響光学光走査装置
US5968738A (en) 1995-12-06 1999-10-19 The Board Of Trustees Of The Leland Stanford Junior University Two-reporter FACS analysis of mammalian cells using green fluorescent proteins
JPH10148778A (ja) * 1996-11-18 1998-06-02 Minolta Co Ltd マルチビーム発生装置
DE19721882C2 (de) 1997-05-26 1999-04-29 Bosch Gmbh Robert Interferometrische Meßvorrichtung
DE19721881C2 (de) 1997-05-26 1999-05-20 Bosch Gmbh Robert Interferometrische Meßvorrichtung
US6031852A (en) 1997-05-30 2000-02-29 The Regents Of The University Of California Rapid acoustooptic tuner and phase-shifter
US6016196A (en) 1997-06-17 2000-01-18 Massachusetts Institute Of Technology Multiple beam pair optical imaging
US6236454B1 (en) 1997-12-15 2001-05-22 Applied Materials, Inc. Multiple beam scanner for an inspection system
US6642018B1 (en) 1998-03-27 2003-11-04 Oncosis Llc Method for inducing a response in one or more targeted cells
US6592822B1 (en) * 1998-05-14 2003-07-15 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
US6271924B1 (en) 1998-12-29 2001-08-07 Bryan Kok Ann Ngoi Noncontact acoustic optic scanning laser vibrometer for determining the difference between an object and a reference surface
AU5760500A (en) 1999-06-23 2001-01-09 Patrick Toomey Water detection and source identification methods for structures using electromagnetic radiation spectroscopy
US6396069B1 (en) 1999-06-25 2002-05-28 Macpherson David C. Topographer for real time ablation feedback having synthetic wavelength generators
US7630063B2 (en) * 2000-08-02 2009-12-08 Honeywell International Inc. Miniaturized cytometer for detecting multiple species in a sample
JP4994560B2 (ja) 2000-08-25 2012-08-08 アムニス コーポレイション 細胞などの小さな移動物体の速度測定
US6778263B2 (en) 2000-08-25 2004-08-17 Amnis Corporation Methods of calibrating an imaging system using calibration beads
JP2002296178A (ja) * 2001-03-30 2002-10-09 Shimadzu Corp フローセル検出器
US6636623B2 (en) 2001-08-10 2003-10-21 Visiongate, Inc. Optical projection imaging system and method for automatically detecting cells with molecular marker compartmentalization associated with malignancy and disease
FR2830629B1 (fr) 2001-10-04 2004-01-09 Commissariat Energie Atomique Procede et dispositif de prelevement d'une partie d'un faisceau lumineux, notamment pour appareil d'analyse de fluorescence
DE20216583U1 (de) 2001-12-20 2003-01-23 Leica Microsystems Heidelberg Gmbh, 68165 Mannheim Mikroskop und Durchflusszytometer
US6868347B2 (en) 2002-03-19 2005-03-15 The Regents Of The University Of California System for real time, non-invasive metrology of microfluidic chips
WO2003089901A2 (en) 2002-04-19 2003-10-30 Palsson Bernhard O Methods for preparing libraries of unique tags and related screening methods
US20060014212A1 (en) 2002-05-10 2006-01-19 Epitome Biosystems, Inc. Proteome epitope tags and methods of use thereof in protein modification analysis
DE10225838B4 (de) 2002-06-11 2021-10-21 Leica Microsystems Cms Gmbh Verfahren zur Scanmikroskopie, Scanmikroskop und Vorrichtung zum Codieren eines Beleuchtungslichtstrahles
GB2401431B (en) 2003-04-02 2005-04-27 Amersham Biosciences Uk Ltd Method of, and computer software for, classification of cells into subpopulations
CA2536360C (en) 2003-08-28 2013-08-06 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
US7803624B2 (en) 2003-09-30 2010-09-28 Cytyc Corporation Automated cytological sample classification
US7103402B2 (en) 2003-10-02 2006-09-05 Ut-Battelle, Llc Advanced synchronous luminescence imaging for chemical and medical diagnostics
US7590991B2 (en) 2003-10-09 2009-09-15 Terayon Communication Systems, Inc. Method and apparatus for determining channel to which a TV or VCR is tuned
EP3009815B1 (en) 2003-10-27 2022-09-07 The General Hospital Corporation Method and apparatus for performing optical imaging using frequency-domain interferometry
DE10357584B4 (de) 2003-12-08 2006-06-14 Leica Microsystems Cms Gmbh Verfahren zum Trennen unterschiedlicher Emissionswellenlängen in einem Scanmikroskop
US7133182B2 (en) 2004-06-07 2006-11-07 Electro Scientific Industries, Inc. AOM frequency and amplitude modulation techniques for facilitating full beam extinction in laser systems
CA2602967A1 (en) 2005-03-29 2006-10-05 Integral Orthopedics Inc. Inter-scapular bolster
CN101278294B (zh) 2005-08-02 2013-04-10 卢米尼克斯股份有限公司 用于分类微粒的方法、数据结构和系统
KR20080066705A (ko) 2005-09-29 2008-07-16 더 제너럴 하스피탈 코포레이션 점진적으로 증가하는 분해능을 이용하여 하나 이상의 생물학적 샘플을 관찰 및 분석하기 위한 방법 및 장치
US7889348B2 (en) 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
GB0525072D0 (en) 2005-12-09 2006-01-18 Enigma Diagnostics Ltd Fluorescence-based detection methods and apparatus
US7800368B2 (en) 2006-02-17 2010-09-21 Regents Of The University Of Minnesota High field magnetic resonance
US20090323061A1 (en) 2006-02-28 2009-12-31 Lukas Novotny Multi-color hetereodyne interferometric apparatus and method for sizing nanoparticles
JP2007285999A (ja) * 2006-04-20 2007-11-01 Furukawa Electric Co Ltd:The 光測定装置
EP2024893B1 (en) 2006-05-12 2015-03-04 Janssen Diagnostics, LLC A laser illumination system in fluorescent microscopy
DE602007002008D1 (de) 2006-05-29 2009-10-01 Olympus Corp Laserscan-Mikroskop und mikroskopisches Überwachungsverfahren
JP5133600B2 (ja) 2006-05-29 2013-01-30 オリンパス株式会社 レーザ走査型顕微鏡および顕微鏡観察方法
JP2008007652A (ja) 2006-06-29 2008-01-17 Fujifilm Corp アゾ色素、感熱転写記録用インクシート、感熱転写記録方法、カラートナー、インクジェット用インクおよびカラーフィルタ
US7542137B2 (en) 2006-07-24 2009-06-02 University Of Ottawa Pathogen detection using coherent anti-stokes Raman scattering microscopy
US20100032584A1 (en) 2006-08-18 2010-02-11 Macquarie University Tiime gated fluorescent flow cytometer
US7697885B2 (en) 2006-09-15 2010-04-13 Aeroflex High Speed Test Solutions, Inc. Multi-band jammer
JP2008089395A (ja) 2006-10-02 2008-04-17 Honda Instrument Service Co Ltd 光触媒計及び光能力測定方法並びにそれに用いるセンサヘッド
US7804594B2 (en) 2006-12-29 2010-09-28 Abbott Laboratories, Inc. Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US7400457B1 (en) 2007-01-04 2008-07-15 Stockeryale Canada Inc. Rectangular flat-top beam shaper
US8101426B2 (en) 2007-03-02 2012-01-24 Icyt Mission Technology, Inc. System and method for the measurement of multiple fluorescence emissions in a flow cytometry system
US8290625B2 (en) 2007-04-04 2012-10-16 Beckman Coulter, Inc. Flow cytometer sorter
US7982944B2 (en) 2007-05-04 2011-07-19 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Method and apparatus for optical frequency comb generation using a monolithic micro-resonator
JP5619344B2 (ja) 2007-05-04 2014-11-05 マツクス−プランク−ゲゼルシャフト ツール フエルデルング デル ヴイツセンシャフテン エー フアウ モノリシックマイクロ共振器を使用した光周波数コム発生のための装置と方法
WO2009005579A1 (en) 2007-06-14 2009-01-08 The General Hospital Corporation High affinity fluorochrome binding peptides
WO2009009081A2 (en) 2007-07-10 2009-01-15 Massachusetts Institute Of Technology Tomographic phase microscopy
JP4509163B2 (ja) * 2007-10-26 2010-07-21 ソニー株式会社 微小粒子の測定方法
US8159670B2 (en) 2007-11-05 2012-04-17 Abbott Laboratories Method and apparatus for rapidly counting and identifying biological particles in a flow stream
US9451884B2 (en) 2007-12-13 2016-09-27 Board Of Trustees Of The University Of Arkansas Device and method for in vivo detection of clots within circulatory vessels
GB0800333D0 (en) 2008-01-09 2008-02-20 Ucl Business Plc Beam deflection apparatus and methods
US20090174935A1 (en) 2008-01-09 2009-07-09 Szulczewski Michael J Scanning microscope having complementary, serial scanners
US20090219607A1 (en) 2008-01-17 2009-09-03 Baylor College Of Medicine Method and apparatus for enhanced resolution microscopy of living biological nanostructures
EP2191770B1 (en) 2008-05-02 2016-04-13 Olympus Corporation Optical inspection device, electromagnetic wave detection method, electromagnetic wave detection device, organism observation method, microscope, endoscope, and optical tomographic image generation device
WO2009149733A1 (en) 2008-06-13 2009-12-17 Embl Heidelberg Next generation flow cytometer sorter
US8184279B2 (en) 2008-06-16 2012-05-22 The Regents Of The University Of Colorado, A Body Corporate Fourier domain sensing
CN102150035A (zh) 2008-09-19 2011-08-10 三井造船株式会社 采用强度调制激光的荧光检测装置和荧光检测方法
US10908084B2 (en) 2008-10-14 2021-02-02 Timothy M. Ragan Devices and methods for direct-sampling analog time-resolved detection
US8440952B2 (en) 2008-11-18 2013-05-14 The Regents Of The University Of California Methods for optical amplified imaging using a two-dimensional spectral brush
TWI523720B (zh) 2009-05-28 2016-03-01 伊雷克托科學工業股份有限公司 應用於雷射處理工件中的特徵的聲光偏轉器及相關雷射處理方法
EP2267430A1 (de) 2009-06-24 2010-12-29 Masterrind GmbH Vorrichtung und Verfahren zur Selektion von Partikeln
WO2011023593A1 (en) 2009-08-24 2011-03-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Method of and apparatus for imaging a cellular sample
GB0919854D0 (en) 2009-11-12 2009-12-30 Stfc Science & Technology Detecting species in a dilute medium
JP5649828B2 (ja) 2010-02-03 2015-01-07 オリンパス株式会社 レーザ顕微鏡装置
JP2011163787A (ja) * 2010-02-05 2011-08-25 Sony Corp 微小粒子分析装置及び微小粒子分析方法
US9057676B2 (en) * 2010-02-05 2015-06-16 Cytonome/St, Llc Multiple flow channel particle analysis system
JP5551477B2 (ja) 2010-03-15 2014-07-16 オリンパス株式会社 光源装置およびレーザ走査型顕微鏡装置
EP2567225B1 (en) 2010-05-04 2019-10-02 Virginia Tech Intellectual Properties, Inc. Lanthionine synthetase component c-like proteins as molecular targets for preventing and treating diseases and disorders
JP2012008055A (ja) 2010-06-25 2012-01-12 Olympus Corp 画像解析方法および画像解析装置
US8384045B2 (en) 2010-07-01 2013-02-26 Sony Corporation Minute particle analyzing device and method
DE102010044013A1 (de) 2010-11-16 2012-05-16 Carl Zeiss Microimaging Gmbh Tiefenauflösungsgesteigerte Mikroskopie
US8941062B2 (en) 2010-11-16 2015-01-27 1087 Systems, Inc. System for identifying and sorting living cells
EP3708674B1 (en) 2010-11-16 2023-06-07 1087 Systems, Inc. System for identifying and sorting living cells
US9066657B2 (en) 2010-11-23 2015-06-30 General Electric Company Methods and systems of optical imaging for target detection in a scattering medium
EP2661614B1 (en) 2011-01-03 2025-03-12 Cytonome/ST, LLC Method and apparatus for monitoring and optimizing particle sorting
EP2671065B1 (en) 2011-02-04 2019-07-10 Cytonome/ST, LLC Particle sorting apparatus and method
JP5930220B2 (ja) 2011-03-18 2016-06-08 国立研究開発法人理化学研究所 非線形光学顕微鏡および非線形光学顕微鏡法
JP5620319B2 (ja) 2011-03-23 2014-11-05 オリンパス株式会社 顕微鏡
US8681827B2 (en) 2011-05-16 2014-03-25 Oewaves, Inc. Generation of single optical tone, RF oscillation signal and optical comb in a triple-oscillator device based on nonlinear optical resonator
ES2886583T3 (es) 2011-05-26 2021-12-20 Massachusetts Gen Hospital Sistema de tromboelastografía óptica y método para la evaluación de las métricas de coagulación sanguínea
KR20160103175A (ko) 2011-07-19 2016-08-31 오비지오 이미징 시스템스 엔.브이. 세포 샘플에서의 암 세포들의 검출 및/또는 분류를 위한 방법 및 시스템
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
JP5870851B2 (ja) 2012-05-29 2016-03-01 ソニー株式会社 情報処理装置、情報処理方法、及びプログラム
WO2014031985A1 (en) 2012-08-24 2014-02-27 The Trustees Of Dartmouth College Method and apparatus for magnetic susceptibility tomography, magnetoencephalography, and taggant or contrast agent detection
US8723104B2 (en) 2012-09-13 2014-05-13 City University Of Hong Kong Methods and means for manipulating particles
CN104769481B (zh) 2012-10-12 2018-12-18 统雷有限公司 紧凑、低色散以及低像差自适应光学扫描系统
CN105008895B (zh) 2012-10-15 2019-02-15 纳诺赛莱克特生物医药股份有限公司 颗粒分选的系统、设备和方法
JP6338597B2 (ja) * 2013-01-09 2018-06-06 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ 無線周波数多重励起を用いた蛍光イメージングのための装置及び方法
US10190963B2 (en) 2013-02-01 2019-01-29 Becton, Dickinson And Company Methods and systems for assessing sample behavior in a flow cytometer
EP2972207B1 (en) 2013-03-14 2022-09-21 Cytonome/ST, LLC Assemblies and methods for reducing optical crosstalk in particle processing systems
GB201305317D0 (en) 2013-03-22 2013-05-08 Iles Raymond K Prenatal screening for fetal abnormalities and disorders of pregnancy
US9372143B2 (en) 2013-05-15 2016-06-21 Captl Llc Scanning image flow cytometer
JP6257312B2 (ja) 2013-12-24 2018-01-10 オリンパス株式会社 顕微鏡システム
US9538926B2 (en) 2013-12-26 2017-01-10 Fundacio Institut De Ciencies Fotoniques Speckle contrast optical tomography
CN103762487B (zh) 2014-01-04 2016-05-25 天津奇谱光电技术有限公司 一种具有双输出光束的可调谐激光器
JP6214402B2 (ja) 2014-01-07 2017-10-18 オリンパス株式会社 光刺激装置および顕微鏡システム
US10451482B2 (en) 2014-02-14 2019-10-22 Palo Alto Research Center Incorporated Determination of color characteristics of objects using spatially modulated light
ES2959506T3 (es) * 2014-03-18 2024-02-26 Univ California Citómetro de flujo paralelo que usa multiplexación por radiofrecuencia, y método
US20170052106A1 (en) 2014-04-28 2017-02-23 The Broad Institute, Inc. Method for label-free image cytometry
US10267736B2 (en) 2014-09-30 2019-04-23 The Regents Of The University Of California Imaging flow cytometer using spatial-temporal transformation
JP6652559B2 (ja) 2014-11-12 2020-02-26 オーボテック リミテッド 光学装置及び光学方法
WO2017053592A1 (en) 2015-09-23 2017-03-30 The Regents Of The University Of California Deep learning in label-free cell classification and machine vision extraction of particles
JP6856635B2 (ja) 2015-10-13 2021-04-07 オメガ バイオシステムズ インコーポレイテッド マルチモードの蛍光撮像フローサイトメトリシステム
WO2017066544A1 (en) 2015-10-15 2017-04-20 Woods Hole Oceanographic Institution System for rapid assessment of water quality and harmful algal bloom toxins
JP7033082B2 (ja) 2016-02-05 2022-03-09 ナノビュー バイオサイエンシズ インコーポレイテッド 表面マーカーを有するエキソソームの検出
AU2017234815B2 (en) 2016-03-17 2022-11-03 Becton, Dickinson And Company Cell sorting using a high throughput fluorescence flow cytometer
WO2017201540A1 (en) 2016-05-20 2017-11-23 Techcyte, Inc. Machine learning classification of particles or substances in digital microscopy images
CN109863384B (zh) 2016-06-10 2022-10-28 加利福尼亚大学董事会 基于图像的细胞分选系统和方法
US10006852B2 (en) 2016-09-13 2018-06-26 Becton, Dickinson And Company Flow cytometer with optical equalization
JP2020537148A (ja) 2017-10-09 2020-12-17 ティーエスアイ インコーポレイテッド 粒子計数器の構成要素の較正
CN112105912B (zh) 2018-04-13 2025-05-23 华盛顿大学 用于单生物纳米颗粒分析的方法和设备
WO2019209723A1 (en) 2018-04-26 2019-10-31 Becton, Dickinson And Company Characterization and sorting for particle analyzers
CN113544490B (zh) 2019-03-29 2024-07-02 贝克顿·迪金森公司 用于颗粒辨别的参数

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