JP6675688B2 - ５−ｈｔ２ｃ受容体アゴニストおよび組成物ならびに使用方法 - Google Patents

５−ｈｔ２ｃ受容体アゴニストおよび組成物ならびに使用方法 Download PDF

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JP6675688B2
JP6675688B2 JP2017555768A JP2017555768A JP6675688B2 JP 6675688 B2 JP6675688 B2 JP 6675688B2 JP 2017555768 A JP2017555768 A JP 2017555768A JP 2017555768 A JP2017555768 A JP 2017555768A JP 6675688 B2 JP6675688 B2 JP 6675688B2
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individual
smoking
composition
tobacco
nicotine
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JP2018519251A5 (OSRAM
JP2018519251A (ja
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アルバート エス． レン，
アルバート エス． レン，
グレアム センプル，
グレアム センプル，
シューウェン チュー，
シューウェン チュー，
カールトン アール． セージ，
カールトン アール． セージ，
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アリーナ ファーマシューティカルズ， インコーポレイテッド
アリーナ ファーマシューティカルズ， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017555768A 2015-04-27 2016-04-26 ５−ｈｔ２ｃ受容体アゴニストおよび組成物ならびに使用方法 Active JP6675688B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562153082P 2015-04-27 2015-04-27
US62/153,082 2015-04-27
PCT/US2016/029308 WO2016176177A1 (en) 2015-04-27 2016-04-26 5-ht2c receptor agonists and compositions and methods of use

Publications (3)

Publication Number Publication Date
JP2018519251A JP2018519251A (ja) 2018-07-19
JP2018519251A5 JP2018519251A5 (OSRAM) 2019-05-30
JP6675688B2 true JP6675688B2 (ja) 2020-04-01

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JP2017555768A Active JP6675688B2 (ja) 2015-04-27 2016-04-26 ５−ｈｔ２ｃ受容体アゴニストおよび組成物ならびに使用方法

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US (1) US10392390B2 (OSRAM)
EP (1) EP3288946B1 (OSRAM)
JP (1) JP6675688B2 (OSRAM)
KR (1) KR102275505B1 (OSRAM)
CN (1) CN107873030B (OSRAM)
AU (1) AU2016255009B2 (OSRAM)
BR (1) BR112017023088B1 (OSRAM)
CA (1) CA3002544C (OSRAM)
DK (1) DK3288946T3 (OSRAM)
EA (1) EA034446B1 (OSRAM)
ES (1) ES2757922T3 (OSRAM)
HK (1) HK1244005B (OSRAM)
HR (1) HRP20192044T1 (OSRAM)
HU (1) HUE047169T2 (OSRAM)
IL (1) IL255171A0 (OSRAM)
MX (2) MX373319B (OSRAM)
PT (1) PT3288946T (OSRAM)
WO (1) WO2016176177A1 (OSRAM)

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GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
PT3746126T (pt) 2018-01-30 2024-10-21 Apnimed Inc Delaware Métodos e composições para o tratamento de apneia do sono ou roncopatia simples
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
PH12021551850A1 (en) * 2019-02-08 2022-05-11 Brigham & Womens Hospital Inc Methods and compositions for treating sleep apnea
JP2022529353A (ja) 2019-04-17 2022-06-21 コンパス パスファインダー リミテッド 神経認知障害、慢性疼痛を治療し、炎症を低減させる方法
US12205686B2 (en) * 2020-02-27 2025-01-21 The Cleveland Clinic Foundation Identifying patients for intensive hyperglycemia management
US20250073206A1 (en) * 2021-10-29 2025-03-06 Sensorium Therapeutics, Inc. Solid forms of mesembrine and therapeutic uses thereof
CA3240561A1 (en) * 2021-12-10 2023-06-15 GATC Health Corp Methods of treating addiction and neurological disorders
EP4489761A1 (en) 2022-03-10 2025-01-15 Arena Pharmaceuticals, Inc. Methods of treatment
CN114965250B (zh) * 2022-05-19 2025-02-14 道生天合材料科技(上海)股份有限公司 胶粘剂储存期的预测方法
WO2023225773A1 (en) * 2022-05-23 2023-11-30 Sensorium Therapeutics, Inc. Solid forms of mesembrine and therapeutic uses thereof
JP2025540125A (ja) * 2022-12-02 2025-12-11 アリーナ ファーマシューティカルズ，インコーポレイテッド 治療の方法
EP4665319A1 (en) * 2023-02-17 2025-12-24 Caamtech, Inc. 2-(2,5-diethoxy-4-(ethylthio)phenyl)ethane-1-aminium chloride
WO2024182807A2 (en) * 2023-03-02 2024-09-06 Alexander Shulgin Research Institute, Inc. Phenylalkylamine prodrugs
WO2025080932A1 (en) * 2023-10-11 2025-04-17 University Of Padova Methods of treatment with psilocybin and psilocin derivatives

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US3642822A (en) * 1969-11-03 1972-02-15 Upjohn Co Hexahydropyrrolobenzodiazepines
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4920989A (en) 1985-04-25 1990-05-01 Regents Of The University Of California Method and apparatus for aiding in the reduction of incidence of tobacco smoking
IL86170A (en) 1987-05-01 1992-12-01 Elan Transdermal Ltd Preparations and compositions comprising nicotine for percutaneous administration
US5004610A (en) 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
AU1919592A (en) 1991-04-16 1992-11-17 National Institutes Of Health Method of treating trichotillomania and onychophagia
ES2230382T3 (es) * 2000-11-03 2005-05-01 Wyeth Ciclopental(b)(1,4)diazpino(6,7,1-hi)indoles como antagonistas de 5ht2c.
WO2002036596A2 (en) 2000-11-03 2002-05-10 Wyeth CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2003086303A2 (en) 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
TW200307540A (en) * 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
JP4782003B2 (ja) * 2003-06-17 2011-09-28 アリーナ ファーマシューティカルズ， インコーポレイテッド ５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体
TW200806321A (en) * 2006-03-24 2008-02-01 Wyeth Corp New therapeutic combinations for the treatment or prevention of psychotic disorders
WO2013133325A1 (ja) * 2012-03-06 2013-09-12 武田薬品工業株式会社 三環性化合物
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Also Published As

Publication number Publication date
HRP20192044T1 (hr) 2020-02-07
MX2017013902A (es) 2018-03-16
CN107873030B (zh) 2021-03-19
BR112017023088A2 (pt) 2018-07-10
CA3002544C (en) 2024-03-05
HUE047169T2 (hu) 2020-04-28
MX2020005898A (es) 2020-08-13
EA201792356A1 (ru) 2018-05-31
WO2016176177A1 (en) 2016-11-03
CN107873030A (zh) 2018-04-03
IL255171A0 (en) 2017-12-31
DK3288946T3 (da) 2019-11-25
MX373319B (es) 2020-06-13
CA3002544A1 (en) 2016-11-03
NZ737412A (en) 2021-06-25
EP3288946B1 (en) 2019-08-21
KR20170140317A (ko) 2017-12-20
KR102275505B1 (ko) 2021-07-08
US20180186797A1 (en) 2018-07-05
PT3288946T (pt) 2019-11-27
EA034446B1 (ru) 2020-02-10
AU2016255009A1 (en) 2017-12-14
HK1244005B (en) 2020-04-17
EP3288946A1 (en) 2018-03-07
JP2018519251A (ja) 2018-07-19
US10392390B2 (en) 2019-08-27
AU2016255009B2 (en) 2020-10-08
BR112017023088B1 (pt) 2023-10-03
ES2757922T3 (es) 2020-04-30

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