ES2757922T3 - Agonistas y composiciones del receptor 5-HT2C y métodos de uso - Google Patents
Agonistas y composiciones del receptor 5-HT2C y métodos de uso Download PDFInfo
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- ES2757922T3 ES2757922T3 ES16721320T ES16721320T ES2757922T3 ES 2757922 T3 ES2757922 T3 ES 2757922T3 ES 16721320 T ES16721320 T ES 16721320T ES 16721320 T ES16721320 T ES 16721320T ES 2757922 T3 ES2757922 T3 ES 2757922T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
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| US201562153082P | 2015-04-27 | 2015-04-27 | |
| PCT/US2016/029308 WO2016176177A1 (en) | 2015-04-27 | 2016-04-26 | 5-ht2c receptor agonists and compositions and methods of use |
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| ES2757922T3 true ES2757922T3 (es) | 2020-04-30 |
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| CN (1) | CN107873030B (OSRAM) |
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| EA (1) | EA034446B1 (OSRAM) |
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| HK (1) | HK1244005B (OSRAM) |
| HR (1) | HRP20192044T1 (OSRAM) |
| HU (1) | HUE047169T2 (OSRAM) |
| IL (1) | IL255171A0 (OSRAM) |
| MX (2) | MX373319B (OSRAM) |
| PT (1) | PT3288946T (OSRAM) |
| WO (1) | WO2016176177A1 (OSRAM) |
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| GB2571696B (en) | 2017-10-09 | 2020-05-27 | Compass Pathways Ltd | Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced |
| US12459965B2 (en) | 2017-10-09 | 2025-11-04 | Compass Pathfinder Limited | Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
| PT3746126T (pt) | 2018-01-30 | 2024-10-21 | Apnimed Inc Delaware | Métodos e composições para o tratamento de apneia do sono ou roncopatia simples |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| PH12021551850A1 (en) * | 2019-02-08 | 2022-05-11 | Brigham & Womens Hospital Inc | Methods and compositions for treating sleep apnea |
| JP2022529353A (ja) | 2019-04-17 | 2022-06-21 | コンパス パスファインダー リミテッド | 神経認知障害、慢性疼痛を治療し、炎症を低減させる方法 |
| US12205686B2 (en) * | 2020-02-27 | 2025-01-21 | The Cleveland Clinic Foundation | Identifying patients for intensive hyperglycemia management |
| US20250073206A1 (en) * | 2021-10-29 | 2025-03-06 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| CA3240561A1 (en) * | 2021-12-10 | 2023-06-15 | GATC Health Corp | Methods of treating addiction and neurological disorders |
| EP4489761A1 (en) | 2022-03-10 | 2025-01-15 | Arena Pharmaceuticals, Inc. | Methods of treatment |
| CN114965250B (zh) * | 2022-05-19 | 2025-02-14 | 道生天合材料科技(上海)股份有限公司 | 胶粘剂储存期的预测方法 |
| WO2023225773A1 (en) * | 2022-05-23 | 2023-11-30 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| JP2025540125A (ja) * | 2022-12-02 | 2025-12-11 | アリーナ ファーマシューティカルズ，インコーポレイテッド | 治療の方法 |
| EP4665319A1 (en) * | 2023-02-17 | 2025-12-24 | Caamtech, Inc. | 2-(2,5-diethoxy-4-(ethylthio)phenyl)ethane-1-aminium chloride |
| WO2024182807A2 (en) * | 2023-03-02 | 2024-09-06 | Alexander Shulgin Research Institute, Inc. | Phenylalkylamine prodrugs |
| WO2025080932A1 (en) * | 2023-10-11 | 2025-04-17 | University Of Padova | Methods of treatment with psilocybin and psilocin derivatives |
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| US3642822A (en) * | 1969-11-03 | 1972-02-15 | Upjohn Co | Hexahydropyrrolobenzodiazepines |
| US4597961A (en) | 1985-01-23 | 1986-07-01 | Etscorn Frank T | Transcutaneous application of nicotine |
| US4920989A (en) | 1985-04-25 | 1990-05-01 | Regents Of The University Of California | Method and apparatus for aiding in the reduction of incidence of tobacco smoking |
| IL86170A (en) | 1987-05-01 | 1992-12-01 | Elan Transdermal Ltd | Preparations and compositions comprising nicotine for percutaneous administration |
| US5004610A (en) | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| AU1919592A (en) | 1991-04-16 | 1992-11-17 | National Institutes Of Health | Method of treating trichotillomania and onychophagia |
| ES2230382T3 (es) * | 2000-11-03 | 2005-05-01 | Wyeth | Ciclopental(b)(1,4)diazpino(6,7,1-hi)indoles como antagonistas de 5ht2c. |
| WO2002036596A2 (en) | 2000-11-03 | 2002-05-10 | Wyeth | CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES |
| WO2003086303A2 (en) | 2002-04-12 | 2003-10-23 | The University Of Chicago | Farnesoid x-activated receptor agonists |
| TW200307540A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
| JP4782003B2 (ja) * | 2003-06-17 | 2011-09-28 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５ｈｔ２ｃレセプター関連疾患の処置に有用なベンズアゼピン誘導体 |
| TW200806321A (en) * | 2006-03-24 | 2008-02-01 | Wyeth Corp | New therapeutic combinations for the treatment or prevention of psychotic disorders |
| WO2013133325A1 (ja) * | 2012-03-06 | 2013-09-12 | 武田薬品工業株式会社 | 三環性化合物 |
| HK1212684A1 (zh) * | 2012-09-14 | 2016-06-17 | AbbVie Deutschland GmbH & Co. KG | 三環喹啉和喹喔啉衍生物 |
| WO2015066344A1 (en) * | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
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| HRP20192044T1 (hr) | 2020-02-07 |
| MX2017013902A (es) | 2018-03-16 |
| CN107873030B (zh) | 2021-03-19 |
| BR112017023088A2 (pt) | 2018-07-10 |
| CA3002544C (en) | 2024-03-05 |
| HUE047169T2 (hu) | 2020-04-28 |
| MX2020005898A (es) | 2020-08-13 |
| EA201792356A1 (ru) | 2018-05-31 |
| WO2016176177A1 (en) | 2016-11-03 |
| CN107873030A (zh) | 2018-04-03 |
| IL255171A0 (en) | 2017-12-31 |
| DK3288946T3 (da) | 2019-11-25 |
| JP6675688B2 (ja) | 2020-04-01 |
| MX373319B (es) | 2020-06-13 |
| CA3002544A1 (en) | 2016-11-03 |
| NZ737412A (en) | 2021-06-25 |
| EP3288946B1 (en) | 2019-08-21 |
| KR20170140317A (ko) | 2017-12-20 |
| KR102275505B1 (ko) | 2021-07-08 |
| US20180186797A1 (en) | 2018-07-05 |
| PT3288946T (pt) | 2019-11-27 |
| EA034446B1 (ru) | 2020-02-10 |
| AU2016255009A1 (en) | 2017-12-14 |
| HK1244005B (en) | 2020-04-17 |
| EP3288946A1 (en) | 2018-03-07 |
| JP2018519251A (ja) | 2018-07-19 |
| US10392390B2 (en) | 2019-08-27 |
| AU2016255009B2 (en) | 2020-10-08 |
| BR112017023088B1 (pt) | 2023-10-03 |
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