EA034446B1 - Агонисты рецептора 5-htи их композиции и способы использования - Google Patents

Агонисты рецептора 5-htи их композиции и способы использования Download PDF

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Publication number
EA034446B1
EA034446B1 EA201792356A EA201792356A EA034446B1 EA 034446 B1 EA034446 B1 EA 034446B1 EA 201792356 A EA201792356 A EA 201792356A EA 201792356 A EA201792356 A EA 201792356A EA 034446 B1 EA034446 B1 EA 034446B1
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EA
Eurasian Patent Office
Prior art keywords
individual
compound
compounds
treating
effective amount
Prior art date
Application number
EA201792356A
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English (en)
Russian (ru)
Other versions
EA201792356A1 (ru
Inventor
Альберт С. Рен
Грейм Сэмпл
Сювэнь Чжу
Карлтон Р. Сейдж
Original Assignee
Арена Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Арена Фармасьютикалз, Инк. filed Critical Арена Фармасьютикалз, Инк.
Publication of EA201792356A1 publication Critical patent/EA201792356A1/ru
Publication of EA034446B1 publication Critical patent/EA034446B1/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/55171,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA201792356A 2015-04-27 2016-04-26 Агонисты рецептора 5-htи их композиции и способы использования EA034446B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562153082P 2015-04-27 2015-04-27
PCT/US2016/029308 WO2016176177A1 (en) 2015-04-27 2016-04-26 5-ht2c receptor agonists and compositions and methods of use

Publications (2)

Publication Number Publication Date
EA201792356A1 EA201792356A1 (ru) 2018-05-31
EA034446B1 true EA034446B1 (ru) 2020-02-10

Family

ID=55949111

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201792356A EA034446B1 (ru) 2015-04-27 2016-04-26 Агонисты рецептора 5-htи их композиции и способы использования

Country Status (18)

Country Link
US (1) US10392390B2 (OSRAM)
EP (1) EP3288946B1 (OSRAM)
JP (1) JP6675688B2 (OSRAM)
KR (1) KR102275505B1 (OSRAM)
CN (1) CN107873030B (OSRAM)
AU (1) AU2016255009B2 (OSRAM)
BR (1) BR112017023088B1 (OSRAM)
CA (1) CA3002544C (OSRAM)
DK (1) DK3288946T3 (OSRAM)
EA (1) EA034446B1 (OSRAM)
ES (1) ES2757922T3 (OSRAM)
HK (1) HK1244005B (OSRAM)
HR (1) HRP20192044T1 (OSRAM)
HU (1) HUE047169T2 (OSRAM)
IL (1) IL255171A0 (OSRAM)
MX (2) MX373319B (OSRAM)
PT (1) PT3288946T (OSRAM)
WO (1) WO2016176177A1 (OSRAM)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
PT3746126T (pt) 2018-01-30 2024-10-21 Apnimed Inc Delaware Métodos e composições para o tratamento de apneia do sono ou roncopatia simples
WO2020087031A1 (en) 2018-10-26 2020-04-30 The Research Foundation For The State University Of New York Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
PH12021551850A1 (en) * 2019-02-08 2022-05-11 Brigham & Womens Hospital Inc Methods and compositions for treating sleep apnea
JP2022529353A (ja) 2019-04-17 2022-06-21 コンパス パスファインダー リミテッド 神経認知障害、慢性疼痛を治療し、炎症を低減させる方法
US12205686B2 (en) * 2020-02-27 2025-01-21 The Cleveland Clinic Foundation Identifying patients for intensive hyperglycemia management
US20250073206A1 (en) * 2021-10-29 2025-03-06 Sensorium Therapeutics, Inc. Solid forms of mesembrine and therapeutic uses thereof
CA3240561A1 (en) * 2021-12-10 2023-06-15 GATC Health Corp Methods of treating addiction and neurological disorders
EP4489761A1 (en) 2022-03-10 2025-01-15 Arena Pharmaceuticals, Inc. Methods of treatment
CN114965250B (zh) * 2022-05-19 2025-02-14 道生天合材料科技(上海)股份有限公司 胶粘剂储存期的预测方法
WO2023225773A1 (en) * 2022-05-23 2023-11-30 Sensorium Therapeutics, Inc. Solid forms of mesembrine and therapeutic uses thereof
JP2025540125A (ja) * 2022-12-02 2025-12-11 アリーナ ファーマシューティカルズ,インコーポレイテッド 治療の方法
EP4665319A1 (en) * 2023-02-17 2025-12-24 Caamtech, Inc. 2-(2,5-diethoxy-4-(ethylthio)phenyl)ethane-1-aminium chloride
WO2024182807A2 (en) * 2023-03-02 2024-09-06 Alexander Shulgin Research Institute, Inc. Phenylalkylamine prodrugs
WO2025080932A1 (en) * 2023-10-11 2025-04-17 University Of Padova Methods of treatment with psilocybin and psilocin derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036596A2 (en) * 2000-11-03 2002-05-10 Wyeth CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2002042304A2 (en) * 2000-11-03 2002-05-30 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
WO2015066344A1 (en) * 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3642822A (en) * 1969-11-03 1972-02-15 Upjohn Co Hexahydropyrrolobenzodiazepines
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
US4920989A (en) 1985-04-25 1990-05-01 Regents Of The University Of California Method and apparatus for aiding in the reduction of incidence of tobacco smoking
IL86170A (en) 1987-05-01 1992-12-01 Elan Transdermal Ltd Preparations and compositions comprising nicotine for percutaneous administration
US5004610A (en) 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
AU1919592A (en) 1991-04-16 1992-11-17 National Institutes Of Health Method of treating trichotillomania and onychophagia
WO2003086303A2 (en) 2002-04-12 2003-10-23 The University Of Chicago Farnesoid x-activated receptor agonists
TW200307540A (en) * 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
JP4782003B2 (ja) * 2003-06-17 2011-09-28 アリーナ ファーマシューティカルズ, インコーポレイテッド 5ht2cレセプター関連疾患の処置に有用なベンズアゼピン誘導体
TW200806321A (en) * 2006-03-24 2008-02-01 Wyeth Corp New therapeutic combinations for the treatment or prevention of psychotic disorders
WO2013133325A1 (ja) * 2012-03-06 2013-09-12 武田薬品工業株式会社 三環性化合物
HK1212684A1 (zh) * 2012-09-14 2016-06-17 AbbVie Deutschland GmbH & Co. KG 三環喹啉和喹喔啉衍生物

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002036596A2 (en) * 2000-11-03 2002-05-10 Wyeth CYCLOALKYL[b][1,4]DIAZEPINO[6,7,1-hi]INDOLES AND DERIVATIVES
WO2002042304A2 (en) * 2000-11-03 2002-05-30 Wyeth Cyclopenta[b][1,4] diazepino[6,7,1-hi]indoles as 5ht2c antagonists
WO2015066344A1 (en) * 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use

Also Published As

Publication number Publication date
HRP20192044T1 (hr) 2020-02-07
MX2017013902A (es) 2018-03-16
CN107873030B (zh) 2021-03-19
BR112017023088A2 (pt) 2018-07-10
CA3002544C (en) 2024-03-05
HUE047169T2 (hu) 2020-04-28
MX2020005898A (es) 2020-08-13
EA201792356A1 (ru) 2018-05-31
WO2016176177A1 (en) 2016-11-03
CN107873030A (zh) 2018-04-03
IL255171A0 (en) 2017-12-31
DK3288946T3 (da) 2019-11-25
JP6675688B2 (ja) 2020-04-01
MX373319B (es) 2020-06-13
CA3002544A1 (en) 2016-11-03
NZ737412A (en) 2021-06-25
EP3288946B1 (en) 2019-08-21
KR20170140317A (ko) 2017-12-20
KR102275505B1 (ko) 2021-07-08
US20180186797A1 (en) 2018-07-05
PT3288946T (pt) 2019-11-27
AU2016255009A1 (en) 2017-12-14
HK1244005B (en) 2020-04-17
EP3288946A1 (en) 2018-03-07
JP2018519251A (ja) 2018-07-19
US10392390B2 (en) 2019-08-27
AU2016255009B2 (en) 2020-10-08
BR112017023088B1 (pt) 2023-10-03
ES2757922T3 (es) 2020-04-30

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM