JP6673895B2 - アサ属抽出方法及び組成物 - Google Patents
アサ属抽出方法及び組成物 Download PDFInfo
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- JP6673895B2 JP6673895B2 JP2017501067A JP2017501067A JP6673895B2 JP 6673895 B2 JP6673895 B2 JP 6673895B2 JP 2017501067 A JP2017501067 A JP 2017501067A JP 2017501067 A JP2017501067 A JP 2017501067A JP 6673895 B2 JP6673895 B2 JP 6673895B2
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- asa
- plant material
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- aloe
- aloe vera
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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Description
本出願は、2014年3月21日に出願された米国仮特許出願第61/968,893号に基づく優先権を主張し、この内容は、参照により本明細書中に組み込まれる。
特に指定しない限り、技術用語は、グローヒル科学技術用語大辞典(McGraw‐Hill Dictionary of Scientific and Technical Terms)(第6版)において、特定された意味を有する。
本発明の方法において、アサ属植物材料は、アロエを含む、本質的にアロエからなる、又はアロエからなる、抽出剤と組み合わせて、アサ属アロエ抽出物を形成する。
上記のように得られたアサ属アロエ抽出物は、アサ属アロエ抽出物、及び少なくとも1つの医薬的に許容される担体を含む、医薬組成物のための主成分を提供する。他の実施態様では、アサ属アロエ抽出物、及び少なくとも1つの皮膚剤を含む、化粧品組成物を提供する。
本出願は、有効な量の本発明の医薬組成物を、対象の皮膚に適用することを含む、皮膚の状態(上記に定義した通り)を治療するか、又はさもなければ、改善する方法を開示する。この文脈において、皮膚の状態を治療することは、必ずしも、治療(medical treatment)を意味するものではなく、そして従って、例えば、化粧品の適用に典型的に関連する利益、例えば、皮膚の状態を整えること、皮膚を軟化させること、又は保湿すること、皮膚の色調調整、及び引締めを容易にすること、毛穴の大きさを縮小すること、しみ、にきび、しわ、及び/又は毛の出現を低減することを提供すること含んでもよい。
本発明のさらなる実施態様では、アサ属アロエ抽出物、又は医薬組成物と共に使用される塗布器を提供し、ここで、塗布器は、抽出物、又は医薬組成物を含み、そして対象の皮膚にそれを適用するために使用される。塗布器は、手動ポンプ、エアロゾル缶、パッチ、又は回転塗布式(roll‐on)装置、例えば、デオドラントの適用のために使用されるものの形態をとることができる。
大麻(Cannabis sativa)の乾燥葉及び茎(100g)を、微粉末に粉砕し、ガラス容器に秤量し、そして、0.1%のソルビン酸カリウムを含む、pH3.7〜4.1の最大量のアントラキノン(アロイン及び/又はアロエエモジン)(1ppm)を有する液体に処理された、アロエバルバデンシス葉汁由来のアロエ(900g)と混合した。
実施例1に記載のように調製した抽出物(実質的に植物材料残渣を含まない)を、医薬組成物の全量ベースで、皮膚剤と、4重量部の抽出物:1重量部の皮膚剤の比率で、組み合わせた。皮膚剤は、グリセリン、メチルスルホニルメタン、コメ(Oryzo Sativa)(ライスブラン)油、トウゴマ(キャスター)油、ステアリン酸グリセリル、スチレン/アクリル酸コポリマー、ステアリン酸PEG‐100、セチルアルコール、ジメチコーン、カルボマー、カプリリル グリコール、グリセリン、カプリル酸グリセリル、フェニルプロパノール、メチルパラベン、トコフェロール(ビタミンE)、及び香料を含む。
Claims (11)
- アサ属植物材料と、アロエの葉の液体を含む抽出剤を混合し、アサ属植物材料を40℃〜100℃の温度で、1時間〜10時間の間加熱することにより抽出し、それによりカンナビノイドを含むアサ属アロエベラ抽出物を形成させ、そのアサ属アロエベラ抽出物をワックス状バラストおよびアサ属植物材料から分離することを含み、ここで抽出剤は、液体形態であり、および/またはアロエベラが粉末形態である場合には水により液体形態に再構成される、アサ属アロエベラ抽出物の調製方法。
- アサ属アロエベラ抽出物から、アサ属植物材料を分離し、アサ属植物材料を含まないアサ属アロエベラ抽出物を回収することをさらに含む、請求項1に記載の方法。
- 前記アサ属植物材料が、大麻(Cannabis sativa)、カンナビス インディカ(Cannabis indica)、及びカンナビス ルデラリス(Cannabis ruderalis)からなる群から選択される種に由来する、請求項1に記載の方法。
- 前記アサ属植物材料が、大麻(Cannabis sativa)に由来する、請求項1に記載の方法。
- 1重量部〜50重量部のアサ属植物材料が、1重量部〜100重量部のアロエと混合される、請求項1に記載の方法。
- 抽出混合物が、任意により、アルコール、ケトン、及びエステルからなる群から選択される少なくとも1つの追加の抽出剤をさらに含む、請求項1に記載の方法。
- 前記追加の抽出剤が、メタノール、エタノール、プロパノール、n‐及びイソ‐プロパノール、n‐ブタノール、tert‐ブタノール、アセトン、メチルエチルケトン、メトキシエタノール、2‐ブトキシエタノール、ジエチルエーテル、アセトン、ブタノン、酢酸エチル、並びにそれらの混合物からなる群から選択される、請求項6に記載の方法。
- 前記分離方法が、濾過、遠心分離、及びデカンテーションからなる群から選択されるか、又はそれらの組み合わせである、請求項2に記載の方法。
- 前記アサ属植物材料が、以下の工程:小片に切断する工程、粉砕する工程、乾燥する工程、及び粉末にする工程の1または複数の工程により処理されている、請求項1に記載の方法。
- 前記アサ属アロエベラ抽出物を凍結乾燥により固体形態に変換することをさらに含む、請求項1に記載の方法。
- 化粧品適用を必要とする対象を特定し、そして請求項1に記載の方法により調製されたアサ属アロエベラ抽出物、及び少なくとも1つの皮膚剤を含む化粧品組成物の美容上有効な量を対象の皮膚に適用することを含む、皮膚を美容的に治療する方法(但し、人間を医学的に治療する方法を除く)。
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