JP6672296B2 - 強力なγ−セクレターゼモジュレータ - Google Patents

強力なγ−セクレターゼモジュレータ Download PDF

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Publication number
JP6672296B2
JP6672296B2 JP2017523912A JP2017523912A JP6672296B2 JP 6672296 B2 JP6672296 B2 JP 6672296B2 JP 2017523912 A JP2017523912 A JP 2017523912A JP 2017523912 A JP2017523912 A JP 2017523912A JP 6672296 B2 JP6672296 B2 JP 6672296B2
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Japan
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substituted
unsubstituted
group
alkyl
hydrogen
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JP2017523912A
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English (en)
Japanese (ja)
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JP2017533237A5 (enExample
JP2017533237A (ja
Inventor
エル． ワグナー，スティーブン
エル． ワグナー，スティーブン
シー． モブリー，ウィリアム
シー． モブリー，ウィリアム
イー． タンシ，ラドルフ
イー． タンシ，ラドルフ
ジョンソン，グラハム
バックル，ロナルド
メイヒュー，ニコラス
ジェイソン ハー，ロバート
ジェイソン ハー，ロバート
ディー． ラインアーソン，ケヴィン
ディー． ラインアーソン，ケヴィン
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University of California
University of California Los Angeles UCLA
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University of California San Diego UCSD
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017523912A 2014-10-31 2015-10-30 強力なγ−セクレターゼモジュレータ Active JP6672296B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462073553P 2014-10-31 2014-10-31
US62/073,553 2014-10-31
PCT/US2015/058429 WO2016070107A1 (en) 2014-10-31 2015-10-30 Potent gamma-secretase modulators

Publications (3)

Publication Number Publication Date
JP2017533237A JP2017533237A (ja) 2017-11-09
JP2017533237A5 JP2017533237A5 (enExample) 2018-12-06
JP6672296B2 true JP6672296B2 (ja) 2020-03-25

Family

ID=55858421

Family Applications (1)

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JP2017523912A Active JP6672296B2 (ja) 2014-10-31 2015-10-30 強力なγ−セクレターゼモジュレータ

Country Status (8)

Country Link
US (2) US10472346B2 (enExample)
EP (1) EP3212633B1 (enExample)
JP (1) JP6672296B2 (enExample)
CN (1) CN107406423B (enExample)
AU (1) AU2015338946B2 (enExample)
CA (1) CA2966423C (enExample)
MX (1) MX381224B (enExample)
WO (1) WO2016070107A1 (enExample)

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JP6672296B2 (ja) 2014-10-31 2020-03-25 ザ ジェネラル ホスピタル コーポレイション 強力なγ−セクレターゼモジュレータ
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TW202112767A (zh) 2019-06-17 2021-04-01 美商佩特拉製藥公司 作為磷脂酸肌醇磷酸激酶抑制劑之胺基吡啶衍生物
CA3169667A1 (en) * 2020-02-28 2021-09-02 Dominic Reynolds Pyridazine derivatives for modulating nucleic acid splicing
US20240368163A1 (en) * 2021-08-30 2024-11-07 Remix Therapeutics Inc. Compounds and methods for modulating splicing

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JP6672296B2 (ja) 2014-10-31 2020-03-25 ザ ジェネラル ホスピタル コーポレイション 強力なγ−セクレターゼモジュレータ

Also Published As

Publication number Publication date
WO2016070107A1 (en) 2016-05-06
US11117884B2 (en) 2021-09-14
US20180093967A1 (en) 2018-04-05
EP3212633B1 (en) 2019-12-04
MX381224B (es) 2025-03-12
CN107406423A (zh) 2017-11-28
CA2966423A1 (en) 2016-05-06
AU2015338946A1 (en) 2017-06-15
US20200055840A1 (en) 2020-02-20
EP3212633A4 (en) 2018-07-25
US10472346B2 (en) 2019-11-12
AU2015338946B2 (en) 2020-06-11
MX2017005715A (es) 2018-02-23
CN107406423B (zh) 2020-06-16
JP2017533237A (ja) 2017-11-09
BR112017009010A2 (pt) 2017-12-26
CA2966423C (en) 2023-10-24
EP3212633A1 (en) 2017-09-06

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