MX2017005715A - Potentes moduladores de gamma-secretasa. - Google Patents
Potentes moduladores de gamma-secretasa.Info
- Publication number
- MX2017005715A MX2017005715A MX2017005715A MX2017005715A MX2017005715A MX 2017005715 A MX2017005715 A MX 2017005715A MX 2017005715 A MX2017005715 A MX 2017005715A MX 2017005715 A MX2017005715 A MX 2017005715A MX 2017005715 A MX2017005715 A MX 2017005715A
- Authority
- MX
- Mexico
- Prior art keywords
- secretase modulators
- potent gamma
- aberrant
- unsubstituted
- potent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
Se proporcionan en la presente compuestos y métodos para tratar un trastorno asociado con niveles aberrantes de péptido Aß, incluyendo enfermedad de Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462073553P | 2014-10-31 | 2014-10-31 | |
PCT/US2015/058429 WO2016070107A1 (en) | 2014-10-31 | 2015-10-30 | Potent gamma-secretase modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017005715A true MX2017005715A (es) | 2018-02-23 |
Family
ID=55858421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017005715A MX2017005715A (es) | 2014-10-31 | 2015-10-30 | Potentes moduladores de gamma-secretasa. |
Country Status (9)
Country | Link |
---|---|
US (2) | US10472346B2 (es) |
EP (1) | EP3212633B1 (es) |
JP (1) | JP6672296B2 (es) |
CN (1) | CN107406423B (es) |
AU (1) | AU2015338946B2 (es) |
BR (1) | BR112017009010A2 (es) |
CA (1) | CA2966423C (es) |
MX (1) | MX2017005715A (es) |
WO (1) | WO2016070107A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112017009010A2 (pt) | 2014-10-31 | 2017-12-26 | Massachusetts Gen Hospital | moduladores potentes de gama-secretase |
WO2019126731A1 (en) | 2017-12-22 | 2019-06-27 | Petra Pharma Corporation | Aminopyridine derivatives as phosphatidylinositol phosphate kinase inhibitors |
US20230365526A1 (en) * | 2020-02-28 | 2023-11-16 | Remix Therapeutics Inc. | Pyridazine derivatives for modulating nucleic acid splicing |
WO2023034827A1 (en) * | 2021-08-30 | 2023-03-09 | Remix Therapeutics Inc. | Compounds and methods for modulating splicing |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
US4044126A (en) | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
USRE28819E (en) | 1972-12-08 | 1976-05-18 | Syntex (U.S.A.) Inc. | Dialkylated glycol compositions and medicament preparations containing same |
US4328245A (en) | 1981-02-13 | 1982-05-04 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4410545A (en) | 1981-02-13 | 1983-10-18 | Syntex (U.S.A.) Inc. | Carbonate diester solutions of PGE-type compounds |
US4358603A (en) | 1981-04-16 | 1982-11-09 | Syntex (U.S.A.) Inc. | Acetal stabilized prostaglandin compositions |
US4409239A (en) | 1982-01-21 | 1983-10-11 | Syntex (U.S.A.) Inc. | Propylene glycol diester solutions of PGE-type compounds |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US5052558A (en) | 1987-12-23 | 1991-10-01 | Entravision, Inc. | Packaged pharmaceutical product |
US5033252A (en) | 1987-12-23 | 1991-07-23 | Entravision, Inc. | Method of packaging and sterilizing a pharmaceutical product |
US5323907A (en) | 1992-06-23 | 1994-06-28 | Multi-Comp, Inc. | Child resistant package assembly for dispensing pharmaceutical medications |
US5523092A (en) | 1993-04-14 | 1996-06-04 | Emory University | Device for local drug delivery and methods for using the same |
US6316652B1 (en) | 1995-06-06 | 2001-11-13 | Kosta Steliou | Drug mitochondrial targeting agents |
US5860957A (en) | 1997-02-07 | 1999-01-19 | Sarcos, Inc. | Multipathway electronically-controlled drug delivery system |
ATE387192T1 (de) | 1997-10-28 | 2008-03-15 | Bando Chemical Ind | Dermatologisches pflaster und verfahren zur herstellung seiner basisschicht |
AU2003259965A1 (en) | 2002-08-20 | 2004-03-11 | Neurogenetics, Inc. | Methods and compositions for modulating amyloid beta |
JP4847868B2 (ja) | 2003-05-14 | 2011-12-28 | ニューロジェネティック ファーマシューティカルズ、 インコーポレイテッド | 化合物、及び、アミロイドベータの調節におけるその使用 |
ATE430142T1 (de) | 2004-12-09 | 2009-05-15 | Hoffmann La Roche | Phenylpiperazin-methanon-derivate |
TW201018678A (en) | 2006-01-27 | 2010-05-16 | Astrazeneca Ab | Novel heteroaryl substituted benzothiazoles |
WO2007111904A2 (en) | 2006-03-22 | 2007-10-04 | Vertex Pharmaceuticals Incorporated | C-met protein kinase inhibitors for the treatment of proliferative disorders |
ES2531002T3 (es) | 2007-01-19 | 2015-03-09 | Xcovery Inc | Compuestos inhibidores de quinasa |
WO2008108991A1 (en) | 2007-03-02 | 2008-09-12 | Merck & Co., Inc. | Bipyridine carboxamide orexin receptor antagonists |
GB0720444D0 (en) * | 2007-10-18 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
CA2718727A1 (en) | 2008-03-25 | 2009-10-01 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CA2753696A1 (en) | 2009-02-26 | 2010-09-02 | Noritaka Kitazawa | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
JP2012051807A (ja) | 2009-02-26 | 2012-03-15 | Eisai R & D Management Co Ltd | アリールイミダゾール化合物 |
JP2012180281A (ja) | 2009-06-29 | 2012-09-20 | Dainippon Sumitomo Pharma Co Ltd | 新規オキサジアゾール誘導体 |
AP2011006034A0 (en) | 2009-07-15 | 2011-12-31 | Janssen Pharmaceuticals Inc | Substituted triazole and imidazole derivatives as gamma secretase modulators. |
JP2013028538A (ja) | 2009-11-13 | 2013-02-07 | Dainippon Sumitomo Pharma Co Ltd | 新規アミド誘導体 |
JP2013523658A (ja) | 2010-03-26 | 2013-06-17 | グラクソ グループ リミテッド | キナーゼ阻害剤としてのピラゾリル‐ピリミジン |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
US9403815B2 (en) * | 2010-06-24 | 2016-08-02 | The Regents Of The University Of California | Compounds and uses thereof in modulating levels of various amyloid beta peptide alloforms |
MY174339A (en) * | 2012-08-13 | 2020-04-09 | Novartis Ag | 1,4-disubstituted pyridazine analogs and methods for treating smn-deficiency-related conditions |
EP2968296B1 (en) | 2013-03-12 | 2020-09-02 | The Regents of the University of California | Gamma-secretase modulators |
BR112017009010A2 (pt) | 2014-10-31 | 2017-12-26 | Massachusetts Gen Hospital | moduladores potentes de gama-secretase |
-
2015
- 2015-10-30 BR BR112017009010A patent/BR112017009010A2/pt active Search and Examination
- 2015-10-30 WO PCT/US2015/058429 patent/WO2016070107A1/en active Application Filing
- 2015-10-30 EP EP15853792.8A patent/EP3212633B1/en active Active
- 2015-10-30 JP JP2017523912A patent/JP6672296B2/ja active Active
- 2015-10-30 US US15/522,969 patent/US10472346B2/en active Active
- 2015-10-30 CA CA2966423A patent/CA2966423C/en active Active
- 2015-10-30 CN CN201580071837.8A patent/CN107406423B/zh active Active
- 2015-10-30 MX MX2017005715A patent/MX2017005715A/es unknown
- 2015-10-30 AU AU2015338946A patent/AU2015338946B2/en active Active
-
2019
- 2019-10-25 US US16/664,621 patent/US11117884B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3212633B1 (en) | 2019-12-04 |
WO2016070107A1 (en) | 2016-05-06 |
US11117884B2 (en) | 2021-09-14 |
AU2015338946B2 (en) | 2020-06-11 |
EP3212633A1 (en) | 2017-09-06 |
CA2966423C (en) | 2023-10-24 |
JP6672296B2 (ja) | 2020-03-25 |
US20180093967A1 (en) | 2018-04-05 |
US20200055840A1 (en) | 2020-02-20 |
CA2966423A1 (en) | 2016-05-06 |
EP3212633A4 (en) | 2018-07-25 |
US10472346B2 (en) | 2019-11-12 |
BR112017009010A2 (pt) | 2017-12-26 |
CN107406423A (zh) | 2017-11-28 |
AU2015338946A1 (en) | 2017-06-15 |
JP2017533237A (ja) | 2017-11-09 |
CN107406423B (zh) | 2020-06-16 |
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