JP6640994B2 - 安定した可溶性ヘテロ二量体ｔｃｒ - Google Patents

安定した可溶性ヘテロ二量体ｔｃｒ Download PDF

Info

Publication number
JP6640994B2
JP6640994B2 JP2018512466A JP2018512466A JP6640994B2 JP 6640994 B2 JP6640994 B2 JP 6640994B2 JP 2018512466 A JP2018512466 A JP 2018512466A JP 2018512466 A JP2018512466 A JP 2018512466A JP 6640994 B2 JP6640994 B2 JP 6640994B2
Authority
JP
Japan
Prior art keywords
tcr
chain
exon
interchain disulfide
trbc2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2018512466A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018522061A (ja
JP2018522061A5 (https=
Inventor
李▲い▼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guangdong Xiangxue Life Sciences Ltd
Original Assignee
Guangdong Xiangxue Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guangdong Xiangxue Life Sciences Ltd filed Critical Guangdong Xiangxue Life Sciences Ltd
Publication of JP2018522061A publication Critical patent/JP2018522061A/ja
Publication of JP2018522061A5 publication Critical patent/JP2018522061A5/ja
Application granted granted Critical
Publication of JP6640994B2 publication Critical patent/JP6640994B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Virology (AREA)
JP2018512466A 2015-05-20 2016-03-29 安定した可溶性ヘテロ二量体ｔｃｒ Expired - Fee Related JP6640994B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201510260322.4 2015-05-20
CN201510260322.4A CN106279404A (zh) 2015-05-20 2015-05-20 一种可溶且稳定的异质二聚tcr
PCT/CN2016/077680 WO2016184258A1 (zh) 2015-05-20 2016-03-29 一种可溶且稳定的异质二聚tcr

Publications (3)

Publication Number Publication Date
JP2018522061A JP2018522061A (ja) 2018-08-09
JP2018522061A5 JP2018522061A5 (https=) 2019-05-09
JP6640994B2 true JP6640994B2 (ja) 2020-02-05

Family

ID=57319412

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018512466A Expired - Fee Related JP6640994B2 (ja) 2015-05-20 2016-03-29 安定した可溶性ヘテロ二量体ｔｃｒ

Country Status (6)

Country Link
US (1) US10316087B2 (https=)
EP (1) EP3299389A4 (https=)
JP (1) JP6640994B2 (https=)
CN (2) CN106279404A (https=)
CA (1) CA2986273A1 (https=)
WO (1) WO2016184258A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117843810A (zh) * 2017-09-22 2024-04-09 上海药明生物技术有限公司 新型双特异性多肽复合物
CN110016074B (zh) * 2018-01-08 2021-03-30 中国科学院广州生物医药与健康研究院 Mage-a3人源化t细胞受体
US20220162312A1 (en) * 2019-01-28 2022-05-26 WuXi Biologics Ireland Limited Novel bispecific cd3/cd20 polypeptide complexes
CN112442119B (zh) * 2019-09-05 2023-02-24 香雪生命科学技术（广东）有限公司 一种识别ssx2的高亲和力t细胞受体
CN113880953A (zh) 2020-07-01 2022-01-04 华夏英泰（北京）生物技术有限公司 T细胞抗原受体、其多聚体复合物及其制备方法和应用
EP4624499A1 (en) 2022-12-19 2025-10-01 Immunotech Applied Science Limited T-cell antigen receptor, preparation method therefor, and use thereof
CN118108833B (zh) * 2024-03-12 2025-05-02 缇纱(合肥)生物技术有限公司 引入外源二硫键的tcr恒定区及其产品和应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999060120A2 (en) * 1998-05-19 1999-11-25 Avidex Limited Soluble t cell receptor
AU5245399A (en) * 1998-07-29 2000-02-21 Heska Corporation T cell receptor proteins, nucleic acid molecules, and uses thereof
AU2002321581C1 (en) * 2001-08-31 2008-09-18 Adaptimmune Limited Soluble T cell receptor
US6913941B2 (en) * 2002-09-09 2005-07-05 Freescale Semiconductor, Inc. SOI polysilicon trench refill perimeter oxide anchor scheme
GB0227351D0 (en) * 2002-11-22 2002-12-31 Isis Innovation Soluble T-cell receptors
JP2006523437A (ja) * 2002-12-03 2006-10-19 アヴィデックス リミテッド レセプター複合体
GB0304068D0 (en) * 2003-02-22 2003-03-26 Avidex Ltd Substances
DK1765860T3 (da) * 2004-05-19 2009-03-09 Immunocore Ltd Ny-ESO-T.cellereceptor med höj affinitet
AU2005291039A1 (en) * 2004-10-01 2006-04-13 Avidex Ltd. T-cell receptors containing a non-native disulfide interchain bond linked to therapeutic agents
EA201390011A1 (ru) * 2010-07-28 2013-07-30 Иммьюнокор Лтд. Т-клеточные рецепторы
EP2502934B1 (en) * 2011-03-24 2018-01-17 Universitätsmedizin der Johannes Gutenberg-Universität Mainz Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds
RU2645256C2 (ru) * 2013-06-26 2018-02-19 Гуандун Сянсюэ Лайф Сайенсис, Лтд. Высокостабильный т-клеточный рецептор и способ его получения и применения
GB201313377D0 (en) * 2013-07-26 2013-09-11 Adaptimmune Ltd T cell receptors
GB201314404D0 (en) * 2013-08-12 2013-09-25 Immunocore Ltd T Cell Receptors

Also Published As

Publication number Publication date
JP2018522061A (ja) 2018-08-09
US10316087B2 (en) 2019-06-11
CN106279404A (zh) 2017-01-04
CN107108717A (zh) 2017-08-29
EP3299389A1 (en) 2018-03-28
CN107108717B (zh) 2021-04-23
CA2986273A1 (en) 2016-11-24
EP3299389A4 (en) 2018-11-21
WO2016184258A1 (zh) 2016-11-24
US20180201682A1 (en) 2018-07-19

Similar Documents

Publication Publication Date Title
JP6640994B2 (ja) 安定した可溶性ヘテロ二量体ｔｃｒ
RU2645256C2 (ru) Высокостабильный т-клеточный рецептор и способ его получения и применения
CN112759641B (zh) 一种识别Kras G12V的高亲和力TCR
CN106632660A (zh) 识别ny‑eso‑1抗原短肽的tcr
CN106188275A (zh) 识别ny-eso-1抗原短肽的t细胞受体
CN106478807B (zh) 识别mage-a3的t细胞受体
JP2022095667A (ja) Ｎｙ－ｅｓｏに対する高親和力のｔｃｒ
CN106336457B (zh) 识别mage‑a3抗原短肽的t细胞受体
CN106478808B (zh) 识别ny-eso-1抗原短肽的t细胞受体
JP6415716B2 (ja) 可溶性のヘテロ二量体ｔ細胞受容体およびその製法と使用
CN106632658B (zh) 识别ny-eso-1抗原短肽的tcr
CN111662374A (zh) 一种识别afp抗原的高亲和力tcr
CN106188274A (zh) 识别rhamm抗原短肽的t细胞受体
CN112442119B (zh) 一种识别ssx2的高亲和力t细胞受体
WO2024217538A1 (zh) 一种识别kras突变的高亲和力t细胞受体及其应用
CN117659163A (zh) 一种识别afp的高亲和力t细胞受体及其应用
CN116836260A (zh) 一种识别mage-a4的t细胞受体及其编码序列和应用
CN117106059A (zh) 一种识别mage的t细胞受体及其应用
CN106459176A (zh) 高亲和力 hcv t细胞受体
WO2023241391A1 (zh) 一种结合ssx2抗原的tcr分子及其应用
WO2022206860A1 (zh) 针对afp的t细胞受体
WO2022262842A1 (zh) 一种针对afp抗原的高亲和力t细胞受体
WO2022166905A1 (zh) 一种针对hpv的高亲和力tcr

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180406

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190329

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190329

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20190329

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20190410

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190507

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190806

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190924

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191101

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20191217

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20191226

R150 Certificate of patent or registration of utility model

Ref document number: 6640994

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees