JP2018522061A5 - - Google Patents
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- Publication number
- JP2018522061A5 JP2018522061A5 JP2018512466A JP2018512466A JP2018522061A5 JP 2018522061 A5 JP2018522061 A5 JP 2018522061A5 JP 2018512466 A JP2018512466 A JP 2018512466A JP 2018512466 A JP2018512466 A JP 2018512466A JP 2018522061 A5 JP2018522061 A5 JP 2018522061A5
- Authority
- JP
- Japan
- Prior art keywords
- tcr
- chain
- exon
- trbc2
- trbc1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101000662909 Homo sapiens T cell receptor beta constant 1 Proteins 0.000 claims 12
- 101000662902 Homo sapiens T cell receptor beta constant 2 Proteins 0.000 claims 12
- 102100037272 T cell receptor beta constant 1 Human genes 0.000 claims 12
- 102100037298 T cell receptor beta constant 2 Human genes 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 9
- 150000001413 amino acids Chemical class 0.000 claims 9
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims 5
- 108091008874 T cell receptors Proteins 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 235000004279 alanine Nutrition 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 230000009466 transformation Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510260322.4 | 2015-05-20 | ||
| CN201510260322.4A CN106279404A (zh) | 2015-05-20 | 2015-05-20 | 一种可溶且稳定的异质二聚tcr |
| PCT/CN2016/077680 WO2016184258A1 (zh) | 2015-05-20 | 2016-03-29 | 一种可溶且稳定的异质二聚tcr |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018522061A JP2018522061A (ja) | 2018-08-09 |
| JP2018522061A5 true JP2018522061A5 (https=) | 2019-05-09 |
| JP6640994B2 JP6640994B2 (ja) | 2020-02-05 |
Family
ID=57319412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018512466A Expired - Fee Related JP6640994B2 (ja) | 2015-05-20 | 2016-03-29 | 安定した可溶性ヘテロ二量体ｔｃｒ |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10316087B2 (https=) |
| EP (1) | EP3299389A4 (https=) |
| JP (1) | JP6640994B2 (https=) |
| CN (2) | CN106279404A (https=) |
| CA (1) | CA2986273A1 (https=) |
| WO (1) | WO2016184258A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117843810A (zh) * | 2017-09-22 | 2024-04-09 | 上海药明生物技术有限公司 | 新型双特异性多肽复合物 |
| CN110016074B (zh) * | 2018-01-08 | 2021-03-30 | 中国科学院广州生物医药与健康研究院 | Mage-a3人源化t细胞受体 |
| US20220162312A1 (en) * | 2019-01-28 | 2022-05-26 | WuXi Biologics Ireland Limited | Novel bispecific cd3/cd20 polypeptide complexes |
| CN112442119B (zh) * | 2019-09-05 | 2023-02-24 | 香雪生命科学技术（广东）有限公司 | 一种识别ssx2的高亲和力t细胞受体 |
| CN113880953A (zh) | 2020-07-01 | 2022-01-04 | 华夏英泰（北京）生物技术有限公司 | T细胞抗原受体、其多聚体复合物及其制备方法和应用 |
| EP4624499A1 (en) | 2022-12-19 | 2025-10-01 | Immunotech Applied Science Limited | T-cell antigen receptor, preparation method therefor, and use thereof |
| CN118108833B (zh) * | 2024-03-12 | 2025-05-02 | 缇纱(合肥)生物技术有限公司 | 引入外源二硫键的tcr恒定区及其产品和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999060120A2 (en) * | 1998-05-19 | 1999-11-25 | Avidex Limited | Soluble t cell receptor |
| AU5245399A (en) * | 1998-07-29 | 2000-02-21 | Heska Corporation | T cell receptor proteins, nucleic acid molecules, and uses thereof |
| AU2002321581C1 (en) * | 2001-08-31 | 2008-09-18 | Adaptimmune Limited | Soluble T cell receptor |
| US6913941B2 (en) * | 2002-09-09 | 2005-07-05 | Freescale Semiconductor, Inc. | SOI polysilicon trench refill perimeter oxide anchor scheme |
| GB0227351D0 (en) * | 2002-11-22 | 2002-12-31 | Isis Innovation | Soluble T-cell receptors |
| JP2006523437A (ja) * | 2002-12-03 | 2006-10-19 | アヴィデックス リミテッド | レセプター複合体 |
| GB0304068D0 (en) * | 2003-02-22 | 2003-03-26 | Avidex Ltd | Substances |
| DK1765860T3 (da) * | 2004-05-19 | 2009-03-09 | Immunocore Ltd | Ny-ESO-T.cellereceptor med höj affinitet |
| AU2005291039A1 (en) * | 2004-10-01 | 2006-04-13 | Avidex Ltd. | T-cell receptors containing a non-native disulfide interchain bond linked to therapeutic agents |
| EA201390011A1 (ru) * | 2010-07-28 | 2013-07-30 | Иммьюнокор Лтд. | Т-клеточные рецепторы |
| EP2502934B1 (en) * | 2011-03-24 | 2018-01-17 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz | Single chain antigen recognizing constructs (scARCs) stabilized by the introduction of novel disulfide bonds |
| RU2645256C2 (ru) * | 2013-06-26 | 2018-02-19 | Гуандун Сянсюэ Лайф Сайенсис, Лтд. | Высокостабильный т-клеточный рецептор и способ его получения и применения |
| GB201313377D0 (en) * | 2013-07-26 | 2013-09-11 | Adaptimmune Ltd | T cell receptors |
| GB201314404D0 (en) * | 2013-08-12 | 2013-09-25 | Immunocore Ltd | T Cell Receptors |
-
2015
- 2015-05-20 CN CN201510260322.4A patent/CN106279404A/zh active Pending
-
2016
- 2016-03-29 CA CA2986273A patent/CA2986273A1/en not_active Abandoned
- 2016-03-29 JP JP2018512466A patent/JP6640994B2/ja not_active Expired - Fee Related
- 2016-03-29 EP EP16795745.5A patent/EP3299389A4/en not_active Withdrawn
- 2016-03-29 CN CN201680003540.2A patent/CN107108717B/zh active Active
- 2016-03-29 WO PCT/CN2016/077680 patent/WO2016184258A1/zh not_active Ceased
- 2016-03-29 US US15/573,692 patent/US10316087B2/en active Active
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