JP6635949B2 - 炎症性および自己免疫性の病気の処置のためのmth1阻害剤 - Google Patents
炎症性および自己免疫性の病気の処置のためのmth1阻害剤 Download PDFInfo
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- JP6635949B2 JP6635949B2 JP2016571095A JP2016571095A JP6635949B2 JP 6635949 B2 JP6635949 B2 JP 6635949B2 JP 2016571095 A JP2016571095 A JP 2016571095A JP 2016571095 A JP2016571095 A JP 2016571095A JP 6635949 B2 JP6635949 B2 JP 6635949B2
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- JKDZFWAOCTVIRR-UHFFFAOYSA-N C=CCNc1cc(Cl)nc(N)n1 Chemical compound C=CCNc1cc(Cl)nc(N)n1 JKDZFWAOCTVIRR-UHFFFAOYSA-N 0.000 description 1
- JZIULQAAQKFJMQ-UHFFFAOYSA-N Cc(c(-c1nc(N)nc(Cl)c1)c1)ccc1Cl Chemical compound Cc(c(-c1nc(N)nc(Cl)c1)c1)ccc1Cl JZIULQAAQKFJMQ-UHFFFAOYSA-N 0.000 description 1
- JOGXEBBCLDMDDA-UHFFFAOYSA-N Cc(c(-c1nc(N)nc(NCCCN)c1)ccc1)c1Cl Chemical compound Cc(c(-c1nc(N)nc(NCCCN)c1)ccc1)c1Cl JOGXEBBCLDMDDA-UHFFFAOYSA-N 0.000 description 1
- QOUAQKOLTZGLCO-UHFFFAOYSA-N Cc(c(-c1nc(N)nc(NCCO)c1)ccc1)c1Cl Chemical compound Cc(c(-c1nc(N)nc(NCCO)c1)ccc1)c1Cl QOUAQKOLTZGLCO-UHFFFAOYSA-N 0.000 description 1
- IBWAUWPRUZNPKW-UHFFFAOYSA-N Cc1c(C)c(-c2nc(N)nc(Cl)c2)ccc1 Chemical compound Cc1c(C)c(-c2nc(N)nc(Cl)c2)ccc1 IBWAUWPRUZNPKW-UHFFFAOYSA-N 0.000 description 1
- VGFWOWKPCVKHIM-UHFFFAOYSA-N NC(COc1cc(B(O)O)ccc1)=O Chemical compound NC(COc1cc(B(O)O)ccc1)=O VGFWOWKPCVKHIM-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450681 | 2014-06-04 | ||
| SE1450681-0 | 2014-06-04 | ||
| PCT/SE2015/050654 WO2015187089A1 (en) | 2014-06-04 | 2015-06-04 | Mth1 inhibitors for treatment of inflammatory and autoimmune conditions |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516826A JP2017516826A (ja) | 2017-06-22 |
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| AU2015268961B9 (en) * | 2014-06-04 | 2019-10-10 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of cancer |
| US10336768B2 (en) | 2014-06-13 | 2019-07-02 | Yuma Therapeutics, Inc. | Pyrimidine compounds and methods using the same |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| WO2017142804A1 (en) * | 2016-02-17 | 2017-08-24 | Merck Sharp & Dohme Corp. | Processes for the preparation of a bace inhibitor |
| SI3433234T1 (sl) | 2016-03-22 | 2022-01-31 | Merck Sharp & Dohme Corp. | Alosterični modulatorji nikotinskih acetilholinskih receptorjev |
| EP3445750A4 (en) * | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
| US10617680B2 (en) | 2017-04-18 | 2020-04-14 | Celgene Quanticel Research, Inc. | Therapeutic compounds |
| WO2018210988A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives as pge2 receptor modulators |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| PL3625222T3 (pl) | 2017-05-18 | 2021-12-27 | Idorsia Pharmaceuticals Ltd | Pochodne fenylu jako modulatory receptora pge2 |
| CA3063788A1 (en) | 2017-05-18 | 2018-11-22 | Idorsia Pharmaceuticals Ltd | Pyrimidine derivatives |
| CN109467538A (zh) * | 2017-09-07 | 2019-03-15 | 和记黄埔医药(上海)有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| US20200360386A1 (en) * | 2017-12-30 | 2020-11-19 | Unity Biotechnology, Inc. | Inhibitors of HSP90, PI3-Kinase, Proteasome, HDAC, and P97 Pathways for Selective Removal of Senescent Cells in the Treatment of Age Related Conditions |
| JP7426939B2 (ja) | 2018-03-01 | 2024-02-02 | トーマス・ヘレデイズ・スティフテルス・フォー・メディシンスク・フォルスクニング | 置換ベンゾジアゾールおよび療法におけるその使用 |
| CN111892516A (zh) * | 2018-08-08 | 2020-11-06 | 中国人民解放军总医院 | 抗肿瘤化合物 |
| AR116635A1 (es) * | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
| WO2022197756A1 (en) * | 2021-03-17 | 2022-09-22 | Shire Human Genetic Therapies, Inc. | Plasma kallikrein inhibitors |
| GB202108249D0 (en) * | 2021-06-09 | 2021-07-21 | Univ Of Sussex | Compounds |
| CN120379972A (zh) * | 2022-12-20 | 2025-07-25 | 深圳湾实验室 | 一种靶向usp1的小分子抑制剂及其应用 |
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Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB681712A (en) | 1949-09-14 | 1952-10-29 | Burroughs Wellcome Co | Improvements in or relating to therapeutically useful pyrimidine compounds |
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| US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| US6573377B1 (en) | 1998-07-24 | 2003-06-03 | Daiichi Pharmaceuticals Co., Ltd. | Pyrazole derivatives and salts thereof |
| PT1313508E (pt) | 2000-06-30 | 2007-06-21 | Lilly Co Eli | Combinação contendo um antifolato e um agente redutor do ácido metilmalónico. |
| AU2002310187A1 (en) | 2001-05-30 | 2002-12-09 | Lg Biomedical Institute | Inhibitors of protein kinase for the treatment of disease |
| EA007933B1 (ru) | 2001-08-13 | 2007-02-27 | Янссен Фармацевтика Н.В. | 2,4,5-тризамещенные производные тиазолила и их противовоспалительная активность |
| US7419984B2 (en) | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
| WO2004080979A1 (en) | 2003-03-14 | 2004-09-23 | Lg Life Sciences Ltd. | Novel 3-(2-amino-4-pyrimidinyl)-4-hydroxyphenyl ketone derivatives |
| US8084457B2 (en) | 2003-09-15 | 2011-12-27 | Lead Discovery Center Gmbh | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| JP5319113B2 (ja) | 2004-03-26 | 2013-10-16 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
| WO2006078886A2 (en) | 2005-01-18 | 2006-07-27 | Irm Llc | Compounds and compositions as wnt signaling pathway modulators |
| EP2066645A2 (en) * | 2006-09-12 | 2009-06-10 | UCB Pharma S.A. | 2 amino-pyrimidine derivatives as h4 receptor antagonists, processes for preparing them and their use in pharmaceutical compositions |
| CL2008000467A1 (es) | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| US8598202B2 (en) | 2008-02-19 | 2013-12-03 | Janssen Pharmaceutica Nv | Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase |
| US8268846B2 (en) | 2008-07-11 | 2012-09-18 | Abbott Laboratories | Amino heterocyclic linked pyrimidine derivatives |
| AR074199A1 (es) * | 2008-11-20 | 2010-12-29 | Glaxosmithkline Llc | Compuesto de 6-(4-pirimidinil)-1h-indazol, composiciones farmaceuticas que lo comprenden y su uso para preparar un medicamento util para el tratamiento o disminucion de la gravedad del cancer. |
| AU2010315190A1 (en) | 2009-11-05 | 2012-05-10 | Lexicon Pharmaceuticals, Inc. | Tryptophan hydroxylase inhibitors for the treatment of cancer |
| JP2013519673A (ja) | 2010-02-10 | 2013-05-30 | レクシコン ファーマシューティカルズ インコーポレイテッド | 転移性骨疾患の治療のためのトリプトファンヒドロキシラーゼ阻害剤 |
| US20140031547A1 (en) | 2010-12-14 | 2014-01-30 | Electrophoretics Limited | CASEIN KINASE 1delta (CK 1delta) INHIBITORS AND THEIR USE IN THE TREATMENT OF NEURODE-GENERATIVE DISEASES SUCH AS TAUOPATHIES |
| WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| GB201215502D0 (en) | 2012-08-31 | 2012-10-17 | Chalkiadakis Spyridon | Medical use |
| CA2888338C (en) * | 2012-11-27 | 2021-07-20 | Thomas Helledays Stiftelse For Medicinsk Forskning | Mth1 inhibitors for treatment of cancer |
| US10064869B2 (en) * | 2014-06-04 | 2018-09-04 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of inflammatory and autoimmune conditions |
| CN104288170B (zh) | 2014-10-22 | 2018-02-16 | 吉林大学 | 松果菊苷在抗肿瘤药物中的应用 |
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| EP3151833A1 (en) | 2017-04-12 |
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| US20190000856A1 (en) | 2019-01-03 |
| SG11201609981RA (en) | 2016-12-29 |
| CN106794181A (zh) | 2017-05-31 |
| US10632125B2 (en) | 2020-04-28 |
| RU2016151390A (ru) | 2018-07-17 |
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