IL249223A0 - Mth1 inhibitors for the treatment of inflammatory and autoimmune conditions - Google Patents
Mth1 inhibitors for the treatment of inflammatory and autoimmune conditionsInfo
- Publication number
- IL249223A0 IL249223A0 IL249223A IL24922316A IL249223A0 IL 249223 A0 IL249223 A0 IL 249223A0 IL 249223 A IL249223 A IL 249223A IL 24922316 A IL24922316 A IL 24922316A IL 249223 A0 IL249223 A0 IL 249223A0
- Authority
- IL
- Israel
- Prior art keywords
- inflammatory
- treatment
- autoimmune conditions
- mth1 inhibitors
- mth1
- Prior art date
Links
- 101150059488 NUDT1 gene Proteins 0.000 title 1
- 230000001363 autoimmune Effects 0.000 title 1
- 230000002757 inflammatory effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- Chemical & Material Sciences (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE1450681 | 2014-06-04 | ||
| PCT/SE2015/050654 WO2015187089A1 (en) | 2014-06-04 | 2015-06-04 | Mth1 inhibitors for treatment of inflammatory and autoimmune conditions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL249223A0 true IL249223A0 (en) | 2017-02-28 |
Family
ID=54767050
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL249223A IL249223A0 (en) | 2014-06-04 | 2016-11-27 | Mth1 inhibitors for the treatment of inflammatory and autoimmune conditions |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10064869B2 (enExample) |
| EP (1) | EP3151833A4 (enExample) |
| JP (1) | JP6635949B2 (enExample) |
| CN (1) | CN106794181A (enExample) |
| AU (1) | AU2015268962A1 (enExample) |
| CA (1) | CA2948601A1 (enExample) |
| IL (1) | IL249223A0 (enExample) |
| RU (1) | RU2016151390A (enExample) |
| SG (1) | SG11201609981RA (enExample) |
| WO (1) | WO2015187089A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102413253B1 (ko) * | 2013-12-11 | 2022-06-27 | 바이오젠 엠에이 인코포레이티드 | 종양, 신경 및 면역에서 인간 질환을 치료하는데 유용한 바이아릴 화합물 |
| CA2949785A1 (en) * | 2014-06-04 | 2015-12-10 | Thomas Helledays Stiftelse For Medicinsk Forskning | Mth1 inhibitors for treatment of cancer |
| AU2015268962A1 (en) * | 2014-06-04 | 2017-01-12 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of inflammatory and autoimmune conditions |
| EP3154547B1 (en) * | 2014-06-13 | 2023-06-07 | Yuma Therapeutics, Inc. | Pyrimidine compounds and methods using the same |
| CR20180323A (es) | 2015-11-20 | 2018-08-06 | Idorsia Pharmaceuticals Ltd | Derivados de indol n-sustituídos como moduladores de los receptores de pge2 |
| US10618892B2 (en) * | 2016-02-17 | 2020-04-14 | Merck Sharp & Dohme Corp. | Processes for the preparation of a BACE inhibitor |
| SI3433234T1 (sl) | 2016-03-22 | 2022-01-31 | Merck Sharp & Dohme Corp. | Alosterični modulatorji nikotinskih acetilholinskih receptorjev |
| EP3445750A4 (en) * | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
| TWI788343B (zh) | 2017-04-18 | 2023-01-01 | 美商塞爾基因定量細胞研究公司 | 治療用化合物 |
| HRP20211533T1 (hr) | 2017-05-18 | 2022-01-07 | Idorsia Pharmaceuticals Ltd | Derivati fenila kao modulatori receptora pge2 |
| ES2896476T3 (es) | 2017-05-18 | 2022-02-24 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina |
| AR111808A1 (es) | 2017-05-18 | 2019-08-21 | Idorsia Pharmaceuticals Ltd | Derivados de pirimidina como moduladores del receptor de pge2 |
| US11325899B2 (en) | 2017-05-18 | 2022-05-10 | Idorsia Pharmaceuticals Ltd | Benzofurane and benzothiophene derivatives as PGE2 receptor modulators |
| CN109467538A (zh) | 2017-09-07 | 2019-03-15 | 和记黄埔医药(上海)有限公司 | 环烯烃取代的杂芳环类化合物及其用途 |
| WO2019133904A1 (en) * | 2017-12-30 | 2019-07-04 | Unity Biotechnology, Inc. | Inhibitors of hsp90, pi3-kinase, proteasome, hdac, and p97 pathways for selective removal of senescent cells in the treatment of age related conditions |
| WO2019166639A1 (en) | 2018-03-01 | 2019-09-06 | Thomas Helledays Stiftelse För Medicinsk Forskning | Substituted benzodiazoles and use thereof in therapy |
| CN111892517A (zh) * | 2018-08-08 | 2020-11-06 | 中国人民解放军总医院 | 抗肿瘤化合物 |
| AR116635A1 (es) * | 2018-10-15 | 2021-05-26 | Servier Lab | Proceso para la síntesis de derivados de piperazinil-etoxi-bromofenilo y su aplicación en la producción de compuestos que los contienen |
| GB202108249D0 (en) * | 2021-06-09 | 2021-07-21 | Univ Of Sussex | Compounds |
| WO2024131742A1 (zh) * | 2022-12-20 | 2024-06-27 | 深圳湾实验室 | 一种靶向usp1的小分子抑制剂及其应用 |
| WO2025143733A1 (ko) * | 2023-12-26 | 2025-07-03 | (주)아이젠사이언스 | 신규한 유비퀴틴 특이적 펩티드 분해효소 1 저해제 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB681712A (en) | 1949-09-14 | 1952-10-29 | Burroughs Wellcome Co | Improvements in or relating to therapeutically useful pyrimidine compounds |
| JPS4921148B1 (enExample) | 1970-12-28 | 1974-05-30 | ||
| JPS4921147B1 (enExample) | 1970-12-28 | 1974-05-30 | ||
| WO1986004583A1 (en) | 1985-02-05 | 1986-08-14 | The Upjohn Company | 4-substituted-6-aryl pyrimidine compounds |
| US6169086B1 (en) | 1997-01-27 | 2001-01-02 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives |
| EP1103551A1 (en) | 1998-07-24 | 2001-05-30 | Daiichi Pharmaceutical Co., Ltd. | Pyrazole derivatives and salts thereof |
| US7053065B2 (en) | 2000-06-30 | 2006-05-30 | Eli Lilly And Company | Vitamin B12 and pemetrexed disodium combination therapies |
| JP2004534779A (ja) | 2001-05-30 | 2004-11-18 | エルジー ライフサイエンス リミテッド | 疾病治療用プロテインキナーゼ阻害剤 |
| HRP20040098B1 (en) | 2001-08-13 | 2012-08-31 | Janssen Pharmaceutica N.V. | 2,4,5-TRlSUBSTITUTED THIAZOLYL DERIVATIVES AND THEIR ANTIINFLAMMATORY ACTIVITY |
| US7419984B2 (en) | 2002-10-17 | 2008-09-02 | Cell Therapeutics, Inc. | Pyrimidines and uses thereof |
| WO2004080979A1 (en) | 2003-03-14 | 2004-09-23 | Lg Life Sciences Ltd. | Novel 3-(2-amino-4-pyrimidinyl)-4-hydroxyphenyl ketone derivatives |
| EP1678147B1 (en) * | 2003-09-15 | 2012-08-08 | Lead Discovery Center GmbH | Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases |
| KR101258504B1 (ko) | 2004-03-26 | 2013-04-26 | 메틸진 인코포레이티드 | 히스톤 데아세틸라제의 억제제 |
| WO2006078886A2 (en) | 2005-01-18 | 2006-07-27 | Irm Llc | Compounds and compositions as wnt signaling pathway modulators |
| US20100035863A1 (en) * | 2006-09-12 | 2010-02-11 | Ucb Pharma, S.A. | 2 Amino-Pyrimidine Derivatives As H4 Receptor Antagonists, Processes For Preparing Them And Their Use In Pharmaceutical Compositions |
| CL2008000467A1 (es) | 2007-02-14 | 2008-08-22 | Janssen Pharmaceutica Nv | Compuestos derivados de 2-aminopirimidina, moduladores del receptor histamina h4; su procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar un trastorno inflamatorio seleccionado de alegia, asma |
| CA2714743C (en) | 2008-02-19 | 2017-01-17 | Janssen Pharmaceutica N.V. | Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase |
| US8268846B2 (en) * | 2008-07-11 | 2012-09-18 | Abbott Laboratories | Amino heterocyclic linked pyrimidine derivatives |
| JP5743897B2 (ja) * | 2008-11-20 | 2015-07-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | 化合物 |
| JP2013510092A (ja) | 2009-11-05 | 2013-03-21 | レクシコン ファーマシューティカルズ インコーポレイテッド | がんの治療のためのトリプトファンヒドロキシラーゼ阻害剤 |
| CN102753168A (zh) | 2010-02-10 | 2012-10-24 | 莱西肯医药有限公司 | 用于治疗转移性骨病的色氨酸羟化酶抑制剂 |
| JP5937102B2 (ja) | 2010-12-14 | 2016-06-22 | エレクトロフォレティクス リミテッド | カゼインキナーゼ1デルタ(ck1デルタ)阻害剤 |
| WO2013066839A2 (en) | 2011-10-31 | 2013-05-10 | Glaxosmithkline Llc | Compounds and methods |
| GB201215502D0 (en) | 2012-08-31 | 2012-10-17 | Chalkiadakis Spyridon | Medical use |
| KR102194646B1 (ko) * | 2012-11-27 | 2020-12-23 | 토마스 헬데이스 스티프텔스 퓌어 메디신스크 포르스닝 | 암 치료를 위한 피리미딘-2,4-다이아민 유도체 |
| AU2015268962A1 (en) * | 2014-06-04 | 2017-01-12 | Thomas Helledays Stiftelse For Medicinsk Forskning | MTH1 inhibitors for treatment of inflammatory and autoimmune conditions |
| CN104288170B (zh) | 2014-10-22 | 2018-02-16 | 吉林大学 | 松果菊苷在抗肿瘤药物中的应用 |
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2015
- 2015-06-04 AU AU2015268962A patent/AU2015268962A1/en not_active Abandoned
- 2015-06-04 CN CN201580029524.6A patent/CN106794181A/zh active Pending
- 2015-06-04 JP JP2016571095A patent/JP6635949B2/ja active Active
- 2015-06-04 CA CA2948601A patent/CA2948601A1/en not_active Abandoned
- 2015-06-04 SG SG11201609981RA patent/SG11201609981RA/en unknown
- 2015-06-04 WO PCT/SE2015/050654 patent/WO2015187089A1/en not_active Ceased
- 2015-06-04 US US15/315,478 patent/US10064869B2/en active Active
- 2015-06-04 RU RU2016151390A patent/RU2016151390A/ru not_active Application Discontinuation
- 2015-06-04 EP EP15802742.5A patent/EP3151833A4/en not_active Withdrawn
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2016
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2018
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| WO2015187089A1 (en) | 2015-12-10 |
| JP2017516826A (ja) | 2017-06-22 |
| SG11201609981RA (en) | 2016-12-29 |
| US10064869B2 (en) | 2018-09-04 |
| US20170196873A1 (en) | 2017-07-13 |
| JP6635949B2 (ja) | 2020-01-29 |
| CN106794181A (zh) | 2017-05-31 |
| AU2015268962A1 (en) | 2017-01-12 |
| RU2016151390A (ru) | 2018-07-17 |
| EP3151833A1 (en) | 2017-04-12 |
| CA2948601A1 (en) | 2015-12-10 |
| RU2016151390A3 (enExample) | 2018-12-20 |
| US20190000856A1 (en) | 2019-01-03 |
| EP3151833A4 (en) | 2018-01-10 |
| US10632125B2 (en) | 2020-04-28 |
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