JP6594303B2 - 微粒子化テコビリマット一水和物の再水和 - Google Patents

微粒子化テコビリマット一水和物の再水和 Download PDF

Info

Publication number
JP6594303B2
JP6594303B2 JP2016522728A JP2016522728A JP6594303B2 JP 6594303 B2 JP6594303 B2 JP 6594303B2 JP 2016522728 A JP2016522728 A JP 2016522728A JP 2016522728 A JP2016522728 A JP 2016522728A JP 6594303 B2 JP6594303 B2 JP 6594303B2
Authority
JP
Japan
Prior art keywords
particles
micronized
moisture
exposing
monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016522728A
Other languages
English (en)
Japanese (ja)
Other versions
JP2016537318A (ja
JP2016537318A5 (enExample
Inventor
シャンタクマール・アール・ティアヴァナギマット
マシュー・リーヴス
エヌ・ケー・ピーター・サミュエル
スティーヴン・プリィーブ
イン・タン
デニス・イー・フルビー
Original Assignee
シガ・テクノロジーズ・インコーポレーテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by シガ・テクノロジーズ・インコーポレーテッド filed Critical シガ・テクノロジーズ・インコーポレーテッド
Publication of JP2016537318A publication Critical patent/JP2016537318A/ja
Publication of JP2016537318A5 publication Critical patent/JP2016537318A5/ja
Application granted granted Critical
Publication of JP6594303B2 publication Critical patent/JP6594303B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP2016522728A 2013-11-19 2014-11-14 微粒子化テコビリマット一水和物の再水和 Active JP6594303B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361906119P 2013-11-19 2013-11-19
US61/906,119 2013-11-19
PCT/US2014/065674 WO2015077143A1 (en) 2013-11-19 2014-11-14 Rehydration of micronized tecovirimat monohydrate

Publications (3)

Publication Number Publication Date
JP2016537318A JP2016537318A (ja) 2016-12-01
JP2016537318A5 JP2016537318A5 (enExample) 2017-12-21
JP6594303B2 true JP6594303B2 (ja) 2019-10-23

Family

ID=53180052

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016522728A Active JP6594303B2 (ja) 2013-11-19 2014-11-14 微粒子化テコビリマット一水和物の再水和

Country Status (8)

Country Link
US (2) US10406103B2 (enExample)
EP (1) EP3043793B1 (enExample)
JP (1) JP6594303B2 (enExample)
CN (1) CN105636585B (enExample)
AU (2) AU2014353235B2 (enExample)
CA (1) CA2930461C (enExample)
IL (2) IL244731B (enExample)
WO (1) WO2015077143A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020252284A1 (en) * 2019-06-13 2020-12-17 Imbucanna, Inc Compressible cannabinoid pharmaceutical composition

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10232113A1 (de) * 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
US7687641B2 (en) * 2003-06-20 2010-03-30 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7737168B2 (en) * 2003-06-20 2010-06-15 Siga Technologies, Inc. Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
UA97349C2 (uk) * 2005-09-08 2012-02-10 Х. Луннбэк А/С Стійкі тверді склади сертиндолу
CA2685153C (en) * 2007-04-23 2014-12-16 Siga Technologies, Inc. Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
CN101445478B (zh) 2008-08-22 2011-04-06 中国人民解放军军事医学科学院生物工程研究所 含一个结晶水的化合物st-246及其晶体与制备方法
JP2011041888A (ja) * 2009-08-20 2011-03-03 Nippon Soda Co Ltd ジェットミル粉砕条件の最適化方法
EP2549871B1 (en) * 2010-03-23 2018-08-22 Siga Technologies, Inc. Polymorphic form st-246 and methods of preparation
SG10202105262QA (en) * 2010-08-05 2021-06-29 Siga Technologies Inc St-246 liquid formulations and methods

Also Published As

Publication number Publication date
IL282098A (en) 2021-05-31
CN105636585B (zh) 2020-02-07
EP3043793A1 (en) 2016-07-20
JP2016537318A (ja) 2016-12-01
EP3043793B1 (en) 2021-01-06
CN105636585A (zh) 2016-06-01
CA2930461C (en) 2022-08-16
AU2014353235A1 (en) 2016-04-21
CA2930461A1 (en) 2015-05-28
IL282098B1 (en) 2023-01-01
AU2019208252B2 (en) 2020-03-19
WO2015077143A1 (en) 2015-05-28
AU2014353235B2 (en) 2019-05-09
US10716759B2 (en) 2020-07-21
IL244731A0 (en) 2016-04-21
US10406103B2 (en) 2019-09-10
US20160235676A1 (en) 2016-08-18
IL244731B (en) 2021-05-31
IL282098B2 (en) 2023-05-01
EP3043793A4 (en) 2017-05-10
US20190380966A1 (en) 2019-12-19
AU2019208252A1 (en) 2019-08-15

Similar Documents

Publication Publication Date Title
JP5657489B2 (ja) オルトポックスウイルス感染及び関連疾患を治療及び予防するための化合物、組成物及び方法
US8039504B2 (en) Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US7687641B2 (en) Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
US8802714B2 (en) Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases
WO2008079159A2 (en) Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
JP2023080234A (ja) アモルファステコビリマット調製
JP6594303B2 (ja) 微粒子化テコビリマット一水和物の再水和
JP6564514B2 (ja) テコビリマットの調製方法
CN116531384B (zh) 一种组合物及其制备方法和用途
AU2012268859B2 (en) Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
AU2016208315A1 (en) Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171113

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171113

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180709

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181009

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190304

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190531

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190701

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190808

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190826

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190924

R150 Certificate of patent or registration of utility model

Ref document number: 6594303

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250