JP6586087B2 - Ｐｄ−１アンタゴニストとジナシクリブとの組合せでの癌治療 - Google Patents

Ｐｄ−１アンタゴニストとジナシクリブとの組合せでの癌治療 Download PDF

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JP6586087B2
JP6586087B2 JP2016536326A JP2016536326A JP6586087B2 JP 6586087 B2 JP6586087 B2 JP 6586087B2 JP 2016536326 A JP2016536326 A JP 2016536326A JP 2016536326 A JP2016536326 A JP 2016536326A JP 6586087 B2 JP6586087 B2 JP 6586087B2
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cancer
cell
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compound
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JP2016528286A (ja
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ストラツク，ピーター・リチヤード
ブーハー，ロバート
スリラム，ベンカタラマン
フイリツプス，ジヨセフ・エイチ
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Merck Sharp and Dohme LLC
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152

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  • General Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016536326A 2013-08-20 2014-08-15 Ｐｄ−１アンタゴニストとジナシクリブとの組合せでの癌治療 Active JP6586087B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361867760P 2013-08-20 2013-08-20
US61/867,760 2013-08-20
PCT/US2014/051171 WO2015026634A1 (fr) 2013-08-20 2014-08-15 Traitement du cancer avec une combinaison d'un antagoniste de pd-1 et du dinaciclib

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JP2016528286A JP2016528286A (ja) 2016-09-15
JP6586087B2 true JP6586087B2 (ja) 2019-10-02

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US (1) US9827309B2 (fr)
EP (1) EP3035964B1 (fr)
JP (1) JP6586087B2 (fr)
KR (1) KR102232153B1 (fr)
CN (1) CN105451770B (fr)
AU (1) AU2014309199B2 (fr)
CA (1) CA2920113A1 (fr)
ES (1) ES2827679T3 (fr)
MX (1) MX2016002273A (fr)
RU (1) RU2705795C2 (fr)
WO (1) WO2015026634A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022004760A1 (fr) 2020-06-30 2022-01-06 塩野義製薬株式会社 Utilisation combinée d'un anticorps anti-ccr8 et d'un agent chimiothérapeutique

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022004760A1 (fr) 2020-06-30 2022-01-06 塩野義製薬株式会社 Utilisation combinée d'un anticorps anti-ccr8 et d'un agent chimiothérapeutique

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US20160193334A1 (en) 2016-07-07
RU2016109811A3 (fr) 2018-06-19
AU2014309199B2 (en) 2018-04-19
RU2016109811A (ru) 2017-09-22
ES2827679T3 (es) 2021-05-24
KR20160044480A (ko) 2016-04-25
EP3035964A1 (fr) 2016-06-29
US9827309B2 (en) 2017-11-28
JP2016528286A (ja) 2016-09-15
AU2014309199A1 (en) 2016-02-18
CN105451770A (zh) 2016-03-30
EP3035964B1 (fr) 2020-09-23
EP3035964A4 (fr) 2017-03-15
MX2016002273A (es) 2016-05-31
RU2705795C2 (ru) 2019-11-12
KR102232153B1 (ko) 2021-03-24
CA2920113A1 (fr) 2015-02-26
CN105451770B (zh) 2020-02-07
WO2015026634A1 (fr) 2015-02-26

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