JP6572130B2 - 内皮機能不全及び炎症の疾患の治療 - Google Patents

内皮機能不全及び炎症の疾患の治療 Download PDF

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JP6572130B2
JP6572130B2 JP2015546770A JP2015546770A JP6572130B2 JP 6572130 B2 JP6572130 B2 JP 6572130B2 JP 2015546770 A JP2015546770 A JP 2015546770A JP 2015546770 A JP2015546770 A JP 2015546770A JP 6572130 B2 JP6572130 B2 JP 6572130B2
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JP2016504311A (ja
JP2016504311A5 (cg-RX-API-DMAC7.html
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グレゴリー キンプトン、ウェイン
グレゴリー キンプトン、ウェイン
リーヴズ ベイリー、サイモン
リーヴズ ベイリー、サイモン
イテシュー、シルビウ
ゴーシュ、ピーター
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メソブラスト、インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
JP2015546770A 2012-12-12 2013-12-12 内皮機能不全及び炎症の疾患の治療 Active JP6572130B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261736361P 2012-12-12 2012-12-12
US61/736,361 2012-12-12
PCT/AU2013/001452 WO2014089623A1 (en) 2012-12-12 2013-12-12 Treatment of diseases of endothelial dysfunction and inflammation

Related Child Applications (1)

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JP2019123243A Division JP6829288B2 (ja) 2012-12-12 2019-07-01 内皮機能不全及び炎症の疾患の治療

Publications (3)

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JP2016504311A JP2016504311A (ja) 2016-02-12
JP2016504311A5 JP2016504311A5 (cg-RX-API-DMAC7.html) 2017-01-19
JP6572130B2 true JP6572130B2 (ja) 2019-09-04

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Family Applications (5)

Application Number Title Priority Date Filing Date
JP2015546770A Active JP6572130B2 (ja) 2012-12-12 2013-12-12 内皮機能不全及び炎症の疾患の治療
JP2019123243A Active JP6829288B2 (ja) 2012-12-12 2019-07-01 内皮機能不全及び炎症の疾患の治療
JP2021008250A Active JP7201715B2 (ja) 2012-12-12 2021-01-21 内皮機能不全及び炎症の疾患の治療
JP2022206042A Pending JP2023030116A (ja) 2012-12-12 2022-12-22 内皮機能不全及び炎症の疾患の治療
JP2024111736A Pending JP2024147655A (ja) 2012-12-12 2024-07-11 内皮機能不全及び炎症の疾患の治療

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JP2019123243A Active JP6829288B2 (ja) 2012-12-12 2019-07-01 内皮機能不全及び炎症の疾患の治療
JP2021008250A Active JP7201715B2 (ja) 2012-12-12 2021-01-21 内皮機能不全及び炎症の疾患の治療
JP2022206042A Pending JP2023030116A (ja) 2012-12-12 2022-12-22 内皮機能不全及び炎症の疾患の治療
JP2024111736A Pending JP2024147655A (ja) 2012-12-12 2024-07-11 内皮機能不全及び炎症の疾患の治療

Country Status (11)

Country Link
US (2) US20160175360A1 (cg-RX-API-DMAC7.html)
EP (2) EP2931876B1 (cg-RX-API-DMAC7.html)
JP (5) JP6572130B2 (cg-RX-API-DMAC7.html)
KR (3) KR102217962B1 (cg-RX-API-DMAC7.html)
CN (2) CN111840329B (cg-RX-API-DMAC7.html)
AU (4) AU2013360024B2 (cg-RX-API-DMAC7.html)
CA (1) CA2893942C (cg-RX-API-DMAC7.html)
ES (1) ES2742035T3 (cg-RX-API-DMAC7.html)
IL (1) IL239308A0 (cg-RX-API-DMAC7.html)
SG (2) SG10201705061RA (cg-RX-API-DMAC7.html)
WO (1) WO2014089623A1 (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101939417B (zh) 2007-12-04 2014-02-05 蛋白生物动力私人有限公司 祖细胞的保护和它们的分化的调节
ES2742035T3 (es) * 2012-12-12 2020-02-12 Mesoblast Inc Tratamiento de las enfermedades de la disfunción y la inflamación endotelial
JPWO2022114111A1 (cg-RX-API-DMAC7.html) * 2020-11-27 2022-06-02

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
AU8200191A (en) 1990-07-09 1992-02-04 United States of America, as represented by the Secretary, U.S. Department of Commerce, The High efficiency packaging of mutant adeno-associated virus using amber suppressions
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
ATE237694T1 (de) 1991-08-20 2003-05-15 Us Gov Health & Human Serv Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
PT1493439E (pt) * 1997-04-02 2012-01-10 Brigham & Womens Hospital Meio de avaliação do perfil de risco de um indivíduo para uma doença aterosclerótica
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
AU2003901668A0 (en) 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
DE19939781C2 (de) 1999-08-21 2003-06-18 Schott Glas Skulltiegel für das Erschmelzen oder das Läutern von anorganischen Substanzen, insbesondere von Gläsern und Glaskeramiken
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
CN102391981B (zh) 2004-09-24 2014-08-20 麦索布莱斯特公司 多能扩增间充质前体细胞子代(memp)及其应用
WO2006108229A1 (en) 2005-04-12 2006-10-19 Angioblast Systems, Inc. Isolation of adult multipotential cells by tissue non-specific alkaline phosphatase
WO2006121445A2 (en) * 2005-05-10 2006-11-16 United States Of America Department Of Veteran's Affairs Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media
US20080260703A1 (en) * 2007-04-23 2008-10-23 Medistem Labortories Treatment of Insulin Resistance and Diabetes
CA2743682A1 (en) * 2007-11-30 2009-06-11 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
CA2743698A1 (en) * 2007-11-30 2009-06-11 New York Medical College Compositions comprising vascular and myocyte progenitor cells and methods of their use
CN101939417B (zh) * 2007-12-04 2014-02-05 蛋白生物动力私人有限公司 祖细胞的保护和它们的分化的调节
CN102076844B (zh) * 2008-06-30 2013-08-07 成血管细胞系统公司 采用组合疗法的眼病和过度血管新生的治疗
CN104546912B (zh) * 2008-11-20 2019-11-08 中胚有限公司 用于治疗胰功能异常的方法
WO2010138180A2 (en) * 2009-05-26 2010-12-02 The University Of Vermont And State Agriculture College Compositions and methods for cardiac tissue repair
WO2011073521A1 (en) * 2009-12-15 2011-06-23 Petri Salven Methods for enriching adult-derived endothelial progenitor cells and uses thereof
US20120195969A1 (en) * 2010-09-29 2012-08-02 Aidan Research And Consulting, Llc Treatment of acne by conditioned media
US9405700B2 (en) 2010-11-04 2016-08-02 Sonics, Inc. Methods and apparatus for virtualization in an integrated circuit
CA2837895C (en) * 2011-06-03 2021-07-27 Mesoblast, Inc. Methods of treating or preventing neurological diseases
ES3013463T3 (en) * 2011-07-04 2025-04-14 Mesoblast Inc Treating or preventing rheumatic disease
CA2880808C (en) * 2012-08-01 2023-01-24 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
ES2742035T3 (es) * 2012-12-12 2020-02-12 Mesoblast Inc Tratamiento de las enfermedades de la disfunción y la inflamación endotelial
ES2963968T3 (es) * 2013-01-09 2024-04-03 United Therapeutics Corp Tratamiento de la vasculopatía con prostaciclina y células madre mesenquimatosas

Also Published As

Publication number Publication date
AU2021250848A1 (en) 2021-11-04
CN111840329A (zh) 2020-10-30
CN105358163B (zh) 2020-09-11
AU2013360024B2 (en) 2019-02-28
CA2893942C (en) 2023-03-28
EP2931876A4 (en) 2016-05-25
AU2013360024A1 (en) 2015-07-02
US20240115618A1 (en) 2024-04-11
JP2021073240A (ja) 2021-05-13
JP2024147655A (ja) 2024-10-16
EP2931876A1 (en) 2015-10-21
IL239308A0 (en) 2015-07-30
AU2019202960B2 (en) 2021-07-29
KR102367981B1 (ko) 2022-02-25
EP3556850A1 (en) 2019-10-23
CN105358163A (zh) 2016-02-24
WO2014089623A1 (en) 2014-06-19
US20160175360A1 (en) 2016-06-23
JP2023030116A (ja) 2023-03-07
AU2019202960A1 (en) 2019-05-16
KR20220029758A (ko) 2022-03-08
SG10201705061RA (en) 2017-07-28
KR102217962B1 (ko) 2021-02-22
JP2016504311A (ja) 2016-02-12
JP2019214571A (ja) 2019-12-19
SG11201504340YA (en) 2015-07-30
CN111840329B (zh) 2024-10-15
JP7201715B2 (ja) 2023-01-10
HK1210209A1 (en) 2016-04-15
KR20210021104A (ko) 2021-02-24
KR102506612B1 (ko) 2023-03-06
EP2931876B1 (en) 2019-05-29
KR20150093732A (ko) 2015-08-18
JP6829288B2 (ja) 2021-02-10
CA2893942A1 (en) 2014-06-19
ES2742035T3 (es) 2020-02-12
AU2024227208A1 (en) 2024-10-31

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