SG10201705061RA - Treatment of Diseases of Endothelial Dysfunction and Inflammation - Google Patents

Treatment of Diseases of Endothelial Dysfunction and Inflammation

Info

Publication number
SG10201705061RA
SG10201705061RA SG10201705061RA SG10201705061RA SG10201705061RA SG 10201705061R A SG10201705061R A SG 10201705061RA SG 10201705061R A SG10201705061R A SG 10201705061RA SG 10201705061R A SG10201705061R A SG 10201705061RA SG 10201705061R A SG10201705061R A SG 10201705061RA
Authority
SG
Singapore
Prior art keywords
inflammation
diseases
treatment
endothelial dysfunction
dysfunction
Prior art date
Application number
SG10201705061RA
Inventor
Itescu Silviu
Ghosh Peter
Gregory KIMPTON Wayne
Reeves Bailey Simon
Original Assignee
Mesoblast Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mesoblast Inc filed Critical Mesoblast Inc
Publication of SG10201705061RA publication Critical patent/SG10201705061RA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
SG10201705061RA 2012-12-12 2013-12-12 Treatment of Diseases of Endothelial Dysfunction and Inflammation SG10201705061RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261736361P 2012-12-12 2012-12-12

Publications (1)

Publication Number Publication Date
SG10201705061RA true SG10201705061RA (en) 2017-07-28

Family

ID=50933585

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201705061RA SG10201705061RA (en) 2012-12-12 2013-12-12 Treatment of Diseases of Endothelial Dysfunction and Inflammation
SG11201504340YA SG11201504340YA (en) 2012-12-12 2013-12-12 Treatment of diseases of endothelial dysfunction and inflammation

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201504340YA SG11201504340YA (en) 2012-12-12 2013-12-12 Treatment of diseases of endothelial dysfunction and inflammation

Country Status (12)

Country Link
US (2) US20160175360A1 (en)
EP (2) EP3556850A1 (en)
JP (4) JP6572130B2 (en)
KR (3) KR102217962B1 (en)
CN (2) CN105358163B (en)
AU (3) AU2013360024B2 (en)
CA (1) CA2893942C (en)
ES (1) ES2742035T3 (en)
HK (1) HK1210209A1 (en)
IL (1) IL239308A0 (en)
SG (2) SG10201705061RA (en)
WO (1) WO2014089623A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101923152B1 (en) 2007-12-04 2018-11-28 프로테오바이오엑티브스 피티와이 엘티디 Protection of progenitor cells and regulation of their differentiation
WO2022114111A1 (en) * 2020-11-27 2022-06-02 マルホ株式会社 Pharmaceutical or cosmetic composition

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
WO1992001070A1 (en) 1990-07-09 1992-01-23 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce High efficiency packaging of mutant adeno-associated virus using amber suppressions
US5173414A (en) 1990-10-30 1992-12-22 Applied Immune Sciences, Inc. Production of recombinant adeno-associated virus vectors
JP3534749B2 (en) 1991-08-20 2004-06-07 アメリカ合衆国 Adenovirus-mediated gene transfer into the gastrointestinal tract
ES2239801T3 (en) * 1997-04-02 2005-10-01 The Brigham And Women's Hospital, Inc. USE OF AN AGENT TO DECREASE THE RISK OF CARDIOVASCULAR DISEASE.
AUPQ147799A0 (en) 1999-07-07 1999-07-29 Medvet Science Pty. Ltd. Mesenchymal precursor cell
AU2003901668A0 (en) * 2003-03-28 2003-05-01 Medvet Science Pty. Ltd. Non-haemopoietic precursor cells
DE19939781C2 (en) 1999-08-21 2003-06-18 Schott Glas Skull crucible for melting or refining inorganic substances, especially glasses and glass ceramics
ES2710099T3 (en) 2004-09-24 2019-04-23 Mesoblast Inc Progeny of multipotential expanded mesenchymal precursor cells (MEMP) and their uses
JP5462483B2 (en) 2005-04-12 2014-04-02 メゾブラスト,インコーポレーテッド Isolation of adult pluripotent cells by tissue non-specific alkaline phosphatase
WO2006121445A2 (en) 2005-05-10 2006-11-16 United States Of America Department Of Veteran's Affairs Therapy of kidney diseases and multiorgan failure with mesenchymal stem cells and mesenchymal stem cell conditioned media
US20080260703A1 (en) * 2007-04-23 2008-10-23 Medistem Labortories Treatment of Insulin Resistance and Diabetes
KR101923152B1 (en) * 2007-12-04 2018-11-28 프로테오바이오엑티브스 피티와이 엘티디 Protection of progenitor cells and regulation of their differentiation
SG10201510586PA (en) * 2008-06-30 2016-01-28 Mesoblast Inc Treatment of Eye Diseases And Excessive Neovascularization Using A Combined Therapy
KR102011609B1 (en) * 2008-11-20 2019-08-16 메소블라스트, 아이엔씨. Method for treating or preventing a pancreatic dysfunction
WO2010138180A2 (en) * 2009-05-26 2010-12-02 The University Of Vermont And State Agriculture College Compositions and methods for cardiac tissue repair
WO2012047733A2 (en) * 2010-09-29 2012-04-12 Aidan Research And Consulting, Llc. Treatment of acne by conditioned media
US9405700B2 (en) 2010-11-04 2016-08-02 Sonics, Inc. Methods and apparatus for virtualization in an integrated circuit
US10206951B2 (en) * 2011-06-03 2019-02-19 Mesoblast, Inc. Methods of treating multiple sclerosis using STRO-1+ and TNAP+ multipotential cells
CN110051693A (en) * 2011-07-04 2019-07-26 麦瑟布莱斯特公司 The method for treating or preventing rheumatic disease
CA2880808C (en) * 2012-08-01 2023-01-24 United Therapeutics Corporation Treatment of pulmonary arterial hypertension with mesenchymal stem cells
EP3415150B1 (en) * 2013-01-09 2021-08-18 United Therapeutics Corporation Treatment of vasculopathy with prostacyclin and mesenchymal stem cells

Also Published As

Publication number Publication date
SG11201504340YA (en) 2015-07-30
JP2019214571A (en) 2019-12-19
CA2893942A1 (en) 2014-06-19
JP6572130B2 (en) 2019-09-04
US20160175360A1 (en) 2016-06-23
AU2013360024A1 (en) 2015-07-02
JP2023030116A (en) 2023-03-07
KR102217962B1 (en) 2021-02-22
JP7201715B2 (en) 2023-01-10
AU2013360024B2 (en) 2019-02-28
HK1210209A1 (en) 2016-04-15
KR20210021104A (en) 2021-02-24
EP2931876B1 (en) 2019-05-29
WO2014089623A1 (en) 2014-06-19
AU2021250848A1 (en) 2021-11-04
AU2019202960B2 (en) 2021-07-29
KR20150093732A (en) 2015-08-18
AU2019202960A1 (en) 2019-05-16
JP6829288B2 (en) 2021-02-10
JP2021073240A (en) 2021-05-13
IL239308A0 (en) 2015-07-30
CN105358163A (en) 2016-02-24
CA2893942C (en) 2023-03-28
EP3556850A1 (en) 2019-10-23
JP2016504311A (en) 2016-02-12
EP2931876A4 (en) 2016-05-25
ES2742035T3 (en) 2020-02-12
EP2931876A1 (en) 2015-10-21
KR20220029758A (en) 2022-03-08
KR102367981B1 (en) 2022-02-25
US20240115618A1 (en) 2024-04-11
KR102506612B1 (en) 2023-03-06
CN111840329A (en) 2020-10-30
CN105358163B (en) 2020-09-11

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