JP6546090B2 - 退縮可能なシース・デバイス、システム、及び方法 - Google Patents
退縮可能なシース・デバイス、システム、及び方法 Download PDFInfo
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- JP6546090B2 JP6546090B2 JP2015531175A JP2015531175A JP6546090B2 JP 6546090 B2 JP6546090 B2 JP 6546090B2 JP 2015531175 A JP2015531175 A JP 2015531175A JP 2015531175 A JP2015531175 A JP 2015531175A JP 6546090 B2 JP6546090 B2 JP 6546090B2
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- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/041—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
- A61L29/085—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/146—Porous materials, e.g. foams or sponges
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/962—Instruments specially adapted for placement or removal of stents or stent-grafts having an outer sleeve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2/958—Inflatable balloons for placing stents or stent-grafts
- A61F2002/9583—Means for holding the stent on the balloon, e.g. using protrusions, adhesives or an outer sleeve
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/105—Balloon catheters with special features or adapted for special applications having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1081—Balloon catheters with special features or adapted for special applications having sheaths or the like for covering the balloon but not forming a permanent part of the balloon, e.g. retractable, dissolvable or tearable sheaths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M25/00—Catheters; Hollow probes
- A61M25/10—Balloon catheters
- A61M2025/1043—Balloon catheters with special features or adapted for special applications
- A61M2025/1086—Balloon catheters with special features or adapted for special applications having a special balloon surface topography, e.g. pores, protuberances, spikes or grooves
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Description
本質的に米国特許第6,120,477号明細書(Campbell他)に教示されている方法を用いて、構造カバーを調製した。20層の高フィブリル化された5ミクロン厚のePTFEフィルム(Bacinoの米国特許第5,476,589号明細書)をチューブ軸線に対して83.4°の角度を成して螺旋状に7mmのステンレス鋼マンドレルに巻き付けることによって、フィルムチューブを形成した。10層のePTFEを一方の方向に巻き付け、10層を反対方向に巻き付けた。マンドレルを炉装置内で、380℃で6分間にわたって焼成することにより層を融合させた。その結果生じたチューブをマンドレルから取り外し、そして、2.2mm未満の直径まで「ネッキングした」(延伸させた)。ネッキングしたこのチューブを2.2mmのステンレス鋼マンドレルに置き、約5層の犠牲ePTFEフィルムを上から巻き付けることにより、後続工程でチューブに皺が生じるのを防止した。次に、チューブ集成体を元の長さの約65%まで均一に圧縮した。集成体を380℃の炉装置内に1分間にわたって置き、続いて犠牲ePTFE層を除去した。この集成体をマンドレルから取り外し、そして、65.0mm長に切断した。別の実施態様では、この構造層は下側に位置するバルーンの再圧密化を支援するためにエラストマーを含んでもよい(例えばCampbell他の米国特許第6,120,477号明細書を参照)。
セミコンプライアント型のバルーンカテーテルをBavaria Medizin Technologie, Oberpfaffenhofen, Germanyから購入した(モデル番号BMT-035、品番08PL-604A、バルーン寸法6.0mm×40mm)。バルーンの仕様は以下の通りである:公称膨張圧力6気圧(atm)、定格破裂圧力14atm、公称直径6mm、バルーン作業長40mmのナイロンバルーン、0.9mmのガイドワイヤ適合カテーテルに載置。
ポリビニルアルコール(PVA、USPグレード、Spectrum Chemicals & Laboratory Products, Gardena, CA)の5wt%水溶液を調製した。この溶液をここでは溶液3と呼ぶ。実施例2に記載されているように構造チューブをバルーンカテーテル上に組み付け、そして回転させながら溶液3で30秒間にわたって浸漬被覆した。30秒後、デバイスを溶液3から取り出した。デバイスを回転させながら、ヒートガンを使用して(約40℃の)熱風をデバイスに約3分間にわたって吹きつけた。次いでこのプロセスをさらに2回繰り返した。次に、デバイスを60℃の炉装置内に約10分間にわたって入れた。
以下の方法を用いて外側シース層を調製した。図11Aに示されているように、(Branca他の米国特許第5,814,405号明細書に記載されるような)薄型ePTFEフィルムを50%オーバーラップさせた状態でチューブ軸線に対してほぼ45°の角度を成して6mmのステンレス鋼製マンドレルに少なくとも1つのパスで螺旋状に巻き付けることによって、外側シース層を調製した。ePTFE層を含むマンドレルを炉装置内で380℃で3分間にわたって焼成することにより層を融合させた。図11Bに示されているように、その結果生じたチューブをマンドレルから取り外した。マンドレルから取り外した後、チューブを平坦化し、バルーン、構造層、及び被膜の周りに螺旋状に巻き付けることによって、外側シース層を形成し、これをバルーンの遠位端及び近位端に取り付け、余剰の長さをトリミングして取り除いた。具体的には、結合された区域をLoctite 7701プライマー (Henkel AG & Co. KgaA, Duesseldorf, Germany)で湿潤した。次いで、5層の6.4mm幅のePTFEフィルムを使用して、外側シース層の端部をバルーンに固定的に取り付けた。具体的には、ePTFEフィルム層をバルーン端部の周りに周方向に巻き付ける一方、Loctite 4981 (Henkel AG & Co. KgaA, Duesseldorf, Germany)をフィルムに塗布した。薬物送達バルーンは図11Cに非拡張状態で示されている。
Claims (23)
- 医療デバイスであって:
a.外面を有する拡張可能な部材と、
b.前記拡張可能な部材の周りに配置された治療薬を含む被膜と、
c.前記拡張可能な部材の外側表面に沿って、平坦化された形態を有するネッキング可能なエレメントを含むシースと、
を含み;
ここで、前記ネッキング可能なエレメントは、離散した1層の材料層であり、該離散した1層の材料層は、非拡張状態にある前記拡張可能な部材の周りに螺旋状、長手方向、又は周方向に巻き付けられているとき、前記離散した1層の材料層の縁が互いに隣接しかつオーバーラップするか又は触れるよう、前記材料層の縁により画定される幅を有する;
d.前記拡張可能な部材が拡張されると、前記ネッキング可能なエレメントが伸長して幅が少なくとも2分の1に減少し、前記離散した1層の材料層の縁が互いに離れるようになり、これにより前記外面の少なくとも一部を露出させるように構成されている、
医療デバイス。 - 前記ネッキング可能なエレメントが内腔を有するチューブ形態を含む、請求項1に記載の医療デバイス。
- 前記チューブ形態が螺旋状に巻き付けられている、請求項2に記載の医療デバイス。
- 前記被膜が、塩化ベンゼトニウム、PEG、ポロキサマー、サリチル酸ナトリウム、及びヒドロキシプロピル−β−シクロデキストリンから成る群から選択された少なくとも1つの化合物を含む、請求項1に記載の医療デバイス。
- 前記治療薬が親水性薬剤である、請求項1に記載の医療デバイス。
- 前記治療薬が疎水性薬剤である、請求項1に記載の医療デバイス。
- 前記ネッキング可能なエレメントが、前記治療薬の大量転移を制限して水和を可能にする透過性マイクロ構造を含む、請求項1に記載の医療デバイス。
- 前記シースが、圧潰された形態では、下側に位置する表面の100%を覆い、拡張時には前記シースは該下側に位置する表面の30%未満を覆う、請求項1に記載の医療デバイス。
- 前記シースが、圧潰された形態では、下側に位置する表面の100%を覆い、拡張時には前記シースは該下側に位置する表面の20%未満を覆う、請求項1に記載の医療デバイス。
- 前記シースが湿潤剤で処理されている、請求項1に記載の医療デバイス。
- 前記湿潤剤が、ヘパリン被膜、ポリビニルアルコール、ポリエチレングリコール、ポリプロピレングリコール、デキストラン、アガロース、アルギネート、ポリアクリルアミド、ポリグリシドール、ポリ(ビニルアルコール−コ−エチレン)、ポリ(エチレングリコール−コ−プロピレングリコール)、ポリ(ビニルアセテート−コ−ビニルアルコール)、ポリ(テトラフルオロエチレン−コ−ビニルアルコール)、ポリ(アクリロニトリル−コ−アクリルアミド)、ポリ(アクリロニトリル−コ−アクリル酸−コ−アクリルアミジン)、ポリアクリル酸、ポリリシン、ポリエチレンイミン、ポリビニルピロリドン、ポリヒドロキシエチルメタクリレート、及びポリスルホン、及びこれらのコポリマーから成る群から、単独又は組み合わせて選択される、請求項10に記載の医療デバイス。
- 前記湿潤剤がポリビニルアルコールである、請求項10に記載の医療デバイス。
- 前記シースがウェットアウトしている、請求項1に記載の医療デバイス。
- 前記シースが、挿入前準備処置(preinsertion preparatory procedure)の結果として湿潤される、請求項1に記載の医療デバイス。
- 前記拡張可能な部材が非拡張状態にあり、管状器官内部の所望の個所へ送達されているときに、前記シースが管状器官内で肉眼的に湿潤される、請求項1に記載の医療デバイス。
- 前記シースの外部に位置する流体が、前記シースを貫流して治療薬と接触することができる、請求項1に記載の医療デバイス。
- 前記拡張可能な部材が医療用バルーンである、請求項1に記載の医療デバイス。
- 前記シースが、親水性モノマーを含むテトラフルオロエチレンコポリマーを含む、請求項1に記載の医療デバイス。
- 前記シースがフルオロポリマー、ポリアミド、ポリウレタン、ポリオレフィン、ポリエステル、ポリグリコール酸、ポリ乳酸、及びトリメチレンカーボネートから成る群からの少なくとも1種の材料を含む、請求項1に記載の医療デバイス。
- 前記シースが、選択的に透過性のマイクロ構造を含むフルオロポリマーを含む、請求項1に記載の医療デバイス。
- 前記シースがePTFEを含む、請求項1に記載の医療デバイス。
- 前記拡張可能な部材がさらに構造層を含む、請求項1に記載の医療デバイス。
- 前記構造層が被膜と治療薬とを含む、請求項22に記載の医療デバイス。
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US61/789,949 | 2013-03-15 | ||
US14/018,053 US10173038B2 (en) | 2012-09-05 | 2013-09-04 | Retractable sheath devices, systems, and methods |
US14/018,053 | 2013-09-04 | ||
PCT/US2013/058171 WO2014039626A1 (en) | 2012-09-05 | 2013-09-05 | Retractable sheath devices, systems, and methods |
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Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9622888B2 (en) | 2006-11-16 | 2017-04-18 | W. L. Gore & Associates, Inc. | Stent having flexibly connected adjacent stent elements |
US8926688B2 (en) | 2008-01-11 | 2015-01-06 | W. L. Gore & Assoc. Inc. | Stent having adjacent elements connected by flexible webs |
WO2009117158A2 (en) | 2008-03-21 | 2009-09-24 | Innovasc Llc | Device and method for opening blood vessels by pre-angioplasty serration and dilatation of aetherosclerotic plaque |
US9480826B2 (en) | 2008-03-21 | 2016-11-01 | Cagent Vascular, Llc | Intravascular device |
US11219750B2 (en) | 2008-03-21 | 2022-01-11 | Cagent Vascular, Inc. | System and method for plaque serration |
US10010654B2 (en) | 2012-10-30 | 2018-07-03 | W. L. Gore & Associates, Inc. | Sleeve for medical device assembly |
US10179227B2 (en) * | 2013-03-12 | 2019-01-15 | Acclarent, Inc. | Resilient tube over dilator balloon |
US10383979B2 (en) * | 2013-05-16 | 2019-08-20 | The George Washington University, A Congressionally Chartered Not-For-Profit Corporation | Myocyte-derived flow assist device: extravasal sheaths of rhythmically contracting myocytes aiding flow of biological fluids |
WO2015179631A1 (en) | 2014-05-21 | 2015-11-26 | The Regents Of The University Of Michigan | Fenestrated decoupling system for internal selective attachment to soft tissue organs |
US10463842B2 (en) | 2014-06-04 | 2019-11-05 | Cagent Vascular, Llc | Cage for medical balloon |
JP2016016122A (ja) * | 2014-07-08 | 2016-02-01 | テルモ・クリニカルサプライ株式会社 | シアノアクリレート系塞栓物質含有液体吐出用カテーテルおよびシアノアクリレート系塞栓物質含有液体吐出用具 |
US10569063B2 (en) * | 2014-10-03 | 2020-02-25 | W. L. Gore & Associates, Inc. | Removable covers for drug eluting medical devices |
WO2016061692A1 (en) * | 2014-10-22 | 2016-04-28 | Jmd Innovation | Anti-adhesion intrauterine balloon |
US10471238B2 (en) | 2014-11-03 | 2019-11-12 | Cagent Vascular, Llc | Serration balloon |
US10299948B2 (en) | 2014-11-26 | 2019-05-28 | W. L. Gore & Associates, Inc. | Balloon expandable endoprosthesis |
US10117738B2 (en) | 2015-01-23 | 2018-11-06 | The Regents Of The University Of Michigan | Atraumatic tip geometry for indwelling devices |
CN107666872B (zh) * | 2015-02-26 | 2021-05-18 | 舒尔默迪克斯公司 | 具有斑块治疗部分的可插入医疗装置系统及其使用方法 |
WO2016160905A1 (en) * | 2015-03-31 | 2016-10-06 | Transmed7, Llc | Devices and methods for vascular interventions |
US10166374B2 (en) | 2015-09-17 | 2019-01-01 | Cagent Vascular, Llc | Wedge dissectors for a medical balloon |
EP3383246A4 (en) | 2015-12-05 | 2019-08-07 | The Regents of the University of Colorado, a body corporate | NOVEL ENDOSCOPIC DEVICES AND METHODS OF USE |
US10792477B2 (en) | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
EP3413964A4 (en) * | 2016-02-08 | 2019-12-04 | Orbusneich Medical Pte. Ltd | DRUG-LEANING BALLOON |
JP6704277B2 (ja) * | 2016-03-29 | 2020-06-03 | テルモ株式会社 | 医療用長尺体 |
US10940294B2 (en) * | 2016-04-25 | 2021-03-09 | Medtronic Vascular, Inc. | Balloon catheter including a drug delivery sheath |
US10568752B2 (en) | 2016-05-25 | 2020-02-25 | W. L. Gore & Associates, Inc. | Controlled endoprosthesis balloon expansion |
DE102016110815B4 (de) * | 2016-06-13 | 2018-05-17 | Dot Gmbh | Beschichteter Ballonkatheter und Zusammensetzung zur Beschichtung des Ballonkatheters |
CA3044046A1 (en) | 2016-11-16 | 2018-05-24 | Cagent Vascular, Llc | Systems and methods of depositing drug into tissue through serrations |
WO2018093329A1 (en) * | 2016-11-17 | 2018-05-24 | Vascuros Medical Pte Ltd | Drug eluting balloon |
CN111491687B (zh) * | 2017-07-05 | 2023-03-24 | 上海脉科医疗科技有限公司 | 药物递送球囊导管 |
CN109419568B (zh) * | 2017-08-28 | 2023-09-19 | 先健科技(深圳)有限公司 | 覆膜支架 |
US10595874B2 (en) | 2017-09-21 | 2020-03-24 | W. L. Gore & Associates, Inc. | Multiple inflation endovascular medical device |
US10786258B2 (en) * | 2017-09-21 | 2020-09-29 | W. L. Gore & Associates, Inc. | Multiple inflation endovascular medical device |
WO2019143709A1 (en) | 2018-01-16 | 2019-07-25 | The Regents Of The University Of Colorado, A Body Corporate | Medical devices including textured inflatable balloons |
US11577056B2 (en) | 2018-01-16 | 2023-02-14 | Aspero Medical, Inc. | Medical devices including textured inflatable balloons |
US11730928B2 (en) | 2018-01-16 | 2023-08-22 | Aspero Medical, Inc. | Split overtube assembly |
CN108815682B (zh) * | 2018-04-20 | 2021-01-08 | 东莞天天向上医疗科技有限公司 | 一种药物涂层保护球囊导管 |
CN110623779B (zh) * | 2018-06-21 | 2023-07-25 | 连新龙 | 一种介入用防护套 |
EP3826707A4 (en) | 2018-07-25 | 2022-05-18 | Cagent Vascular, Inc. | MEDICAL BALLOON CATHETER WITH IMPROVED PUSHABILITY |
US11259944B2 (en) * | 2019-06-27 | 2022-03-01 | Cook Medical Technologies Llc | Stent deployment system with unwrapping deployment constraint |
CA3167786A1 (en) * | 2020-02-04 | 2021-08-12 | Boston Scientific Scimed, Inc. | Devices, systems, and methods for an instrument accessory |
WO2021161545A1 (ja) * | 2020-02-14 | 2021-08-19 | 日本ライフライン株式会社 | 薬剤投与バルーンカテーテル |
WO2021183614A1 (en) * | 2020-03-11 | 2021-09-16 | Stryker Corporation | Slotted medical devices with fillers |
CN111672018B (zh) * | 2020-06-15 | 2022-08-09 | 上海微创医疗器械(集团)有限公司 | 载药医疗器械及制备方法、药物球囊、药物涂层制备方法 |
CN114159676A (zh) * | 2020-09-09 | 2022-03-11 | 上海鸿脉医疗科技有限公司 | 球囊导管 |
CN113350648A (zh) * | 2021-07-18 | 2021-09-07 | 温州医科大学附属第一医院 | 一种可准确局麻的气管导管 |
GB2612594A (en) * | 2021-11-03 | 2023-05-10 | Arterius Ltd | Drug coated balloon |
Family Cites Families (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3996938A (en) | 1975-07-10 | 1976-12-14 | Clark Iii William T | Expanding mesh catheter |
GB1537448A (en) | 1976-08-20 | 1978-12-29 | Sumitomo Electric Industries | Vascular prostheses and process for production thereof |
USRE32983E (en) | 1983-07-05 | 1989-07-11 | E. I. Du Pont De Nemours And Company | Balloon and manufacture thereof |
USRE33561E (en) | 1983-07-05 | 1991-03-26 | E. I. Du Pont De Nemours And Company | Balloon and manufacture thereof |
US4490421A (en) | 1983-07-05 | 1984-12-25 | E. I. Du Pont De Nemours And Company | Balloon and manufacture thereof |
US4650466A (en) | 1985-11-01 | 1987-03-17 | Angiobrade Partners | Angioplasty device |
DE3821544C2 (de) * | 1988-06-25 | 1994-04-28 | H Prof Dr Med Just | Dilatationskatheter |
DK170965B1 (da) * | 1988-08-31 | 1996-04-09 | Meadox Medicals Inc | Dilatationskateter |
US4906244A (en) | 1988-10-04 | 1990-03-06 | Cordis Corporation | Balloons for medical devices and fabrication thereof |
US5091205A (en) * | 1989-01-17 | 1992-02-25 | Union Carbide Chemicals & Plastics Technology Corporation | Hydrophilic lubricious coatings |
US4902423A (en) | 1989-02-02 | 1990-02-20 | W. L. Gore & Associates, Inc. | Highly air permeable expanded polytetrafluoroethylene membranes and process for making them |
US5066298A (en) | 1989-11-30 | 1991-11-19 | Progressive Angioplasty Systems, Inc. | Article and method of sheathing angioplasty balloons |
US5074871A (en) | 1989-12-07 | 1991-12-24 | Evi Corporation | Catheter atherotome |
US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
US5304121A (en) * | 1990-12-28 | 1994-04-19 | Boston Scientific Corporation | Drug delivery system making use of a hydrogel polymer coating |
DE4018525C2 (de) | 1990-06-09 | 1994-05-05 | Kaltenbach Martin | Katheter mit einem aufweitbaren Bereich |
US5049275A (en) * | 1990-06-15 | 1991-09-17 | Hoechst Celanese Corp. | Modified microporous structures |
US5222971A (en) | 1990-10-09 | 1993-06-29 | Scimed Life Systems, Inc. | Temporary stent and methods for use and manufacture |
US6524274B1 (en) | 1990-12-28 | 2003-02-25 | Scimed Life Systems, Inc. | Triggered release hydrogel drug delivery system |
JP3372950B2 (ja) | 1990-12-28 | 2003-02-04 | ボストン サイエンティフィック コーポレーション | ドラッグデリバリーシステム |
US5893840A (en) | 1991-01-04 | 1999-04-13 | Medtronic, Inc. | Releasable microcapsules on balloon catheters |
US5330428A (en) | 1991-05-14 | 1994-07-19 | Scimed Life Systems, Inc. | Dilatation catheter having a random copolymer balloon |
US5458568A (en) | 1991-05-24 | 1995-10-17 | Cortrak Medical, Inc. | Porous balloon for selective dilatation and drug delivery |
US5318531A (en) | 1991-06-11 | 1994-06-07 | Cordis Corporation | Infusion balloon catheter |
US5213576A (en) | 1991-06-11 | 1993-05-25 | Cordis Corporation | Therapeutic porous balloon catheter |
US5447497A (en) | 1992-08-06 | 1995-09-05 | Scimed Life Systems, Inc | Balloon catheter having nonlinear compliance curve and method of using |
US5269755A (en) | 1992-09-11 | 1993-12-14 | Sherwood Medical Company | Catheter with outer membrane medicament delivery system |
US5348538A (en) | 1992-09-29 | 1994-09-20 | Scimed Life Systems, Inc. | Shrinking balloon catheter having nonlinear or hybrid compliance curve |
US5336178A (en) * | 1992-11-02 | 1994-08-09 | Localmed, Inc. | Intravascular catheter with infusion array |
EP0746362B1 (en) * | 1993-08-23 | 2002-01-16 | Boston Scientific Corporation | Improved balloon catheter |
ES2141928T5 (es) | 1994-03-02 | 2009-04-16 | Boston Scientific Limited | Balones de elastomero de copolimero en bloques para cateter. |
US6171278B1 (en) | 1994-03-02 | 2001-01-09 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US5830182A (en) | 1994-03-02 | 1998-11-03 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US5951941A (en) | 1994-03-02 | 1999-09-14 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US6146356A (en) | 1994-03-02 | 2000-11-14 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US6406457B1 (en) | 1994-03-02 | 2002-06-18 | Scimed Life Systems, Inc. | Block copolymer elastomer catheter balloons |
US5599306A (en) * | 1994-04-01 | 1997-02-04 | Localmed, Inc. | Method and apparatus for providing external perfusion lumens on balloon catheters |
US5478349A (en) | 1994-04-28 | 1995-12-26 | Boston Scientific Corporation | Placement of endoprostheses and stents |
US5562652A (en) | 1994-10-07 | 1996-10-08 | Davis; William M. | Antiseptic medical apparatus |
US5476589A (en) | 1995-03-10 | 1995-12-19 | W. L. Gore & Associates, Inc. | Porpous PTFE film and a manufacturing method therefor |
AU5561296A (en) | 1995-06-07 | 1996-12-30 | W.L. Gore & Associates, Inc. | Fluid treated transparent polytetrafluoroethylene product |
US5609629A (en) | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
US6774278B1 (en) | 1995-06-07 | 2004-08-10 | Cook Incorporated | Coated implantable medical device |
US5814405A (en) | 1995-08-04 | 1998-09-29 | W. L. Gore & Associates, Inc. | Strong, air permeable membranes of polytetrafluoroethylene |
US5868704A (en) | 1995-09-18 | 1999-02-09 | W. L. Gore & Associates, Inc. | Balloon catheter device |
WO1997010807A1 (en) | 1995-09-22 | 1997-03-27 | Gore Hybrid Technologies, Inc. | Improved cell encapsulation device |
US5773019A (en) | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
US5868707A (en) * | 1996-08-15 | 1999-02-09 | Advanced Cardiovascular Systems, Inc. | Protective sheath for catheter balloons |
EP0835673A3 (en) | 1996-10-10 | 1998-09-23 | Schneider (Usa) Inc. | Catheter for tissue dilatation and drug delivery |
US6447540B1 (en) * | 1996-11-15 | 2002-09-10 | Cook Incorporated | Stent deployment device including splittable sleeve containing the stent |
US6306166B1 (en) | 1997-08-13 | 2001-10-23 | Scimed Life Systems, Inc. | Loading and release of water-insoluble drugs |
CA2298543A1 (en) | 1997-08-13 | 1999-02-25 | James Barry | Loading and release of water-insoluble drugs |
US5866561A (en) | 1997-08-21 | 1999-02-02 | Scimed Life Systems, Inc. | Local delivery of estrogen for angiogenesis |
US6284333B1 (en) | 1997-09-10 | 2001-09-04 | Scimed Life Systems, Inc. | Medical devices made from polymer blends containing low melting temperature liquid crystal polymers |
US6364856B1 (en) * | 1998-04-14 | 2002-04-02 | Boston Scientific Corporation | Medical device with sponge coating for controlled drug release |
US6450989B2 (en) * | 1998-04-27 | 2002-09-17 | Artemis Medical, Inc. | Dilating and support apparatus with disease inhibitors and methods for use |
US6074339A (en) | 1998-05-07 | 2000-06-13 | Medtronic Ave, Inc. | Expandable braid device and method for radiation treatment |
US8177743B2 (en) | 1998-05-18 | 2012-05-15 | Boston Scientific Scimed, Inc. | Localized delivery of drug agents |
US6206283B1 (en) | 1998-12-23 | 2001-03-27 | At&T Corp. | Method and apparatus for transferring money via a telephone call |
US6280411B1 (en) | 1998-05-18 | 2001-08-28 | Scimed Life Systems, Inc. | Localized delivery of drug agents |
US7947015B2 (en) | 1999-01-25 | 2011-05-24 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US6955661B1 (en) | 1999-01-25 | 2005-10-18 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents and method of making |
AU3475200A (en) | 1999-01-25 | 2000-08-07 | Atrium Medical Corporation | Expandable fluoropolymer device for delivery of therapeutic agents |
US6395208B1 (en) | 1999-01-25 | 2002-05-28 | Atrium Medical Corporation | Method of making an expandable fluoropolymer device |
US7637886B2 (en) | 1999-01-25 | 2009-12-29 | Atrium Medical Corporation | Expandable fluoropolymer device and method of making |
US7892201B1 (en) | 1999-08-27 | 2011-02-22 | Gore Enterprise Holdings, Inc. | Balloon catheter and method of mounting same |
US6733513B2 (en) | 1999-11-04 | 2004-05-11 | Advanced Bioprosthetic Surfaces, Ltd. | Balloon catheter having metal balloon and method of making same |
US6756094B1 (en) | 2000-02-28 | 2004-06-29 | Scimed Life Systems, Inc. | Balloon structure with PTFE component |
US20020077693A1 (en) * | 2000-12-19 | 2002-06-20 | Barclay Bruce J. | Covered, coiled drug delivery stent and method |
US6716444B1 (en) | 2000-09-28 | 2004-04-06 | Advanced Cardiovascular Systems, Inc. | Barriers for polymer-coated implantable medical devices and methods for making the same |
US6544222B1 (en) | 2000-11-14 | 2003-04-08 | Advanced Cardiovascular Systems, Inc. | Visualization through an opaque medical device component |
US7179251B2 (en) | 2001-01-17 | 2007-02-20 | Boston Scientific Scimed, Inc. | Therapeutic delivery balloon |
US7020529B2 (en) | 2001-05-02 | 2006-03-28 | Gore Enterprise Holdings, Inc. | Defibrillation electrode cover |
JP2004538090A (ja) | 2001-07-23 | 2004-12-24 | ノボバスキュラー インコーポレーテッド | 酸化窒素放出ePTFEコーティング医療用デバイスサンドイッチ |
US6753071B1 (en) | 2001-09-27 | 2004-06-22 | Advanced Cardiovascular Systems, Inc. | Rate-reducing membrane for release of an agent |
US6923787B2 (en) | 2001-12-20 | 2005-08-02 | Scimed Life Systems, Inc. | Catheter having an improved balloon-to-catheter bond |
US6939374B2 (en) | 2001-12-21 | 2005-09-06 | Scimed Life Systems, Inc. | Stents, stenting systems, and related methods for agent delivery |
US20030225439A1 (en) | 2002-05-31 | 2003-12-04 | Cook Alonzo D. | Implantable product with improved aqueous interface characteristics and method for making and using same |
EP2324866B1 (en) | 2002-07-12 | 2014-06-18 | Cook Medical Technologies LLC | Angioplasty balloons drug-coated in an expanded condition |
US20040024448A1 (en) | 2002-08-05 | 2004-02-05 | Chang James W. | Thermoplastic fluoropolymer-coated medical devices |
US20060121080A1 (en) * | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
US8388628B2 (en) | 2003-04-24 | 2013-03-05 | Medtronic, Inc. | Expandable sheath for delivering instruments and agents into a body lumen and methods for use |
US20040230316A1 (en) | 2003-05-12 | 2004-11-18 | Iulian Cioanta | Method for treating the prostate and inhibiting obstruction of the prostatic urethra using biodegradable stents |
US8062270B2 (en) | 2003-07-15 | 2011-11-22 | Spinal Generations, Llc | Method and device for delivering medicine to bone |
WO2005027996A2 (en) | 2003-09-15 | 2005-03-31 | Atrium Medical Corporation | Application of a therapeutic substance to a tissue location using an expandable medical device |
US8431145B2 (en) | 2004-03-19 | 2013-04-30 | Abbott Laboratories | Multiple drug delivery from a balloon and a prosthesis |
EP1773439A4 (en) | 2004-07-14 | 2010-01-20 | By Pass Inc | MATERIAL DISTRIBUTION SYSTEM |
CN101437467A (zh) | 2004-08-13 | 2009-05-20 | 斯特根有限公司 | 具有纳米多孔层的医疗装置及其制造方法 |
US8002742B2 (en) * | 2005-04-22 | 2011-08-23 | Accessclosure, Inc. | Apparatus and methods for sealing a puncture in tissue |
US8048503B2 (en) * | 2005-07-29 | 2011-11-01 | Gore Enterprise Holdings, Inc. | Highly porous self-cohered web materials |
WO2007016348A2 (en) | 2005-07-29 | 2007-02-08 | Cvdevices, Llc | Devices and methods for magnetic tissue support |
US7919108B2 (en) | 2006-03-10 | 2011-04-05 | Cook Incorporated | Taxane coatings for implantable medical devices |
US7875284B2 (en) | 2006-03-10 | 2011-01-25 | Cook Incorporated | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20100021519A1 (en) | 2006-04-27 | 2010-01-28 | Narmada Shenoy | Compositions and Methods for Treating or Preventing Diseases of Body Passageways |
US20080045986A1 (en) | 2006-06-30 | 2008-02-21 | Atheromed, Inc. | Atherectomy devices and methods |
EP2043704B2 (en) | 2006-06-30 | 2017-04-19 | Cook Medical Technologies LLC | Methods of manufacturing and modifying taxane coatings for implantable medical devices |
US20080033476A1 (en) * | 2006-08-07 | 2008-02-07 | Greene Joel M | Catheter balloon with controlled failure sheath |
US20080175887A1 (en) | 2006-11-20 | 2008-07-24 | Lixiao Wang | Treatment of Asthma and Chronic Obstructive Pulmonary Disease With Anti-proliferate and Anti-inflammatory Drugs |
US8414910B2 (en) * | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
JP5557373B2 (ja) | 2006-11-21 | 2014-07-23 | アボット ラボラトリーズ | 薬剤溶出性コーティングにおけるテトラフルオロエチレン、ヘキサフルオロプロピレン、及びフッ化ビニリデンのターポリマーの使用 |
US20080140002A1 (en) * | 2006-12-06 | 2008-06-12 | Kamal Ramzipoor | System for delivery of biologically active substances with actuating three dimensional surface |
WO2009005779A1 (en) | 2007-06-29 | 2009-01-08 | Atheromed, Inc. | Atherectomy devices, systems, and methods |
US8100855B2 (en) | 2007-09-17 | 2012-01-24 | Abbott Cardiovascular Systems, Inc. | Methods and devices for eluting agents to a vessel |
US8236016B2 (en) | 2007-10-22 | 2012-08-07 | Atheromed, Inc. | Atherectomy devices and methods |
US20090163985A1 (en) * | 2007-12-19 | 2009-06-25 | Vipul Dave | Method of Retaining a Polymeric Stent on an Expansion Member |
US8162880B2 (en) | 2008-01-18 | 2012-04-24 | Swaminathan Jayaraman | Delivery of therapeutic and marking substance through intra lumen expansion of a delivery device |
WO2009111716A1 (en) | 2008-03-06 | 2009-09-11 | Boston Scientific Scimed, Inc. | Balloon catheter devices with sheath covering |
WO2009131911A2 (en) | 2008-04-22 | 2009-10-29 | Boston Scientific Scimed, Inc. | Medical devices having a coating of inorganic material |
US8668668B2 (en) | 2008-05-14 | 2014-03-11 | Onset Medical Corporation | Expandable iliac sheath and method of use |
US20100042199A1 (en) | 2008-08-18 | 2010-02-18 | Burton David G | Dilation balloon catheter and methods of use thereof |
US20100228333A1 (en) * | 2009-03-04 | 2010-09-09 | William Joseph Drasler | Drug eluting surface covering |
US20100233266A1 (en) | 2009-03-13 | 2010-09-16 | Cleek Robert L | Articles and methods of treating vascular conditions |
US8658707B2 (en) * | 2009-03-24 | 2014-02-25 | W. L. Gore & Associates, Inc. | Expandable functional TFE copolymer fine powder, the expanded functional products obtained therefrom and reaction of the expanded products |
WO2011028419A1 (en) | 2009-08-27 | 2011-03-10 | Boston Scientific Scimed, Inc. | Balloon catheter devices with drug-coated sheath |
US10034748B2 (en) | 2009-09-18 | 2018-07-31 | The Regents Of The University Of California | Endovascular prosthetic heart valve replacement |
US8167836B2 (en) * | 2009-12-08 | 2012-05-01 | Taris Biomedical, Inc. | Tissue expander configured for drug delivery |
WO2011097098A1 (en) | 2010-02-03 | 2011-08-11 | Boston Scientific Scimed, Inc. | A therapeutic balloon with systemic drug loss protection and controlled particle size release |
US20110301565A1 (en) | 2010-06-07 | 2011-12-08 | Boston Scientific Scimed, Inc. | Medical balloons having a sheath designed to facilitate release of therapeutic agent |
PL2600800T3 (pl) * | 2010-08-05 | 2021-04-06 | Taris Biomedical Llc | Urządzenie stentu moczowodowego do podawania leku i zestaw |
KR101879012B1 (ko) * | 2011-02-25 | 2018-07-16 | 마이크로벤션, 인코포레이티드 | 강화 풍선 카테터 |
US9415193B2 (en) * | 2011-03-04 | 2016-08-16 | W. L. Gore & Associates, Inc. | Eluting medical devices |
US9808605B2 (en) | 2011-10-06 | 2017-11-07 | W. L. Gore & Associates, Inc. | Controlled porosity devices for tissue treatments, methods of use, and methods of manufacture |
-
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CN104822397A (zh) | 2015-08-05 |
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CN104822397B (zh) | 2017-11-03 |
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BR112015004771A2 (pt) | 2017-07-04 |
ES2726815T3 (es) | 2019-10-09 |
US10173038B2 (en) | 2019-01-08 |
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Free format text: JAPANESE INTERMEDIATE CODE: R250 |