JP6530059B2 - ロピニロール含有貼付剤 - Google Patents
ロピニロール含有貼付剤 Download PDFInfo
- Publication number
- JP6530059B2 JP6530059B2 JP2017512595A JP2017512595A JP6530059B2 JP 6530059 B2 JP6530059 B2 JP 6530059B2 JP 2017512595 A JP2017512595 A JP 2017512595A JP 2017512595 A JP2017512595 A JP 2017512595A JP 6530059 B2 JP6530059 B2 JP 6530059B2
- Authority
- JP
- Japan
- Prior art keywords
- pressure
- sensitive adhesive
- patch
- organic amine
- ropinirole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229960001879 ropinirole Drugs 0.000 title claims description 29
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims description 90
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- 150000003839 salts Chemical class 0.000 claims description 26
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- 239000012790 adhesive layer Substances 0.000 claims description 10
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- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 6
- HXKKHQJGJAFBHI-UHFFFAOYSA-N 1-aminopropan-2-ol Chemical compound CC(O)CN HXKKHQJGJAFBHI-UHFFFAOYSA-N 0.000 claims description 5
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- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
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- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
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- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
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- KSCKTBJJRVPGKM-UHFFFAOYSA-N octan-1-olate;titanium(4+) Chemical compound [Ti+4].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-].CCCCCCCC[O-] KSCKTBJJRVPGKM-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- BNIXVQGCZULYKV-UHFFFAOYSA-N pentachloroethane Chemical compound ClC(Cl)C(Cl)(Cl)Cl BNIXVQGCZULYKV-UHFFFAOYSA-N 0.000 description 1
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- 229940026235 propylene glycol monolaurate Drugs 0.000 description 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 description 1
- 150000003230 pyrimidines Chemical class 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
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- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
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- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 description 1
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- 235000013769 triethyl citrate Nutrition 0.000 description 1
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- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
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- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
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- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
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- A61P25/00—Drugs for disorders of the nervous system
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Description
る。剥離ライナーとしては、シリコーンによる離型処理を施したポリエチレンテレフタレートフィルムが好ましい。
表1の記載にしたがい、比較例1及び実施例1〜5の貼付剤をそれぞれ調製した。具体的には、表1に記載の各成分を有機溶媒に溶解させて得られる溶液を、ポリエステル製の剥離ライナー上に塗布した後、乾燥することにより溶媒を除去して粘着剤層を得た。ここで、「SIS系粘着剤」とは、表2に記載の成分を混合して得られる組成物を意味する。次に、ポリエステルフィルム(支持体)を粘着剤層上に積層した後、適宜裁断して貼付剤を得た。なお、表1中の数値は質量%を意味する。すなわち、各実施例において、ロピニロール塩酸塩と有機アミンのモル比は、互いに同一である。
得られた貼付剤の粘着力を、プローブタック法(JIS Z0237:1991に記載の方法)に準じて、ステンレス製プローブ(5mmΦ)に対し、接触及び引き剥がし速さ120mm/分、接触荷重200gf/cm2、接触時間1秒の条件にて測定した。なお、測定は、各貼付剤に関して、貼付剤製造直後(保存前)と、60℃で2週間保存後(保存後)の2回行った。
引き剥がしに要した力を経時的に測定し、引き剥がしに要した力(単位:gf)を縦軸として、引き剥がしの開始点からの距離(引き剥がし距離)を横軸として、グラフ(粘着力曲線)を作成した。引き剥がしに要した力の最大値を、粘着力(単位:gf)として表3に記載した。
表4の記載にしたがい、実施例6の貼付剤を調製した。具体的には、表4に記載の各成分を有機溶媒に溶解させて得られる溶液を、ポリエステル製の剥離ライナー上に塗布した後、乾燥することにより溶媒を除去して粘着剤層を得た。次に、ポリエステルフィルム(支持体)を粘着剤層上に積層した後、適宜裁断して貼付剤を得た。シリコーン系粘着剤としてBIO−PSA 7−4302(ダウコーニング社製)を使用し、表4中の数値は固形分の質量を意味する。なお、表4中の数値は、特記しない限り、質量%を意味する。
表6の記載にしたがい、実施例7の貼付剤を調製した。具体的には、表6に記載の各成分を有機溶媒に溶解させて得られる溶液を、ポリエステル製の剥離ライナー上に塗布した後、乾燥することにより溶媒を除去して粘着剤層を得た。次に、ポリエステルフィルム(支持体)を粘着剤層上に積層した後、適宜裁断して貼付剤を得た。アクリル系粘着剤としてDuroTak 87−4098(Henkel社製)を使用し、表6中の数値は固形分の質量を意味する。なお、表6中の数値は、特記しない限り、質量%を意味する。
Claims (3)
- 支持体と、支持体上に積層された粘着剤層とを備え、
粘着剤層が、ロピニロール又はその薬学的に許容される塩と、有機アミン又はその酸付加塩と、粘着剤とを含み、
前記粘着剤が、ゴム系粘着剤、アクリル系粘着剤及びシリコーン系粘着剤からなる群から選択され、
前記粘着剤がシリコーン系粘着剤である場合に、前記有機アミンが、モノエタノールアミン、トリエタノールアミン、モノイソプロパノールアミン、エチレンジアミン、メグルミン及びトロメタモールからなる群から選択される少なくとも一つの有機アミンであり、
前記粘着剤がゴム系粘着剤又はアクリル系粘着剤である場合に、前記有機アミンが、式(2)で表される化合物である、貼付剤。
[式中、R1、R2及びR3は、それぞれ独立に、水素原子であるか、または、ヒドロキシ基もしくはアミノ基で置換されていてもよい炭素数が1〜12であるアルキル基であり、但し、R1、R2及びR3 の全てが水素原子である場合を除く。] - 前記粘着剤がゴム系粘着剤又はアクリル系粘着剤である場合における有機アミンが、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン、モノイソプロパノールアミン、ジイソプロパノールアミン及びエチレンジアミンからなる群から選択される少なくとも一つの有機アミンである、請求項1に記載の貼付剤。
- 前記ゴム系粘着剤が、スチレン−イソプレン−スチレンブロック共重合体を含む、請求項1又は2に記載の貼付剤。
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JP2008208076A (ja) * | 2007-02-27 | 2008-09-11 | Royal Kaken:Kk | 二重瞼形成剤 |
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KR101709361B1 (ko) * | 2009-05-21 | 2017-02-22 | 히사미쓰 세이야꾸 가부시키가이샤 | 경피 흡수 제제 |
KR101292768B1 (ko) * | 2010-04-23 | 2013-08-05 | 아이큐어 주식회사 | 경피 흡수 제제 |
EP2601944B1 (en) * | 2010-08-03 | 2021-02-17 | Hisamitsu Pharmaceutical Co., Inc. | Transdermal patch and method for augmenting adhesive strength thereof |
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EP2799066B1 (en) * | 2011-12-27 | 2021-01-20 | Teikoku Seiyaku Co., Ltd. | Tolterodine-containing adhesive patch |
JP6292768B2 (ja) | 2013-05-30 | 2018-03-14 | 帝國製薬株式会社 | 貼付剤及び貼付剤製品の製造方法 |
JP5415645B1 (ja) | 2013-06-28 | 2014-02-12 | 久光製薬株式会社 | 貼付剤の製造方法、貼付剤及び包装体 |
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CN107484412B (zh) | 2020-05-08 |
WO2016167345A1 (ja) | 2016-10-20 |
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ES2758350T3 (es) | 2020-05-05 |
US20180055783A1 (en) | 2018-03-01 |
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