JP6525877B2 - 反応チューブ - Google Patents

反応チューブ Download PDF

Info

Publication number
JP6525877B2
JP6525877B2 JP2015534674A JP2015534674A JP6525877B2 JP 6525877 B2 JP6525877 B2 JP 6525877B2 JP 2015534674 A JP2015534674 A JP 2015534674A JP 2015534674 A JP2015534674 A JP 2015534674A JP 6525877 B2 JP6525877 B2 JP 6525877B2
Authority
JP
Japan
Prior art keywords
fluid
chamber
well
reaction tube
planar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2015534674A
Other languages
English (en)
Japanese (ja)
Other versions
JP2015532094A5 (https=
JP2015532094A (ja
Inventor
ユ‐ミン チャン、
ユ‐ミン チャン、
ドグ ドリティ、
ドグ ドリティ、
ダスティン ディケンス、
ダスティン ディケンス、
ジェニファー グラス、
ジェニファー グラス、
アタ、 ロウエル ヴァン
アタ、 ロウエル ヴァン
Original Assignee
セフェィド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by セフェィド filed Critical セフェィド
Publication of JP2015532094A publication Critical patent/JP2015532094A/ja
Publication of JP2015532094A5 publication Critical patent/JP2015532094A5/ja
Application granted granted Critical
Publication of JP6525877B2 publication Critical patent/JP6525877B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0673—Handling of plugs of fluid surrounded by immiscible fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • B01L3/50851—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates specially adapted for heating or cooling samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Biomedical Technology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Food Science & Technology (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sustainable Development (AREA)
  • Cell Biology (AREA)
  • External Artificial Organs (AREA)
JP2015534674A 2012-09-26 2013-09-26 反応チューブ Active JP6525877B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261706115P 2012-09-26 2012-09-26
US61/706,115 2012-09-26
US13/843,739 2013-03-15
US13/843,739 US9914968B2 (en) 2012-09-26 2013-03-15 Honeycomb tube
PCT/US2013/062042 WO2014052671A1 (en) 2012-09-26 2013-09-26 Honeycomb tube

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019087554A Division JP2019141092A (ja) 2012-09-26 2019-05-07 ハニカムチューブ

Publications (3)

Publication Number Publication Date
JP2015532094A JP2015532094A (ja) 2015-11-09
JP2015532094A5 JP2015532094A5 (https=) 2016-11-17
JP6525877B2 true JP6525877B2 (ja) 2019-06-05

Family

ID=50339439

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2015534674A Active JP6525877B2 (ja) 2012-09-26 2013-09-26 反応チューブ
JP2019087554A Pending JP2019141092A (ja) 2012-09-26 2019-05-07 ハニカムチューブ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019087554A Pending JP2019141092A (ja) 2012-09-26 2019-05-07 ハニカムチューブ

Country Status (12)

Country Link
US (10) US9914968B2 (https=)
JP (2) JP6525877B2 (https=)
KR (1) KR102214419B1 (https=)
CN (2) CN111979092A (https=)
AP (1) AP2015008394A0 (https=)
AU (1) AU2013323428B2 (https=)
BR (1) BR112015006566B1 (https=)
CA (1) CA2886484C (https=)
EA (1) EA031989B1 (https=)
MX (1) MX363399B (https=)
WO (1) WO2014052671A1 (https=)
ZA (1) ZA201502463B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12203135B2 (en) 2012-09-26 2025-01-21 Cepheid Honeycomb tube

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013176767A1 (en) 2012-05-25 2013-11-28 The University Of North Carolina At Chapel Hill Microfluidic devices, solid supports for reagents and related methods
SG2012075792A (en) * 2012-10-09 2014-05-29 Jn Medsys Pte Ltd An improved device and method
CA2902735C (en) * 2013-03-15 2021-11-02 Cepheid Multi-chambered lid apparatus
WO2015069743A1 (en) * 2013-11-05 2015-05-14 Biofire Diagnostics, Llc Induction pcr
WO2016089477A1 (en) 2014-10-16 2016-06-09 Cepheid Biosecurity screening system and method
BR112017021256A2 (pt) * 2015-04-03 2018-06-26 Abbott Laboratories dispositivos e métodos para a análise de amostras
CN114272966B (zh) * 2015-07-22 2023-11-07 北卡罗来纳-查佩尔山大学 含有具有空间分离的珠保留和信号检测段的珠孔几何结构的流体装置和相关方法
US10797567B2 (en) 2015-07-23 2020-10-06 Life Technologies Corporation Rotor assembly including a housing for a sensor array component and methods for using same
EA039230B1 (ru) 2015-07-24 2021-12-21 Сифиид Система для выполнения молекулярных диагностических анализов
JP6808940B2 (ja) * 2016-01-29 2021-01-06 凸版印刷株式会社 アレイデバイス、生体分子解析用キット及び溶媒の封止方法
GB2554377A (en) * 2016-09-23 2018-04-04 Dnanudge Ltd Method and apparatus for analysing a biological sample
KR101997116B1 (ko) * 2016-10-14 2019-07-05 연세대학교 산학협력단 Kras 유전자에 상보적인 가이드 rna 및 이의 용도
CN210916083U (zh) * 2017-01-23 2020-07-03 长沙深宇生物科技有限公司 直接定量pcr装置
US11305282B2 (en) * 2017-03-29 2022-04-19 Cornell University Devices, processes, and systems for determination of nucleic acid sequence, expression, copy number, or methylation changes using combined nuclease, ligase, polymerase, and sequencing reactions
WO2018185871A1 (ja) * 2017-04-05 2018-10-11 株式会社日立ハイテクノロジーズ 核酸増幅方法および核酸解析用装置
WO2019131592A1 (ja) * 2017-12-26 2019-07-04 凸版印刷株式会社 標的分子の検出における偽陰性判定の発生を抑制する方法および検出デバイス
PL425106A1 (pl) 2018-03-30 2019-10-07 Bacteromic Spółka Z Ograniczoną Odpowiedzialnością Chip mikroprzepływowy
CN111218383B (zh) * 2018-11-26 2025-09-09 杭州比格飞序生物科技有限公司 一种核酸提取装置及其方法
WO2020126985A1 (en) * 2018-12-20 2020-06-25 Imec Vzw Addressable micro-reaction chamber array
US11976269B2 (en) * 2019-03-18 2024-05-07 Cellular Research, Inc. Precise delivery of components into fluids
MX2021011433A (es) 2019-03-21 2021-12-10 Sherlock Biosciences Inc Sistema.
JP7280101B2 (ja) * 2019-04-23 2023-05-23 株式会社日立製作所 測定セル製造方法、測定セル
EP3966346B1 (en) * 2019-05-08 2023-08-23 DNAe Diagnostics Limited Combined solution phase and solid phase dna amplification
CN113892035B (zh) * 2019-05-30 2025-05-09 凸版印刷株式会社 向孔中导入液体的方法
US11008627B2 (en) 2019-08-15 2021-05-18 Talis Biomedical Corporation Diagnostic system
AU2019467751B2 (en) * 2019-09-23 2025-09-04 Cepheid Multi-chambered lid apparatus with reagent port
US12054320B2 (en) 2019-09-23 2024-08-06 Cepheid Multi-chambered lid apparatus with reagent port
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
US11254979B2 (en) 2020-06-01 2022-02-22 Shaheen Innovations Holding Limited Systems and devices for infectious disease screening
CN111190021B (zh) * 2020-02-22 2023-08-11 武汉泰沃科技有限责任公司 一种生物样品处理盒
KR20230034987A (ko) 2020-06-01 2023-03-10 샤힌 이노베이션즈 홀딩 리미티드 감염증 스크리닝 장치
CA3180786A1 (en) 2020-06-01 2021-05-28 Imad Lahoud An infectious disease screening system
WO2022071716A1 (en) * 2020-09-29 2022-04-07 Seegene, Inc. Chamber for nucleic acid reaction, method for nucleic acid reaction using the same, and cartridge for sample processing comprising the same
KR20230129190A (ko) 2021-01-13 2023-09-06 세페이드 손실 메카트로닉스 시스템 및 추정 방법
WO2022246723A1 (zh) * 2021-05-27 2022-12-01 京东方科技集团股份有限公司 检测芯片及其制备方法和进样方法
KR20240033032A (ko) * 2021-07-09 2024-03-12 세페이드 높은 수준의 다중화 반응 용기, 시약 점적 장치 및 관련 방법
WO2023028044A1 (en) * 2021-08-25 2023-03-02 Entegris, Inc. Rigid frame bags
WO2024263523A1 (en) 2023-06-21 2024-12-26 Cepheid Real-time monitoring of liquid temperature

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US4988617A (en) 1988-03-25 1991-01-29 California Institute Of Technology Method of detecting a nucleotide change in nucleic acids
US5168038A (en) 1988-06-17 1992-12-01 The Board Of Trustees Of The Leland Stanford Junior University In situ transcription in cells and tissues
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
JPH03126208A (ja) 1989-10-11 1991-05-29 Nippon Chemicon Corp 電解コンデンサ用電解液
US5427930A (en) 1990-01-26 1995-06-27 Abbott Laboratories Amplification of target nucleic acids using gap filling ligase chain reaction
US5210015A (en) 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
SE9002579D0 (sv) * 1990-08-07 1990-08-07 Pharmacia Ab Method and apparatus for carrying out biochemical reactions
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
JP3080178B2 (ja) 1991-02-18 2000-08-21 東洋紡績株式会社 核酸配列の増幅方法およびそのための試薬キット
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
EP1033411B1 (en) 1996-06-04 2006-02-22 University of Utah Research Foundation Fluorescent donor-acceptor pair
GB9620934D0 (en) * 1996-10-08 1996-11-27 Molecular Drives Limited Multi-well containers
US6818185B1 (en) * 1999-05-28 2004-11-16 Cepheid Cartridge for conducting a chemical reaction
US6403037B1 (en) * 2000-02-04 2002-06-11 Cepheid Reaction vessel and temperature control system
CA2311622A1 (en) * 2000-06-15 2001-12-15 Moussa Hoummady Sub-nanoliter liquid drop dispensing system and method therefor
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US6716629B2 (en) 2000-10-10 2004-04-06 Biotrove, Inc. Apparatus for assay, synthesis and storage, and methods of manufacture, use, and manipulation thereof
US20080202927A1 (en) * 2000-11-03 2008-08-28 Clinical Micro Sensors, Inc. Devices and methods for biochip multiplexing
US8277753B2 (en) 2002-08-23 2012-10-02 Life Technologies Corporation Microfluidic transfer pin
GB0321158D0 (en) * 2003-09-10 2003-10-08 Central Research Lab Ltd Apparatus and method for handling cells,embryos or oocytes
CN1942590B (zh) 2004-02-18 2012-09-05 周小川 多元化学和生化反应的流体装置和方法
US7414118B1 (en) 2004-04-14 2008-08-19 Applied Biosystems Inc. Modified oligonucleotides and applications thereof
CA2570649A1 (en) 2004-06-07 2005-12-22 Strides Arcolab Limited Pharmaceutical composition containing a stable and clear solution of anti-inflammatory drug in soft gelatin capsule and process for producing the same
US7473533B2 (en) 2004-12-30 2009-01-06 Corning Incorporated Membrane arrays and methods of manufacture
GB2423710A (en) 2005-03-01 2006-09-06 Boots Healthcare Int Ltd Lozenge production process
EP1717585B1 (en) * 2005-04-28 2013-01-16 FUJIFILM Corporation Microchip and analysis method using the same
WO2007002588A2 (en) * 2005-06-23 2007-01-04 Applera Corporation Thermal-cycling pipette tip
WO2007043619A1 (ja) * 2005-10-13 2007-04-19 Nissui Pharmaceutical Co., Ltd. 試験デバイス
CA2620219A1 (en) 2005-11-02 2007-05-18 Teikoku Pharma Usa, Inc. Organoleptically acceptable ibuprofen oral dosage formulations, methods of making and using the same
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US8119352B2 (en) 2006-06-20 2012-02-21 Cepheld Multi-stage amplification reactions by control of sequence replication times
US8187557B2 (en) 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
JP3126208U (ja) * 2006-08-04 2006-10-19 株式会社島津製作所 示差屈折率検出器及び液体クロマトグラフ。
US20080108122A1 (en) 2006-09-01 2008-05-08 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Microchemical nanofactories
US20090093374A1 (en) * 2007-01-25 2009-04-09 Kahp-Yang Suh Method of arraying cells at single-cell level inside microfluidic channel and method of analysing cells using the same, and cell analysis chip used for carrying out the same
ES2453107T3 (es) 2007-06-11 2014-04-04 Wako Pure Chemical Industries, Ltd. Procedimiento de amplificación de ácidos nucleicos usando una PCR sobre microchip con detección integrada de CE en tiempo real
WO2009078812A1 (en) * 2007-12-17 2009-06-25 Hai-Qing Gong Microfluidic device
NL1036865C2 (en) 2009-04-16 2010-10-19 Maxi Miliaan Bv Child vehicle seat.
JP5881936B2 (ja) * 2009-04-20 2016-03-09 ソニー株式会社 試料溶液導入キット及び試料溶液注入器
WO2011063332A2 (en) * 2009-11-23 2011-05-26 3M Innovative Properties Company Microwell array articles and methods of use
DE102010041478A1 (de) 2010-09-27 2012-03-29 Zumtobel Lighting Gmbh Anordnung zur gerichteten Lichtabgabe
EP2441520A1 (en) 2010-10-12 2012-04-18 Eppendorf AG Real-time amplification and micro-array based detection of nucleic acid targets in a flow chip assay
US8968684B2 (en) * 2011-04-28 2015-03-03 Bin Lian Microplates, reaction modules and detection systems
US9095852B2 (en) * 2011-08-22 2015-08-04 The Regents Of The University Of California Multilayer high density microwells
GB201118774D0 (en) * 2011-10-31 2011-12-14 British American Tobacco Co Fluid distribution in an exposure device
US9808798B2 (en) * 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
US9914968B2 (en) 2012-09-26 2018-03-13 Cepheid Honeycomb tube
US10850278B2 (en) * 2014-01-29 2020-12-01 Arizona Board Of Regents On Behalf Of Arizona State University Microreactor array platform
WO2015143442A2 (en) * 2014-03-21 2015-09-24 The Trustees Of Columbia University In The City Of New York Methods and devices for selection and isolation of aptamers
AU2017338914B2 (en) * 2016-10-05 2023-07-13 Abbott Laboratories Devices and methods for sample analysis
CN111479928A (zh) * 2017-11-17 2020-07-31 凸版印刷株式会社 靶分子的检测方法
JP7694382B2 (ja) * 2019-05-21 2025-06-18 Ｔｏｐｐａｎホールディングス株式会社 標的分子の検出方法

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12203135B2 (en) 2012-09-26 2025-01-21 Cepheid Honeycomb tube

Also Published As

Publication number Publication date
EA031989B1 (ru) 2019-03-29
CN111979092A (zh) 2020-11-24
KR102214419B1 (ko) 2021-02-08
WO2014052671A1 (en) 2014-04-03
AP2015008394A0 (en) 2015-04-30
US20180245153A1 (en) 2018-08-30
US11795506B2 (en) 2023-10-24
AU2013323428B2 (en) 2017-11-30
ZA201502463B (en) 2019-09-25
JP2019141092A (ja) 2019-08-29
US10190165B2 (en) 2019-01-29
US20190211396A1 (en) 2019-07-11
BR112015006566B1 (pt) 2021-10-13
MX363399B (es) 2019-03-22
US20250243541A1 (en) 2025-07-31
BR112015006566A2 (pt) 2017-08-08
US9914968B2 (en) 2018-03-13
AU2013323428A1 (en) 2015-04-16
US20210147933A1 (en) 2021-05-20
US20240076737A1 (en) 2024-03-07
US12281358B2 (en) 2025-04-22
CA2886484A1 (en) 2014-04-03
US12203135B2 (en) 2025-01-21
US20240068030A1 (en) 2024-02-29
US11739383B2 (en) 2023-08-29
CN105051546A (zh) 2015-11-11
US20140087958A1 (en) 2014-03-27
US20250327123A1 (en) 2025-10-23
MX2015003859A (es) 2015-10-29
US20210164044A1 (en) 2021-06-03
CA2886484C (en) 2022-08-02
US10767226B2 (en) 2020-09-08
US20150275292A1 (en) 2015-10-01
EA201500369A1 (ru) 2015-08-31
JP2015532094A (ja) 2015-11-09
US10870884B2 (en) 2020-12-22
KR20150067222A (ko) 2015-06-17

Similar Documents

Publication Publication Date Title
JP6525877B2 (ja) 反応チューブ
CA2682761C (en) Methods for rapid multiplexed amplification of target nucleic acids
CN101679932A (zh) 用于热交换化学过程的基于数字微流体的装置
US20220032294A1 (en) System and self-metering cartridges for point of care bioassays
JP2006223309A (ja) 化学的な増幅反応のためのマクロ多孔質支持体及びその利用
Brennan et al. Incorporating asymmetric PCR and microarray hybridization protocols onto an integrated microfluidic device, screening for the Escherichia coli ssrA gene
US11898197B2 (en) System and self-metering cartridges for point of care bioassays
US20230043483A1 (en) High-level multiplexing reaction vessel, reagent spotting device and associated methods
US12428674B2 (en) System and self-metering cartridges for point of care bioassays

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20160926

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20160927

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20170704

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20171003

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171228

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180522

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20180821

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181122

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190402

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190507

R150 Certificate of patent or registration of utility model

Ref document number: 6525877

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250