JP6513729B2 - 同種異系移植片 - Google Patents
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- JP6513729B2 JP6513729B2 JP2017074729A JP2017074729A JP6513729B2 JP 6513729 B2 JP6513729 B2 JP 6513729B2 JP 2017074729 A JP2017074729 A JP 2017074729A JP 2017074729 A JP2017074729 A JP 2017074729A JP 6513729 B2 JP6513729 B2 JP 6513729B2
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Description
本出願は、2011年6月9日に出願された米国特許仮出願番号第61/495,342号に対する優先権を主張する。この出願は、その開示内容全体が参考として本明細書で援用される。
本発明の開発は、アメリカ国立衛生研究所によって授与された許可番号第R01CA138541号によって、また国立癌研究所によって授与された許可番号第R21CA149869号によって、一部支援を受けた。したがって、米国政府は本発明に一定の権利を有する可能性がある。
本発明は、同種異系移植片、ならびに細胞集団、ヒト生体試料におけるCD3 + Tリンパ球の増殖を阻害するための方法に関する。
移植片対宿主病(GVHD)は、アロ反応性Tリンパ球の免疫低下患者への移入から生じる、生命に関わる可能性がある臨床的合併症である。特に、GVHDの主原因の1つには、移植された生成物中に存在する成熟ドナーCD3+Tリンパ球の免疫低下レシピエントへの移入が含まれる。一旦注入されると、ドナーT細胞は宿主細胞性抗原を認識し、その結果、肝臓、胃腸管および皮膚にしばしば影響を及ぼす免疫反応カスケードが生じる(1、2)。
以下の実施例では、以下の材料および方法を使用した。
1.S.W.Choi,J.E.Levine,J.L.Ferrara,Immunol Allergy Clin North Am 30,75(Feb)
2.B.R.Blazar,R.Korngold,D.A.Vallera,Immunol Rev 157,79(Jun,1997)
3.S.Paczesny,S.W.Choi,J.L.Ferrara,Curr Opin Hematol 16,427(Nov,2009)
4.P.J.Martin et al.,Bone Marrow Transplant 3,445 Sep,1988)
5.M.Delain et al.,Leuk Lymphoma 11,359(Nov,1993)
6.M.M.Stanford et al.,Mol Ther 16,52(Jan,2008)
7.Y.Woo et al.,Ann Surg Oncol 15,2329(Aug,2008)
8.X.Q.Lun et al.,Cancer Res 67,8818(Sep 15,2007)
9.F.Fenner,F.N.Ratcliffe,Myxomatosis.(Cambridge University Press,Cambridge,UK,1965)
10.M.M.Stanford,G.McFadden,Expert Opin Biol Ther 7,1415(Sep,2007)
11.M.Kim et al.,Leukemia 23,2313(Dec,2009)
12.A.Gratwohl et al.,Bone Marrow Transplant 41,687(Apr,2008)
13.D.Gallardo et al.,Haematologica 94,1282(Sep,2009)
14.J.Tanaka,Rinsho Ketsueki 43,442(Jun,2002)
15.R.Ito et al.,Transplantation 87,1654(Jun 15,2009)
16.R.K.Burt et al.,J Autoimmun 30,116(May,2008)
17.C.Annaloro,F.Onida,G.Lambertenghi Deliliers,Expert Rev Hematol 2,699(Dec,2009)
18.B.Moss,in Fields Virology,D.M.K.a.P.M.Howley,Ed.(Lippincott,Williams&Wilkins,New York 2007),vol.2,pp.p.2849−2855
19.J.W.Hiemenz,Semin Hematol 46,289(Jul,2009)
20.G.Madlambayan et al.,Cancer Res Submitted,(2011)
21.J.B.Johnston et al.,J Virol 77,5877(May,2003)
Claims (10)
- ヒトの造血細胞と粘液腫ウイルスを含む同種異系移植片であって、
該同種異系移植片中のCD3+Tリンパ球の増殖を阻害するために有効な量のex vivoの粘液腫ウイルスで処理された、同種異系移植片。 - 前記同種異系移植片は、減少した量のTリンパ球を含むことを特徴とする請求項1に記載の同種異系移植片。
- ガンを治療する宿主対象に移植される同種異系移植片であって、
該同種異系移植片は、ヒトの造血細胞を含み、該同種異系移植片中のCD3 + Tリンパ球の増殖を阻害するために有効な量のex vivoの粘液腫ウイルスで処理されており、
該ウイルス処理された同種異系移植片は、化学療法、生物療法、免疫抑制または放射線治療の少なくとも1つが施された後の該宿主対象に移植される、同種異系移植片。 - 該ガンは、血液悪性腫瘍であることを特徴とする請求項3に記載の同種異系移植片。
- 該ウイルス処理された同種異系移植片は、ガンを治療する宿主対象に移植される請求項1に記載の同種異系移植片。
- ヒトの造血細胞と粘液腫ウイルスを含む同種異系移植片であって、
該同種異系移植片は、造血細胞を含む移植片を受ける対象におけるGVHDの治療または予防に用いるために、該移植片中のCD3+Tリンパ球の増殖を阻害し、該同種異系移植片を該対象に注入した後の該対象における移植片対宿主病(GVHD)を治療または予防するべく、有効な量のex vivoの粘液腫ウイルスと接触され、該ウイルス処理された同種異系移植片は、該対象に移植される、同種異系移植片。 - 該移植は、同種異系造血細胞移植、ドナー細胞注入、および支持的血液製剤の輸注からなる群から選択される技術を含むことを特徴とする請求項6に記載の同種異系移植片。
- 該移植片は、骨髄またはヒト末梢血細胞を含むことを特徴とする請求項1または6に記載の同種異系移植片。
- ヒト生体試料におけるCD3+Tリンパ球の増殖を阻害するための方法であって、
該ヒト生体試料における該CD3+Tリンパ球の増殖を阻害するために有効な量の粘液腫ウイルスと該生体試料を接触させることを含む、方法。 - 該ヒト生体試料は、骨髄試料および血液試料からなる群の少なくとも1つの構成要素を含む、
ことを特徴とする請求項9に記載の方法。
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