JP6506768B2 - 多重アプタマー標的の検出 - Google Patents
多重アプタマー標的の検出 Download PDFInfo
- Publication number
- JP6506768B2 JP6506768B2 JP2016544355A JP2016544355A JP6506768B2 JP 6506768 B2 JP6506768 B2 JP 6506768B2 JP 2016544355 A JP2016544355 A JP 2016544355A JP 2016544355 A JP2016544355 A JP 2016544355A JP 6506768 B2 JP6506768 B2 JP 6506768B2
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- deoxyuridine
- target
- complex
- carboxamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1048—SELEX
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C12N2320/13—Applications; Uses in screening processes in a process of directed evolution, e.g. SELEX, acquiring a new function
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/205—Aptamer
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361881629P | 2013-09-24 | 2013-09-24 | |
| US61/881,629 | 2013-09-24 | ||
| PCT/US2014/057143 WO2015048084A1 (en) | 2013-09-24 | 2014-09-24 | Multiaptamer target detection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531593A JP2016531593A (ja) | 2016-10-13 |
| JP2016531593A5 JP2016531593A5 (cg-RX-API-DMAC7.html) | 2017-11-02 |
| JP6506768B2 true JP6506768B2 (ja) | 2019-04-24 |
Family
ID=52744404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016544355A Active JP6506768B2 (ja) | 2013-09-24 | 2014-09-24 | 多重アプタマー標的の検出 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US9926566B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3049523B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6506768B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102348283B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN105555957A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2014326975B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112016005957A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2924987C (cg-RX-API-DMAC7.html) |
| HK (1) | HK1218765A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL244284B (cg-RX-API-DMAC7.html) |
| MX (1) | MX361451B (cg-RX-API-DMAC7.html) |
| SG (1) | SG11201602063UA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2015048084A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX361451B (es) | 2013-09-24 | 2018-12-06 | Somalogic Inc | Detección objetivo de múltiples aptámeros. |
| RU2708170C2 (ru) | 2014-11-24 | 2019-12-04 | Сомалоджик, Инк. | Соединения нуклеиновой кислоты для связывания ростового фактора дифференцировки 11 |
| WO2017100441A1 (en) * | 2015-12-08 | 2017-06-15 | Twinstrand Biosciences, Inc. | Improved adapters, methods, and compositions for duplex sequencing |
| TWI733772B (zh) | 2016-03-14 | 2021-07-21 | 美商身體邏輯股份有限公司 | 用於合成吲哚環核鹼基結合物之組成物及方法 |
| WO2017218881A1 (en) * | 2016-06-17 | 2017-12-21 | Proximity Biosciences, Llc | Method for aptamer pair selection |
| US10927380B2 (en) * | 2016-07-01 | 2021-02-23 | Somalogic, Inc. | Oligonucleotides comprising modified nucleosides |
| JP2020514746A (ja) | 2016-12-01 | 2020-05-21 | ノーティラス バイオテクノロジー インコーポレイテッド | タンパク質をアッセイする方法 |
| WO2019103131A1 (ja) * | 2017-11-24 | 2019-05-31 | 国立大学法人 東京大学 | アプタマーの結合部位判別方法、アプタマーペアおよび目的物質からなる三元錯体の解離定数等の測定方法並びに最適なアプタマーペアの選択方法 |
| CA3086915A1 (en) | 2017-12-29 | 2019-07-04 | Sujal M. Patel | Decoding approaches for protein identification |
| US20210247387A1 (en) * | 2018-06-22 | 2021-08-12 | Somalogic, Inc. | Improved proteomic multiplex assays |
| CA3182266A1 (en) | 2020-06-11 | 2021-12-16 | Vadim Lobanov | Methods and systems for computational decoding of biological, chemical, and physical entities |
| CA3203106A1 (en) | 2021-01-20 | 2022-07-28 | Parag Mallick | Systems and methods for biomolecule quantitation |
| US20220227890A1 (en) | 2021-01-21 | 2022-07-21 | Nautilus Biotechnology, Inc. | Systems and methods for biomolecule preparation |
| IL305336B2 (en) | 2021-03-11 | 2025-09-01 | Nautilus Subsidiary Inc | Systems and methods for preserving biomolecules |
| EP4399528A1 (en) | 2021-09-09 | 2024-07-17 | Nautilus Subsidiary, Inc. | Characterization and localization of protein modifications |
| EP4405683A1 (en) | 2021-09-22 | 2024-07-31 | Nautilus Subsidiary, Inc. | Methods and systems for determining polypeptide interactions |
| WO2023081728A1 (en) | 2021-11-03 | 2023-05-11 | Nautilus Biotechnology, Inc. | Systems and methods for surface structuring |
| EP4441503A1 (en) | 2021-11-30 | 2024-10-09 | Nautilus Subsidiary, Inc. | Particle-based isolation of proteins and other analytes |
| CA3245990A1 (en) | 2022-03-29 | 2023-10-05 | Nautilus Subsidiary, Inc. | INTEGRATED NETWORKS FOR SINGLE-ANALYTE PROCESSES |
| EP4515026A1 (en) | 2022-04-25 | 2025-03-05 | Nautilus Subsidiary, Inc. | Systems and methods for assessing and improving the quality of multiplex molecular assays |
| WO2023250364A1 (en) | 2022-06-21 | 2023-12-28 | Nautilus Subsidiary, Inc. | Method for detecting analytes at sites of optically non-resolvable distances |
| WO2024059655A1 (en) | 2022-09-15 | 2024-03-21 | Nautilus Subsidiary, Inc. | Characterizing accessibility of macromolecule structures |
| WO2024073599A1 (en) | 2022-09-29 | 2024-04-04 | Nautilus Subsidiary, Inc. | Preparation of array surfaces for single-analyte processes |
| US20240183858A1 (en) | 2022-11-15 | 2024-06-06 | Nautilus Subsidiary, Inc. | Standard polypeptides |
| US20240192202A1 (en) | 2022-12-09 | 2024-06-13 | Nautilus Subsidiary, Inc. | Fluidic media for single-analtye arrays |
| EP4634285A1 (en) | 2022-12-15 | 2025-10-22 | Nautilus Subsidiary, Inc. | Inhibition of photon phenomena on single molecule arrays |
| US20240241110A1 (en) | 2023-01-12 | 2024-07-18 | Nautilus Subsidiary, Inc. | Characterization of glycans and glycoconjugates |
| EP4689173A1 (en) | 2023-03-24 | 2026-02-11 | Nautilus Subsidiary, Inc. | Improved transfer of nanoparticles to array surfaces |
| WO2024216233A1 (en) | 2023-04-13 | 2024-10-17 | Nautilus Subsidiary, Inc. | Artificial proteins for displaying epitopes |
| US20240394902A1 (en) | 2023-05-24 | 2024-11-28 | Nautilus Subsidiary, Inc. | Systems and methods for machine vision |
| US20250189519A1 (en) | 2023-12-11 | 2025-06-12 | Nautilus Subsidiary, Inc. | Methods and compositions of particle-based arrays |
| US20250205706A1 (en) | 2023-12-20 | 2025-06-26 | Nautilus Subsidiary, Inc. | Fluidic devices for single-analyte assays |
| US20250298016A1 (en) | 2024-03-22 | 2025-09-25 | Nautilus Subsidiary, Inc. | Plasmonic particle systems for single-analyte assays |
| US20250305034A1 (en) | 2024-04-01 | 2025-10-02 | Nautilus Subsidiary, Inc. | Nanostructures for modulation of analyte conformation |
| WO2026073213A1 (en) * | 2024-09-30 | 2026-04-02 | Illumina, Inc. | Protein capture techniques with surface linked aptamers |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2001257091A1 (en) * | 2000-04-18 | 2001-10-30 | Gilead Sciences, Inc. | Aptamer based two-site binding assay |
| WO2002026932A2 (en) * | 2000-09-26 | 2002-04-04 | Duke University | Rna aptamers and methods for identifying the same |
| US20070071744A1 (en) * | 2002-06-07 | 2007-03-29 | Gotz Munch | Agents which bind to epitopes of glycoprotein VI |
| US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
| US7795009B2 (en) * | 2005-06-15 | 2010-09-14 | Saint Louis University | Three-component biosensors for detecting macromolecules and other analytes |
| US20100035247A1 (en) | 2005-11-04 | 2010-02-11 | U.S. Genomics, Inc. | Heterogeneous Assay of Analytes in Solution Using Polymers |
| US8658670B2 (en) | 2006-09-26 | 2014-02-25 | Crestone, Inc. | Methods and compounds for treatment of clostridium based infection |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| ES3045958T3 (en) * | 2007-07-17 | 2025-12-01 | Somalogic Operating Co Inc | Method for generating aptamers with improved off-rates |
| US20100239682A1 (en) | 2007-09-17 | 2010-09-23 | Antoine Andremont | Colonic delivery of antimicrobial agents |
| US8569252B2 (en) | 2009-04-15 | 2013-10-29 | Postech Academy-Industry Foundation | Nucleolin specific aptamer and use thereof |
| US20110256535A1 (en) | 2010-02-11 | 2011-10-20 | Intelligent Medical Devices, Inc. | Optimized oligonucleotides and methods of using same for the detection, isolation, amplification, quantification, monitoring, screening and sequencing of clostridium difficile genes encoding toxin b, and/or toxin a and/or binary toxin |
| GB201002627D0 (en) | 2010-02-16 | 2010-03-31 | Loxbridge Res Llp | Aptamer based analyte detection method |
| NZ602618A (en) * | 2010-04-12 | 2013-12-20 | Somalogic Inc | Aptamers to beta-ngf and their use in treating beta-ngf mediated diseases and disorders |
| US8785132B2 (en) * | 2010-04-23 | 2014-07-22 | Postech Academy-Industry Foundation | Aptamer sandwich assays |
| US20150031585A1 (en) | 2011-03-10 | 2015-01-29 | Somalogic, Inc. | Multiaptamer Target Detection |
| WO2012122540A1 (en) | 2011-03-10 | 2012-09-13 | Somalogic, Inc. | Aptamers for clostridium difficile diagnostics |
| AU2012249658A1 (en) * | 2011-04-26 | 2013-05-09 | Regado Biosciences, Inc. | A method for manufacturing pegylated oligonucleotides |
| KR102248900B1 (ko) | 2011-09-30 | 2021-05-07 | 소마로직, 인크. | 심혈관 위험 사건 예측 및 그것의 용도 |
| MX355567B (es) | 2011-12-30 | 2018-04-23 | Quest Diagnostics Invest Inc | Aptameros y metodos de diagnostico para detectar el receptor de egf. |
| MX361451B (es) | 2013-09-24 | 2018-12-06 | Somalogic Inc | Detección objetivo de múltiples aptámeros. |
-
2014
- 2014-09-24 MX MX2016003320A patent/MX361451B/es active IP Right Grant
- 2014-09-24 EP EP14847780.5A patent/EP3049523B1/en active Active
- 2014-09-24 CA CA2924987A patent/CA2924987C/en active Active
- 2014-09-24 JP JP2016544355A patent/JP6506768B2/ja active Active
- 2014-09-24 US US15/023,182 patent/US9926566B2/en active Active
- 2014-09-24 WO PCT/US2014/057143 patent/WO2015048084A1/en not_active Ceased
- 2014-09-24 HK HK16106780.3A patent/HK1218765A1/zh unknown
- 2014-09-24 CN CN201480051210.1A patent/CN105555957A/zh active Pending
- 2014-09-24 AU AU2014326975A patent/AU2014326975B2/en active Active
- 2014-09-24 CN CN202210264586.7A patent/CN114703193A/zh active Pending
- 2014-09-24 SG SG11201602063UA patent/SG11201602063UA/en unknown
- 2014-09-24 KR KR1020167006262A patent/KR102348283B1/ko active Active
- 2014-09-24 BR BR112016005957A patent/BR112016005957A2/pt not_active IP Right Cessation
-
2016
- 2016-02-25 IL IL244284A patent/IL244284B/en active IP Right Grant
-
2018
- 2018-02-13 US US15/895,723 patent/US10392621B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3049523A4 (en) | 2017-05-17 |
| MX361451B (es) | 2018-12-06 |
| CN105555957A (zh) | 2016-05-04 |
| JP2016531593A (ja) | 2016-10-13 |
| AU2014326975A2 (en) | 2017-01-05 |
| AU2014326975A1 (en) | 2016-04-07 |
| KR102348283B1 (ko) | 2022-01-10 |
| WO2015048084A1 (en) | 2015-04-02 |
| CA2924987C (en) | 2022-08-16 |
| SG11201602063UA (en) | 2016-04-28 |
| IL244284A0 (en) | 2016-04-21 |
| KR20160058777A (ko) | 2016-05-25 |
| US9926566B2 (en) | 2018-03-27 |
| HK1218765A1 (zh) | 2017-03-10 |
| US10392621B2 (en) | 2019-08-27 |
| CA2924987A1 (en) | 2015-04-02 |
| BR112016005957A2 (pt) | 2017-09-26 |
| EP3049523B1 (en) | 2019-08-07 |
| CN114703193A (zh) | 2022-07-05 |
| MX2016003320A (es) | 2016-05-31 |
| EP3049523A1 (en) | 2016-08-03 |
| US20180187197A1 (en) | 2018-07-05 |
| IL244284B (en) | 2019-12-31 |
| US20160237435A1 (en) | 2016-08-18 |
| AU2014326975B2 (en) | 2020-05-07 |
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