JP6502315B2 - 分解速度が調整可能なマグネシウム合金 - Google Patents
分解速度が調整可能なマグネシウム合金 Download PDFInfo
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- JP6502315B2 JP6502315B2 JP2016501134A JP2016501134A JP6502315B2 JP 6502315 B2 JP6502315 B2 JP 6502315B2 JP 2016501134 A JP2016501134 A JP 2016501134A JP 2016501134 A JP2016501134 A JP 2016501134A JP 6502315 B2 JP6502315 B2 JP 6502315B2
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- 229910000861 Mg alloy Inorganic materials 0.000 title description 17
- 238000000354 decomposition reaction Methods 0.000 title description 15
- 229910045601 alloy Inorganic materials 0.000 claims description 185
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- 239000007943 implant Substances 0.000 claims description 76
- 239000002244 precipitate Substances 0.000 claims description 70
- 229910052725 zinc Inorganic materials 0.000 claims description 53
- 229910052791 calcium Inorganic materials 0.000 claims description 41
- 238000000034 method Methods 0.000 claims description 41
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- 239000012535 impurity Substances 0.000 claims description 19
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- 238000000338 in vitro Methods 0.000 claims description 10
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- 238000005266 casting Methods 0.000 claims description 8
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- 229910052782 aluminium Inorganic materials 0.000 claims description 5
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- 229910052748 manganese Inorganic materials 0.000 claims description 5
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- 230000002526 effect on cardiovascular system Effects 0.000 claims description 4
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 11
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/84—Fasteners therefor or fasteners being internal fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/44—Joints for the spine, e.g. vertebrae, spinal discs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
- A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/58—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C23/00—Alloys based on magnesium
- C22C23/04—Alloys based on magnesium with zinc or cadmium as the next major constituent
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22F—CHANGING THE PHYSICAL STRUCTURE OF NON-FERROUS METALS AND NON-FERROUS ALLOYS
- C22F1/00—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working
- C22F1/06—Changing the physical structure of non-ferrous metals or alloys by heat treatment or by hot or cold working of magnesium or alloys based thereon
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Physics & Mathematics (AREA)
- Neurology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Thermal Sciences (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Materials For Medical Uses (AREA)
- Extrusion Of Metal (AREA)
- Powder Metallurgy (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361783554P | 2013-03-14 | 2013-03-14 | |
| US61/783,554 | 2013-03-14 | ||
| US201361909100P | 2013-11-26 | 2013-11-26 | |
| US61/909,100 | 2013-11-26 | ||
| US201461942951P | 2014-02-21 | 2014-02-21 | |
| US61/942,951 | 2014-02-21 | ||
| PCT/US2014/023047 WO2014159328A1 (en) | 2013-03-14 | 2014-03-11 | Magnesium alloy with adjustable degradation rate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018237050A Division JP6840716B2 (ja) | 2013-03-14 | 2018-12-19 | 分解速度が調整可能なマグネシウム合金 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016519209A JP2016519209A (ja) | 2016-06-30 |
| JP2016519209A5 JP2016519209A5 (enExample) | 2018-05-24 |
| JP6502315B2 true JP6502315B2 (ja) | 2019-04-17 |
Family
ID=50442663
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501134A Active JP6502315B2 (ja) | 2013-03-14 | 2014-03-11 | 分解速度が調整可能なマグネシウム合金 |
| JP2018237050A Expired - Fee Related JP6840716B2 (ja) | 2013-03-14 | 2018-12-19 | 分解速度が調整可能なマグネシウム合金 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018237050A Expired - Fee Related JP6840716B2 (ja) | 2013-03-14 | 2018-12-19 | 分解速度が調整可能なマグネシウム合金 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10478529B2 (enExample) |
| EP (1) | EP2971206A1 (enExample) |
| JP (2) | JP6502315B2 (enExample) |
| KR (1) | KR102253200B1 (enExample) |
| CN (1) | CN105143483B (enExample) |
| BR (1) | BR112015022632B1 (enExample) |
| CA (1) | CA2906419C (enExample) |
| WO (1) | WO2014159328A1 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014001321A1 (en) | 2012-06-26 | 2014-01-03 | Biotronik Ag | Magnesium-zinc-calcium alloy, method for production thereof, and use thereof |
| BR112014032649A2 (pt) | 2012-06-26 | 2017-06-27 | Biotronik Ag | liga de magnésio-zinco-cálcio, método de produção da mesma e seu uso |
| SG11201406024QA (en) | 2012-06-26 | 2014-10-30 | Biotronik Ag | Magnesium alloy, method for the production thereof and use thereof |
| RU2754035C2 (ru) | 2012-06-26 | 2021-08-25 | Биотроник Аг | Магниевый сплав, способ его производства и использования |
| US9469889B2 (en) | 2012-08-31 | 2016-10-18 | DePuy Synthes Products, Inc. | Ultrapure magnesium alloy with adjustable degradation rate |
| US9593397B2 (en) | 2013-03-14 | 2017-03-14 | DePuy Synthes Products, Inc. | Magnesium alloy with adjustable degradation rate |
| JP6502315B2 (ja) | 2013-03-14 | 2019-04-17 | デピュイ・シンセス・プロダクツ・インコーポレイテッド | 分解速度が調整可能なマグネシウム合金 |
| EP2857536B1 (de) | 2013-10-03 | 2015-12-30 | Annelie-Martina Weinberg | Implantat für Patienten im Wachstum, Verfahren zu dessen Herstellung und Verwendung |
| KR20170115429A (ko) * | 2016-04-07 | 2017-10-17 | 랩앤피플주식회사 | 생체분해성 금속을 이용한 마이크로 니들 |
| CN106498251B (zh) * | 2016-10-09 | 2018-04-27 | 北京工业大学 | 一种生物医用镁合金及其制备方法 |
| KR101888091B1 (ko) * | 2016-10-31 | 2018-08-14 | 유앤아이 주식회사 | 생체분해 마그네슘 합금 및 그 제조방법 |
| CN106676352B (zh) * | 2016-12-06 | 2019-05-24 | 湖南大学 | 一种低成本、高性能的高Ca/Al比Mg-XAl-YCa-ZZn合金及制备方法 |
| CN110191971A (zh) | 2017-01-10 | 2019-08-30 | 不二轻金属株式会社 | 镁合金 |
| JP6671731B2 (ja) | 2017-01-30 | 2020-03-25 | 株式会社 日本医療機器技研 | 高機能生体吸収性ステント |
| CN107198796B (zh) * | 2017-05-22 | 2020-08-25 | 北京科技大学 | 一种生物医用Zn-Mn-Cu系锌合金及其制备方法 |
| CN107523732B (zh) * | 2017-08-15 | 2019-04-05 | 太原科技大学 | 一种含Na快速降解镁合金及其制备方法 |
| WO2019164828A1 (en) * | 2018-02-20 | 2019-08-29 | Thixomat, Inc. | Improved magnesium alloy and process for making the same |
| CN111315420A (zh) | 2018-03-22 | 2020-06-19 | 株式会社日本医疗机器技研 | 生物可吸收支架 |
| CN108330368B (zh) * | 2018-03-30 | 2024-06-18 | 西安卓恰医疗器械有限公司 | 生物体植入物、其成分及制备方法 |
| KR102310566B1 (ko) * | 2018-05-21 | 2021-10-08 | 랩앤피플주식회사 | 여드름 완화 및 예방용 패치 |
| CN114686739A (zh) | 2018-07-09 | 2022-07-01 | 株式会社日本医疗机器技研 | 镁合金 |
| CN113260338A (zh) * | 2018-09-27 | 2021-08-13 | 汀布特Ip有限公司 | 椎间盘置换物及其制造方法 |
| CN109295365B (zh) * | 2018-10-23 | 2019-09-06 | 西安卓恰医疗器械有限公司 | 一种可降解镁合金成型胚料，其制备设备，制备方法及由该成型胚料制备的加压螺钉 |
| KR102157333B1 (ko) * | 2018-11-08 | 2020-09-17 | 포항공과대학교 산학협력단 | 마그네슘 합금의 처리방법 및 강소성 가공된 마그네슘 합금재 |
| KR102054191B1 (ko) * | 2019-09-26 | 2020-01-22 | 유앤아이 주식회사 | 생체분해성 금속 합금 |
| WO2020111854A1 (ko) * | 2018-11-30 | 2020-06-04 | 유앤아이 주식회사 | 생체분해성 금속 합금 |
| CN110106413B (zh) * | 2019-04-18 | 2021-06-04 | 北京大学 | Mg-Si-Ca-Zn系镁合金及其制备方法与应用 |
| WO2020247383A1 (en) | 2019-06-03 | 2020-12-10 | Fort Wayne Metals Research Products Corp | Magnesium-based absorbable alloys |
| WO2021040988A1 (en) * | 2019-08-26 | 2021-03-04 | Ohio State Innovation Foundation | Magnesium alloy based objects and methods of making and use thereof |
| CN110694121A (zh) * | 2019-10-22 | 2020-01-17 | 兰州理工大学 | 一种体内可降解镁合金吻合钉及其制备方法 |
| CN111939327B (zh) * | 2020-08-25 | 2022-06-03 | 南京工程学院 | 一种时空可控降解的覆膜金属材料及其制备方法 |
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| US10478529B2 (en) | 2019-11-19 |
| BR112015022632A2 (pt) | 2017-07-18 |
| CA2906419C (en) | 2021-07-06 |
| CN105143483B (zh) | 2017-11-10 |
| WO2014159328A1 (en) | 2014-10-02 |
| JP2016519209A (ja) | 2016-06-30 |
| KR20150130488A (ko) | 2015-11-23 |
| CN105143483A (zh) | 2015-12-09 |
| KR102253200B1 (ko) | 2021-05-21 |
| BR112015022632B1 (pt) | 2020-01-07 |
| EP2971206A1 (en) | 2016-01-20 |
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