JP6492236B1 - 血清尿酸値低減用組成物 - Google Patents
血清尿酸値低減用組成物 Download PDFInfo
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- JP6492236B1 JP6492236B1 JP2019502102A JP2019502102A JP6492236B1 JP 6492236 B1 JP6492236 B1 JP 6492236B1 JP 2019502102 A JP2019502102 A JP 2019502102A JP 2019502102 A JP2019502102 A JP 2019502102A JP 6492236 B1 JP6492236 B1 JP 6492236B1
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- Prior art keywords
- composition
- uric acid
- glycine
- tryptophan
- serum uric
- Prior art date
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Abstract
Description
血清尿酸値低減用組成物は、グリシンとトリプトファンとを有効成分として含み、必要に応じて他の成分をさらに含んでいてもよい。グリシンが血清尿酸値の低減作用を有することは知られているが、さらにトリプトファンを併用することで血清尿酸値の低減作用が相乗的に向上する。
組成物は、血清尿酸値低減によって病態が改善される疾患の予防及び/又は治療用の医薬組成物として用いることができる。かかる疾患としては、例えば、痛風、高尿酸血症、痛風結節、尿路結石(腎結石、尿管結石、膀胱結石)、腎不全、痛風腎、前立腺肥大、浮腫などが挙げられる。組成物は上記疾患の発症を抑制する予防薬として、及び/又は、正常な状態に改善する治療薬としても機能し得る。
飲食品は、上述したグリシン及びトリプトファンを含む血清尿酸値低減用の組成物を含む。飲食品を摂取することで、上述した組成物の効果を得ることができる。本発明の血清尿酸値低減用組成物を含有する飲食品には、健康飲食品、機能性飲食品、病者用飲食品などの他、上記血清尿酸値低減用組成物を配合できる全ての飲食品が含まれる。なかでも、機能性飲食品はとりわけ好ましい。「機能性飲食品」は、生体に対して一定の機能性を有する飲食品を意味し、例えば、特定保健用飲食品(条件付きトクホ[特定保健用食品]を含む)及び栄養機能飲食品を含む保健機能飲食品、特別用途飲食品、栄養補助飲食品、健康補助飲食品、サプリメント(例えば、錠剤、被覆錠、糖衣錠、カプセル及び液剤などの各種剤形のもの)及び美容飲食品(例えばダイエット飲食品)などのいわゆる健康飲食品全般を包含する。機能性飲食品はまた、コーデックス(FAO/WHO合同食品規格委員会)の食品規格に基づく健康強調表示(Health claim)が適用される健康飲食品を包含する。
アルデヒド、ターピネオール、δ−デカラクトン、デカナール、ノナナール、γ―ノナラクトン、バニリン、フェニルエチルアルコール、フラネオール、フルフリルメルカプタン、2−ヘキセナール、3−ヘキセノール、ヘリオトロピン、ペリラアルデヒド、ベンズアルデヒド、マルトール、メチルアンスラニレート、メチルサリシレート、メントール、α−ヨノン、リナロール等が挙げられる。
健康な成人男女を被験者として、書面でのインフォームドコンセントに同意を得た後に試験を実施した。対照としての難溶性デキストリン6g(n=7;Cont)、グリシン6g(n=7;Gly)、グリシン6gとトリプトファン0.1gを含む組成物(n=5;GlyTrp01)、グリシン6gとトリプトファン0.2gを含む組成物(n=7;GlyTrp02)、又はグリシン6gとトリプトファン0.4gを含む組成物(n=7;GlyTrp04)のいずれかを経口投与し、その30分後に甲類焼酎をアルコール量0.32g/kgで摂取させた。組成物の摂取前、摂取から60分後、120分後、及び180分後に採血して、血清中の尿酸濃度(mg/dl)を測定した。測定結果を表1に示す。また表1には血清中の尿酸濃度の経時変化として、組成物の摂取前(0)と各経過時間との測定値間における有意差についてt検定における確率(p値)を示す。
血清尿酸値が高め(7.1mg/dl以上)の高尿酸血症者を被験者として、書面でのインフォームドコンセントに同意を得た後に試験を実施した。対照群にはグリシン3g(n=4)を、組成物摂取群にはグリシン3gとトリプトファン0.2gを含む組成物(n=4)を、それぞれ8週間に渡って毎日摂取させた。摂取開始前と8週間摂取後に血清中の尿酸値を測定した。結果を表2に示す。なお、有意差検定は符号検定により実施した。
Claims (5)
- グリシン及びトリプトファンを含む血清尿酸値低減用の組成物。
- グリシンに対するトリプトファンの含有比が重量基準で0.01以上0.15以下である請求項1に記載の組成物。
- グリシンの摂取量が1回当たり1g以上10g以下である請求項1又は2に記載の組成物。
- 請求項1から3のいずれか1項に記載の組成物を含む血清尿酸値低減用飲食品。
- 請求項1から3のいずれか1項に記載の組成物を含む血清尿酸値低減剤。
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