JP6491228B2 - HTLVキャプシド抗原p24の可溶性かつ免疫反応性バリアント - Google Patents

HTLVキャプシド抗原p24の可溶性かつ免疫反応性バリアント Download PDF

Info

Publication number
JP6491228B2
JP6491228B2 JP2016553811A JP2016553811A JP6491228B2 JP 6491228 B2 JP6491228 B2 JP 6491228B2 JP 2016553811 A JP2016553811 A JP 2016553811A JP 2016553811 A JP2016553811 A JP 2016553811A JP 6491228 B2 JP6491228 B2 JP 6491228B2
Authority
JP
Japan
Prior art keywords
htlv
antigen
seq
protein
skp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016553811A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017512200A5 (enExample
JP2017512200A (ja
Inventor
ファーツ,エルケ
ショルツ,クリスティアン
ムエンフ,ペーター
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JP2017512200A publication Critical patent/JP2017512200A/ja
Publication of JP2017512200A5 publication Critical patent/JP2017512200A5/ja
Application granted granted Critical
Publication of JP6491228B2 publication Critical patent/JP6491228B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • G01N33/56988HIV or HTLV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983Viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/35Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/14011Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/14011Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14031Uses of virus other than therapeutic or vaccine, e.g. disinfectant
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/14011Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14051Methods of production or purification of viral material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08RNA viruses
    • G01N2333/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00Immunoassays for the detection of microorganisms
    • G01N2469/20Detection of antibodies in sample from host which are directed against antigens from microorganisms
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016553811A 2014-02-28 2015-02-26 HTLVキャプシド抗原p24の可溶性かつ免疫反応性バリアント Active JP6491228B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157165.3 2014-02-28
EP14157165.3A EP2913338A1 (en) 2014-02-28 2014-02-28 Soluable and immunoreactive variants of HTLV capsid antigen p24
PCT/EP2015/053966 WO2015128394A2 (en) 2014-02-28 2015-02-26 Soluble and immunoreactive variants of htlv capsid antigen p24

Publications (3)

Publication Number Publication Date
JP2017512200A JP2017512200A (ja) 2017-05-18
JP2017512200A5 JP2017512200A5 (enExample) 2017-10-26
JP6491228B2 true JP6491228B2 (ja) 2019-03-27

Family

ID=50184798

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016553811A Active JP6491228B2 (ja) 2014-02-28 2015-02-26 HTLVキャプシド抗原p24の可溶性かつ免疫反応性バリアント

Country Status (7)

Country Link
US (2) US10466242B2 (enExample)
EP (2) EP2913338A1 (enExample)
JP (1) JP6491228B2 (enExample)
CN (1) CN106029687B (enExample)
CA (1) CA2938712C (enExample)
ES (1) ES2662611T3 (enExample)
WO (1) WO2015128394A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108780092A (zh) 2016-03-07 2018-11-09 豪夫迈·罗氏有限公司 抗p53抗体的检测
WO2019164402A1 (en) * 2018-02-26 2019-08-29 Technische Universiteit Eindhoven Bioluminescent biosensor for detecting and quantifying biomolecules
JP2023522278A (ja) * 2020-04-23 2023-05-29 エフ. ホフマン-ラ ロシュ アーゲー 抗体-免疫アッセイでの使用のためのコロナヌクレオカプシド抗原

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2564268B2 (ja) * 1985-08-28 1996-12-18 協和醗酵工業株式会社 融合抗原ポリペプチド
NZ238855A (en) 1990-07-18 1994-03-25 Iaf Biochem Int Peptides, mixtures thereof and compositions useful for detecting htlv-i and htlv-ii infections
CA2117378C (en) * 1992-02-24 2003-04-15 Steven K. H. Foung Htlv-i/htlv-ii assay and method
CA2223235A1 (en) * 1995-06-05 1996-12-12 Abbott Laboratories Detection of htlv antibodies utilizing recombinant proteins
AU736670B2 (en) 1996-09-26 2001-08-02 Medical Research Council Chaperone fragments
JP2000078973A (ja) * 1998-09-03 2000-03-21 Tonen Corp Htlv−i組換え抗原
PL354122A1 (en) * 1999-08-09 2003-12-29 Tripep Abtripep Ab Pharmaceutical compositions containing tripeptides
US6258932B1 (en) * 1999-08-09 2001-07-10 Tripep Ab Peptides that block viral infectivity and methods of use thereof
PL215170B1 (pl) 2001-06-22 2013-10-31 Hoffmann La Roche Sposób wytwarzania rozpuszczalnego kompleksu zawierajacego amyloidogenne bialko docelowe oraz bialko opiekuncze z klasy izomeraz peptydyloprolilowych
DK2112158T3 (da) * 2007-04-20 2012-01-23 Hoffmann La Roche Påvisning af primære infektioner med patogener
EP2127678A1 (en) * 2008-05-26 2009-12-02 Roche Diagnostics GmbH SlpA as a tool for recombinant protein and enzyme technology

Also Published As

Publication number Publication date
US10466242B2 (en) 2019-11-05
EP3110831B1 (en) 2018-01-10
WO2015128394A2 (en) 2015-09-03
US20200033342A1 (en) 2020-01-30
CA2938712C (en) 2018-10-23
JP2017512200A (ja) 2017-05-18
CA2938712A1 (en) 2015-09-03
EP2913338A1 (en) 2015-09-02
CN106029687B (zh) 2020-07-31
CN106029687A (zh) 2016-10-12
EP3110831A2 (en) 2017-01-04
WO2015128394A3 (en) 2015-11-05
US11567079B2 (en) 2023-01-31
US20170184591A1 (en) 2017-06-29
ES2662611T3 (es) 2018-04-09

Similar Documents

Publication Publication Date Title
CN104080801B (zh) 可溶的免疫反应性的苍白密螺旋体TpN47抗原
CN101939330B (zh) 新型风疹e1包膜蛋白变体及其在检测抗风疹抗体中的用途
US11567079B2 (en) Soluble and immunoreactive variants of HTLV capsid antigen P24
JP6285934B2 (ja) イムノアッセイの干渉の低減、及び安定化のためのシャペロン−シャペロン融合ポリペプチド
JP6374720B2 (ja) 抗トレポネーマ属(Treponema)抗体の検出のためのTpN17に基づくイムノアッセイにおける、抗干渉添加剤としてのコレラ菌(Vibriocholerae)リポタンパク質15(Lp15)変異体
HK1229824B (zh) Htlv衣壳抗原p24的可溶性和免疫反应性变体
HK1229824A1 (en) Soluble and immunoreactive variants of htlv capsid antigen p24
HK1201919B (zh) Vclp15变体在基於tpn17的检测抗密螺旋体抗体的免疫测定中作为抗干扰添加剂
HK1209784B (en) Chaperone-chaperone fusion polypeptides for reduction of interference and stabilization of immunoassays

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170912

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20170912

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20180724

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180731

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180911

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20190130

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20190228

R150 Certificate of patent or registration of utility model

Ref document number: 6491228

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250