JP6484178B2 - 生物活性剤の細胞標的の捕捉のための組成物および方法 - Google Patents

生物活性剤の細胞標的の捕捉のための組成物および方法 Download PDF

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JP6484178B2
JP6484178B2 JP2015547559A JP2015547559A JP6484178B2 JP 6484178 B2 JP6484178 B2 JP 6484178B2 JP 2015547559 A JP2015547559 A JP 2015547559A JP 2015547559 A JP2015547559 A JP 2015547559A JP 6484178 B2 JP6484178 B2 JP 6484178B2
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capture
protein
bioactive agent
ligand
cellular target
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JP2016502843A5 (OSRAM
JP2016502843A (ja
Inventor
カロリン ダブリュ ヒトコ
カロリン ダブリュ ヒトコ
ロビン ハースト
ロビン ハースト
トーマス カークランド
トーマス カークランド
ディーター クラウベルト
ディーター クラウベルト
ポンチョ マイセンハイマー
ポンチョ マイセンハイマー
ニディー ナス
ニディー ナス
ラチェル エフ オハナ
ラチェル エフ オハナ
ポール オットー
ポール オットー
マルジェタ ウラー
マルジェタ ウラー
ハリー テツオ ウエダ
ハリー テツオ ウエダ
キース ウッド
キース ウッド
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Promega Corp
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Promega Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54306—Solid-phase reaction mechanisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G01N33/54333—Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2015547559A 2012-12-12 2013-12-12 生物活性剤の細胞標的の捕捉のための組成物および方法 Active JP6484178B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261736426P 2012-12-12 2012-12-12
US61/736,426 2012-12-12
US201361788313P 2013-03-15 2013-03-15
US61/788,313 2013-03-15
PCT/US2013/074756 WO2014093671A1 (en) 2012-12-12 2013-12-12 Compositions and methods for capture of cellular targets of bioactive agents

Related Child Applications (1)

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JP2019025449A Division JP6999589B2 (ja) 2012-12-12 2019-02-15 生物活性剤の細胞標的の捕捉のための組成物および方法

Publications (3)

Publication Number Publication Date
JP2016502843A JP2016502843A (ja) 2016-02-01
JP2016502843A5 JP2016502843A5 (OSRAM) 2019-02-07
JP6484178B2 true JP6484178B2 (ja) 2019-03-13

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JP2015547559A Active JP6484178B2 (ja) 2012-12-12 2013-12-12 生物活性剤の細胞標的の捕捉のための組成物および方法
JP2019025449A Active JP6999589B2 (ja) 2012-12-12 2019-02-15 生物活性剤の細胞標的の捕捉のための組成物および方法

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Country Link
US (2) US9551705B2 (OSRAM)
EP (1) EP2931305B1 (OSRAM)
JP (2) JP6484178B2 (OSRAM)
KR (2) KR102272233B1 (OSRAM)
CN (1) CN104853767B (OSRAM)
AU (2) AU2013359160B2 (OSRAM)
BR (1) BR112015013715A2 (OSRAM)
CA (1) CA2894432C (OSRAM)
IL (1) IL239213B (OSRAM)
SG (1) SG11201504520XA (OSRAM)
WO (1) WO2014093671A1 (OSRAM)

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CN102652175B (zh) 2009-12-09 2016-02-10 宝洁公司 织物和家居护理产品
JP6522339B2 (ja) * 2011-11-21 2019-05-29 プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ カルボキシｘローダミン類似体
KR102272233B1 (ko) 2012-12-12 2021-07-01 프로메가 코포레이션 생체활성 제제의 세포 표적 포획을 위한 조성물 및 방법
US10168323B2 (en) 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
WO2014151282A1 (en) 2013-03-15 2014-09-25 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
EP3304078B1 (en) 2015-06-05 2022-08-31 Promega Corporation Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements
US10458988B2 (en) * 2017-03-03 2019-10-29 Musc Foundation For Research Development Biotinylated luminescent probe
US12181452B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US12180581B2 (en) 2017-09-18 2024-12-31 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
US11709156B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved analytical analysis
US11709155B2 (en) 2017-09-18 2023-07-25 Waters Technologies Corporation Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
JP7584433B2 (ja) 2019-03-20 2024-11-15 プロメガ コーポレイション 光親和性プローブ
US11918936B2 (en) 2020-01-17 2024-03-05 Waters Technologies Corporation Performance and dynamic range for oligonucleotide bioanalysis through reduction of non specific binding
EP4217730B1 (en) 2020-09-24 2025-08-20 Waters Technologies Corporation Chromatographic hardware improvements for the separation of reactive molecules
JP2022182394A (ja) * 2021-05-28 2022-12-08 独立行政法人国立病院機構 抗原固相化デバイス
WO2023287984A1 (en) * 2021-07-14 2023-01-19 University Of Maryland, Baltimore Suberoylanilide hydroxamic acid (saha) drugs, conjugates, and nanoparticles, and methods of use thereof

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US5914095A (en) 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
EP0575955B1 (en) 1992-06-22 1999-09-15 Kyowa Hakko Kogyo Co., Ltd. Process for producing staurosporine derivatives
AU5323794A (en) 1992-10-14 1994-05-09 Sterling Winthrop Inc. Chelating polymers
US5756688A (en) 1992-10-14 1998-05-26 Sterling Winthrop Inc. MR imaging compositions and methods
GB9503969D0 (en) 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
AU2001229741A1 (en) 2000-01-24 2001-07-31 The Trustees Of Columbia University In The City Of New York An in vivo screen using chemical inducers of dimerization
US20020168737A1 (en) 2001-01-24 2002-11-14 Cornish Virginia W. Binding and catalysis screen for high throughput determination of protein function using chemical inducers of dimerization
PT2357006E (pt) 2002-07-31 2016-01-22 Seattle Genetics Inc Conjugados de fármacos e sua utilização para tratamento do cancro, de uma doença autoimune ou de uma doença infeciosa
AU2004211584B2 (en) 2003-01-31 2009-11-12 Promega Corporation Covalent tethering of functional groups to proteins
US7429472B2 (en) 2003-01-31 2008-09-30 Promega Corporation Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule
KR100507796B1 (ko) 2003-04-03 2005-08-17 한미약품 주식회사 생체내 반감기가 증가된 ｐｅｇ-생리활성 폴리펩티드 동종이량체 결합체 및 이의 제조방법
US7425436B2 (en) 2004-07-30 2008-09-16 Promega Corporation Covalent tethering of functional groups to proteins and substrates therefor
US20070224620A1 (en) * 2006-02-08 2007-09-27 Promega Corporation Compositions and methods for capturing and analyzing cross-linked biomolecules
JP5420198B2 (ja) * 2008-06-16 2014-02-19 オリンパス株式会社 タンパク質相互作用解析方法、ポリヌクレオチド、および、組成物
KR100891456B1 (ko) 2008-11-06 2009-04-01 씨지케이 주식회사 생리활성물질에 대한 세포내 표적물질을 검출하는 방법 및 장치
SG10201901453PA (en) 2009-05-01 2019-03-28 Promega Corp Synthetic oplophorus luciferases with enhanced light output
BR112013010855A2 (pt) 2010-11-02 2017-06-27 Promega Corp luciferases derivadas de oplophorus, novos substratos de coelenterazina e métodos de uso
KR102272233B1 (ko) * 2012-12-12 2021-07-01 프로메가 코포레이션 생체활성 제제의 세포 표적 포획을 위한 조성물 및 방법
WO2014151282A1 (en) * 2013-03-15 2014-09-25 Promega Corporation Substrates for covalent tethering of proteins to functional groups or solid surfaces
US10168323B2 (en) * 2013-03-15 2019-01-01 Promega Corporation Compositions and methods for capture of cellular targets of bioactive agents
EP3304078B1 (en) * 2015-06-05 2022-08-31 Promega Corporation Cell-permeable, cell-compatible, and cleavable linkers for covalent tethering of functional elements

Also Published As

Publication number Publication date
US9551705B2 (en) 2017-01-24
CN104853767A (zh) 2015-08-19
EP2931305A1 (en) 2015-10-21
AU2013359160B2 (en) 2018-11-15
KR102272233B1 (ko) 2021-07-01
US10976312B2 (en) 2021-04-13
EP2931305B1 (en) 2018-11-28
SG11201504520XA (en) 2015-07-30
BR112015013715A2 (pt) 2017-09-26
KR102227321B1 (ko) 2021-03-12
IL239213A0 (en) 2015-07-30
JP2019092517A (ja) 2019-06-20
AU2019201035B9 (en) 2021-02-11
AU2013359160A1 (en) 2015-07-09
EP2931305A4 (en) 2016-08-17
CA2894432A1 (en) 2014-06-19
CA2894432C (en) 2022-06-07
AU2019201035B2 (en) 2020-09-03
KR20200103867A (ko) 2020-09-02
WO2014093671A1 (en) 2014-06-19
JP6999589B2 (ja) 2022-02-04
AU2013359160A2 (en) 2015-11-12
CN104853767B (zh) 2017-04-05
US20170115283A1 (en) 2017-04-27
US20140199712A1 (en) 2014-07-17
IL239213B (en) 2020-03-31
KR20150093222A (ko) 2015-08-17
AU2019201035A1 (en) 2019-03-07
JP2016502843A (ja) 2016-02-01

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